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Protein kinase C epsilon Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
StaurosporineIC501.5 [1]
Indolactam VKi7.7 [1], 4110.0 [2]
BalanolIC5010.0 [1], 38.0 [2], 49.0 [3], 50.0 [4]
Balanol analog 5IC5050.0 [1]
Balanol analog 4IC5010.0 [1]
8-Decyl-5-hydroxymethyl-2-isopropyl-1-methyl-1,2,5,6-tetrahydro-benzo[e][1,4]oxazocin-3-oneKi262.0 [1], 262.3 [2], 10000.0 [3]
2-[2,6-Dihydroxy-4-[3-[(4-hydroxybenzoyl)amino]azepan-4-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC5020.0 [1], 38.0 [2], 40.0 [3], 340.0 [4]
Bisindolylmaleimide iIC506.0 [1], 6.6 [2], 12.0 [3]
SotrastaurinIC506.2 [1]
CID 25053598Ki21.1 [1], 31.0 [2], 42.8 [3]
8-Octyl-benzolactam-V9Ki510.0 [1], 10000.0 [2]
(2S,5S)-8-Decyl-5-(hydroxymethyl)-1-methyl-2-propan-2-yl-2,4,5,6-tetrahydro-1,4-benzodiazocin-3-oneKi13.1 [1], 187.0 [2], 8361.0 [3]
2-[2,6-Dihydroxy-4-[2-[(4-hydroxybenzoyl)amino]cyclopentyl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC5050.0 [1]
Phorbol 12,13-dibutyrateKi1.35 [1], 14.9 [2]
FasudilIC503000.0 [1]
EnzastaurinIC50110.0 [1], 300.0 [2]
RuboxistaurinIC50600.0 [1]
1-(Tert-Butyl)-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC5021.0 [1], 100000.0 [2]
PKCbeta InhibitorIC502800.0 [1], 2807.0 [2]
(E)-2-(2-(Hydroxymethyl)-4-(3-isobutyl-5-methylhexylidene)-5-oxo-tetrahydrofuran-2-yl)ethyl pivalateKi1.03 [1], 1.43 [2]
8-Dec-1-ynyl-5-hydroxymethyl-2-isopropyl-1-methyl-1,4,5,6-tetrahydro-2H-benzo[e][1,4]diazocin-3-oneKi40.0 [1], 142.0 [2]
(1S,3R,5R,9R,13R)-9-(Hydroxymethyl)-3-[4-(3-hydroxyphenyl)butyl]-16,16-dimethyl-2,6,10,17-tetraoxatricyclo[11.3.1.11,5]octadecane-7,11-dioneKi25.0 [1]
3-(1H-Indol-3-yl)-4-[3-(4-methylpiperazin-1-yl)naphthalen-1-yl]pyrrole-2,5-dioneIC5019.0 [1]
[(4Z)-2-(Hydroxymethyl)-4-(3-methylbutylidene)-5-oxooxolan-2-yl]methyl 5-methyl-3-(2-methylpropyl)hexanoateKi2.37 [1], 15.6 [2]
5-Hydroxymethyl-2-isopropyl-1-undecyl-1,2,5,6-tetrahydro-benzo[e][1,4]oxazocin-3-oneKi411.0 [1], 5360.0 [2]
(10S,13S)-13-(Hydroxymethyl)-9-methyl-10-propan-2-yl-3,9,12-triazatricyclo[6.6.1.04,15]pentadeca-1,4(15),5,7-tetraene-11-thioneKi41.5 [1], 3860.0 [2]
7-Decyl-5-hydroxymethyl-2-isopropyl-1-methyl-1,2,5,6-tetrahydro-benzo[e][1,4]oxazocin-3-oneKi540.0 [1], 7880.0 [2]
9-Decyl-5-hydroxymethyl-2-isopropyl-1-methyl-1,2,5,6-tetrahydro-benzo[e][1,4]oxazocin-3-oneKi83.0 [1], 4830.0 [2]
[(4Z)-2-(Hydroxymethyl)-4-(3-methylbutylidene)-5-oxooxolan-2-yl]methyl (9E,12E)-octadeca-9,12-dienoateKi12.2 [1], 19.5 [2]
[(4E)-2-(Hydroxymethyl)-4-(3-methylbutylidene)-5-oxooxolan-2-yl]methyl (9E,12E)-octadeca-9,12-dienoateKi2.14 [1], 13.1 [2]
[(4Z)-2-(Hydroxymethyl)-4-(3-methylbutylidene)-5-oxooxolan-2-yl]methyl 8-[2-[(2-pentylcyclopropyl)methyl]cyclopropyl]octanoateKi9.8 [1], 30.7 [2]
[(4E)-2-(Hydroxymethyl)-4-(3-methylbutylidene)-5-oxooxolan-2-yl]methyl 8-[2-[(2-pentylcyclopropyl)methyl]cyclopropyl]octanoateKi5.5 [1], 19.84 [2]
[(4Z)-2-(Hydroxymethyl)-4-(3-methylbutylidene)-5-oxooxolan-2-yl]methyl 8-[3-[(3-pentyloxiran-2-yl)methyl]oxiran-2-yl]octanoateKi16.3 [1], 63.0 [2]
[(4E)-2-(Hydroxymethyl)-4-(3-methylbutylidene)-5-oxooxolan-2-yl]methyl 8-[3-[(3-pentyloxiran-2-yl)methyl]oxiran-2-yl]octanoateKi7.46 [1], 16.9 [2]
[(4Z)-2-(Hydroxymethyl)-4-(3-methylbutylidene)-5-oxooxolan-2-yl]methyl octadecanoateKi19.3 [1], 34.0 [2]
[(4E)-2-(Hydroxymethyl)-4-(3-methylbutylidene)-5-oxooxolan-2-yl]methyl octadecanoateKi11.4 [1], 47.0 [2]
[(4E)-2-(Hydroxymethyl)-4-(3-methylbutylidene)-5-oxooxolan-2-yl]methyl 5-methyl-3-(2-methylpropyl)hexanoateKi1.21 [1], 3.0 [2]
[(4Z)-2-(Hydroxymethyl)-4-(3-methylbutylidene)-5-oxooxolan-2-yl]methyl octadec-9-ynoateKi7.12 [1], 34.6 [2]
[(4E)-2-(Hydroxymethyl)-4-(3-methylbutylidene)-5-oxooxolan-2-yl]methyl octadec-9-ynoateKi4.79 [1], 9.1 [2]
[(4Z)-2-(Hydroxymethyl)-4-(3-methylbutylidene)-5-oxooxolan-2-yl]methyl octadeca-9,11-diynoateKi13.4 [1], 40.3 [2]
[(4E)-2-(Hydroxymethyl)-4-(3-methylbutylidene)-5-oxooxolan-2-yl]methyl octadeca-9,11-diynoateKi5.24 [1], 12.8 [2]
[(4Z)-2-(Hydroxymethyl)-4-[(9Z,12Z)-octadeca-9,12-dienylidene]-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoateKi5.06 [1], 9.6 [2]
[(4E)-2-(Hydroxymethyl)-4-[(9Z,12Z)-octadeca-9,12-dienylidene]-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoateKi4.1 [1], 5.2 [2]
[(4Z)-2-(Hydroxymethyl)-5-oxo-4-[8-[2-[(2-pentylcyclopropyl)methyl]cyclopropyl]octylidene]oxolan-2-yl]methyl 2,2-dimethylpropanoateKi15.2 [1], 58.8 [2]
[(4E)-2-(Hydroxymethyl)-5-oxo-4-[8-[2-[(2-pentylcyclopropyl)methyl]cyclopropyl]octylidene]oxolan-2-yl]methyl 2,2-dimethylpropanoateKi8.3 [1], 41.0 [2]
[(3E)-2-(Hydroxymethyl)-3-octadecylidene-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoateKi11.5 [1], 45.1 [2]
[(3Z)-2-(Hydroxymethyl)-3-octadecylidene-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoateKi5.9 [1], 34.2 [2]
2-[2,6-Dihydroxy-4-[[2-[(4-hydroxybenzoyl)amino]-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]oxycarbonyl]benzoyl]-3-hydroxybenzoic acidIC5027000.0 [1]
[2-(Hydroxymethyl)-5-oxo-4-propan-2-ylideneoxolan-2-yl]methyl 3-[4-[2-(4-methylphenyl)ethynyl]phenoxy]propanoateKi78.7 [1], 153.0 [2]
[2-(Hydroxymethyl)-5-oxo-4-propan-2-ylideneoxolan-2-yl]methyl 2-[4-[2-(4-methylphenyl)ethynyl]phenoxy]acetateKi147.0 [1], 268.0 [2]
[2-(Hydroxymethyl)-5-oxo-4-propan-2-ylideneoxolan-2-yl]methyl 4-[4-[2-(4-methylphenyl)ethynyl]phenoxy]butanoateKi31.9 [1], 37.9 [2]
[2-(Hydroxymethyl)-5-oxo-4-propan-2-ylideneoxolan-2-yl]methyl 4-[2-(4-methylphenyl)ethynyl]benzoateKi8.3 [1], 10.0 [2]
[2-[(4-Hydroxyphenyl)methyl]cyclopentyl] 3,5-dihydroxy-4-(2-hydroxy-6-methoxycarbonylbenzoyl)benzoateIC504500.0 [1]
2-[2,6-Dihydroxy-4-[4-[(4-hydroxybenzoyl)amino]pyrrolidin-3-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC5010.0 [1]
2-[2,6-Dihydroxy-4-[2-[(4-hydroxyphenyl)methyl]cyclopentyl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC50500.0 [1]
2-[2,6-Dihydroxy-4-[2-(4-hydroxyphenoxy)cyclopentyl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC50240.0 [1]
2-[2,6-Dihydroxy-4-[4-[(4-hydroxyphenyl)methyl]pyrrolidin-3-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC5020.0 [1], 1800.0 [2]
[4-[(4-Hydroxyphenyl)methyl]pyrrolidin-3-yl] 3,5-dihydroxy-4-(2-hydroxy-6-methoxycarbonylbenzoyl)benzoateIC504000.0 [1]
[(1R,2R,6S,10S,11R,13S,14R,15R)-13-Butanoyloxy-1-hydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxo-14-tetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dienyl] butanoateKi0.58 [1], 4.49 [2]
2-[2,6-Dihydroxy-4-[(1R,2R)-2-[(4-hydroxybenzoyl)amino]cycloheptyl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC50280.0 [1]
Balanol analog 3IC501800.0 [1]
2-[3-(3-Piperazin-1-ylpropoxy)phenyl]-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamideIC501000.0 [1], 10000.0 [2]
2-[2,6-Dihydroxy-4-[(3R)-3-[(4-hydroxybenzoyl)amino]azepan-4-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC5010.0 [1], 44.0 [2]
Phorbol 12-myristate 13-acetateKi0.45 [1]
ZidovudineIC50150000.0 [1]
Y-27632 DihydrochlorideIC50335.0 [1]
Betulinic acidIC50150000.0 [1]
AlvocidibIC50480.0 [1]
Chelerythrine chlorideIC5024.0 [1]
BetulinIC50150000.0 [1]
Bisindolylmaleimide IVIC507516.0 [1]
Purvalanol BIC50100000.0 [1]
Purvalanol AIC50100000.0 [1]
AplysiatoxinKi1.3 [1]
Gsk-690693IC5021.0 [1]
DebromoaplysiatoxinKi0.63 [1]
Platanic acidIC50150000.0 [1]
Rac-syn-BalanolIC5049.0 [1]
4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenolIC50100000.0 [1]
Acetobetulinic acidIC50150000.0 [1]
7-Octylindolactam VKi1.0 [1]
(1S,3As,5aR,5bR,9S,11aR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-propan-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acidIC50150000.0 [1]
CID 59604787IC5010000.0 [1]
(2S)-1-(1H-Indol-3-yl)-3-(5-isoquinolin-6-ylpyridin-3-yl)oxy-propan-2-amineIC506100.0 [1]
(5-Hydroxy-1H-indol-2-yl)-(1H-indol-2-yl)methanoneIC5030000.0 [1]
(2R)-2-[(2S)-4-[3-Chloro-5-fluoro-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-olKi1.0 [1]
Betulinic acid 3-O-succinateIC50150000.0 [1]
Betulinic acid 3-O-crotonateIC50150000.0 [1]
5-(3,4-Dimethoxyphenyl)-4-(1H-indol-5-ylamino)nicotinonitrileIC502330.0 [1]
4-(4-Methyl-1H-indol-5-ylamino)-5-(4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)nicotinonitrileIC5054.0 [1]
N'-(3-Pyridin-4-yl-2,6-naphthyridin-1-yl)ethane-1,2-diamineIC505.0 [1]
Unii-09RR39UU4VIC505600.0 [1]
Glycine, N,N-dimethyl-, 2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl esterIC5030000.0 [1]
Meridianin EIC504000.0 [1]
Betulinic acid 3-O-benzoateIC50150000.0 [1]
20-Ethyl-17,23-dioxa-4,14,20,26-tetrazahexacyclo[24.6.1.17,14.02,6.08,13.027,32]tetratriaconta-1(33),2(6),7(34),8,10,12,27,29,31-nonaene-3,5-dioneIC5075.0 [1]
6-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)propoxy]-2-chloropyridin-3-yl}isoquinolineIC505000.0 [1]
(2S,5S)-8-Dec-1-ynyl-5-(hydroxymethyl)-7-methoxy-1-methyl-2-propan-2-yl-2,4,5,6-tetrahydro-1,4-benzodiazocin-3-oneKi121.3 [1]
3-(1-Methyl-1H-indol-3-yl)-4-(1-piperidin-4-yl-1H-indol-3-yl)-pyrrole-2,5-dioneIC501000.0 [1]
3-(1H-Indol-3-yl)-4-(2-piperazin-1-ylquinazolin-4-yl)pyrrole-2,5-dioneIC500.9 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Protein kinase C epsilon Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/protein-kinase-c-epsilon-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Protein kinase C epsilon Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/protein-kinase-c-epsilon-inhibitors-ic50-ki.
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