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Prostanoid EP2 receptor Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
DinoprostoneIC502.2 [1], 2.6 [2], 3.3 [3], 37.7 [4]
DinoprostoneKi4.9 [1], 38.0 [2]
ButaprostKi110.0 [1], 2400.0 [2]
Acetic acid, (3-(((1S)-2-(4,5-diphenyl-2-oxazolyl)-2-cyclohexen-1-yl)methyl)phenoxy)-, sodium saltKi1000.0 [1]
5-[[(2R)-1-(4-Tert-butylphenyl)-5-oxopyrrolidin-2-yl]methoxymethyl]furan-2-carboxylic acidKi189.0 [1], 4000.0 [2]
5-[[(2R)-1-(4-Tert-butylphenyl)-5-oxopyrrolidin-2-yl]methoxymethyl]thiophene-2-carboxylic acidKi27.0 [1], 501.0 [2]
4-[(1S)-1-[[(2R)-1-(2-Phenoxyethyl)piperidine-2-carbonyl]amino]ethyl]benzoic acidKi1210.0 [1], 1550.0 [2]
DinoprostIC5010000.0 [1], 100000.0 [2]
6-Isopropoxy-9-oxoxanthene-2-carboxylic acidKi1150.0 [1]
(S)-4-(1-(5-Chloro-2-(4-fluorophenoxy)benzamido)ethyl)benzoic acidIC50709.0 [1], 1000.0 [2]
trans-2-(4-(1-Hydroxyhexyl)phenyl)-5-oxocyclopentaneheptanoic acidKi240.0 [1], 871.0 [2]
4-(2-((R)-2-((S)-3-Hydroxyoct-1-enyl)-5-oxopyrrolidin-1-yl)ethyl)benzoateKi120.0 [1], 130.0 [2]
2-[(3R)-5-Acetyl-4-[(4-chlorophenyl)methyl]-7-methylsulfonyl-2,3-dihydro-1H-cyclopenta[b]indol-3-yl]acetic acidKi230.0 [1]
(E)-3-{2-[(E)-3-(2-Benzyloxy-3-methyl-phenyl)-allyl]-phenyl}-acrylic acidKi8100.0 [1]
(E)-3-[2-(3,4-Dichlorophenyl)phenyl]-N-thiophen-2-ylsulfonylprop-2-enamideKi10000.0 [1], 27000.0 [2]
2-[(3R)-4-[(4-Chlorophenyl)methyl]-5-(1-hydroxyethyl)-7-methylsulfonyl-2,3-dihydro-1H-cyclopenta[b]indol-3-yl]acetic acidKi390.0 [1]
2-(2-Benzoyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)acetic acidIC5010000.0 [1]
7-{(R)-2-[(E)-3-Hydroxy-3-(1-phenyl-cyclopropyl)-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acidKi13000.0 [1], 164000.0 [2]
3-(2-((E)-3-(4-(Benzyloxy)-3-methoxyphenyl)prop-1-enyl)phenyl)-N-(thiophen-2-ylsulfonyl)acrylamideKi2415.0 [1], 8700.0 [2]
N-[5-(2,6-Dichlorophenyl)-1,3,4-thiadiazol-2-yl]-4-ethyl-2,3-dihydro-1,4-benzoxazine-6-carboxamideKi10000.0 [1]
7-[(R)-2-((E)-3-Hydroxy-4-phenyl-but-1-enyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acidKi13000.0 [1], 31000.0 [2]
4-(2-((R)-2-((S)-3-Hydroxyhept-1-enyl)-5-oxopyrrolidin-1-yl)ethyl)benzoateKi125.5 [1], 425.0 [2]
2-(4-Methyl-3,5-diphenyl-1H-pyrazole-1-yl)-4-thiazolecarboxylic acidKi8000.0 [1], 8700.0 [2]
(E)-3-[2-[(E)-3-Phenylprop-1-enyl]phenyl]prop-2-enoic acid;(E)-3-[2-[(E)-3-phenylprop-2-enyl]phenyl]prop-2-enoic acidKi1400.0 [1]
(E)-3-[2-[(E)-3-(4-Methoxyphenyl)prop-1-enyl]phenyl]prop-2-enoic acid;(E)-3-[2-[(E)-3-(4-methoxyphenyl)prop-2-enyl]phenyl]prop-2-enoic acidKi2500.0 [1]
(Z)-7-[(1R,2R,3R,5R)-5-Chloro-2-[(E,4S)-4-(1-ethylcyclobutyl)-4-hydroxybut-1-enyl]-3-hydroxycyclopentyl]hept-5-enoic acidKi0.74 [1], 3.3 [2]
3-(2-(Naphthalen-2-ylmethyl)phenyl)acrylic acidKi12000.0 [1]
7-(1-Benzothiophen-3-yl)-9-ethoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepineIC5014000.0 [1], 30000.0 [2]
7-(1-Benzothiophen-3-yl)-9-methoxy-4-(pyrimidin-5-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepineIC5020.0 [1], 80.0 [2]
7-(1-Benzothiophen-3-yl)-9-methoxy-4-[(2-methoxypyridin-3-yl)methyl]-3,5-dihydro-2H-1,4-benzoxazepineIC50200.0 [1], 1100.0 [2]
7-(1-Benzothiophen-3-yl)-9-methoxy-4-[(6-methoxypyridin-3-yl)methyl]-3,5-dihydro-2H-1,4-benzoxazepineIC50100.0 [1], 1500.0 [2]
5-[[7-(1-Benzothiophen-3-yl)-9-methoxy-3,5-dihydro-2H-1,4-benzoxazepin-4-yl]methyl]-1H-pyridin-2-oneIC50200.0 [1], 500.0 [2]
7-(1-Benzothiophen-3-yl)-4-benzyl-9-methoxy-3,5-dihydro-2H-1,4-benzoxazepineIC5010000.0 [1], 30000.0 [2]
7-(1-Benzothiophen-3-yl)-4-[(4-chlorophenyl)methyl]-9-methoxy-3,5-dihydro-2H-1,4-benzoxazepineIC5030000.0 [1]
7-(1-Benzothiophen-3-yl)-9-methoxy-4-[(4-methylphenyl)methyl]-3,5-dihydro-2H-1,4-benzoxazepineIC5030000.0 [1]
7-(1-Benzothiophen-3-yl)-9-methoxy-4-[(4-methoxyphenyl)methyl]-3,5-dihydro-2H-1,4-benzoxazepineIC501800.0 [1], 30000.0 [2]
Methyl 4-[[7-(1-benzothiophen-3-yl)-9-methoxy-3,5-dihydro-2H-1,4-benzoxazepin-4-yl]methyl]benzoateIC50600.0 [1], 30000.0 [2]
4-[[7-(1-Benzothiophen-3-yl)-9-methoxy-3,5-dihydro-2H-1,4-benzoxazepin-4-yl]methyl]benzonitrileIC50600.0 [1], 30000.0 [2]
3-[[7-(1-Benzothiophen-3-yl)-9-methoxy-3,5-dihydro-2H-1,4-benzoxazepin-4-yl]methyl]benzonitrileIC50100.0 [1], 1000.0 [2]
9-Methoxy-4-(pyridin-3-ylmethyl)-7-thiophen-3-yl-3,5-dihydro-2H-1,4-benzoxazepineIC5030000.0 [1]
7-(1-Benzothiophen-2-yl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepineIC502800.0 [1], 4800.0 [2]
9-Methoxy-7-phenyl-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepineIC5015000.0 [1], 30000.0 [2]
9-Methoxy-7-naphthalen-1-yl-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepineIC50300.0 [1], 2500.0 [2]
9-Methoxy-7-(2-methylphenyl)-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepineIC5030000.0 [1]
9-Methoxy-7-(3-methylphenyl)-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepineIC5013000.0 [1], 15000.0 [2]
9-Methoxy-7-(4-methylphenyl)-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepineIC5030000.0 [1]
7-(2-Chlorophenyl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepineIC5012000.0 [1], 30000.0 [2]
7-(3-Chlorophenyl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepineIC50700.0 [1], 1900.0 [2]
7-(4-Chlorophenyl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepineIC5010000.0 [1], 30000.0 [2]
7-(1,2-Benzothiazol-3-yl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepineIC50400.0 [1], 600.0 [2]
7-(Benzimidazol-1-yl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepineIC506400.0 [1], 15000.0 [2]
7-Indol-1-yl-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepineIC50300.0 [1], 1000.0 [2]
7-(1H-Indol-3-yl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepineIC502700.0 [1], 3000.0 [2]
9-Methoxy-7-(1-methylindol-3-yl)-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepineIC501100.0 [1], 2500.0 [2]
7-(3-Chloroindol-1-yl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepineIC5060.0 [1], 900.0 [2]
7-(4-Chloroindol-1-yl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepineIC50400.0 [1], 3300.0 [2]
7-(5-Chloroindol-1-yl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepineIC5080.0 [1], 700.0 [2]
7-(6-Chloroindol-1-yl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepineIC50800.0 [1], 4000.0 [2]
7-(7-Chloroindol-1-yl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepineIC505600.0 [1], 30000.0 [2]
1-[9-Methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepin-7-yl]indole-5-carbonitrileIC50100.0 [1], 200.0 [2]
7-(5-Fluoroindol-1-yl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepineIC5040.0 [1], 90.0 [2]
7-(5-Chloro-2,3-dihydroindol-1-yl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepineIC5030.0 [1], 60.0 [2]
7-(1-Benzothiophen-3-yl)-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepineIC501100.0 [1], 30000.0 [2]
7-(1-Benzothiophen-3-yl)-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepin-9-olIC501500.0 [1], 3800.0 [2]
7-(1-Benzothiophen-3-yl)-9-propan-2-yloxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepineIC5030000.0 [1]
7-(1-Benzothiophen-3-yl)-9-methyl-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepineIC50200.0 [1], 1000.0 [2]
7-(1-Benzothiophen-3-yl)-9-chloro-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepineIC5080.0 [1], 2500.0 [2]
8-(1-Benzothiophen-3-yl)-2-(pyridin-3-ylmethyl)-1,3,4,5-tetrahydro-2-benzazepineIC501600.0 [1], 30000.0 [2]
7-(1-Benzothiophen-3-yl)-4-(pyridin-3-ylmethyl)-1,2,3,5-tetrahydro-1,4-benzodiazepineIC506000.0 [1], 30000.0 [2]
7-(1-Benzothiophen-3-yl)-1-methyl-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzodiazepineIC504000.0 [1], 30000.0 [2]
7-(1-Benzothiophen-3-yl)-9-methoxy-4-(pyridin-3-ylmethyl)-5H-1,4-benzoxazepin-3-oneIC5013000.0 [1], 30000.0 [2]
7-(1-Benzothiophen-3-yl)-9-methoxy-4-(pyridin-3-ylmethyl)-2,3-dihydro-1,4-benzoxazepin-5-oneIC5030000.0 [1]
4-[[7-(1-Benzothiophen-3-yl)-9-chloro-3,5-dihydro-2H-1,4-benzoxazepin-4-yl]methyl]-1H-pyridin-2-oneIC5020.0 [1], 200.0 [2]
4-[[(3R)-7-(1-Benzothiophen-3-yl)-9-chloro-3-methyl-3,5-dihydro-2H-1,4-benzoxazepin-4-yl]methyl]-1H-pyridin-2-oneIC508.0 [1], 200.0 [2]
4-[[(3R)-9-Chloro-7-(5-fluoroindol-1-yl)-3-methyl-3,5-dihydro-2H-1,4-benzoxazepin-4-yl]methyl]-1H-pyridin-2-oneIC502.0 [1], 10.0 [2]
2-[5-(4-Methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1,3-thiazole-4-carboxylic acidIC508000.0 [1]
2-[5-(4-Methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1,3-thiazole-4-carboxylic acidKi8000.0 [1]
7-(1-Benzothiophen-3-yl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepineIC5070.0 [1], 600.0 [2]
7-(1-Benzothiophen-3-yl)-9-methoxy-4-(pyridin-4-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepineIC50200.0 [1], 900.0 [2]
4-(2-Pyridyl)methyl-7-(1-benzothiophene-3-yl)-9-methoxy-2,3,4,5-tetrahydro-1,4-benzooxazepineIC50700.0 [1], 3000.0 [2]
4-[[9-Chloro-7-(5-fluoroindol-1-yl)-3,5-dihydro-2H-1,4-benzoxazepin-4-yl]methyl]-1H-pyridin-2-oneIC508.0 [1], 50.0 [2]
5-[[(2R)-1-[4-(1-Hydroxyhexyl)phenyl]-5-oxopyrrolidin-2-yl]methoxymethyl]thiophene-2-carboxylic acidKi115.0 [1]
7-[(2S)-1-(4-Tert-butylphenyl)-5-oxopyrrolidin-2-yl]heptanoic acidKi10000.0 [1]
5-[[(2R)-1-[4-(1-Hydroxy-2-methylpropyl)phenyl]-5-oxopyrrolidin-2-yl]methoxymethyl]furan-2-carboxylic acidKi10000.0 [1]
5-[[(2R)-1-[4-(1-Hydroxy-2-phenylethyl)phenyl]-5-oxopyrrolidin-2-yl]methoxymethyl]furan-2-carboxylic acidKi2293.0 [1]
5-[[(2R)-1-[4-(1-Hydroxypentyl)phenyl]-5-oxopyrrolidin-2-yl]methoxymethyl]thiophene-2-carboxylic acidKi387.0 [1]
5-[[(2R)-1-[4-(1-Hydroxyheptyl)phenyl]-5-oxopyrrolidin-2-yl]methoxymethyl]thiophene-2-carboxylic acidKi10.0 [1], 190.0 [2]
5-[[(2R)-1-[4-(1-Hydroxybutyl)phenyl]-5-oxopyrrolidin-2-yl]methoxymethyl]thiophene-2-carboxylic acidKi1639.0 [1]
5-[[(2R)-1-[4-(1-Hydroxypropyl)phenyl]-5-oxopyrrolidin-2-yl]methoxymethyl]thiophene-2-carboxylic acidKi5731.0 [1]
5-(3-{(S)-1-[4-(1-Hydroxyhexyl)-phenyl]-5-oxo-pyrrolidin-2-yl}-propyl)-thiophene-2-carboxylic acidKi15.0 [1]
5-[3-[(2S)-1-(4-Hexanoylphenyl)-5-oxopyrrolidin-2-yl]propyl]thiophene-2-carboxylic acidKi31.0 [1]
5-[[(2R)-1-(4-Hexanoylphenyl)-5-oxopyrrolidin-2-yl]methoxymethyl]thiophene-2-carboxylic acidKi163.0 [1]
5-[3-[(2S)-1-[4-(1-Hydroxyheptyl)phenyl]-5-oxopyrrolidin-2-yl]propyl]thiophene-2-carboxylic acidKi8.0 [1]
4-[[(2R)-1-[4-(1-Hydroxyhexyl)phenyl]-5-oxopyrrolidin-2-yl]methoxy]benzoic acidKi22726.0 [1]
(E)-3-[2-[(Z)-3-(3-Methoxy-4-phenylmethoxyphenyl)prop-2-enyl]phenyl]prop-2-enoic acidKi750.0 [1]
5-[[(2R)-1-[4-(1-Hydroxyhexyl)phenyl]-5-oxopyrrolidin-2-yl]methoxymethyl]furan-2-carboxylic acidKi2028.0 [1]
CloprostenolIC503700.0 [1]
LaropiprantKi136.0 [1]
GrapiprantKi5000.0 [1]
Ono-AE1-259Ki1.7 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Prostanoid EP2 receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/prostanoid-ep2-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Prostanoid EP2 receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/prostanoid-ep2-receptor-inhibitors-ic50-ki.
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