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Protein kinase C iota Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
N'-[2-(1-Methylpyrazol-4-yl)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl]ethane-1,2-diamineIC5060000.0 [1]
StaurosporineIC50364.0 [1]
Bisindolylmaleimide iIC503463.0 [1]
1(2H)-PhthalazinoneIC50589000.0 [1]
1-(Tert-Butyl)-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC50100000.0 [1]
CID 59604787IC5010000.0 [1]
5-AminobenzimidazoleIC50728000.0 [1]
1-Methyl-1H-indol-5-amineIC501312000.0 [1]
4-Amino-2-[(Diethylamino)Methyl]PhenolIC501570000.0 [1]
6-Hydroxy-1-tetraloneIC501677000.0 [1]
1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acidIC5010000.0 [1]
4-Chloro-1H-pyrrolo[2,3-b]pyridineIC501300000.0 [1]
(13R,15S)-13-Methyl-16-oxa-8,9,12,22,24-pentazahexacyclo[15.6.2.16,9.112,15.02,7.021,25]heptacosa-1(24),2,4,6,17,19,21(25)-heptaene-23,27-dioneIC501000.0 [1]
4-Methyl-N-(1,2-oxazol-3-yl)-3-[(1-phenylpyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamideIC5040000.0 [1]
7-Chloro-9-ethyl-6-hydroxy-1H,3H,4H,9H-quinolino[2,3-c][1,2]oxazole-3,4-dioneKi8330.0 [1]
1-(2,6-Dihydroxy-3-propylphenyl)ethanoneIC501556000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
2-Anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-oneIC5010000.0 [1]
2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi10000.0 [1]
2-[3-[3-(4-Methylpiperazin-1-yl)propoxy]phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi10000.0 [1]
6-Methoxy-7-[5-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrazolo[1,5-a]pyridin-3-yl]-1,2,3,4-tetrahydroisoquinolineIC502.8 [1]
6-Methoxy-3-methyl-7-[5-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrazolo[1,5-a]pyridin-3-yl]-1,2,3,4-tetrahydroisoquinolineIC503.8 [1]
1-Piperidin-4-yl-6-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzimidazoleIC509500.0 [1]
[3-Methoxy-4-[6-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzimidazol-1-yl]phenyl]methanamineIC50120.0 [1]
3-(6-Methoxy-2,3-dihydro-1H-isoindol-5-yl)-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrazolo[1,5-a]pyrimidineIC50110.0 [1]
6-(1H-Pyrrolo[2,3-b]pyridin-4-yl)-3,4-dihydro-2H-1,4-benzoxazineIC50148000.0 [1]
[3-[6-(1H-Pyrrolo[2,3-b]pyridin-4-yl)benzimidazol-1-yl]phenyl]methanamineIC501100.0 [1]
3-(6-Methoxy-2,3-dihydro-1H-isoindol-5-yl)-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[4,5-b]pyridineIC5065.0 [1]
1-(6-Methoxy-2,3-dihydro-1H-isoindol-5-yl)-6-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzimidazoleIC5048.0 [1]
4-(1H-Indol-6-yl)-1H-pyrrolo[2,3-b]pyridineIC50384000.0 [1]
4-(3H-Benzimidazol-5-yl)-1H-pyrrolo[2,3-b]pyridineIC5041000.0 [1]
3-(Fluoromethyl)-6-methoxy-7-[5-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrazolo[1,5-a]pyridin-3-yl]-1,2,3,4-tetrahydroisoquinolineIC502.7 [1]
7-(1H-Pyrrolo[2,3-b]pyridin-4-yl)isoquinolineIC5095000.0 [1]
1-Pyridin-3-yl-6-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzimidazoleIC506000.0 [1]
3-(6-Methoxy-2,3-dihydro-1H-isoindol-5-yl)-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrazolo[1,5-a]pyridineIC506.5 [1]
1-(3-Methylphenyl)-6-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzimidazoleIC507000.0 [1]
1-[5-Methoxy-6-[5-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrazolo[1,5-a]pyridin-3-yl]-1,3-dihydroisoindol-2-yl]ethanoneIC5038000.0 [1]
1-(2,3-Dihydro-1H-isoindol-5-yl)-6-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzimidazoleIC50290.0 [1]
1-(Pyridin-2-ylmethyl)-6-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzimidazoleIC507500.0 [1]
1-Piperidin-3-yl-6-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzimidazoleIC507700.0 [1]
1-Methyl-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzimidazoleIC50384000.0 [1]
3-(6-Methoxy-2,3-dihydro-1H-isoindol-5-yl)-6-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazineIC504800.0 [1]
1-(6-Methoxy-2,3-dihydro-1H-isoindol-5-yl)-6-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[4,5-c]pyridineIC5030.0 [1]
3-(6-Methoxy-2-methyl-1,3-dihydroisoindol-5-yl)-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrazolo[1,5-a]pyridineIC505.0 [1]
5-(1H-Pyrrolo[2,3-b]pyridin-4-yl)-2,3-dihydroisoindol-1-oneIC50105000.0 [1]
2-Methyl-6-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-benzimidazoleIC50215000.0 [1]
1-Methyl-6-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzimidazoleIC5020000.0 [1]
6-Methoxy-2-[5-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrazolo[1,5-a]pyridin-3-yl]-3H-isoindol-1-oneIC50384000.0 [1]
1-(Azetidin-3-yl)-6-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzimidazoleIC50188000.0 [1]
3-(6-Methoxy-2,3-dihydro-1H-isoindol-5-yl)-6-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-a]pyridineIC50570.0 [1]
6-(1H-Pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazineIC5075000.0 [1]
[4-[6-(1H-Pyrrolo[2,3-b]pyridin-4-yl)benzimidazol-1-yl]phenyl]methanamineIC50800.0 [1]
4-Imidazo[1,5-a]pyridin-7-yl-1H-pyrrolo[2,3-b]pyridineIC50221000.0 [1]
Ethyl 2-amino-4-(benzo[d][1,3]dioxol-5-yl)thiophene-3-carboxylateIC502000.0 [1]
4-Bromo-1H-pyrrolo[2,3-b]pyridineIC50615000.0 [1]
1H-Pyrrolo[2,3-b]pyridine-4-carboxamideIC50384000.0 [1]
4-Pyridin-2-yl-1H-pyrrolo[2,3-b]pyridineIC50374000.0 [1]
N-Methyl-(5-pyrid-4-ylthien-2-yl)methylamineIC50229000.0 [1]
4-Chloro-5-methyl-1H-pyrrolo[2,3-b]pyridineIC50452000.0 [1]
2,3-Dihydrobenzo[B]furan-5-carbothioamideIC50927000.0 [1]
1-(3-Amino-4-(methylamino)phenyl)ethanoneIC501423000.0 [1]
(3-Pyrid-4-ylphenyl)methanolIC502216000.0 [1]
3-Pyridinecarboxamide, 2-amino-N-phenyl-IC50424000.0 [1]
N-[(4-Methoxyphenyl)methyl]-[1]benzofuro[2,3-b]pyridin-4-amineKi1000000.0 [1]
4-Phenyl-[1]benzofuro[2,3-b]pyridine-3,6-diolKi1000000.0 [1]
4-(4-Bromo-1H-pyrazol-1-yl)-1H-pyrrolo[2,3-b]pyridineIC50201000.0 [1]
3-(1H-Pyrrolo[2,3-b]pyridin-4-yl)benzamideIC50371000.0 [1]
Ethyl 2-amino-4-[4-(dimethylamino)phenyl]thiophene-3-carboxylateIC50900.0 [1]
(2S)-3-Phenyl-1-N-(2-pyridin-4-yl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)propane-1,2-diamineIC50100.0 [1]
(3-Methoxyphenyl)methyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylateIC50900.0 [1]
1-[3-(2,5-Dimethyl-1H-pyrrol-1-yl)propyl]-1H-imidazoleIC5037000.0 [1]
Isopropyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylateIC505000.0 [1]
[3-[[(2R)-2-Amino-3-phenylpropyl]amino]-5-pyridin-4-yl-8-thia-4,6,11-triazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6-tetraen-11-yl]-phenylmethanoneIC501000.0 [1]
2-[2-(3-Propan-2-ylsulfonylanilino)pyridin-4-yl]-N-[(3R)-pyrrolidin-3-yl]thieno[3,2-d]pyrimidin-4-amineIC501000.0 [1]
2-[2-[(5-Morpholin-4-ylpyridin-2-yl)amino]pyridin-4-yl]-N-[(3R)-pyrrolidin-3-yl]thieno[3,2-d]pyrimidin-4-amineIC50100.0 [1]
N-[4-[[(2S)-2-Amino-3-phenylpropyl]amino]-2-pyridin-4-ylthieno[3,2-d]pyrimidin-7-yl]-2,2-dimethylbutanamideIC5010000.0 [1]
2-(3,5-Dimethyl-1H-pyrazol-4-yl)-N-[(3R)-pyrrolidin-3-yl]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-amineIC50100.0 [1]
7-Bromo-2-pyridin-4-yl-N-[(3S)-pyrrolidin-3-yl]thieno[3,2-d]pyrimidin-4-amineIC501000.0 [1]
9-Chloro-2-pyridin-4-yl-4-[[(2R)-pyrrolidin-2-yl]methoxy]-[1]benzothiolo[3,2-d]pyrimidineIC5010000.0 [1]
4-(4-Methylpiperazin-1-yl)-N-[4-[4-[[(3R)-pyrrolidin-3-yl]amino]thieno[3,2-d]pyrimidin-2-yl]pyridin-2-yl]benzamideIC50100.0 [1]
2-Pyridin-4-yl-4-[[(2S)-pyrrolidin-2-yl]methoxy]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidineIC501000.0 [1]
2-[2-[(5-Phenylpyridin-2-yl)amino]pyridin-4-yl]-N-[(3R)-pyrrolidin-3-yl]thieno[3,2-d]pyrimidin-4-amineIC50100.0 [1]
7-Bromo-6-methyl-2-pyridin-4-yl-N-[(3R)-pyrrolidin-3-yl]thieno[3,2-d]pyrimidin-4-amineIC50100.0 [1]
(2S)-1-Cyclohexyl-3-[(2-pyridin-4-yl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)oxy]propan-2-amineIC501000.0 [1]
2-(1H-Pyrazol-4-yl)-N-[(3R)-pyrrolidin-3-yl]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-amineIC50100.0 [1]
2-Methyl-4-[6-methyl-2-pyridin-4-yl-4-[[(3R)-pyrrolidin-3-yl]amino]thieno[3,2-d]pyrimidin-7-yl]but-3-yn-2-olIC50100.0 [1]
4-[4-[[(2S)-2-Amino-3-phenylpropyl]amino]-2-pyridin-4-ylthieno[3,2-d]pyrimidin-7-yl]but-3-yn-2-olIC50100.0 [1]
(2S)-1-(3-Methylphenyl)-3-[(2-pyridin-4-yl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)oxy]propan-2-amineIC501000.0 [1]
(2S)-1-Naphthalen-2-yl-3-[(2-pyridin-4-yl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)oxy]propan-2-amineIC5010000.0 [1]
(2S)-1-(2-Fluorophenyl)-3-[(2-pyridin-4-yl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)oxy]propan-2-amineIC501000.0 [1]
N-[(3R)-Pyrrolidin-3-yl]-2-[2-(4-thiophen-3-ylanilino)pyridin-4-yl]thieno[3,2-d]pyrimidin-4-amineIC50100.0 [1]
(2R)-4-Phenyl-1-[(2-pyridin-4-yl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)oxy]butan-2-amineIC5010000.0 [1]
5-[4-[[(2S)-2-Amino-3-phenylpropyl]amino]-2-pyridin-4-ylthieno[3,2-d]pyrimidin-7-yl]pent-4-yn-2-olIC50100.0 [1]
(2S)-1-(3-Fluorophenyl)-3-[(2-pyridin-4-yl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)oxy]propan-2-amineIC501000.0 [1]
N-[(3S,4S)-1-Benzyl-4-fluoropyrrolidin-3-yl]-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-amineIC5010000.0 [1]
2-Pyridin-4-yl-N-[(3R)-pyrrolidin-3-yl]thieno[3,2-d]pyrimidin-4-amineIC501000.0 [1]
9-Chloro-2-pyridin-4-yl-4-[[(2S)-pyrrolidin-2-yl]methoxy]-[1]benzothiolo[3,2-d]pyrimidineIC501000.0 [1]
(2R)-1-(7-Methyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl)oxy-3-phenylpropan-2-amineIC5010000.0 [1]
(2S)-1-Naphthalen-1-yl-3-[(2-pyridin-4-yl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)oxy]propan-2-amineIC501000.0 [1]
N,N-Dimethyl-4-[[4-[4-[[(3R)-pyrrolidin-3-yl]amino]thieno[3,2-d]pyrimidin-2-yl]pyridin-2-yl]amino]benzenesulfonamideIC501000.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Protein kinase C iota Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/protein-kinase-c-iota-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Protein kinase C iota Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/protein-kinase-c-iota-inhibitors-ic50-ki.
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