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Protein kinase C beta Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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StaurosporineIC5023.0 [1]
BalanolIC5030.0 [1]
Balanol analog 5IC5050.0 [1]
Balanol analog 4IC5033.0 [1]
Indolactam VKi173.5 [1]
2-[2,6-Dihydroxy-4-[3-[(4-hydroxybenzoyl)amino]azepan-4-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC5030.0 [1]
RuboxistaurinIC505.9 [1]
2-[2,6-Dihydroxy-4-[2-[(4-hydroxybenzoyl)amino]cyclopentyl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC5040.0 [1], 50.0 [2]
PKCbeta InhibitorIC505.0 [1], 21.0 [2]
8-Octyl-benzolactam-V9Ki10000.0 [1]
6,6-Dimethyl-8-[1-(oxetan-3-yl)piperidin-4-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrileIC5050000.0 [1]
2-[2,6-Dihydroxy-4-[[2-[(4-hydroxybenzoyl)amino]-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]oxycarbonyl]benzoyl]-3-hydroxybenzoic acidIC504400.0 [1], 14000.0 [2]
[2-[(4-Hydroxyphenyl)methyl]cyclopentyl] 3,5-dihydroxy-4-(2-hydroxy-6-methoxycarbonylbenzoyl)benzoateIC5090.0 [1], 100.0 [2]
2-[2,6-Dihydroxy-4-[2-[(4-hydroxyphenyl)methyl]cyclopentyl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC5020.0 [1]
2-[2,6-Dihydroxy-4-[2-(4-hydroxyphenoxy)cyclopentyl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC5020.0 [1]
2-[2,6-Dihydroxy-4-[4-[(4-hydroxyphenyl)methyl]pyrrolidin-3-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC5010.0 [1], 30.0 [2]
[4-[(4-Hydroxyphenyl)methyl]pyrrolidin-3-yl] 3,5-dihydroxy-4-(2-hydroxy-6-methoxycarbonylbenzoyl)benzoateIC50110.0 [1], 250.0 [2]
2-[2,6-Dihydroxy-4-[(1R,2R)-2-[(4-hydroxybenzoyl)amino]cycloheptyl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC50220.0 [1], 430.0 [2]
Balanol analog 3IC502200.0 [1], 4700.0 [2]
2-[2,6-Dihydroxy-4-[(3R)-3-[(4-hydroxybenzoyl)amino]azepan-4-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC5010.0 [1], 32.0 [2], 44.0 [3]
EnzastaurinIC506.0 [1], 30.0 [2]
SotrastaurinIC502.0 [1]
20-Ethyl-17,23-dioxa-4,14,20,26-tetrazahexacyclo[24.6.1.17,14.02,6.08,13.027,32]tetratriaconta-1(33),2(6),7(34),8,10,12,27,29,31-nonaene-3,5-dioneIC509.0 [1], 14.0 [2], 25.0 [3]
8-Decyl-5-hydroxymethyl-2-isopropyl-1-methyl-1,2,5,6-tetrahydro-benzo[e][1,4]oxazocin-3-oneKi10000.0 [1], 22000.0 [2]
20-(2-Hydroxyethyl)-17,23-dioxa-4,14,20,26-tetrazahexacyclo[24.6.1.17,14.02,6.08,13.027,32]tetratriaconta-1(33),2(6),7(34),8,10,12,27,29,31-nonaene-3,5-dioneIC5040.0 [1], 58.0 [2], 68.0 [3]
3-[1-[3-(Dimethylamino)propyl]indazol-3-yl]-4-(1-naphthalen-1-ylindol-3-yl)pyrrole-2,5-dioneIC5029.0 [1], 87.0 [2], 600.0 [3]
3-[1-(3-Morpholin-4-ylpropyl)indazol-3-yl]-4-(1-naphthalen-2-ylindol-3-yl)pyrrole-2,5-dioneIC5018.0 [1], 72.0 [2], 190.0 [3]
3-[1-[3-(Dimethylamino)propyl]indazol-3-yl]-4-(1-pyridin-3-ylindol-3-yl)pyrrole-2,5-dioneIC507.0 [1], 19.0 [2], 82.0 [3]
3-[1-[3-(Dimethylamino)propyl]indazol-3-yl]-4-(1-thiophen-2-ylindol-3-yl)pyrrole-2,5-dioneIC5010.0 [1], 15.0 [2], 75.0 [3]
3-[1-(1-Benzothiophen-3-yl)indol-3-yl]-4-[1-[3-(dimethylamino)propyl]indazol-3-yl]pyrrole-2,5-dioneIC5037.0 [1], 86.0 [2], 630.0 [3]
3-(1-Naphthalen-2-ylindol-3-yl)-4-[1-(3-pyrrolidin-1-ylpropyl)indazol-3-yl]pyrrole-2,5-dioneIC5044.0 [1], 120.0 [2], 170.0 [3]
23-Methyl-17,20-dioxa-4,14,23,27-tetrazahexacyclo[25.6.1.17,14.02,6.08,13.028,33]pentatriaconta-1(34),2(6),7(35),8,10,12,28,30,32-nonaene-3,5-dioneIC5045.0 [1], 46.0 [2], 73.0 [3]
3-[1-[3-(Dimethylamino)propyl]indazol-3-yl]-4-(1-naphthalen-2-ylindol-3-yl)pyrrole-2,5-dioneIC505.0 [1], 24.0 [2], 33.0 [3]
3-[1-[3-(Dimethylamino)propyl]indazol-3-yl]-4-(1-isoquinolin-4-ylindol-3-yl)pyrrole-2,5-dioneIC5015.0 [1], 86.0 [2], 92.0 [3]
17,20,23-Trimethyl-4,14,17,20,23,26-hexazahexacyclo[24.6.1.17,14.02,6.08,13.027,32]tetratriaconta-1(33),2(6),7(34),8,10,12,27,29,31-nonaene-3,5-dioneIC5027.0 [1], 31.0 [2], 82.0 [3]
3-[1-[3-(Dimethylamino)propyl]indazol-3-yl]-4-(1-quinolin-3-ylindol-3-yl)pyrrole-2,5-dioneIC504.0 [1], 7.0 [2], 20.0 [3]
(18S)-18-(Hydroxymethyl)-17-oxa-4,14,21-triazahexacyclo[19.6.1.17,14.02,6.08,13.022,27]nonacosa-1(28),2(6),7(29),8,10,12,22,24,26-nonaene-3,5-dioneIC5028.0 [1], 32.0 [2], 73.0 [3]
3-(1H-Indol-3-yl)-4-phenylamino-pyrrole-2,5-dioneIC50223.0 [1], 395.0 [2]
2-[2,6-Dihydroxy-4-[4-[(4-hydroxybenzoyl)amino]pyrrolidin-3-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC5010.0 [1], 33.0 [2]
20,23-Dimethyl-17-oxa-4,14,20,23,26-pentazahexacyclo[24.6.1.17,14.02,6.08,13.027,32]tetratriaconta-1(33),2(6),7(34),8,10,12,27,29,31-nonaene-3,5-dioneIC509.0 [1], 10.0 [2], 46.0 [3]
Phorbol 12,13-dibutyrateKi1.8 [1], 1.97 [2]
Go-6976IC502.0 [1], 6.2 [2]
Bisindolylmaleimide IVIC50212.0 [1], 304.0 [2]
DoramapimodIC506900.0 [1], 40000.0 [2]
Purvalanol BIC50100000.0 [1]
Purvalanol AIC5010000.0 [1]
CercosporamideIC50300.0 [1], 350.0 [2]
Rac-syn-BalanolIC5032.0 [1], 44.0 [2]
CID 59604787IC5010000.0 [1]
8-Dec-1-ynyl-5-hydroxymethyl-2-isopropyl-1-methyl-1,4,5,6-tetrahydro-2H-benzo[e][1,4]diazocin-3-oneKi17.4 [1], 70.0 [2]
(2R)-2-[(2S)-4-[3-Chloro-5-fluoro-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-olKi15.0 [1], 393.0 [2]
(1S,3R,5R,9R,13R)-9-(Hydroxymethyl)-3-[4-(3-hydroxyphenyl)butyl]-16,16-dimethyl-2,6,10,17-tetraoxatricyclo[11.3.1.11,5]octadecane-7,11-dioneKi89.0 [1]
9-Ethyl-6,6-dimethyl-8-[4-(oxetan-3-yl)piperazin-1-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrileIC5050000.0 [1]
3-[[5-[6-[(3-Chlorophenyl)amino]pyrazinyl]-3-pyridinyl]amino]-1-propanolIC5010000.0 [1]
(2S,5S)-8-Decyl-5-(hydroxymethyl)-1-methyl-2-propan-2-yl-2,4,5,6-tetrahydro-1,4-benzodiazocin-3-oneKi58.2 [1], 442.4 [2]
3-(1-Methyl-1H-indol-3-yl)-4-(1-piperidin-4-yl-1H-indol-3-yl)-pyrrole-2,5-dioneIC5030.0 [1]
17,23-Dimethyl-20-oxa-4,14,17,23,26-pentazahexacyclo[24.6.1.17,14.02,6.08,13.027,32]tetratriaconta-1(33),2(6),7(34),8,10,12,27,29,31-nonaene-3,5-dioneIC5027.0 [1], 41.0 [2]
3-(1H-Indol-3-yl)-4-[3-(4-methylpiperazin-1-yl)naphthalen-1-yl]pyrrole-2,5-dioneIC501.8 [1]
1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)ureaIC5030000.0 [1], 32000.0 [2]
N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamideIC5050000.0 [1]
Acyclic Balanol Analog 16bIC501800.0 [1], 2800.0 [2]
3-[1-(1-Benzylpiperidin-4-yl)indol-3-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dioneIC5030.0 [1], 50.0 [2]
2-[2,6-Dihydroxy-4-[(3R,4R)-3-[(4-hydroxybenzoyl)amino]oxepan-4-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC502500.0 [1], 3300.0 [2]
2-[2,6-Dihydroxy-4-[(3S,4R)-3-[(4-hydroxybenzoyl)amino]thiepan-4-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC502400.0 [1], 3800.0 [2]
2-[2,6-Dihydroxy-4-[[(3R,4R)-3-[(4-hydroxybenzoyl)amino]-1-azabicyclo[3.2.2]nonan-4-yl]oxycarbonyl]benzoyl]-3-hydroxybenzoic acidIC5026.0 [1], 69.0 [2]
20-Methyl-17,23-dioxa-4,14,20,26-tetrazahexacyclo[24.6.1.17,14.02,6.08,13.027,32]tetratriaconta-1(33),2(6),7(34),8,10,12,27,29,31-nonaene-3,5-dioneIC5041.0 [1], 47.0 [2]
3-[1-[3-(Dimethylamino)propyl]indazol-3-yl]-4-(1-phenylindol-3-yl)pyrrole-2,5-dioneIC5013.0 [1], 46.0 [2]
3-[1-[3-(4-Methylpiperazin-1-yl)propyl]indazol-3-yl]-4-(1-naphthalen-2-ylindol-3-yl)pyrrole-2,5-dioneIC5062.0 [1], 92.0 [2]
3-(1H-Indazol-3-yl)-4-(1-pyridin-3-ylindol-3-yl)pyrrole-2,5-dioneIC50220.0 [1], 460.0 [2]
5-Hydroxymethyl-2-isopropyl-1-undecyl-1,2,5,6-tetrahydro-benzo[e][1,4]oxazocin-3-oneKi2070.0 [1], 4690.0 [2]
2-[4-[(1R,2R,4S)-4-(Aminomethyl)-2-[(4-hydroxybenzoyl)amino]cyclopentyl]oxycarbonyl-2,6-dihydroxybenzoyl]-3-hydroxybenzoic acidIC504.0 [1]
(10S,13S)-13-(Hydroxymethyl)-9-methyl-10-propan-2-yl-3,9,12-triazatricyclo[6.6.1.04,15]pentadeca-1,4(15),5,7-tetraene-11-thioneKi179.5 [1], 225.9 [2]
7-Decyl-5-hydroxymethyl-2-isopropyl-1-methyl-1,2,5,6-tetrahydro-benzo[e][1,4]oxazocin-3-oneKi539.0 [1], 2690.0 [2]
2-[2,6-Dihydroxy-4-[(1R,2R,4S)-2-[(4-hydroxybenzoyl)amino]-4-(hydroxymethyl)cyclopentyl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC503.0 [1], 4.0 [2]
2-[4-[(1R,2R,4R)-4-Amino-2-[(4-hydroxybenzoyl)amino]cyclopentyl]oxycarbonyl-2,6-dihydroxybenzoyl]-3-hydroxybenzoic acidIC502.0 [1], 4.0 [2]
2-[2,6-Dihydroxy-4-[(1R,2R,4R)-4-hydroxy-2-[(4-hydroxybenzoyl)amino]cyclopentyl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC5020.0 [1], 30.0 [2]
(18S)-18-(Aminomethyl)-17-oxa-4,14,21-triazahexacyclo[19.6.1.17,14.02,6.08,13.022,27]nonacosa-1(28),2(6),7(29),8,10,12,22,24,26-nonaene-3,5-dioneIC5033.0 [1], 48.0 [2]
2-[2,6-Dihydroxy-4-[(1R,2R,4R)-2-[(4-hydroxybenzoyl)amino]-4-(hydroxymethyl)cyclopentyl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC5020.0 [1], 60.0 [2]
2-[2,6-Dihydroxy-4-[(3S,4S)-3-[(4-hydroxybenzoyl)amino]azepan-4-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC50500.0 [1], 880.0 [2]
2-[2,6-Dihydroxy-4-[(3S,4R)-3-[(4-hydroxybenzoyl)amino]-1,1-dioxothiepan-4-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC503600.0 [1], 5200.0 [2]
N-[[(18S)-3,5-Dioxo-17-oxa-4,14,21-triazahexacyclo[19.6.1.17,14.02,6.08,13.022,27]nonacosa-1(28),2(6),7(29),8,10,12,22,24,26-nonaen-18-yl]methyl]benzenesulfonamideIC5044.0 [1], 170.0 [2]
(18S)-18-(Methylaminomethyl)-17-oxa-4,14,21-triazahexacyclo[19.6.1.17,14.02,6.08,13.022,27]nonacosa-1(28),2(6),7(29),8,10,12,22,24,26-nonaene-3,5-dioneIC505.0 [1]
(18S)-18-(Morpholin-4-ylmethyl)-17-oxa-4,14,21-triazahexacyclo[19.6.1.17,14.02,6.08,13.022,27]nonacosa-1(28),2(6),7(29),8,10,12,22,24,26-nonaene-3,5-dioneIC5038.0 [1], 49.0 [2]
(18S)-18-[(4-Methylpiperazin-1-yl)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.17,14.02,6.08,13.022,27]nonacosa-1(28),2(6),7(29),8,10,12,22,24,26-nonaene-3,5-dioneIC5024.0 [1], 30.0 [2]
(18S)-18-[(Benzylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.17,14.02,6.08,13.022,27]nonacosa-1(28),2(6),7(29),8,10,12,22,24,26-nonaene-3,5-dioneIC50310.0 [1], 330.0 [2]
2-[4-[(1R,2R,4R)-4-(Aminomethyl)-2-[(4-hydroxybenzoyl)amino]cyclopentyl]oxycarbonyl-2,6-dihydroxybenzoyl]-3-hydroxybenzoic acidIC505.0 [1]
Tert-butyl 4-[3-[4-(1-methylindol-3-yl)-2,5-dioxopyrrol-3-yl]indol-1-yl]piperidine-1-carboxylateIC5080.0 [1], 200.0 [2]
3-[1-(1-Benzylpyrrolidin-3-yl)indol-3-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dioneIC5022.0 [1], 24.0 [2]
9-Decyl-5-hydroxymethyl-2-isopropyl-1-methyl-1,2,5,6-tetrahydro-benzo[e][1,4]oxazocin-3-oneKi610.0 [1], 1140.0 [2]
Ruboxistaurin mesylateIC504.7 [1], 5.9 [2]
2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2000.0 [1], 2090.0 [2]
3-(1H-Indol-3-yl)-4-[1-(1-methylpiperidin-4-yl)indol-3-yl]pyrrole-2,5-dioneIC5010.0 [1], 20.0 [2]
(18S)-18-(Pyrrolidin-1-ylmethyl)-17-oxa-4,14,21-triazahexacyclo[19.6.1.17,14.02,6.08,13.022,27]nonacosa-1(28),2(6),7(29),8,10,12,22,24,26-nonaene-3,5-dioneIC5044.0 [1], 120.0 [2]
3-(Cyclohexylamino)-4-(1H-indol-3-yl)pyrrole-2,5-dioneIC502448.0 [1]
3-Phenylamino-4-[1-(3-pyrrolidin-1-yl-propyl)-1H-indol-3-yl]-pyrrole-2,5-dioneIC5018.0 [1]
1-Hexylindolactam-VKi9.8 [1], 11.0 [2]
3-(1-Methylindol-3-yl)-4-[1-(1-propan-2-ylpiperidin-4-yl)indol-3-yl]pyrrole-2,5-dioneIC5019.0 [1], 26.0 [2]
3-[1-(1-Ethyl-piperidin-4-yl)-indol-3-yl]-4-(1-methyl-indol-3-yl)-pyrrole-2,5-dioneIC505.0 [1], 20.0 [2]
2-[2,6-Dihydroxy-4-[[(8R,9R)-9-[(4-hydroxybenzoyl)amino]-8-tricyclo[5.2.1.02,6]decanyl]oxycarbonyl]benzoyl]-3-hydroxybenzoic acidIC5030.0 [1], 150.0 [2]
(3S,6S)-11-Hexyl-6-(hydroxymethyl)-2-methyl-3-propan-2-yl-2,5,11-triazatricyclo[7.6.1.012,16]hexadeca-1(15),9,12(16),13-tetraen-4-oneKi440.0 [1], 9200.0 [2]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Protein kinase C beta Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/protein-kinase-c-beta-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Protein kinase C beta Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/protein-kinase-c-beta-inhibitors-ic50-ki.
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