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Protein arginine N-methyltransferase 3 Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
1-Isoquinolin-6-Yl-3-[2-Oxo-2-(Pyrrolidin-1-Yl)ethyl]ureaIC5019.0 [1], 91.0 [2], 225.0 [3]
1-(1,2,3-Benzothiadiazol-6-Yl)-3-[2-(Cyclohex-1-En-1-Yl)ethyl]ureaIC501600.0 [1], 2400.0 [2], 2500.0 [3]
1-(1,2,3-Benzothiadiazol-6-yl)-3-(2-oxo-2-piperidin-1-ylethyl)ureaIC50134.0 [1], 230.0 [2]
1-Isoquinolin-6-yl-3-[2-oxo-2-(3,3,4,4-tetrafluoropyrrolidin-1-yl)ethyl]ureaIC5024.0 [1], 240.0 [2]
1-[2-(2,5-Dimethylpyrrolidin-1-yl)-2-oxoethyl]-3-isoquinolin-6-ylureaIC5022.0 [1], 134.0 [2]
1-(7-Fluoroisoquinolin-6-yl)-3-(2-oxo-2-pyrrolidin-1-ylethyl)ureaIC5019.0 [1], 134.0 [2]
1-[2-(4-Aminocyclohexyl)ethyl]-3-(1,2,3-benzothiadiazol-6-yl)ureaIC503600.0 [1], 10000.0 [2]
CID 71268957IC5074000.0 [1]
CID 46901937IC5040000.0 [1]
N,N,N'-TrimethylethylenediamineIC5035000.0 [1]
CID 44251522IC5040000.0 [1]
C.I. Direct Red 23IC507100.0 [1]
CID 53315882IC5010000.0 [1]
Bromo-deaza-SAHIC502300.0 [1]
6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amineIC50100000.0 [1]
BMS pyrazole inhibitor 7fIC5025000.0 [1]
2-[3-[[[(2S)-2-Aminopropanoyl]amino]methyl]phenyl]-N-benzyl-5-(trifluoromethyl)pyrazole-3-carboxamideIC5025000.0 [1]
Benzo[d]imidazole inhibitors of PRMT4 from BMSIC5025000.0 [1]
CID 53868701IC5022000.0 [1]
MS023IC504.0 [1]
PRMT5 Inhibitor C17IC50100000.0 [1]
2-[4-[(3-Fluorophenyl)methoxy]piperidin-1-yl]-N-methylethanamineIC5028000.0 [1]
N-Methyl-2-[4-[(3-phenylphenyl)methoxy]piperidin-1-yl]ethanamineIC501970.0 [1]
1-(2-Oxo-2-piperidin-1-ylethyl)-3-quinazolin-7-ylureaIC50967.0 [1]
1-Isoquinolin-6-yl-3-(2-phenylethyl)ureaIC50833.0 [1]
N,N-Diethyl-2-(isoquinolin-6-ylcarbamoylamino)acetamideIC50114.0 [1]
N-Cyclopentyl-2-(isoquinolin-6-ylcarbamoylamino)acetamideIC50292.0 [1]
1-(1-Methylisoquinolin-6-yl)-3-(2-oxo-2-pyrrolidin-1-ylethyl)ureaIC50194.0 [1]
1-(8-Chloroisoquinolin-6-yl)-3-(2-oxo-2-pyrrolidin-1-ylethyl)ureaIC5019.0 [1]
1-[2-(8-Azabicyclo[3.2.1]octan-8-yl)-2-oxoethyl]-3-isoquinolin-6-ylureaIC5022.0 [1]
1-Isoquinolin-6-yl-1-methyl-3-(2-oxo-2-pyrrolidin-1-ylethyl)ureaIC5050000.0 [1]
1-Isoquinolin-6-yl-3-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]ureaIC501900.0 [1]
3-Isoquinolin-6-yl-1-methyl-1-(2-oxo-2-pyrrolidin-1-ylethyl)ureaIC502594.0 [1]
1-[2-(4,4-Difluoropiperidin-1-yl)-2-oxoethyl]-3-isoquinolin-6-ylureaIC5035.0 [1]
1-(1-Oxo-3H-2-benzofuran-5-yl)-3-(2-oxo-2-piperidin-1-ylethyl)ureaIC50757.0 [1]
1-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-3-isoquinolin-6-ylureaIC505000.0 [1]
2-(Isoquinolin-6-ylcarbamoylamino)-N,N-dimethylacetamideIC50150.0 [1]
1-Isoquinolin-6-yl-3-(2-oxo-2-piperidin-1-ylethyl)ureaIC5084.0 [1]
1-[2-(7-Azabicyclo[2.2.1]heptan-7-yl)-2-oxoethyl]-3-isoquinolin-6-ylureaIC5046.0 [1]
N-Cyclopentyl-2-(isoquinolin-6-ylcarbamoylamino)-N-methylacetamideIC5087.0 [1]
1-Isoquinolin-7-yl-3-(2-oxo-2-piperidin-1-ylethyl)ureaIC502000.0 [1]
1-(2-Cyclopentylethyl)-3-isoquinolin-6-ylureaIC50295.0 [1]
N-Cyclohexyl-2-(isoquinolin-6-ylcarbamoylamino)acetamideIC50477.0 [1]
1-(2-Cyclopropylethyl)-3-isoquinolin-6-ylureaIC508000.0 [1]
1-[2-(Azepan-1-yl)-2-oxoethyl]-3-isoquinolin-6-ylureaIC5017.0 [1]
N-Cyclopropyl-2-(isoquinolin-6-ylcarbamoylamino)acetamideIC50158.0 [1]
1-(3-Fluoroisoquinolin-6-yl)-3-(2-oxo-2-pyrrolidin-1-ylethyl)ureaIC5010.0 [1]
1-(7-Methylisoquinolin-6-yl)-3-(2-oxo-2-pyrrolidin-1-ylethyl)ureaIC5036.0 [1]
N'-[[2-(2-Chlorophenyl)sulfanylphenyl]methyl]-N'-methylethane-1,2-diamineIC5022.0 [1]
1-[2-(Cyclohexen-1-yl)ethyl]-3-isoquinolin-6-ylureaIC50421.0 [1]
1-[2-(3,3a,4,5,6,6a-Hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-2-oxoethyl]-3-isoquinolin-6-ylureaIC5055.0 [1]
2-(Isoquinolin-6-ylcarbamoylamino)-N-methylacetamideIC501938.0 [1]
2-(Isoquinolin-6-ylcarbamoylamino)-N-methoxy-N-methylacetamideIC50476.0 [1]
Methyl (2S)-1-[2-(isoquinolin-6-ylcarbamoylamino)acetyl]pyrrolidine-2-carboxylateIC50166.0 [1]
1-[2-(Azetidin-1-yl)-2-oxoethyl]-3-isoquinolin-6-ylureaIC5061.0 [1]
1-(2-Cyclohexylethyl)-3-isoquinolin-6-ylureaIC50540.0 [1]
2-(4-Benzylpiperidin-1-yl)ethanamineIC5019000.0 [1]
N-Methyl-2-(4-methylpiperidin-1-yl)ethanamineIC50500000.0 [1]
N-[(6-Methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1-propan-2-ylindazole-4-carboxamideIC5054000.0 [1]
N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-6-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1-propan-2-ylindazole-4-carboxamideIC50100000.0 [1]
1-(1,2,3-Benzothiadiazol-6-Yl)-3-(2-Oxo-2-Phenylethyl)ureaIC50480.0 [1]
(2Z)-1-Ethyl-2-[(E)-3-(1-ethylbenzo[cd]indol-1-ium-2-yl)prop-2-enylidene]benzo[cd]indole;iodideIC508300.0 [1]
(2R)-2-Amino-N-ethylpropanamideIC501000000.0 [1]
1-(2H-Benzotriazol-5-yl)-3-(2-cyclohexylethyl)ureaIC50100000.0 [1]
1-(2-Cyclohexylethyl)-3-(1H-indazol-6-yl)ureaIC50100000.0 [1]
1-(2-Cyclohexylethyl)-3-(1H-indazol-5-yl)ureaIC50100000.0 [1]
1-(2-Cyclohexylethyl)-3-(2-oxo-3H-1,3-benzoxazol-6-yl)ureaIC50100000.0 [1]
3-(1,2,3-Benzothiadiazol-6-ylamino)-4-(2-cyclohexylethylamino)cyclobut-3-ene-1,2-dioneIC50100000.0 [1]
3-(1,2,3-Benzothiadiazol-6-ylamino)-4-(phenacylamino)cyclobut-3-ene-1,2-dioneIC50100000.0 [1]
1-(1,2,3-Benzothiadiazol-6-yl)-3-cyano-2-(2-cyclohexylethyl)guanidineIC50100000.0 [1]
N-[5-(2-Cyclohexylethyl)-1H-1,2,4-triazol-3-yl]-1,2,3-benzothiadiazol-6-amineIC50100000.0 [1]
1-(2-Amino-2-phenylethyl)-3-(1,2,3-benzothiadiazol-6-yl)ureaIC505900.0 [1]
1-(1,2,3-Benzothiadiazol-6-yl)-3-(2-hydroxy-2-phenylethyl)ureaIC501900.0 [1]
1-(1,2,3-Benzothiadiazol-6-yl)-3-(2,2-difluoro-2-phenylethyl)ureaIC505000.0 [1]
1-(1,2,3-Benzothiadiazol-6-yl)-3-[2-(4-fluorophenyl)-2-hydroxyethyl]ureaIC504400.0 [1]
1-(1,2,3-Benzothiadiazol-6-yl)-3-[2-(2-fluorophenyl)-2-hydroxyethyl]ureaIC503300.0 [1]
1-(1,2,3-Benzothiadiazol-6-yl)-3-(2-cyclohexyl-2-hydroxyethyl)ureaIC50490.0 [1]
1-(1,2,3-Benzothiadiazol-6-yl)-3-(2-cyclohexyl-2-oxoethyl)ureaIC50840.0 [1]
1-(1,2,3-Benzothiadiazol-6-yl)-3-[2-(4-fluorophenyl)-2-oxoethyl]ureaIC50360.0 [1]
1-(1,2,3-Benzothiadiazol-6-yl)-3-[2-(oxan-4-yl)ethyl]ureaIC503600.0 [1]
1-(1,2,3-Benzothiadiazol-6-yl)-3-(2-piperidin-1-ylethyl)ureaIC505200.0 [1]
1-(1,2,3-Benzothiadiazol-6-yl)-3-(2-morpholin-4-ylethyl)ureaIC5010000.0 [1]
1-(1,2,3-Benzothiadiazol-6-yl)-3-(3-morpholin-4-ylpropyl)ureaIC507200.0 [1]
1-(1,2,3-Benzothiadiazol-6-yl)-3-(2-pyrrolidin-1-ylethyl)ureaIC5010000.0 [1]
1-(1,2,3-Benzothiadiazol-6-yl)-3-(cyclohexylmethyl)ureaIC5050000.0 [1]
1-(1,2,3-Benzothiadiazol-6-yl)-3-ethylureaIC5015000.0 [1]
1-(1,2,3-Benzothiadiazol-6-yl)-3-(3,3-dimethylbutyl)ureaIC5010000.0 [1]
1-(1,2,3-Benzothiadiazol-6-yl)-3-(pyridin-2-ylmethyl)ureaIC5015000.0 [1]
1-(1,2,3-Benzothiadiazol-6-yl)-3-(pyridin-3-ylmethyl)ureaIC5015000.0 [1]
1-(1,2,3-Benzothiadiazol-6-yl)-3-(pyridin-4-ylmethyl)ureaIC5010000.0 [1]
1-(1,2,3-Benzothiadiazol-6-yl)-3-[[4-(dimethylamino)phenyl]methyl]ureaIC5015000.0 [1]
1-(1,2,3-Benzothiadiazol-6-yl)-3-[(4-methoxyphenyl)methyl]ureaIC5010000.0 [1]
1-(1,2,3-Benzothiadiazol-6-yl)-3-[(4-nitrophenyl)methyl]ureaIC50300.0 [1]
1-(1,2,3-Benzothiadiazol-6-yl)-3-[(4-methylsulfonylphenyl)methyl]ureaIC50850.0 [1]
1-(1,2,3-Benzothiadiazol-6-yl)-3-[(4-cyanophenyl)methyl]ureaIC501800.0 [1]
1-(1,2,3-Benzothiadiazol-6-yl)-3-[[4-(trifluoromethyl)phenyl]methyl]ureaIC503100.0 [1]
1-(1,2,3-Benzothiadiazol-6-yl)-3-[(4-fluorophenyl)methyl]ureaIC504000.0 [1]
1-(1,2,3-Benzothiadiazol-6-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]ureaIC5025000.0 [1]
1-(1,2,3-Benzothiadiazol-6-yl)-3-[3-(4-fluorophenyl)propyl]ureaIC502200.0 [1]
1-(1,2,3-Benzothiadiazol-6-yl)-3-(2-piperidin-4-ylethyl)ureaIC502700.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Protein arginine N-methyltransferase 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/protein-arginine-n-methyltransferase-3-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Protein arginine N-methyltransferase 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/protein-arginine-n-methyltransferase-3-inhibitors-ic50-ki.
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