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Prostanoid DP receptor Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
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▼
Standard Type
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Standard Values (in nM)
▲
▼
Amg-009Ki148.0 [1]
2-[(3R)-5-Acetyl-4-[(4-chlorophenyl)methyl]-7-methylsulfonyl-2,3-dihydro-1H-cyclopenta[b]indol-3-yl]acetic acidIC502.0 [1], 7.9 [2]
2-[(3R)-5-Acetyl-4-[(4-chlorophenyl)methyl]-7-methylsulfonyl-2,3-dihydro-1H-cyclopenta[b]indol-3-yl]acetic acidKi2.6 [1]
2-[(3R)-4-[(4-Chlorophenyl)methyl]-5-(1-hydroxyethyl)-7-methylsulfonyl-2,3-dihydro-1H-cyclopenta[b]indol-3-yl]acetic acidIC502.0 [1], 8.6 [2]
2-[(3R)-4-[(4-Chlorophenyl)methyl]-5-(1-hydroxyethyl)-7-methylsulfonyl-2,3-dihydro-1H-cyclopenta[b]indol-3-yl]acetic acidKi1.8 [1]
RamatrobanIC5010000.0 [1], 33400.0 [2]
RamatrobanKi10000.0 [1], 11020.0 [2]
7-[2-(Dibenzofuran-2-sulfonylamino)-6,6-dimethyl-bicyclo[3.1.1]hept-3-yl]-hept-5-enoic acidIC50780.0 [1], 1000.0 [2]
7-[6,6-Dimethyl-2-(4-phenylazo-benzenesulfonylamino)-bicyclo[3.1.1]hept-3-yl]-hept-5-enoic acidIC501000.0 [1], 1300.0 [2]
7-[6,6-Dimethyl-2-(4-phenylazo-benzoylamino)-bicyclo[3.1.1]hept-3-yl]-hept-5-enoic acidIC50380.0 [1], 540.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-[[4-(2-Phenylethynyl)phenyl]sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC508.5 [1], 8.6 [2], 210.0 [3], 250.0 [4]
(Z)-7-[(1S,2R,3R,4R)-3-[(7-Nitrodibenzofuran-2-yl)sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC5057.0 [1], 250.0 [2], 550.0 [3], 1100.0 [4]
7-(2-Benzoylamino-6,6-dimethyl-bicyclo[3.1.1]hept-3-yl)-hept-5-enoic acidIC50360.0 [1], 5200.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-[(2-Methoxydibenzofuran-3-yl)sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC5024.0 [1], 27.0 [2], 52.0 [3], 68.0 [4]
(Z)-7-[(1S,2R,3R,4R)-3-[(4-Phenylphenyl)sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC50450.0 [1], 600.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-[(4-Phenoxyphenyl)sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC50570.0 [1], 680.0 [2], 720.0 [3], 780.0 [4]
(Z)-7-[(1S,2R,3R,4R)-3-(Dibenzofuran-2-sulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acidIC5070.0 [1], 130.0 [2]
(Z)-7-[(1R,2R,6S,7R)-3-(4-Phenylazo-benzenesulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acidIC5025.0 [1], 27.0 [2], 320.0 [3]
(Z)-7-[(1S,2R,3R,4R)-3-[(2-Phenyl-1H-indol-6-yl)sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC5047.0 [1], 71.0 [2], 120.0 [3]
LaropiprantIC500.09 [1], 1.4 [2], 4.0 [3]
MK-7246IC501000.0 [1]
MK-7246Ki373.0 [1]
Acetic acid, (3-(((1S)-2-(4,5-diphenyl-2-oxazolyl)-2-cyclohexen-1-yl)methyl)phenoxy)-, sodium saltKi1000.0 [1]
2-[2-Methyl-1-[4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]indol-4-yl]acetic acidIC501.2 [1], 57.0 [2]
2-[2-Methyl-1-[4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]indol-4-yl]acetic acidKi3.5 [1]
2-[(3R)-3-[(4-Fluorophenyl)sulfonyl-methylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acidIC5010000.0 [1]
2-[(3R)-3-[(4-Fluorophenyl)sulfonyl-methylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acidKi1115.0 [1], 1200.0 [2]
2-[4-[4-(Cyclopropylcarbamoyl)-2-[(2,4-dichlorophenyl)sulfonylamino]phenoxy]-3-methoxyphenyl]acetic acidIC5041.0 [1], 1030.0 [2]
2-[(3R)-5-Acetyl-4-[(4-chlorophenyl)methyl]-7-fluoro-2,3-dihydro-1H-cyclopenta[b]indol-3-yl]acetic acidIC500.29 [1], 15.0 [2]
2-[(3R)-5-Acetyl-4-[(4-chlorophenyl)methyl]-7-fluoro-2,3-dihydro-1H-cyclopenta[b]indol-3-yl]acetic acidKi1.1 [1]
[(3R)-5-Bromo-4-(4-chlorobenzyl)-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acidIC500.26 [1], 23.0 [2]
[(3R)-5-Bromo-4-(4-chlorobenzyl)-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acidKi1.5 [1]
2-[(6S)-5-(3,4-Dichlorophenyl)sulfanyl-4-propan-2-yl-7,8-dihydro-6H-pyrido[4,3-e]pyrrolizin-6-yl]acetic acidIC500.22 [1], 4.99 [2]
2-[(6S)-5-(3,4-Dichlorophenyl)sulfanyl-4-propan-2-yl-7,8-dihydro-6H-pyrido[4,3-e]pyrrolizin-6-yl]acetic acidKi0.64 [1]
2-[(6R)-5-(3,4-Dichlorophenyl)sulfanyl-4-propan-2-yl-7,8-dihydro-6H-pyrido[4,3-e]pyrrolizin-6-yl]acetic acidIC500.14 [1], 2.15 [2]
2-[(6R)-5-(3,4-Dichlorophenyl)sulfanyl-4-propan-2-yl-7,8-dihydro-6H-pyrido[4,3-e]pyrrolizin-6-yl]acetic acidKi0.32 [1]
DinoprostIC504500.0 [1]
VidupiprantIC504.0 [1], 35.0 [2]
(Z)-7-[(1R,2R,3S,5S)-2-[(5-Hydroxy-1-benzothiophene-3-carbonyl)amino]-6,6-dimethyl-3-bicyclo[3.1.1]heptanyl]hept-5-enoic acidIC500.4 [1], 1.0 [2]
2-[4-[4-(Butylcarbamoyl)-2-[(4-chlorophenyl)sulfonylamino]phenoxy]-3-methoxyphenyl]acetic acidIC5013.0 [1]
2-[4-[(4-Chlorophenyl)methyl]-7-fluoro-5-methylsulfonyl-2,3-dihydro-1H-cyclopenta[b]indol-3-yl]acetic acidKi0.57 [1], 8.9 [2]
2-(2-Benzoyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)acetic acidIC5010000.0 [1]
2-[(7R)-7-[(4-Fluorophenyl)sulfonyl-methylamino]-6,7,8,9-tetrahydropyrido[2,3-b]indolizin-10-yl]acetic acidIC5041700.0 [1]
2-[(7R)-7-[(4-Fluorophenyl)sulfonyl-methylamino]-6,7,8,9-tetrahydropyrido[2,3-b]indolizin-10-yl]acetic acidKi1300.0 [1]
2-[3-[2-[(2,4-Dichlorophenyl)sulfonylamino]-4-(ethylcarbamoyl)phenoxy]phenyl]acetic acidIC5010000.0 [1]
2-[1-[4-[(3,4-Dichlorobenzoyl)amino]benzoyl]isoquinolin-4-yl]acetic acidIC501000.0 [1]
2-[4-Chloro-2-[2-(2-methyl-5-propylsulfonylphenyl)ethynyl]phenoxy]acetic acidIC5010000.0 [1]
2-[4-Chloro-2-[2-(2-methyl-5-propylsulfonylphenyl)ethynyl]phenoxy]acetic acidKi1580.0 [1]
AsapiprantIC50520.0 [1]
AsapiprantKi240.0 [1]
3-(2-(Naphthalen-2-ylmethyl)phenyl)acrylic acidKi500.0 [1], 530.0 [2]
2-[4-[2-[(2,4-Dichlorophenyl)sulfonylamino]-4-(ethylcarbamoyl)phenoxy]-3,5-dimethoxyphenyl]acetic acidIC5016000.0 [1]
(Z)-7-[(1R,2R,3S,5S)-2-(1-Benzothiophene-3-carbonylamino)-6,6-dimethyl-3-bicyclo[3.1.1]heptanyl]hept-5-enoic acidIC5022.0 [1], 32.0 [2]
2-[2-Methyl-1-[4-[[(2R)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]indol-4-yl]acetic acidIC5010.0 [1]
2-[2-Methyl-1-[4-[[(2R)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]indol-4-yl]acetic acidKi170.0 [1]
2-[1-[4-[[(2S)-7-Fluoro-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]-2-methylindol-4-yl]acetic acidIC500.81 [1]
2-[1-[4-[[(2S)-7-Fluoro-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]-2-methylindol-4-yl]acetic acidKi5.3 [1]
(Z)-7-[(1R,2R,3S,5S)-2-(1-Benzothiophene-7-carbonylamino)-6,6-dimethyl-3-bicyclo[3.1.1]heptanyl]hept-5-enoic acidIC505.6 [1], 26.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-(Naphthalen-2-ylsulfonylamino)-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC50420.0 [1], 1200.0 [2]
(Z)-7-[(1R,2R,3S,5S)-6,6-Dimethyl-2-(thiophene-3-carbonylamino)-3-bicyclo[3.1.1]heptanyl]hept-5-enoic acidIC5038.0 [1], 1600.0 [2]
(Z)-7-[(1R,2R,3S,5S)-6,6-Dimethyl-2-(1H-pyrrole-2-carbonylamino)-3-bicyclo[3.1.1]heptanyl]hept-5-enoic acidIC5032.0 [1], 64.0 [2]
(Z)-7-[(1R,2R,3S,5S)-2-[(6-Hydroxy-1-benzothiophene-3-carbonyl)amino]-6,6-dimethyl-3-bicyclo[3.1.1]heptanyl]hept-5-enoic acidIC501.3 [1], 2.8 [2]
(Z)-7-[(1S,2R,3R,4R)-3-[(4-Phenyldiazenylbenzoyl)amino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC501000.0 [1], 3000.0 [2]
(Z)-7-[(1R,2S,3S,4S)-3-(Naphthalen-2-ylsulfonylamino)-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC501000.0 [1], 4900.0 [2]
(Z)-7-[(1R,2R,3S,5S)-2-[(5-Fluoro-1-benzothiophene-3-carbonyl)amino]-6,6-dimethyl-3-bicyclo[3.1.1]heptanyl]hept-5-enoic acidIC500.27 [1], 1.8 [2]
(Z)-7-[(1R,2R,3S,5S)-2-(Dibenzofuran-2-carbonylamino)-6,6-dimethyl-3-bicyclo[3.1.1]heptanyl]hept-5-enoic acidIC5032.0 [1], 220.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-[(2-Ethoxydibenzofuran-3-yl)sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC5032.0 [1], 34.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-[(4-Anilinophenyl)sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC50160.0 [1], 330.0 [2]
7-[(1S,2R,3R,4R)-3-(Dibenzofuran-2-ylsulfonylamino)-2-bicyclo[2.2.1]heptanyl]heptanoic acidIC50120.0 [1], 430.0 [2]
7-[(1S,2R,3R,4R)-3-[(2-Methoxydibenzofuran-3-yl)sulfonylamino]-2-bicyclo[2.2.1]heptanyl]-6-oxoheptanoic acidIC5033.0 [1], 960.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-[(8-Hydroxydibenzofuran-2-yl)sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC50200.0 [1], 250.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-[[5-[(E)-2-Phenylethenyl]thiophen-2-yl]sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC5090.0 [1], 100.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-[[2-(4-Hydroxyphenyl)-1H-indol-6-yl]sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC5018.0 [1], 25.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-[(4-Methoxy-3-nitrophenyl)sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC50280.0 [1], 5400.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-[[4-(4-Methoxyphenyl)phenyl]sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC50200.0 [1], 450.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-[(2-Hydroxydibenzofuran-3-yl)sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC50180.0 [1], 190.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-(Dibenzofuran-2-ylsulfonylamino)-2-bicyclo[2.2.1]heptanyl]-2,2-dimethylhept-5-enoic acidIC50180.0 [1], 320.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-[(2-Methoxydibenzofuran-3-yl)sulfonylamino]-2-bicyclo[2.2.1]heptanyl]-2,2-dimethylhept-5-enoic acidIC5057.0 [1], 320.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-[[4-[(E)-2-Phenylethenyl]phenyl]sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC50100.0 [1], 180.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-[[4-[(Z)-2-Phenylethenyl]phenyl]sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC50180.0 [1], 200.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-(Dibenzofuran-2-ylsulfonylamino)-2-bicyclo[2.2.1]heptanyl]-N-methylsulfonylhept-5-enamideIC5032.0 [1], 42.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-[(4-Methoxyphenyl)sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC50390.0 [1], 10000.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-[(4-Benzamidophenyl)sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC50120.0 [1], 6000.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-[(1-Methyl-2-phenylindol-6-yl)sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC50190.0 [1], 380.0 [2]
7-[(1R,2R,3R,5S)-6,6-Dimethyl-2-(thiophene-3-carbonylamino)-3-bicyclo[3.1.1]heptanyl]-6-oxoheptanoic acidIC501000.0 [1], 10000.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-[(5-Phenylthiophen-2-yl)sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC50220.0 [1], 580.0 [2]
(Z)-7-[(1S,2S,3S,5R)-6,6-Dimethyl-3-[(4-phenylbenzoyl)amino]-2-bicyclo[3.1.1]heptanyl]hept-5-enoic acidIC501000.0 [1], 5100.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-[(4-Phenylphenyl)methylsulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC501000.0 [1], 8600.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-[[7-(Dimethylamino)dibenzofuran-2-yl]sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC5036.0 [1], 170.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-[(5-Thiophen-2-ylthiophen-2-yl)sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC50200.0 [1], 410.0 [2]
(Z)-7-[(1R,2R,3S,5S)-6,6-Dimethyl-2-[(4-phenylphenyl)sulfonylamino]-3-bicyclo[3.1.1]heptanyl]hept-5-enoic acidIC50530.0 [1], 1200.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-(Dibenzothiophen-2-ylsulfonylamino)-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC5064.0 [1], 180.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-[(8-Methoxydibenzofuran-2-yl)sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC5034.0 [1], 330.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-(9H-Carbazol-3-ylsulfonylamino)-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC5022.0 [1]
(Z)-7-[(1S,2R,3R,5R)-6,6-Dimethyl-3-[(4-phenylbenzoyl)amino]-2-bicyclo[3.1.1]heptanyl]hept-5-enoic acidIC501000.0 [1], 3600.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-[(2-Bromophenyl)sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC50340.0 [1], 5300.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-[[4-(1-Phenyltetrazol-5-yl)phenyl]sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC5062.0 [1], 380.0 [2]
(Z)-7-[(1S,2S,3S,5R)-6,6-Dimethyl-3-[(4-phenylphenyl)sulfonylamino]-2-bicyclo[3.1.1]heptanyl]hept-5-enoic acidIC501000.0 [1], 1300.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-[[4-(1H-Indol-2-yl)phenyl]sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC50190.0 [1], 210.0 [2]
(Z)-7-[(1S,2R,3R,4R)-3-[[4-(Phenylcarbamoyl)phenyl]sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acidIC5086.0 [1], 1100.0 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Prostanoid DP receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/prostanoid-dp-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Prostanoid DP receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/prostanoid-dp-receptor-inhibitors-ic50-ki.
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