 | 3-Fluoro-4-[3-methoxy-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | IC50 | 34.0 [1] |
| 3-Fluoro-4-[3-methoxy-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | Ki | 15.0 [1] |
 | 4-[3-(Dimethylamino)-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile | IC50 | 46.0 [1] |
| 4-[3-(Dimethylamino)-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile | Ki | 8.0 [1] |
 | 6-(4-Chlorobenzoyl)-2-[[(1S)-1-(4-chlorophenyl)ethyl]amino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 204.0 [1] |
| 6-(4-Chlorobenzoyl)-2-[[(1S)-1-(4-chlorophenyl)ethyl]amino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 28.0 [1] |
 | 6-(4-Chlorobenzoyl)-3-prop-2-ynyl-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 378.0 [1] |
| 6-(4-Chlorobenzoyl)-3-prop-2-ynyl-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 29.0 [1] |
 | 6-(4-Chlorobenzoyl)-2-[[(1S)-1-(4-chlorophenyl)ethyl]amino]-3-prop-2-ynyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 1722.0 [1] |
| 6-(4-Chlorobenzoyl)-2-[[(1S)-1-(4-chlorophenyl)ethyl]amino]-3-prop-2-ynyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 42.0 [1] |
 | 3-But-2-ynyl-6-(4-imidazol-1-ylbenzoyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 99.0 [1] |
| 3-But-2-ynyl-6-(4-imidazol-1-ylbenzoyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 6.0 [1] |
 | 4-[3-But-2-ynyl-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile | IC50 | 78.0 [1] |
| 4-[3-But-2-ynyl-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile | Ki | 2.0 [1] |
 | 3-But-2-ynyl-6-[4-(1,3-oxazol-5-yl)benzoyl]-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 665.0 [1] |
| 3-But-2-ynyl-6-[4-(1,3-oxazol-5-yl)benzoyl]-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 10.0 [1] |
 | 3-But-2-ynyl-6-(pyrazolo[1,5-a]pyridine-2-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 776.0 [1] |
| 3-But-2-ynyl-6-(pyrazolo[1,5-a]pyridine-2-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 20.0 [1] |
 | 3-But-2-ynyl-6-(quinoline-2-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 3350.0 [1] |
| 3-But-2-ynyl-6-(quinoline-2-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 24.0 [1] |
 | 6-(4-Chlorobenzoyl)-2-[[1-(4-chlorophenyl)-2-methylpropyl]amino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 4494.0 [1] |
| 6-(4-Chlorobenzoyl)-2-[[1-(4-chlorophenyl)-2-methylpropyl]amino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 37.0 [1] |
 | 3-But-2-ynyl-6-(quinoline-3-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 2794.0 [1] |
| 3-But-2-ynyl-6-(quinoline-3-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 28.0 [1] |
 | 4-[3-But-3-ynyl-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile | IC50 | 68.0 [1] |
| 4-[3-But-3-ynyl-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile | Ki | 2.0 [1] |
 | 6-[2-(4-Chlorophenyl)iminoacetyl]-3-methoxy-2-[1-[4-(trifluoromethyl)phenyl]ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 5793.0 [1] |
| 6-[2-(4-Chlorophenyl)iminoacetyl]-3-methoxy-2-[1-[4-(trifluoromethyl)phenyl]ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 12.0 [1] |
 | 6-[2-(4-Chlorophenoxy)acetyl]-2-[2-(4-chlorophenyl)-2-methylhydrazinyl]-3-(dimethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 3600.0 [1] |
| 6-[2-(4-Chlorophenoxy)acetyl]-2-[2-(4-chlorophenyl)-2-methylhydrazinyl]-3-(dimethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 207.0 [1] |
 | 4-[2-[2-Methyl-2-[4-(trifluoromethyl)phenyl]hydrazinyl]-3-morpholin-4-yl-4-oxo-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | IC50 | 238.0 [1] |
| 4-[2-[2-Methyl-2-[4-(trifluoromethyl)phenyl]hydrazinyl]-3-morpholin-4-yl-4-oxo-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | Ki | 36.0 [1] |
 | 4-[3-But-3-ynyl-2-[2-methyl-2-[4-(trifluoromethyl)phenyl]hydrazinyl]-4-oxo-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | IC50 | 62.0 [1] |
| 4-[3-But-3-ynyl-2-[2-methyl-2-[4-(trifluoromethyl)phenyl]hydrazinyl]-4-oxo-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | Ki | 5.0 [1] |
 | 3-But-3-ynyl-6-[4-(1,3-oxazol-5-yl)benzoyl]-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 26.0 [1] |
 | 3-(Dimethylamino)-2-[2-methyl-2-[4-(trifluoromethyl)phenyl]hydrazinyl]-6-(2,4,6-trifluorobenzoyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 216.0 [1] |
| 3-(Dimethylamino)-2-[2-methyl-2-[4-(trifluoromethyl)phenyl]hydrazinyl]-6-(2,4,6-trifluorobenzoyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 6.0 [1] |
 | 3-Methoxy-6-[4-(trifluoromethoxy)benzoyl]-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 686.0 [1] |
| 3-Methoxy-6-[4-(trifluoromethoxy)benzoyl]-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 16.0 [1] |
 | 6-(4-Chlorobenzoyl)-3-ethoxy-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 3710.0 [1] |
| 6-(4-Chlorobenzoyl)-3-ethoxy-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 25.0 [1] |
 | 4-[3-Ethoxy-4-oxo-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | IC50 | 156.0 [1] |
| 4-[3-Ethoxy-4-oxo-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | Ki | 11.0 [1] |
 | 4-[3-Ethoxy-4-oxo-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile | IC50 | 227.0 [1] |
| 4-[3-Ethoxy-4-oxo-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile | Ki | 5.0 [1] |
 | 3-Ethoxy-6-[4-(1,3-oxazol-5-yl)benzoyl]-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 158.0 [1] |
| 3-Ethoxy-6-[4-(1,3-oxazol-5-yl)benzoyl]-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 20.0 [1] |
 | 3-Ethoxy-6-(thieno[2,3-b]pyridine-2-carbonyl)-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 1684.0 [1] |
| 3-Ethoxy-6-(thieno[2,3-b]pyridine-2-carbonyl)-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 17.0 [1] |
 | 4-[4-Oxo-3-pyrrolidin-1-yl-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | IC50 | 648.0 [1] |
| 4-[4-Oxo-3-pyrrolidin-1-yl-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | Ki | 10.0 [1] |
 | 3-Fluoro-4-[4-oxo-3-pyrrolidin-1-yl-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | IC50 | 298.0 [1] |
| 3-Fluoro-4-[4-oxo-3-pyrrolidin-1-yl-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | Ki | 6.0 [1] |
 | 6-(4-Chlorobenzoyl)-3-(dimethylamino)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one;hydrochloride | IC50 | 187.0 [1] |
| 6-(4-Chlorobenzoyl)-3-(dimethylamino)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one;hydrochloride | Ki | 17.0 [1] |
 | 6-(4-Chlorobenzoyl)-2-[[(1S)-1-(4-chlorophenyl)ethyl]amino]-3-(dimethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one;hydrochloride | IC50 | 253.0 [1] |
| 6-(4-Chlorobenzoyl)-2-[[(1S)-1-(4-chlorophenyl)ethyl]amino]-3-(dimethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one;hydrochloride | Ki | 25.0 [1] |
 | 6-(4-Chlorobenzoyl)-3-methoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one;hydrochloride | IC50 | 140.0 [1] |
| 6-(4-Chlorobenzoyl)-3-methoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one;hydrochloride | Ki | 17.0 [1] |
 | 3-Fluoro-4-[4-oxo-3-prop-2-ynyl-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile;hydrochloride | IC50 | 42.0 [1] |
| 3-Fluoro-4-[4-oxo-3-prop-2-ynyl-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile;hydrochloride | Ki | 5.0 [1] |
 | 6-[2-(4-Chlorophenoxy)acetyl]-2-[[(1R)-1-(4-chlorophenyl)ethyl]amino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 1183.0 [1] |
| 6-[2-(4-Chlorophenoxy)acetyl]-2-[[(1R)-1-(4-chlorophenyl)ethyl]amino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 15.0 [1] |
 | 6-(4-Chlorobenzoyl)-3-methoxy-2-[2-[4-(trifluoromethyl)phenyl]pyrrolidin-1-yl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 34.0 [1] |
 | 6-(4-Chlorobenzoyl)-3-ethoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 3710.0 [1] |
| 6-(4-Chlorobenzoyl)-3-ethoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 25.0 [1] |
 | 3-Methoxy-6-[4-(trifluoromethoxy)benzoyl]-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 686.0 [1] |
| 3-Methoxy-6-[4-(trifluoromethoxy)benzoyl]-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 16.0 [1] |
 | 4-[3-Ethoxy-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | IC50 | 156.0 [1] |
| 4-[3-Ethoxy-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | Ki | 11.0 [1] |
 | 4-[3-Ethoxy-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile | IC50 | 227.0 [1] |
| 4-[3-Ethoxy-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile | Ki | 5.0 [1] |
 | 3-Ethoxy-6-[4-(1,3-oxazol-5-yl)benzoyl]-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 158.0 [1] |
| 3-Ethoxy-6-[4-(1,3-oxazol-5-yl)benzoyl]-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 20.0 [1] |
 | 3-Ethoxy-6-(thieno[2,3-b]pyridine-2-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 1684.0 [1] |
| 3-Ethoxy-6-(thieno[2,3-b]pyridine-2-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 17.0 [1] |
 | 3-Fluoro-4-[4-oxo-3-pyrrolidin-1-yl-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | IC50 | 298.0 [1] |
| 3-Fluoro-4-[4-oxo-3-pyrrolidin-1-yl-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | Ki | 6.0 [1] |
 | 6-[2-(4-Chlorophenyl)sulfanylacetyl]-3-methoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 1140.0 [1] |
| 6-[2-(4-Chlorophenyl)sulfanylacetyl]-3-methoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 8.0 [1] |
 | 6-(5-Chloro-1-benzofuran-2-carbonyl)-3-methoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 824.0 [1] |
| 6-(5-Chloro-1-benzofuran-2-carbonyl)-3-methoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 12.0 [1] |
 | 3-Methoxy-6-(5-methylthiophene-2-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 1128.0 [1] |
| 3-Methoxy-6-(5-methylthiophene-2-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 10.0 [1] |
 | 6-(4-Chlorobenzoyl)-2-[[(1S)-1-(4-chlorophenyl)ethyl]amino]-3-(dimethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 253.0 [1] |
| 6-(4-Chlorobenzoyl)-2-[[(1S)-1-(4-chlorophenyl)ethyl]amino]-3-(dimethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 25.0 [1] |
 | 6-(4-Chlorobenzoyl)-3-(dimethylamino)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 187.0 [1] |
| 6-(4-Chlorobenzoyl)-3-(dimethylamino)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 17.0 [1] |
 | 6-(5-Chloro-1-benzofuran-2-carbonyl)-3-methoxy-2-[1-[4-(trifluoromethyl)phenyl]ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 824.0 [1] |
| 6-(5-Chloro-1-benzofuran-2-carbonyl)-3-methoxy-2-[1-[4-(trifluoromethyl)phenyl]ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 12.0 [1] |
 | 6-(2,6-Dimethoxypyridine-3-carbonyl)-3-methoxy-2-[1-[4-(trifluoromethyl)phenyl]ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 228.0 [1] |
| 6-(2,6-Dimethoxypyridine-3-carbonyl)-3-methoxy-2-[1-[4-(trifluoromethyl)phenyl]ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 7.0 [1] |
 | 6-(4-Chlorobenzoyl)-2-[1-(4-chlorophenyl)propylamino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 1570.0 [1] |
| 6-(4-Chlorobenzoyl)-2-[1-(4-chlorophenyl)propylamino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 44.0 [1] |
 | 6-[2-(4-Chlorophenoxy)acetyl]-2-[1-(4-chlorophenyl)ethylamino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 1183.0 [1] |
| 6-[2-(4-Chlorophenoxy)acetyl]-2-[1-(4-chlorophenyl)ethylamino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 15.0 [1] |
 | 6-(4-Ethoxybenzoyl)-3-methoxy-2-[1-[4-(trifluoromethyl)phenyl]ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 1285.0 [1] |
| 6-(4-Ethoxybenzoyl)-3-methoxy-2-[1-[4-(trifluoromethyl)phenyl]ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 9.0 [1] |
 | 6-[2-(4-Chlorophenoxy)acetyl]-3-methoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 678.0 [1] |
| 6-[2-(4-Chlorophenoxy)acetyl]-3-methoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 8.0 [1] |
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