Protein-arginine deiminase type-4 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Cl-amidine (TFA)	IC50	3400.0 [1], 4000.0 [2], 9000.0 [3], 15000.0 [4]
	Cl-amidine (TFA)	Ki	180000.0 [1]
	F-Amidine	IC50	15000.0 [1], 21000.0 [2], 51000.0 [3], 530000.0 [4]
	F-Amidine	Ki	330000.0 [1]
	2-{[(2s)-1-Amino-5-{[(1z)-2-Fluoroethanimidoyl]amino}-1-Oxopentan-2-Yl]carbamoyl}benzoic Acid	IC50	400.0 [1], 1100.0 [2], 4600.0 [3], 32000.0 [4]
	2-{[(2s)-1-Amino-5-{[(1z)-2-Fluoroethanimidoyl]amino}-1-Oxopentan-2-Yl]carbamoyl}benzoic Acid	Ki	16000.0 [1]
	2-{[(2s)-1-Amino-5-{[(1z)-2-Chloroethanimidoyl]amino}-1-Oxopentan-2-Yl]carbamoyl}benzoic Acid	IC50	1100.0 [1], 2400.0 [2], 5300.0 [3], 22000.0 [4]
	2-{[(2s)-1-Amino-5-{[(1z)-2-Chloroethanimidoyl]amino}-1-Oxopentan-2-Yl]carbamoyl}benzoic Acid	Ki	13000.0 [1]
	Minocycline	IC50	620000.0 [1]
	Minocycline	Ki	180000.0 [1], 540000.0 [2]
	Chlortetracycline	IC50	100000.0 [1]
	Chlortetracycline	Ki	110000.0 [1], 540000.0 [2]
	Streptomycin	IC50	1800000.0 [1]
	Streptomycin	Ki	560000.0 [1]
	Doxycycline	IC50	860000.0 [1]
	Doxycycline	Ki	630000.0 [1]
	Methotrexate	IC50	10000000.0 [1]
	Tetracycline	IC50	780000.0 [1]
	Azathioprine	IC50	8100000.0 [1]
	Clindamycin	IC50	5100000.0 [1]
	Azithromycin	IC50	10000000.0 [1]
	Trimethoprim	IC50	7500000.0 [1]
	Sulfamethoxazole	IC50	10000000.0 [1]
	Mesalamine	IC50	10000000.0 [1]
	Leflunomide	IC50	2400000.0 [1]
	Sulfapyridine	IC50	10000000.0 [1]
	Streptonigrin	IC50	2500.0 [1]
	Cl-amidine	IC50	5900.0 [1]
	7-Amino-2-pyridin-2-ylquinoline-5,8-dione	IC50	640.0 [1]
	7-Bromo-6-methoxyquinoline-5,8-dione	IC50	3300.0 [1]
	6-(7-Amino-5,8-dioxo-5,8-dihydroquinolin-2-yl)picolinic acid	IC50	240.0 [1]
	7-Aminoquinoline-5,8-dione	IC50	1000.0 [1]
	5,5-Dimethyl-3-(piperazin-1-ylmethyl)imidazolidine-2,4-dione	Ki	183000.0 [1]
	[(3S,4R)-3-Amino-4-hydroxypiperidin-1-yl]-[7-methoxy-1-methyl-2-[1-(2,2,2-trifluoroethyl)indol-2-yl]benzimidazol-5-yl]methanone	IC50	79.43 [1]
	[(3R)-3-Aminopiperidin-1-yl]-[2-(1-ethylindol-2-yl)-7-methoxy-1-methylbenzimidazol-5-yl]methanone	IC50	100.0 [1]
	[(3R)-3-Aminopiperidin-1-yl]-[7-methoxy-1-methyl-2-[1-(2,2,2-trifluoroethyl)indol-2-yl]benzimidazol-5-yl]methanone	IC50	50.12 [1]
	[(3R)-3-Aminopiperidin-1-yl]-[2-[1-(cyclopropylmethyl)indol-2-yl]-7-methoxy-1-methylbenzimidazol-5-yl]methanone	IC50	39.81 [1]
	[(3R)-3-Aminopiperidin-1-yl]-[1-methyl-2-[1-(2,2,2-trifluoroethyl)indol-2-yl]benzimidazol-5-yl]methanone	IC50	158.49 [1]
	[(3R)-3-Aminopiperidin-1-yl]-[2-[1-(cyclopropylmethyl)indol-2-yl]-1-methylbenzimidazol-5-yl]methanone	IC50	125.89 [1]
	N-[(2S)-4-(4-Methylpiperazin-1-yl)-1-oxo-1-(propan-2-ylamino)butan-2-yl]furan-2-carboxamide	Ki	488000.0 [1]
	N-[(2S)-1-(Benzylamino)-1-oxo-4-(triazol-1-yl)butan-2-yl]furan-2-carboxamide	Ki	2823000.0 [1]
	N-[(2S)-4-(4-Methylpiperazin-1-yl)-1-oxo-1-(propan-2-ylamino)butan-2-yl]cyclohexanecarboxamide	Ki	10000000.0 [1]
	N-[(2S)-1-(Benzylamino)-4-imidazol-1-yl-1-oxobutan-2-yl]furan-2-carboxamide	Ki	10000000.0 [1]
	N-[(2S)-4-(4-Methylpiperazin-1-yl)-1-oxo-1-(propan-2-ylamino)butan-2-yl]morpholine-4-carboxamide	Ki	10000000.0 [1]
	N-[(2S)-1-(Benzylamino)-4-imidazol-1-yl-1-oxobutan-2-yl]-1-methylpyrrole-2-carboxamide	Ki	180000.0 [1]
	N-[(2S)-4-[4-(Cyanomethyl)imidazol-1-yl]-1-oxo-1-(propan-2-ylamino)butan-2-yl]furan-2-carboxamide	Ki	591000.0 [1]
	5,5-Dimethyl-3-[2-(2H-tetrazol-5-yl)ethyl]imidazolidine-2,4-dione	Ki	47000.0 [1]
	N-[(2S)-1-(Benzylamino)-1-oxo-4-(triazol-1-yl)butan-2-yl]-1-methylpyrrole-2-carboxamide	Ki	64000.0 [1]
	N-[(2S)-4-Imidazol-1-yl-1-oxo-1-(propan-2-ylamino)butan-2-yl]furan-2-carboxamide	Ki	88000.0 [1]
	N'-[3-(1-Benzylindol-3-yl)propyl]-2-chloroethanimidamide	IC50	29000.0 [1]
	2-Chloro-N'-[3-[1-(cyclopentylmethyl)indazol-3-yl]propyl]ethanimidamide	IC50	16000.0 [1]
	2-Chloro-N'-[3-[1-(cyclopentylmethyl)indol-3-yl]propyl]ethanimidamide	IC50	21000.0 [1]
	2-Chloro-N'-[3-(1-methylindol-3-yl)propyl]ethanimidamide	IC50	190000.0 [1]
	2-Chloro-N'-[3-(1-ethylindol-3-yl)propyl]ethanimidamide	IC50	36000.0 [1]
	5,5-Dimethyl-3-(2-morpholin-4-ylethyl)imidazolidine-2,4-dione	Ki	1430000.0 [1]
	2-Fluoroacetimidamide hydrochloride	IC50	10000000.0 [1]
	5,5-Dimethyl-3-(2-pyrrolidin-1-ylethyl)imidazolidine-2,4-dione	Ki	4643000.0 [1]
	3-(2-Imidazol-1-ylethyl)-5,5-dimethylimidazolidine-2,4-dione	Ki	632000.0 [1]
	7-Amino-6-bromoquinoline-5,8-dione	IC50	560.0 [1]
	(2S)-5-[(1-Amino-2-fluoroethylidene)amino]-2-(benzenesulfonamido)pentanamide	IC50	500000.0 [1]
	N-[(2S)-1-Amino-5-[(1-amino-2-fluoroethylidene)amino]-1-oxopentan-2-yl]-1H-imidazole-5-carboxamide	IC50	230000.0 [1]
	N-[(2S)-1-Amino-5-[(1-amino-2-fluoroethylidene)amino]-1-oxopentan-2-yl]-1H-pyrrole-3-carboxamide	IC50	19000.0 [1]
	N-[(2S)-1-Amino-5-[(1-amino-2-fluoroethylidene)amino]-1-oxopentan-2-yl]-2-hydroxy-5-nitrobenzamide	IC50	12000.0 [1]
	2-Fluoro-N'-propylethanimidamide	IC50	1000000.0 [1]
	N'-Benzyl-2-fluoroethanimidamide	IC50	1000000.0 [1]
	2-Fluoro-N'-phenylethanimidamide	IC50	500000.0 [1]
	N-[(2S)-1-Amino-3-[3-[(1-amino-2-fluoroethylidene)amino]phenyl]-1-oxopropan-2-yl]benzamide	IC50	310000.0 [1]
	N-[(1S)-2-Amino-1-[3-[(1-amino-2-fluoroethylidene)amino]phenyl]-2-oxoethyl]benzamide	IC50	2100000.0 [1]
	N-[(2S)-1-Amino-3-[4-[(1-amino-2-fluoroethylidene)amino]phenyl]-1-oxopropan-2-yl]benzamide	IC50	310000.0 [1]
	N-[(2S)-1-Amino-3-[4-[[(1-amino-2-fluoroethylidene)amino]methyl]phenyl]-1-oxopropan-2-yl]benzamide	IC50	1000000.0 [1]
	N-[4-[(1-Amino-2-fluoroethylidene)amino]butyl]benzamide	IC50	1000000.0 [1]
	N'-[4-(Benzenesulfonamido)butyl]-2-fluoroethanimidamide	IC50	1000000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 72 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Protein-arginine deiminase type-4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 31 Mar. 2025, https://www.aatbio.com/data-sets/protein-arginine-deiminase-type-4-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, March 31). Quest Database™ Protein-arginine deiminase type-4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/protein-arginine-deiminase-type-4-inhibitors-ic50-ki.
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