![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_3d4e429f9bb87872b5404790b72b0743.svg) | 3-Fluoro-4-[3-methoxy-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | IC50 | 34.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_3d4e429f9bb87872b5404790b72b0743.svg) | 3-Fluoro-4-[3-methoxy-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | Ki | 15.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_bb4ab3268cadf8d1de9c6d136ab97b70.svg) | 4-[3-(Dimethylamino)-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile | IC50 | 46.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_bb4ab3268cadf8d1de9c6d136ab97b70.svg) | 4-[3-(Dimethylamino)-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile | Ki | 8.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_24277f947d628a04a701de5bcbb1cb97.svg) | 6-(4-Chlorobenzoyl)-2-[[(1S)-1-(4-chlorophenyl)ethyl]amino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 204.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_24277f947d628a04a701de5bcbb1cb97.svg) | 6-(4-Chlorobenzoyl)-2-[[(1S)-1-(4-chlorophenyl)ethyl]amino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 28.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_04ce6461ee57865020ca09c501ab3d79.svg) | 6-(4-Chlorobenzoyl)-3-prop-2-ynyl-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 378.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_04ce6461ee57865020ca09c501ab3d79.svg) | 6-(4-Chlorobenzoyl)-3-prop-2-ynyl-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 29.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_e4be95c01b25eb53398d442bfd754628.svg) | 6-(4-Chlorobenzoyl)-2-[[(1S)-1-(4-chlorophenyl)ethyl]amino]-3-prop-2-ynyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 1722.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_e4be95c01b25eb53398d442bfd754628.svg) | 6-(4-Chlorobenzoyl)-2-[[(1S)-1-(4-chlorophenyl)ethyl]amino]-3-prop-2-ynyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 42.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_7a7b2c868d002370a6e57acb6f1e0399.svg) | 3-But-2-ynyl-6-(4-imidazol-1-ylbenzoyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 99.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_7a7b2c868d002370a6e57acb6f1e0399.svg) | 3-But-2-ynyl-6-(4-imidazol-1-ylbenzoyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 6.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_403d2dc07c379dfc4330ef345d298752.svg) | 4-[3-But-2-ynyl-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile | IC50 | 78.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_403d2dc07c379dfc4330ef345d298752.svg) | 4-[3-But-2-ynyl-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile | Ki | 2.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_f0c8c54d10c1ad00cc2649945795c861.svg) | 3-But-2-ynyl-6-[4-(1,3-oxazol-5-yl)benzoyl]-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 665.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_f0c8c54d10c1ad00cc2649945795c861.svg) | 3-But-2-ynyl-6-[4-(1,3-oxazol-5-yl)benzoyl]-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_16ce8701ae16fb1a2c0dab829c932ff3.svg) | 3-But-2-ynyl-6-(pyrazolo[1,5-a]pyridine-2-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 776.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_16ce8701ae16fb1a2c0dab829c932ff3.svg) | 3-But-2-ynyl-6-(pyrazolo[1,5-a]pyridine-2-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 20.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_9ef28f653f23c15ef88ac0716d9367e0.svg) | 3-But-2-ynyl-6-(quinoline-2-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 3350.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_9ef28f653f23c15ef88ac0716d9367e0.svg) | 3-But-2-ynyl-6-(quinoline-2-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 24.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_d5f87ab40200ad82552f7208a882704f.svg) | 6-(4-Chlorobenzoyl)-2-[[1-(4-chlorophenyl)-2-methylpropyl]amino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 4494.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_d5f87ab40200ad82552f7208a882704f.svg) | 6-(4-Chlorobenzoyl)-2-[[1-(4-chlorophenyl)-2-methylpropyl]amino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 37.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_c8bfbb936319d8416e648602596d98c2.svg) | 3-But-2-ynyl-6-(quinoline-3-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 2794.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_c8bfbb936319d8416e648602596d98c2.svg) | 3-But-2-ynyl-6-(quinoline-3-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 28.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_9a6a938203d7e060adb0fc1292a40524.svg) | 4-[3-But-3-ynyl-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile | IC50 | 68.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_9a6a938203d7e060adb0fc1292a40524.svg) | 4-[3-But-3-ynyl-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile | Ki | 2.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_19474dfe922f22a7d318af63082fd4ac.svg) | 6-[2-(4-Chlorophenyl)iminoacetyl]-3-methoxy-2-[1-[4-(trifluoromethyl)phenyl]ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 5793.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_19474dfe922f22a7d318af63082fd4ac.svg) | 6-[2-(4-Chlorophenyl)iminoacetyl]-3-methoxy-2-[1-[4-(trifluoromethyl)phenyl]ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 12.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_23dcfcde7171c993b709ad8cd6f33663.svg) | 6-[2-(4-Chlorophenoxy)acetyl]-2-[2-(4-chlorophenyl)-2-methylhydrazinyl]-3-(dimethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 3600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_23dcfcde7171c993b709ad8cd6f33663.svg) | 6-[2-(4-Chlorophenoxy)acetyl]-2-[2-(4-chlorophenyl)-2-methylhydrazinyl]-3-(dimethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 207.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_e717b920fc6e99c9409f0eb548b472e1.svg) | 4-[2-[2-Methyl-2-[4-(trifluoromethyl)phenyl]hydrazinyl]-3-morpholin-4-yl-4-oxo-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | IC50 | 238.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_e717b920fc6e99c9409f0eb548b472e1.svg) | 4-[2-[2-Methyl-2-[4-(trifluoromethyl)phenyl]hydrazinyl]-3-morpholin-4-yl-4-oxo-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | Ki | 36.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_8f28637defa1af098942ee57a96fbe96.svg) | 4-[3-But-3-ynyl-2-[2-methyl-2-[4-(trifluoromethyl)phenyl]hydrazinyl]-4-oxo-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | IC50 | 62.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_8f28637defa1af098942ee57a96fbe96.svg) | 4-[3-But-3-ynyl-2-[2-methyl-2-[4-(trifluoromethyl)phenyl]hydrazinyl]-4-oxo-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | Ki | 5.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_9d4768424ba043821c73e140fe7685a1.svg) | 3-But-3-ynyl-6-[4-(1,3-oxazol-5-yl)benzoyl]-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 26.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_d13bf62dd58449982588543a818bffe6.svg) | 3-(Dimethylamino)-2-[2-methyl-2-[4-(trifluoromethyl)phenyl]hydrazinyl]-6-(2,4,6-trifluorobenzoyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 216.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_d13bf62dd58449982588543a818bffe6.svg) | 3-(Dimethylamino)-2-[2-methyl-2-[4-(trifluoromethyl)phenyl]hydrazinyl]-6-(2,4,6-trifluorobenzoyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 6.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_eb7718f9518729f941c0f7d678e29c2f.svg) | 3-Methoxy-6-[4-(trifluoromethoxy)benzoyl]-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 686.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_eb7718f9518729f941c0f7d678e29c2f.svg) | 3-Methoxy-6-[4-(trifluoromethoxy)benzoyl]-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 16.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_dd6bf0eefcea1e5bbb9cc60d2f8a0af6.svg) | 6-(4-Chlorobenzoyl)-3-ethoxy-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 3710.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_dd6bf0eefcea1e5bbb9cc60d2f8a0af6.svg) | 6-(4-Chlorobenzoyl)-3-ethoxy-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 25.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_ed39a135a51e42fa37c53c6f84f59249.svg) | 4-[3-Ethoxy-4-oxo-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | IC50 | 156.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_ed39a135a51e42fa37c53c6f84f59249.svg) | 4-[3-Ethoxy-4-oxo-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | Ki | 11.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_44447982fd9e10dcf4a04203299ea8b5.svg) | 4-[3-Ethoxy-4-oxo-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile | IC50 | 227.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_44447982fd9e10dcf4a04203299ea8b5.svg) | 4-[3-Ethoxy-4-oxo-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile | Ki | 5.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_dff43ec8f01cd9eafdd9d4708eebf299.svg) | 3-Ethoxy-6-[4-(1,3-oxazol-5-yl)benzoyl]-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 158.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_dff43ec8f01cd9eafdd9d4708eebf299.svg) | 3-Ethoxy-6-[4-(1,3-oxazol-5-yl)benzoyl]-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 20.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_403bcbae979d64f927377c4cb53535e5.svg) | 3-Ethoxy-6-(thieno[2,3-b]pyridine-2-carbonyl)-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 1684.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_403bcbae979d64f927377c4cb53535e5.svg) | 3-Ethoxy-6-(thieno[2,3-b]pyridine-2-carbonyl)-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 17.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_18867fe53e118435b95761902afddca5.svg) | 4-[4-Oxo-3-pyrrolidin-1-yl-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | IC50 | 648.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_18867fe53e118435b95761902afddca5.svg) | 4-[4-Oxo-3-pyrrolidin-1-yl-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | Ki | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_6d69ea7d071d5e1349255efa29cb92c0.svg) | 3-Fluoro-4-[4-oxo-3-pyrrolidin-1-yl-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | IC50 | 298.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_6d69ea7d071d5e1349255efa29cb92c0.svg) | 3-Fluoro-4-[4-oxo-3-pyrrolidin-1-yl-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | Ki | 6.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_0cfbaba585e0ce1cadf943f5e3b4f265.svg) | 6-(4-Chlorobenzoyl)-3-(dimethylamino)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one;hydrochloride | IC50 | 187.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_0cfbaba585e0ce1cadf943f5e3b4f265.svg) | 6-(4-Chlorobenzoyl)-3-(dimethylamino)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one;hydrochloride | Ki | 17.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_0e4f2e59eeff35ea1f646bea7515e3a7.svg) | 6-(4-Chlorobenzoyl)-2-[[(1S)-1-(4-chlorophenyl)ethyl]amino]-3-(dimethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one;hydrochloride | IC50 | 253.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_0e4f2e59eeff35ea1f646bea7515e3a7.svg) | 6-(4-Chlorobenzoyl)-2-[[(1S)-1-(4-chlorophenyl)ethyl]amino]-3-(dimethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one;hydrochloride | Ki | 25.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_69d2d262ee68451993a1d315437fde2e.svg) | 6-(4-Chlorobenzoyl)-3-methoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one;hydrochloride | IC50 | 140.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_69d2d262ee68451993a1d315437fde2e.svg) | 6-(4-Chlorobenzoyl)-3-methoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one;hydrochloride | Ki | 17.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_7cd9d8fbb4d0d3f7631f049fe836edff.svg) | 3-Fluoro-4-[4-oxo-3-prop-2-ynyl-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile;hydrochloride | IC50 | 42.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_7cd9d8fbb4d0d3f7631f049fe836edff.svg) | 3-Fluoro-4-[4-oxo-3-prop-2-ynyl-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile;hydrochloride | Ki | 5.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_5e89fc782177036b158e7706e56cd141.svg) | 6-[2-(4-Chlorophenoxy)acetyl]-2-[[(1R)-1-(4-chlorophenyl)ethyl]amino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 1183.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_5e89fc782177036b158e7706e56cd141.svg) | 6-[2-(4-Chlorophenoxy)acetyl]-2-[[(1R)-1-(4-chlorophenyl)ethyl]amino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 15.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_2afe04311b8a63610bedeb7f699f10d5.svg) | 6-(4-Chlorobenzoyl)-3-methoxy-2-[2-[4-(trifluoromethyl)phenyl]pyrrolidin-1-yl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 34.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_7644e0c60eebb0f88971c13dc33d03e8.svg) | 6-(4-Chlorobenzoyl)-3-ethoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 3710.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_7644e0c60eebb0f88971c13dc33d03e8.svg) | 6-(4-Chlorobenzoyl)-3-ethoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 25.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_9a567d18619a2e060c61a346277a2694.svg) | 3-Methoxy-6-[4-(trifluoromethoxy)benzoyl]-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 686.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_9a567d18619a2e060c61a346277a2694.svg) | 3-Methoxy-6-[4-(trifluoromethoxy)benzoyl]-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 16.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_14ac170f866e1e6043ceb1a5476caaeb.svg) | 4-[3-Ethoxy-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | IC50 | 156.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_14ac170f866e1e6043ceb1a5476caaeb.svg) | 4-[3-Ethoxy-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | Ki | 11.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_15d5af8d7f39d666f2ef599650a03033.svg) | 4-[3-Ethoxy-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile | IC50 | 227.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_15d5af8d7f39d666f2ef599650a03033.svg) | 4-[3-Ethoxy-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile | Ki | 5.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_2f958a4a73130400e6d7e97fbd7b6de2.svg) | 3-Ethoxy-6-[4-(1,3-oxazol-5-yl)benzoyl]-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 158.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_2f958a4a73130400e6d7e97fbd7b6de2.svg) | 3-Ethoxy-6-[4-(1,3-oxazol-5-yl)benzoyl]-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 20.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_fb9e5cdf8ccaadcd7eac1d5817ebc2ab.svg) | 3-Ethoxy-6-(thieno[2,3-b]pyridine-2-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 1684.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_fb9e5cdf8ccaadcd7eac1d5817ebc2ab.svg) | 3-Ethoxy-6-(thieno[2,3-b]pyridine-2-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 17.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_652a8d8af33365a0584eb3d1ba34d597.svg) | 3-Fluoro-4-[4-oxo-3-pyrrolidin-1-yl-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | IC50 | 298.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_652a8d8af33365a0584eb3d1ba34d597.svg) | 3-Fluoro-4-[4-oxo-3-pyrrolidin-1-yl-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile | Ki | 6.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_5dfd67a2219bbff39dbdbdc148cf65c7.svg) | 6-[2-(4-Chlorophenyl)sulfanylacetyl]-3-methoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 1140.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_5dfd67a2219bbff39dbdbdc148cf65c7.svg) | 6-[2-(4-Chlorophenyl)sulfanylacetyl]-3-methoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 8.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_9af5e8dd750007df27b132eb26a6441f.svg) | 6-(5-Chloro-1-benzofuran-2-carbonyl)-3-methoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 824.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_9af5e8dd750007df27b132eb26a6441f.svg) | 6-(5-Chloro-1-benzofuran-2-carbonyl)-3-methoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 12.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_b6126b0c9cab0a11562489ae4df87f3f.svg) | 3-Methoxy-6-(5-methylthiophene-2-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 1128.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_b6126b0c9cab0a11562489ae4df87f3f.svg) | 3-Methoxy-6-(5-methylthiophene-2-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_1e63931cbf496b4c6ce8156ae8d0181f.svg) | 6-(4-Chlorobenzoyl)-2-[[(1S)-1-(4-chlorophenyl)ethyl]amino]-3-(dimethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 253.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_1e63931cbf496b4c6ce8156ae8d0181f.svg) | 6-(4-Chlorobenzoyl)-2-[[(1S)-1-(4-chlorophenyl)ethyl]amino]-3-(dimethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 25.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_136bcd81547a767fef6178ab1e746b56.svg) | 6-(4-Chlorobenzoyl)-3-(dimethylamino)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 187.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_136bcd81547a767fef6178ab1e746b56.svg) | 6-(4-Chlorobenzoyl)-3-(dimethylamino)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 17.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_3852fb82a58560413a46c28edea65acc.svg) | 6-(5-Chloro-1-benzofuran-2-carbonyl)-3-methoxy-2-[1-[4-(trifluoromethyl)phenyl]ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 824.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_3852fb82a58560413a46c28edea65acc.svg) | 6-(5-Chloro-1-benzofuran-2-carbonyl)-3-methoxy-2-[1-[4-(trifluoromethyl)phenyl]ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 12.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_5e4eb7b72f2d390f896232556f557e33.svg) | 6-(2,6-Dimethoxypyridine-3-carbonyl)-3-methoxy-2-[1-[4-(trifluoromethyl)phenyl]ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 228.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_5e4eb7b72f2d390f896232556f557e33.svg) | 6-(2,6-Dimethoxypyridine-3-carbonyl)-3-methoxy-2-[1-[4-(trifluoromethyl)phenyl]ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 7.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_869d409bab5f00ec934e2299c4ed9e33.svg) | 6-(4-Chlorobenzoyl)-2-[1-(4-chlorophenyl)propylamino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 1570.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_869d409bab5f00ec934e2299c4ed9e33.svg) | 6-(4-Chlorobenzoyl)-2-[1-(4-chlorophenyl)propylamino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 44.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_2ce848fe5a3b6e973ac6b3b16a8cbdef.svg) | 6-[2-(4-Chlorophenoxy)acetyl]-2-[1-(4-chlorophenyl)ethylamino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 1183.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_2ce848fe5a3b6e973ac6b3b16a8cbdef.svg) | 6-[2-(4-Chlorophenoxy)acetyl]-2-[1-(4-chlorophenyl)ethylamino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 15.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_90be17fea8a0378b3968fb11bef3ff58.svg) | 6-(4-Ethoxybenzoyl)-3-methoxy-2-[1-[4-(trifluoromethyl)phenyl]ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 1285.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_90be17fea8a0378b3968fb11bef3ff58.svg) | 6-(4-Ethoxybenzoyl)-3-methoxy-2-[1-[4-(trifluoromethyl)phenyl]ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 9.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_c27515901eaf7c0e04aeca42fbdad412.svg) | 6-[2-(4-Chlorophenoxy)acetyl]-3-methoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | IC50 | 678.0 [1] |
![](https://images.aatbio.com/dataset/ic50/prolactin-releasing-peptide-receptor_c27515901eaf7c0e04aeca42fbdad412.svg) | 6-[2-(4-Chlorophenoxy)acetyl]-3-methoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one | Ki | 8.0 [1] |