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Protein kinase C delta Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
Indolactam VKi8.3 [1], 135.6 [2], 1900.0 [3]
StaurosporineIC5041.0 [1]
Phorbol 12,13-dibutyrateKi0.8 [1], 12.0 [2], 21.6 [3], 100.0 [4]
BalanolIC504.0 [1], 23.0 [2], 30.0 [3], 32.0 [4]
8-Dec-1-ynyl-5-hydroxymethyl-2-isopropyl-1-methyl-1,4,5,6-tetrahydro-2H-benzo[e][1,4]diazocin-3-oneKi10.7 [1], 114.0 [2], 134.0 [3], 730.0 [4], 933.0 [5]
Balanol analog 5IC500.9 [1]
(1S,3R,5R,9R,13R)-9-(Hydroxymethyl)-3-[4-(3-hydroxyphenyl)butyl]-16,16-dimethyl-2,6,10,17-tetraoxatricyclo[11.3.1.11,5]octadecane-7,11-dioneKi7.4 [1], 140.0 [2]
(2S,5S)-8-Decyl-5-(hydroxymethyl)-1-methyl-2-propan-2-yl-2,4,5,6-tetrahydro-1,4-benzodiazocin-3-oneKi14.6 [1], 32.0 [2], 185.0 [3], 260.8 [4], 2771.0 [5]
8-Decyl-5-hydroxymethyl-2-isopropyl-1-methyl-1,2,5,6-tetrahydro-benzo[e][1,4]oxazocin-3-oneKi1155.0 [1], 1160.0 [2], 22010.0 [3], 70600.0 [4], 70641.0 [5]
Balanol analog 4IC505.0 [1]
2-[2,6-Dihydroxy-4-[3-[(4-hydroxybenzoyl)amino]azepan-4-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC5016.0 [1], 20.0 [2], 23.0 [3], 50.0 [4]
SotrastaurinIC501.3 [1]
(E)-2-(2-(Hydroxymethyl)-4-(3-isobutyl-5-methylhexylidene)-5-oxo-tetrahydrofuran-2-yl)ethyl pivalateKi0.9 [1], 103.0 [2]
8-Octyl-benzolactam-V9Ki216.0 [1], 220.0 [2], 10000.0 [3]
5-(3,4-Dimethoxyphenyl)-4-(1H-indol-5-ylamino)nicotinonitrileIC50350.0 [1]
5-(3,4-Dimethoxyphenyl)-4-(1H-indol-5-ylamino)nicotinonitrileKi1600.0 [1]
4-(1H-Indol-5-ylamino)-2-phenylthieno[2,3-b]pyridine-5-carbonitrileIC50370.0 [1], 2000.0 [2], 33000.0 [3]
Bisindolylmaleimide iIC508.7 [1], 32.0 [2]
AplysiatoxinKi0.41 [1], 12.0 [2]
DebromoaplysiatoxinKi0.2 [1], 9.7 [2]
N-[4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamideIC50500000.0 [1]
(Z)-(2-(Hydroxymethyl)-4-(3-isobutyl-5-methylhexylidene)-5-oxo-tetrahydrofuran-2-yl)methyl pivalateKi1.16 [1]
Benzolactam-V8Ki410.0 [1], 1700.0 [2]
4-[(4-Methyl-1H-indol-5-yl)amino]-2-phenylthieno[2,3-b]pyridine-5-carbonitrileIC50370.0 [1], 3400.0 [2]
4-(4-Methyl-1H-indol-5-ylamino)-5-(4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)nicotinonitrileIC5051.0 [1]
(2S,5S)-9-Decyl-5-(hydroxymethyl)-2-isopropyl-1-methyl-2,4,5,6-tetrahydro-1,4-benzodiazocin-3-oneKi1.8 [1], 5.9 [2]
N'-(3-Pyridin-4-yl-2,6-naphthyridin-1-yl)ethane-1,2-diamineIC5020.0 [1]
4-Methyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideIC50500000.0 [1]
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamineIC50500000.0 [1]
N-[3-(4-Pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideIC5023000.0 [1]
[(4E)-2-(Hydroxymethyl)-4-[(4-hydroxyphenyl)methylidene]-5-oxooxolan-2-yl]methyl 4-methyl-3-propan-2-ylpentanoateKi1.4 [1], 170.0 [2]
2-[3-[(Dimethylamino)methyl]phenyl]-4-[(4-methyl-1H-indol-5-yl)amino]thieno[2,3-b]pyridine-5-carbonitrileIC5026.0 [1]
2-[3-[(Dimethylamino)methyl]phenyl]-4-[(4-methyl-1H-indol-5-yl)amino]thieno[2,3-b]pyridine-5-carbonitrileKi96.0 [1]
3-(1H-Indol-3-yl)-4-[3-(4-methylpiperazin-1-yl)naphthalen-1-yl]pyrrole-2,5-dioneIC507.3 [1]
N-[4-Methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-acetamideIC50500000.0 [1]
4-(4-Methyl-1H-indol-5-ylamino)-5-(4-(2-(4-methylpiperazin-1-yl)ethoxy)styryl)nicotinonitrileIC5041.0 [1]
1-Piperazin-1-yl-3-pyridin-4-yl[2,6]naphthyridineIC5031.0 [1]
(1S,3R,5R,9R,13R)-9-(Hydroxymethyl)-16,16-dimethyl-3-(4-phenylbutyl)-2,6,10,17-tetraoxatricyclo[11.3.1.11,5]octadecane-7,11-dioneKi9.8 [1], 130.0 [2]
2-[2,6-Dihydroxy-4-[2-[(4-hydroxybenzoyl)amino]cyclopentyl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC500.9 [1], 1.0 [2]
(1R,3R,4R,5S,9R,13R)-9-(Hydroxymethyl)-3-[4-(3-hydroxyphenyl)butyl]-4,16,16-trimethyl-2,6,10,17-tetraoxatricyclo[11.3.1.11,5]octadecane-7,11-dioneKi0.46 [1], 22.0 [2]
2-Methoxy-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideIC50100000.0 [1], 500000.0 [2]
N-[4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]naphthalene-2-carboxamideIC50500000.0 [1]
5-Hydroxymethyl-2-isopropyl-1-undecyl-1,2,5,6-tetrahydro-benzo[e][1,4]oxazocin-3-oneKi415.0 [1], 30300.0 [2]
[(1R,3S,7S,8E,11S,12S,13E,17R,21R,23S)-11,21-Dihydroxy-17-[(1R)-1-hydroxyethyl]-13-(2-methoxy-2-oxoethylidene)-10,10-dimethyl-19-oxo-6,18,27,28,29-pentaoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl] octanoateKi2.5 [1], 65.9 [2]
(10S,13S)-13-(Hydroxymethyl)-9-methyl-10-propan-2-yl-3,9,12-triazatricyclo[6.6.1.04,15]pentadeca-1,4(15),5,7-tetraene-11-thioneKi67.5 [1], 2950.0 [2]
7-Decyl-5-hydroxymethyl-2-isopropyl-1-methyl-1,2,5,6-tetrahydro-benzo[e][1,4]oxazocin-3-oneKi92.0 [1], 10000.0 [2]
9-Decyl-5-hydroxymethyl-2-isopropyl-1-methyl-1,2,5,6-tetrahydro-benzo[e][1,4]oxazocin-3-oneKi149.0 [1], 6150.0 [2]
(3E)-5-(2,2-Dimethylpropoxymethyl)-5-(hydroxymethyl)-3-[5-methyl-3-(2-methylpropyl)hexylidene]oxolan-2-oneKi1890.0 [1], 101000.0 [2]
[(4E)-2-(Hydroxymethyl)-4-(4-methyl-3-propan-2-ylpentylidene)-5-oxooxolan-2-yl]methyl 4-hydroxybenzoateKi980.0 [1], 16900.0 [2]
[(4E)-2-(Hydroxymethyl)-4-[5-methyl-3-(2-methylpropyl)hexylidene]-5-sulfanylideneoxolan-2-yl]methyl 2,2-dimethylpropanoateKi3.13 [1], 173.4 [2]
O-[[(4E)-2-(Hydroxymethyl)-4-[5-methyl-3-(2-methylpropyl)hexylidene]-5-oxooxolan-2-yl]methyl] 2,2-dimethylpropanethioateKi20.6 [1], 606.0 [2]
2-[2,6-Dihydroxy-4-[[2-[(4-hydroxybenzoyl)amino]-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]oxycarbonyl]benzoyl]-3-hydroxybenzoic acidIC505000.0 [1]
[2-(Hydroxymethyl)-5-oxo-4-propan-2-ylideneoxolan-2-yl]methyl 3-[4-[2-(4-methylphenyl)ethynyl]phenoxy]propanoateKi31.3 [1], 35.8 [2]
[2-(Hydroxymethyl)-5-oxo-4-propan-2-ylideneoxolan-2-yl]methyl 2-[4-[2-(4-methylphenyl)ethynyl]phenoxy]acetateKi46.4 [1], 47.7 [2]
[2-(Hydroxymethyl)-5-oxo-4-propan-2-ylideneoxolan-2-yl]methyl 4-[4-[2-(4-methylphenyl)ethynyl]phenoxy]butanoateKi11.6 [1], 11.9 [2]
[2-(Hydroxymethyl)-5-oxo-4-propan-2-ylideneoxolan-2-yl]methyl 4-[2-(4-methylphenyl)ethynyl]benzoateKi2.74 [1], 5.4 [2]
(1R,3R,5R,9R,13R)-9-(Hydroxymethyl)-3-(4-phenylbutyl)-2,6,10,17-tetraoxatricyclo[11.3.1.11,5]octadecane-7,11-dioneKi170.0 [1], 6800.0 [2]
[2-[(2R,4R)-4-[(1R,3S,4S,5S)-3-(Benzylamino)-4-hydroxy-5-methylcyclohexyl]oxy-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]-2-oxoethyl] pentanoateKi2500.0 [1], 2700.0 [2]
[(1R,3S,7S,8E,11S,12S,13E,17R,21S,23S)-11,21-Dihydroxy-17-[(1R)-1-hydroxyethyl]-13-(2-methoxy-2-oxoethylidene)-10,10-dimethyl-19-oxo-6,18,27,28,29-pentaoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl] octanoateKi64.2 [1], 494.4 [2]
[(1S,3E,5S,9S,11S,15R,19R,23E,24S)-11-Tert-butyl-1,15-dihydroxy-19-[(1R)-1-hydroxyethyl]-23-(2-methoxy-2-oxoethylidene)-2,2-dimethyl-17-oxo-6,12,18,25,26-pentaoxatricyclo[19.3.1.15,9]hexacos-3-en-24-yl] octanoateKi6.3 [1], 85.4 [2]
[2-[(4-Hydroxyphenyl)methyl]cyclopentyl] 3,5-dihydroxy-4-(2-hydroxy-6-methoxycarbonylbenzoyl)benzoateIC5050.0 [1]
2-[2,6-Dihydroxy-4-[2-[(4-hydroxyphenyl)methyl]cyclopentyl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC5030.0 [1]
2-[2,6-Dihydroxy-4-[2-(4-hydroxyphenoxy)cyclopentyl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC5020.0 [1]
2-[2,6-Dihydroxy-4-[4-[(4-hydroxyphenyl)methyl]pyrrolidin-3-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC505.0 [1], 1800.0 [2]
[4-[(4-Hydroxyphenyl)methyl]pyrrolidin-3-yl] 3,5-dihydroxy-4-(2-hydroxy-6-methoxycarbonylbenzoyl)benzoateIC50100.0 [1]
[(1R,2R,6S,10S,11R,13S,14R,15R)-13-Butanoyloxy-1-hydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxo-14-tetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dienyl] butanoateKi0.55 [1], 70.2 [2]
[(4E)-2-(Hydroxymethyl)-4-[5-methyl-3-(2-methylpropyl)hexylidene]oxolan-2-yl]methyl 2,2-dimethylpropanoateKi219.0 [1], 6620.0 [2]
2-[2,6-Dihydroxy-4-[(1R,2R)-2-[(4-hydroxybenzoyl)amino]cycloheptyl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC5090.0 [1]
Balanol analog 3IC5050.0 [1]
N-[4-Hydroxy-2-[4-[(1S,3R,5R,9R,13R)-9-(hydroxymethyl)-16,16-dimethyl-7,11-dioxo-2,6,10,17-tetraoxatricyclo[11.3.1.11,5]octadecan-3-yl]butyl]phenyl]acetamideKi690.0 [1], 8700.0 [2]
N-[2-Hydroxy-4-[4-[(1S,3R,5R,9R,13R)-9-(hydroxymethyl)-16,16-dimethyl-7,11-dioxo-2,6,10,17-tetraoxatricyclo[11.3.1.11,5]octadecan-3-yl]butyl]phenyl]acetamideKi36.0 [1], 290.0 [2]
(1S,3R,5R,9R,13R)-3-[4-(2-Bromo-5-hydroxyphenyl)butyl]-9-(hydroxymethyl)-16,16-dimethyl-2,6,10,17-tetraoxatricyclo[11.3.1.11,5]octadecane-7,11-dioneKi3.5 [1], 66.0 [2]
(1S,3R,5R,9R,13R)-3-[4-(2,4-Dibromo-5-hydroxyphenyl)butyl]-9-(hydroxymethyl)-16,16-dimethyl-2,6,10,17-tetraoxatricyclo[11.3.1.11,5]octadecane-7,11-dioneKi4.1 [1], 93.0 [2]
(1S,3R,5R,9R,13R)-9-(Hydroxymethyl)-16,16-dimethyl-3-[4-(2,4,6-tribromo-3-hydroxyphenyl)butyl]-2,6,10,17-tetraoxatricyclo[11.3.1.11,5]octadecane-7,11-dioneKi6.9 [1], 79.0 [2]
(1S,3R,5R,9R,13R)-3-[4-(3-Hydroxy-4-iodophenyl)butyl]-9-(hydroxymethyl)-16,16-dimethyl-2,6,10,17-tetraoxatricyclo[11.3.1.11,5]octadecane-7,11-dioneKi1.3 [1], 82.0 [2]
(1S,3R,5R,9R,13R)-3-[4-(5-Hydroxy-2-iodophenyl)butyl]-9-(hydroxymethyl)-16,16-dimethyl-2,6,10,17-tetraoxatricyclo[11.3.1.11,5]octadecane-7,11-dioneKi4.6 [1], 110.0 [2]
(1S,3R,5R,9R,13R)-9-(Hydroxymethyl)-3-[4-(3-methoxyphenyl)butyl]-16,16-dimethyl-2,6,10,17-tetraoxatricyclo[11.3.1.11,5]octadecane-7,11-dioneKi9.7 [1], 330.0 [2]
4-Chloro-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideIC50100000.0 [1], 500000.0 [2]
2-[2,6-Dihydroxy-4-[(3R)-3-[(4-hydroxybenzoyl)amino]azepan-4-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC504.0 [1], 32.0 [2]
Phorbol 12-myristate 13-acetateKi0.8 [1]
ImatinibIC50100000.0 [1]
DasatinibIC5050000.0 [1]
AlvocidibIC50890.0 [1]
RottlerinIC503000.0 [1]
Bryostatin 1Ki0.44 [1]
Go-6976IC50446.0 [1]
EnzastaurinIC501000.0 [1]
Teleocidin B4Ki0.32 [1]
RuboxistaurinIC50250.0 [1]
DoramapimodIC501900.0 [1]
Purvalanol BIC50100000.0 [1]
Purvalanol AIC50100000.0 [1]
Gsk-690693IC5014.0 [1]
(5e)-5-(Quinolin-6-Ylmethylidene)-2-[(Thiophen-2-Ylmethyl)amino]-1,3-Thiazol-4(5h)-OneKi318.0 [1]
(5Z)-5-(Quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-oneKi320.0 [1]
(2S,3R)-3-Hydroxy-N-[3-[(2R,3S,6S,8R)-8-[(E,3S,6S)-6-hydroxy-3,5-dimethylhept-4-enyl]-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]propyl]-2-methyl-4-[[2-[(2S,3S,6R)-3-methyl-6-[(E)-2-oxopent-3-enyl]oxan-2-yl]acetyl]amino]butanamideKi27000.0 [1]
A-674563Ki360.0 [1]
Rac-syn-BalanolIC5032.0 [1]
4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenolIC50100000.0 [1]
1-(Tert-Butyl)-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC50100000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Protein kinase C delta Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/protein-kinase-c-delta-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Protein kinase C delta Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/protein-kinase-c-delta-inhibitors-ic50-ki.
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