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Proteasome Macropain subunit Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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BortezomibIC501880.0 [1]
Z-Leu-leu-leu-alIC5052.0 [1], 2100.0 [2]
Z-Leu-leu-leu-alKi1.0 [1], 330.0 [2], 5520.0 [3], 22100.0 [4]
(2S)-N-[(2S)-1-[[(E,2S)-1-[4-(Aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]-4-methylpentanamideIC5010.8 [1], 50.0 [2], 84.0 [3], 170.0 [4], 2700.0 [5]
(2S)-N-[(E,2S)-1-[4-(Aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]-2-[[(2S)-3-(4-aminophenyl)-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]propanoyl]amino]-4-methylpentanamideIC5047.0 [1], 110.0 [2], 580.0 [3], 10000.0 [4]
(2S)-2-[[(2S)-3-[4-(Aminomethyl)phenyl]-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]propanoyl]amino]-N-[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]-4-methylpentanamideIC5022.0 [1], 170.0 [2], 420.0 [3], 50000.0 [4]
1-[2-[4-[1-[4-[2-(Azepan-1-yl)ethoxy]phenyl]-2-phenylbut-1-enyl]phenoxy]ethyl]azepaneIC50340.0 [1], 100000.0 [2]
N-[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-Amino-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-2-oxoethyl]-3-[1,1-bis[4-[2-(azepan-1-yl)ethoxy]phenyl]but-1-en-2-yl]benzamideIC501200.0 [1], 8000.0 [2], 45000.0 [3]
N-[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-Acetamido-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-2-oxoethyl]-3-[1,1-bis[4-[2-(azepan-1-yl)ethoxy]phenyl]but-1-en-2-yl]benzamideIC503500.0 [1], 4100.0 [2], 40000.0 [3]
(2S)-N-[(E,2S)-1-[4-(Aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]-2-[[(2S)-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]-3-pyridin-4-ylpropanoyl]amino]-4-methylpentanamideIC5051.0 [1], 270.0 [2], 27000.0 [3]
VincaleukoblastineIC504900.0 [1], 14500.0 [2]
LactacystinIC503250.0 [1], 40000.0 [2]
EpoxomicinIC50160.0 [1], 980.0 [2]
IxazomibIC503500.0 [1], 10000.0 [2]
Onx-0914 (PR-957)IC50930.0 [1], 4700.0 [2]
(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-Acetamido-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-2-[[2-[[3-[1,1-bis[4-[2-(azepan-1-yl)ethoxy]phenyl]but-1-en-2-yl]phenyl]methylamino]-2-oxoethyl]amino]-5-(diaminomethylideneamino)pentanamideIC503200.0 [1], 40000.0 [2]
N-[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[(2-Amino-2-oxoethyl)amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-3-[1,1-bis[4-[2-(azepan-1-yl)ethoxy]phenyl]but-1-en-2-yl]benzamideIC506900.0 [1], 40000.0 [2]
N-[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[2-[[2-[(2-Amino-2-oxoethyl)amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-3-[1,1-bis[4-[2-(azepan-1-yl)ethoxy]phenyl]but-1-en-2-yl]benzamideIC503800.0 [1], 32000.0 [2]
2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]acetic acidIC508000.0 [1], 40000.0 [2]
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-Aminoacetyl)amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanamideIC508000.0 [1], 40000.0 [2]
(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-Acetamido-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-2-[[2-[[3-[1,1-bis[4-[2-(azepan-1-yl)ethoxy]phenyl]but-1-en-2-yl]phenyl]methylamino]-2-oxoethyl]amino]-5-(diaminomethylideneamino)pentanamideIC503700.0 [1], 40000.0 [2]
N-[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-Amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-2-oxoethyl]-3-[1,1-bis[4-[2-(azepan-1-yl)ethoxy]phenyl]but-1-en-2-yl]benzamideIC50200.0 [1], 40000.0 [2]
(4S)-5-Amino-4-[[(2S)-2-[[(2S)-2-[[2-[[3-[1,1-bis[4-[2-(azepan-1-yl)ethoxy]phenyl]but-1-en-2-yl]benzoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoic acidIC508000.0 [1], 40000.0 [2]
(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-Acetamido-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-[[2-[[3-[1,1-bis[4-[2-(azepan-1-yl)ethoxy]phenyl]but-1-en-2-yl]phenyl]methylamino]-2-oxoethyl]amino]-4-methylpentanamideIC508000.0 [1], 40000.0 [2]
N-[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-Amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-2-oxoethyl]-3-[1,1-bis[4-[2-(azepan-1-yl)ethoxy]phenyl]but-1-en-2-yl]benzamideIC50350.0 [1], 40000.0 [2]
N-[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-Amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-3-[1,1-bis[4-[2-(azepan-1-yl)ethoxy]phenyl]but-1-en-2-yl]benzamideIC508900.0 [1], 40000.0 [2]
N-[(2S)-1-[[(2S)-1-[[(2S)-5-(Diaminomethylideneamino)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-3-hydroxy-2-methylbenzamideIC50900.0 [1], 24000.0 [2]
N-[(2S)-1-[[(2S)-1-[[(E,2S)-1-[4-(Aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-3-hydroxy-2-methylbenzamideIC50200.0 [1], 3200.0 [2]
(5Z)-5-[(4-Methylsulfanylphenyl)methylidene]-3-phenyl-2-sulfanylideneimidazolidin-4-oneKi4380.0 [1], 20000.0 [2]
OrlistatIC50100000.0 [1]
CarfilzomibIC50203.0 [1]
Mln9708IC507954.0 [1]
MarizomibIC5028.0 [1]
Z-Ile-Glu(O-t-butyl)-Ala-LeucinalKi2700.0 [1]
PS-IIIKi110000.0 [1]
DelanzomibIC50100.0 [1]
Ridaifen-BIC5010000.0 [1]
Benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(E,3S)-5-methyl-1-methylsulfonylhex-1-en-3-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamateIC502430.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S)-1-(benzylamino)-3-[(3R)-3-hydroxy-2-oxo-1H-indol-3-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-(4-phenylmethoxyphenyl)propan-2-yl]carbamateIC507160.0 [1]
(2S)-N'-(2,2-Dimethylpropyl)-N-[(2S)-1-[[(2S)-4-methyl-1-oxo-1-(5-phenyl-1,3,4-oxadiazol-2-yl)pentan-2-yl]amino]-1-oxopropan-2-yl]-2-[(4-methylphenyl)sulfonylamino]butanediamideKi300000.0 [1]
1-[2-(4-Benzyl-phenoxy)-ethyl]-azepaneIC5010000.0 [1]
1-[2-[4-[2-Phenyl-1-[4-(2-piperidin-1-ylethoxy)phenyl]but-1-enyl]phenoxy]ethyl]piperidineIC5010000.0 [1]
(2S)-N-[(2S)-1-[[(2S)-1-[5-[4-(Dimethylamino)phenyl]-1,3,4-oxadiazol-2-yl]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]-N'-(2,2-dimethylpropyl)-2-[(4-methylphenyl)sulfonylamino]butanediamideKi290000.0 [1]
Chembl4126890IC5050000.0 [1]
4-[2-[4-[1-[4-(2-Morpholin-4-ylethoxy)phenyl]-2-phenylbut-1-enyl]phenoxy]ethyl]morpholineIC5010000.0 [1]
(2S)-2-Amino-N-[(2S)-1-[[(2S)-1-(benzylamino)-3-[(3R)-3-hydroxy-2-oxo-1H-indol-3-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-3-(4-phenylmethoxyphenyl)propanamideIC5024800.0 [1]
Benzyl N-[(2S)-1-[[(2R)-1-[(1S,2S)-2-[[(2R,3S)-3-[(2S)-butan-2-yl]-4-oxooxetane-2-carbonyl]amino]cyclopropyl]-4-phenylbutan-2-yl]amino]-1-oxopropan-2-yl]carbamateIC501920.0 [1]
(2R,3S)-3-[(2S)-Butan-2-yl]-N-[(1S,2S)-2-[(2R)-2-[[(2S)-2-(naphthalene-2-carbonylamino)propanoyl]amino]-4-phenylbutyl]cyclopropyl]-4-oxooxetane-2-carboxamideIC503000.0 [1]
(2S)-N-[(2S)-1-[[(2S)-1-[5-[4-(Dimethylamino)phenyl]-1,3,4-oxadiazol-2-yl]-4-methyl-1-oxopentan-2-yl]amino]-3-methoxy-1-oxopropan-2-yl]-N'-(2,2-dimethylpropyl)-2-[(4-methylphenyl)sulfonylamino]butanediamideKi300000.0 [1]
2,5,7-Trimethyl-3-(1-cyclohexenyl)quinolineIC5025000.0 [1]
(2S)-N'-(2,2-Dimethylpropyl)-2-(dimethylsulfamoylamino)-N-[(2S)-1-[[(2S)-4-methyl-1-oxo-1-(5-propan-2-yl-1,3,4-oxadiazol-2-yl)pentan-2-yl]amino]-1-oxopropan-2-yl]butanediamideKi900000.0 [1]
(2S)-N'-(2,2-Dimethylpropyl)-N-[(2S)-1-[[(2S)-4-methyl-1-oxo-1-(5-phenyl-1,3,4-oxadiazol-2-yl)pentan-2-yl]amino]-1-oxopropan-2-yl]-2-[(3-methylphenyl)sulfonylamino]butanediamideKi450000.0 [1]
Tert-butyl (4S)-5-[[(2S)-3-hydroxy-1-[[(E,3S)-5-methyl-1-methylsulfonylhex-1-en-3-yl]amino]-1-oxopropan-2-yl]amino]-5-oxo-4-(phenylmethoxycarbonylamino)pentanoateIC50450000.0 [1]
Cbz-Ile-t-ButylhomoGlu-Ala-LeuVSMeIC50150000.0 [1]
Benzyl N-[(2S,3S)-3-methyl-1-[[(2S)-1-[[(2S)-1-[[(E,3S)-5-methyl-1-methylsulfonylhex-1-en-3-yl]amino]-1-oxopropan-2-yl]amino]-1,5-dioxo-5-(propan-2-ylamino)pentan-2-yl]amino]-1-oxopentan-2-yl]carbamateIC50150000.0 [1]
2-[4-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenoxy]-N,N-dimethylethanamineIC5010000.0 [1]
Tert-butyl (4S)-4-benzamido-5-[[(2S)-1-[[(E,3S)-5-methyl-1-methylsulfonylhex-1-en-3-yl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoateIC50450000.0 [1]
Cbz-Ile-Leu-Ala-LeuVSMeIC5039000.0 [1]
Benzyl N-[(2S,3S)-1-[[(2S)-4-(2,2-dimethylpropylamino)-1-[[(2S)-1-[[(E,3S)-5-methyl-1-methylsulfonylhex-1-en-3-yl]amino]-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamateIC50150000.0 [1]
(2S)-3-Methoxy-N-[(2S)-4-methyl-1-oxo-1-(5-phenyl-1,3,4-oxadiazol-2-yl)pentan-2-yl]-2-[[(2S)-2-[(4-methylphenyl)sulfonylamino]-3-phenylmethoxypropanoyl]amino]propanamideKi51000.0 [1]
Tert-butyl (4S)-5-[[(2S)-1-[[(E,3S)-5-methyl-1-methylsulfonylhex-1-en-3-yl]amino]-1-oxopropan-2-yl]amino]-4-[[(2S,3S)-3-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-5-oxopentanoateIC50150000.0 [1]
Benzyl N-[(2S,3S)-3-methyl-1-[[(2S)-5-(2-methylbutan-2-ylamino)-1-[[(2S)-1-[[(E,3S)-5-methyl-1-methylsulfonylhex-1-en-3-yl]amino]-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamateIC50150000.0 [1]
(2S)-N'-(2,2-Dimethylpropyl)-N-[(2S)-3-hydroxy-1-[[(E,3S)-5-methyl-1-methylsulfonylhex-1-en-3-yl]amino]-1-oxopropan-2-yl]-2-[(4-methylphenyl)sulfonylamino]butanediamideIC50450000.0 [1]
Tert-butyl (3S)-4-[[(2S)-1-[[(E,3S)-5-methyl-1-methylsulfonylhex-1-en-3-yl]amino]-1-oxopropan-2-yl]amino]-3-[[(2S,3S)-3-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-4-oxobutanoateIC50150000.0 [1]
Cbz-Glu(OtBu)-Ala-LeuVSMeIC50150000.0 [1]
Ptosyl-Glu(OtBu)-Ala-LeuVSMeIC50450000.0 [1]
Tert-butyl (4S)-4-(benzenesulfonamido)-5-[[(2S)-3-hydroxy-1-[[(E,3S)-5-methyl-1-methylsulfonylhex-1-en-3-yl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoateIC50450000.0 [1]
Cbz-Ile-t-ButylGln-Ala-LeuVSMeIC50150000.0 [1]
Benzyl N-[(2S,3S)-3-methyl-1-[[(2S)-1-[[(2S)-1-[[(E,3S)-5-methyl-1-methylsulfonylhex-1-en-3-yl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-phenylmethoxypropan-2-yl]amino]-1-oxopentan-2-yl]carbamateIC50150000.0 [1]
(2S)-N'-(2,2-Dimethylpropyl)-N-[(2S)-1-[[(E,3S)-5-methyl-1-methylsulfonylhex-1-en-3-yl]amino]-1-oxopropan-2-yl]-2-[(4-methylphenyl)sulfonylamino]butanediamideIC50450000.0 [1]
(2S)-N'-(2,2-Dimethylpropyl)-N-[(2S)-1-[[2-methyl-1-oxo-1-(5-phenyl-1,3,4-oxadiazol-2-yl)propan-2-yl]amino]-1-oxopropan-2-yl]-2-[(4-methylphenyl)sulfonylamino]butanediamideKi450000.0 [1]
(2S)-N'-(2,2-Dimethylpropyl)-N-[2-methyl-1-[[(E,3S)-5-methyl-1-methylsulfonylhex-1-en-3-yl]amino]-1-oxopropan-2-yl]-2-[(4-methylphenyl)sulfonylamino]butanediamideIC50450000.0 [1]
Tert-butyl (4S)-4-[(2,2-diphenylacetyl)amino]-5-[[(2S)-1-[[(E,3S)-5-methyl-1-methylsulfonylhex-1-en-3-yl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoateIC50450000.0 [1]
Ac-hPhe-Leu-Phe-LeuVSMeIC50150000.0 [1]
Cbz-Ile-hPhe-Ala-LeuVSMeIC50150000.0 [1]
Benzyl N-[(2S,3S)-1-[[(2S)-5-(2,2-dimethylpropylamino)-1-[[(2S)-1-[[(E,3S)-5-methyl-1-methylsulfonylhex-1-en-3-yl]amino]-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamateIC50150000.0 [1]
N-[(2S)-3-Hydroxy-1-[[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]-6-oxo-1H-pyridine-2-carboxamideIC50250000.0 [1]
N-[(2S)-3-(4-Methoxyphenyl)-1-[[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]-6-oxo-1H-pyridine-2-carboxamideIC50250000.0 [1]
N-[(2S)-1-[[(2S)-1-[(2R)-2-Methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]-6-oxo-1H-pyridine-2-carboxamideIC50250000.0 [1]
4-[4-[3-(2-Methylpropyl)-4-oxophthalazin-1-yl]phenoxy]butyl-triphenylphosphaniumIC50276200.0 [1]
4-[4-[3-(Cyclopropylmethyl)-4-oxophthalazin-1-yl]phenoxy]butyl-triphenylphosphaniumIC50588700.0 [1]
4-[4-[3-(Cyclobutylmethyl)-4-oxophthalazin-1-yl]phenoxy]butyl-triphenylphosphaniumIC50475200.0 [1]
4-[4-[3-(Cyclohexylmethyl)-4-oxophthalazin-1-yl]phenoxy]butyl-triphenylphosphaniumIC50643300.0 [1]
4-[4-[3-[4-(Methylamino)phenyl]-4-oxophthalazin-1-yl]phenoxy]butyl-triphenylphosphaniumIC50389800.0 [1]
4-[4-(3-Naphthalen-2-yl-4-oxophthalazin-1-yl)phenoxy]butyl-triphenylphosphaniumIC50729800.0 [1]
Tricyclohexyl-[4-[4-[3-[4-(diethylamino)phenyl]-4-oxophthalazin-1-yl]phenoxy]butyl]phosphaniumIC50155600.0 [1]
4-[4-[3-[4-(Diethylamino)phenyl]-4-oxophthalazin-1-yl]phenoxy]butyl-triphenylphosphaniumIC50152200.0 [1]
4-[4-(4-Oxo-3-thiophen-2-ylphthalazin-1-yl)phenoxy]butyl-triphenylphosphaniumIC50557700.0 [1]
4-[4-(4-Oxo-3-phenylphthalazin-1-yl)phenoxy]butyl-triphenylphosphaniumIC50220100.0 [1]
4-[4-(3-Benzyl-4-oxophthalazin-1-yl)phenoxy]butyl-triphenylphosphaniumIC50125700.0 [1]
3-(Cyclohexen-1-yl)-2-methyl-6-piperidin-1-ylquinolineIC5025000.0 [1]
Benzyl (2S)-2-[[(2S)-6-[[(2R,3S)-3-hexyl-4-oxooxetane-2-carbonyl]amino]-2-(phenylmethoxycarbonylamino)hexanoyl]amino]propanoateIC50100000.0 [1]
[(1R)-1-[[(2S)-2-[[Benzyl(methyl)carbamoyl]amino]-3-phenylpropanoyl]amino]-3-methylbutyl]boronic acidIC50190.0 [1]
Benzyl (2S)-6-[[(2S,3R)-3-hexyl-3-methyl-4-oxooxetane-2-carbonyl]amino]-2-[[(2S)-2-(phenylmethoxycarbonylamino)propanoyl]amino]hexanoateIC50100000.0 [1]
[(1R)-3-Methyl-1-[[(2S)-3-phenyl-2-(pyrazin-2-ylmethylcarbamoylamino)propanoyl]amino]butyl]boronic acidIC5011400.0 [1]
Benzyl (2S)-2-[[(2S)-2-[(4-bromobenzoyl)amino]propanoyl]amino]-6-[[(2R,3S)-3-hexyl-4-oxooxetane-2-carbonyl]amino]hexanoateIC50100000.0 [1]
(4-Ethynylphenyl)methyl (2S)-2-[[(2S)-6-[[(2R,3S)-3-hexyl-4-oxooxetane-2-carbonyl]amino]-2-(phenylmethoxycarbonylamino)hexanoyl]amino]propanoateIC50100000.0 [1]
Benzyl (2S)-2-[(4S)-4-[4-[[(2R,3S)-3-hexyl-4-oxooxetane-2-carbonyl]amino]butyl]-2,5-dioxoimidazolidin-1-yl]propanoateIC50100000.0 [1]
[(1R)-3-Methyl-1-[[(2S)-3-phenyl-2-[(3-phenylphenyl)methylcarbamoylamino]propanoyl]amino]butyl]boronic acidIC501150.0 [1]
Benzyl (2S)-6-[[(2R,3S)-3-hexyl-4-oxooxetane-2-carbonyl]amino]-2-[[(2S)-2-(phenylmethoxycarbonylamino)propanoyl]amino]hexanoateIC50100000.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Proteasome Macropain subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/proteasome-macropain-subunit-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Proteasome Macropain subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/proteasome-macropain-subunit-inhibitors-ic50-ki.
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