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Protein kinase C theta Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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N2-(2-Chlorobenzyl)-N4-((4-(aminomethyl)cyclohexyl)methyl)-5-nitropyrimidine-2,4-diamineIC5018.0 [1], 29.0 [2], 46.0 [3], 290.0 [4], 630.0 [5]
SotrastaurinIC501.0 [1], 81.0 [2]
Indolactam VKi8.7 [1]
5-(3,4-Dimethoxyphenyl)-4-(1H-indol-5-ylamino)nicotinonitrileIC5070.0 [1], 150.0 [2]
5-(3,4-Dimethoxyphenyl)-4-(1H-indol-5-ylamino)nicotinonitrileKi79.0 [1]
4-[(3-Bromophenyl)amino]-5-(3,4-dimethoxyphenyl)nicotinonitrileIC50150.0 [1], 4600.0 [2]
4-[(3-Bromophenyl)amino]-5-(3,4-dimethoxyphenyl)nicotinonitrileKi4900.0 [1]
2-[3-[(Dimethylamino)methyl]phenyl]-4-[(4-methyl-1H-indol-5-yl)amino]thieno[2,3-b]pyridine-5-carbonitrileIC507.5 [1], 230.0 [2]
2-[3-[(Dimethylamino)methyl]phenyl]-4-[(4-methyl-1H-indol-5-yl)amino]thieno[2,3-b]pyridine-5-carbonitrileKi9.0 [1]
(2R)-2-[(2S)-4-[3-Chloro-5-fluoro-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-olIC5011.0 [1]
(2R)-2-[(2S)-4-[3-Chloro-5-fluoro-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-olKi0.08 [1]
CID 76285722IC5023.0 [1]
8-Octyl-benzolactam-V9Ki290.0 [1]
4-(4-Methyl-1H-indol-5-ylamino)-5-(4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)nicotinonitrileIC507.4 [1]
(1S,3R,5R,9R,13R)-9-(Hydroxymethyl)-3-[4-(3-hydroxyphenyl)butyl]-16,16-dimethyl-2,6,10,17-tetraoxatricyclo[11.3.1.11,5]octadecane-7,11-dioneKi4.0 [1]
N'-(3-Pyridin-4-yl-2,6-naphthyridin-1-yl)ethane-1,2-diamineIC5077.0 [1]
2,2-Dimethyl-7-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)-1-[(1R)-1-phenylethyl]-3H-quinazolin-4-oneIC500.25 [1], 11.0 [2]
8-Decyl-5-hydroxymethyl-2-isopropyl-1-methyl-1,2,5,6-tetrahydro-benzo[e][1,4]oxazocin-3-oneKi1097.0 [1], 1100.0 [2]
5-(3,4-Dimethoxyphenyl)-4-(1H-indol-6-ylamino)pyridine-3-carbonitrileIC502000.0 [1], 2300.0 [2]
5-(3,4-Dimethoxyphenyl)-4-(1H-indol-4-ylamino)pyridine-3-carbonitrileIC5013.0 [1]
(2-Aminopyridine-3-yl)(6-(1,4-diazepan-1-yl)pyridine-2-yl)methanoneKi164.0 [1]
2-Methyl-N~1~-[3-(Pyridin-4-Yl)-2,6-Naphthyridin-1-Yl]propane-1,2-DiamineIC50141.0 [1]
3,5-Dihydro[1,2,4]triazino[3,4-C][1,4]benzoxazin-2(1h)-OneIC5019000.0 [1], 453000.0 [2]
3-(1H-Indol-3-yl)-4-[3-(4-methylpiperazin-1-yl)naphthalen-1-yl]pyrrole-2,5-dioneIC504.8 [1]
4-(1H-Indol-5-ylamino)-2-phenylthieno[2,3-b]pyridine-5-carbonitrileIC5052.0 [1], 460.0 [2]
4-(4-Methyl-1H-indol-5-ylamino)-5-(4-(2-(4-methylpiperazin-1-yl)ethoxy)styryl)nicotinonitrileIC503.6 [1]
(2-Aminopyridin-3-yl)-(6-piperazin-1-ylpyridin-2-yl)methanoneKi32.0 [1]
3-(2-Chloro-6-dimethylaminomethyl-naphthalen-1-yl)-4-(1-methyl-1H-indol-3-yl)-pyrrole-2,5-dioneIC5019.0 [1], 185.0 [2]
3-[2-Chloro-7-[(dimethylamino)methyl]naphthalen-1-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dioneIC50216.0 [1], 708.0 [2]
3-[2-Chloro-6-[(dimethylamino)methyl]naphthalen-1-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dioneIC5012.0 [1], 156.0 [2]
1-Benzyl-2,2-dimethyl-7-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)-3H-quinazolin-4-oneIC500.46 [1], 16.0 [2]
1-(Cyclopropylmethyl)-2,2-dimethyl-7-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)-3H-quinazolin-4-oneIC50170.0 [1], 1000.0 [2]
1-Ethyl-2,2-dimethyl-7-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)-3H-quinazolin-4-oneIC50260.0 [1], 1000.0 [2]
2,2-Dimethyl-1-(2-methylpropyl)-7-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)-3H-quinazolin-4-oneIC5045.0 [1], 1000.0 [2]
2,2-Dimethyl-7-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)-1-(2-phenylethyl)-3H-quinazolin-4-oneIC50300.0 [1], 1000.0 [2]
1-(Cyclopentylmethyl)-2,2-dimethyl-7-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)-3H-quinazolin-4-oneIC504.3 [1], 170.0 [2]
5-Fluoro-2-[(3S)-3-[(2R)-2-hydroxy-3-methylbutan-2-yl]piperazin-1-yl]-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-3-olIC504.0 [1]
5-Fluoro-2-[(3S)-3-[(2R)-2-hydroxy-3-methylbutan-2-yl]piperazin-1-yl]-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-3-olKi0.1 [1]
3-[2-Chloro-7-[[cyclopropyl(methyl)amino]methyl]naphthalen-1-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dioneIC50316.0 [1], 3555.0 [2]
(2-Aminopyridin-3-yl)-[6-[(3S)-3-(2-methylpropyl)piperazin-1-yl]pyridin-2-yl]methanoneIC50165.0 [1]
(2-Aminopyridin-3-yl)-[6-[(3S)-3-(2-methylpropyl)piperazin-1-yl]pyridin-2-yl]methanoneKi3.0 [1]
(2-Aminopyridin-3-yl)-[3-cyclopropyl-6-[(3S)-3-(2-methylpropyl)piperazin-1-yl]pyridin-2-yl]methanoneIC502600.0 [1]
(2-Aminopyridin-3-yl)-[3-cyclopropyl-6-[(3S)-3-(2-methylpropyl)piperazin-1-yl]pyridin-2-yl]methanoneKi28.0 [1]
(S)-(2-Aminopyridin-3-yl)(6-(3-isobutylpiperazin-1-yl)-3-(trifluoromethyl)pyridin-2-yl)methanoneIC5052.0 [1]
(S)-(2-Aminopyridin-3-yl)(6-(3-isobutylpiperazin-1-yl)-3-(trifluoromethyl)pyridin-2-yl)methanoneKi3.0 [1]
(2-Aminopyridin-3-yl)-[3-chloro-6-[(3S)-3-(2-methylpropyl)piperazin-1-yl]pyridin-2-yl]methanoneIC5058.0 [1]
(2-Aminopyridin-3-yl)-[3-chloro-6-[(3S)-3-(2-methylpropyl)piperazin-1-yl]pyridin-2-yl]methanoneKi2.0 [1]
(2R)-2-[(2S)-4-[3,5-Difluoro-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-olIC502.0 [1]
(2R)-2-[(2S)-4-[3,5-Difluoro-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-olKi0.1 [1]
5-Fluoro-2-[(3S)-3-[(2R)-2-hydroxy-3-methylbutan-2-yl]piperazin-1-yl]-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridine-3-carbonitrileIC50120.0 [1]
5-Fluoro-2-[(3S)-3-[(2R)-2-hydroxy-3-methylbutan-2-yl]piperazin-1-yl]-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridine-3-carbonitrileKi1.0 [1]
(2R)-2-[(2S)-4-[5-Fluoro-3-(hydroxymethyl)-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-olIC501.0 [1]
(2R)-2-[(2S)-4-[5-Fluoro-3-(hydroxymethyl)-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-olKi0.1 [1]
3-(2-Chloro-7-dimethylaminomethyl-naphthalen-1-yl)-4-(1-methyl-1H-indol-3-yl)-pyrrole-2,5-dioneIC50263.0 [1], 402.0 [2]
(2-Aminopyridin-3-yl)-[6-[(3S)-3-(2-methylpropyl)piperazin-1-yl]-3-propylpyridin-2-yl]methanoneIC50410.0 [1]
(2-Aminopyridin-3-yl)-[6-[(3S)-3-(2-methylpropyl)piperazin-1-yl]-3-propylpyridin-2-yl]methanoneKi20.0 [1]
(2-Aminopyridin-3-yl)-[3-(difluoromethoxy)-6-[(3S)-3-(2-methylpropyl)piperazin-1-yl]pyridin-2-yl]methanoneIC50229.0 [1]
(2-Aminopyridin-3-yl)-[3-(difluoromethoxy)-6-[(3S)-3-(2-methylpropyl)piperazin-1-yl]pyridin-2-yl]methanoneKi7.0 [1]
(2-Aminopyridin-3-yl)-[6-[(3S)-3-(2-methylpropyl)piperazin-1-yl]-3-phenylpyridin-2-yl]methanoneIC505.0 [1]
(2-Aminopyridin-3-yl)-[6-[(3S)-3-(2-methylpropyl)piperazin-1-yl]-3-phenylpyridin-2-yl]methanoneKi0.6 [1]
4-[[(3R,5S)-4-Amino-1-adamantyl]methylamino]-2-[[2-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carbonitrileIC501.3 [1], 22.0 [2]
4-[[(3R,5S)-4-Amino-1-adamantyl]methylamino]-2-(3-bromoanilino)pyrimidine-5-carbonitrileIC503.9 [1], 100.0 [2]
4-[[(3R,5S)-4-Amino-1-adamantyl]methylamino]-2-anilinopyrimidine-5-carbonitrileIC5028.0 [1], 660.0 [2]
2-[[(1R,3S)-5-[[[5-Cyano-2-[[2-(trifluoromethoxy)phenyl]methylamino]pyrimidin-4-yl]amino]methyl]-2-adamantyl]amino]acetamideIC501.9 [1], 41.0 [2]
4-[[(3R,5S)-4-(2-Hydroxyethylamino)-1-adamantyl]methylamino]-2-[[2-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carbonitrileIC500.7 [1], 6.3 [2]
4-[[(3R,5S)-4-Amino-1-adamantyl]methylamino]-2-[(2-bromophenyl)methylamino]pyrimidine-5-carbonitrileIC505.9 [1], 31.0 [2]
(2-Aminopyridin-3-yl)-[4-methyl-6-[(3S)-3-(2-methylpropyl)piperazin-1-yl]pyridin-2-yl]methanoneIC50410.0 [1]
(2-Aminopyridin-3-yl)-[4-methyl-6-[(3S)-3-(2-methylpropyl)piperazin-1-yl]pyridin-2-yl]methanoneKi24.0 [1]
(2R)-2-[(2S)-4-[5-Fluoro-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-olIC506.0 [1]
(2R)-2-[(2S)-4-[5-Fluoro-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-olKi0.2 [1]
(2R)-2-[(2S)-4-[5-Chloro-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-olIC50170.0 [1]
(2R)-2-[(2S)-4-[5-Chloro-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-olKi21.0 [1]
(2R)-3-Methyl-2-[(2S)-4-[6-(2H-pyrazolo[3,4-b]pyridin-3-yl)-5-(trifluoromethyl)pyridin-2-yl]piperazin-2-yl]butan-2-olIC50420.0 [1]
(2R)-3-Methyl-2-[(2S)-4-[6-(2H-pyrazolo[3,4-b]pyridin-3-yl)-5-(trifluoromethyl)pyridin-2-yl]piperazin-2-yl]butan-2-olKi20.0 [1]
Phorbol 12,13-dibutyrateKi1.54 [1]
Bisindolylmaleimide iIC506.7 [1]
XanthohumolIC50100000.0 [1]
DoramapimodIC5030000.0 [1]
AplysiatoxinKi0.16 [1]
IsoxanthohumolIC5031600.0 [1]
Gsk-690693IC502.0 [1]
DebromoaplysiatoxinKi0.11 [1]
Tak-285IC5010000.0 [1]
CID 46209401IC5010000.0 [1]
CID 59604787IC5010000.0 [1]
1-[2-Fluoro-4-(5-methylpyrrolo[3,2-d]pyrimidin-4-yl)oxyphenyl]-3-[3-(trifluoromethyl)phenyl]ureaIC5010000.0 [1]
3-[5-[4-(2-Hydroxy-2-methylpropanoyl)piperazin-1-yl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)pyrrole-2,5-dioneIC5068.0 [1]
CID 44814409IC504100.0 [1]
17,20,23-Trioxa-4,12,14,26,28-pentazahexacyclo[24.6.1.17,14.02,6.08,13.027,32]tetratriaconta-1(33),2(6),7(34),8(13),9,11,27(32),28,30-nonaene-3,5-dioneIC5010000.0 [1]
Indolylylmaleimide 1IC50835.0 [1]
4-[(4-Methyl-1H-indol-5-yl)amino]-2-phenylthieno[2,3-b]pyridine-5-carbonitrileIC5052.0 [1]
8-Bromo-4-(3-chloro-4-fluoroanilino)-6-[(1-methylimidazol-4-yl)methylamino]quinoline-3-carbonitrileIC5050000.0 [1]
Khk-IN-1IC5040000.0 [1]
cis-3-[4-Amino-7-(3-azetidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-phenolIC50230.0 [1]
Indolylylmaleimide 2IC5065.0 [1]
(2S,5S)-8-Decyl-5-(hydroxymethyl)-1-methyl-2-propan-2-yl-2,4,5,6-tetrahydro-1,4-benzodiazocin-3-oneKi13.2 [1]
Methyl 6-bromo-2-[(4-methylsulfonylphenyl)methyl]-1-oxo-4-phenylisoquinoline-3-carboxylateIC5011000.0 [1]
17,20,23,26-Tetraoxa-4,12,14,29,31-pentazahexacyclo[27.6.1.17,14.02,6.08,13.030,35]heptatriaconta-1(36),2(6),7(37),8(13),9,11,30(35),31,33-nonaene-3,5-dioneIC5010000.0 [1]
(2,6-Dimethylphenyl) N-[2-[3,5-dimethoxy-4-[3-(4-methylpiperazin-1-yl)propoxy]anilino]pyrimidin-4-yl]-N-(2,4-dimethoxyphenyl)carbamateIC505000.0 [1]
3-(1H-Indol-3-yl)-4-(2-piperazin-1-ylquinazolin-4-yl)pyrrole-2,5-dioneIC500.5 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Protein kinase C theta Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/protein-kinase-c-theta-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Protein kinase C theta Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/protein-kinase-c-theta-inhibitors-ic50-ki.
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