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Prokineticin receptor 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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CID 11950660IC5033.0 [1]
CID 11951384Ki22.0 [1]
2-[2-[[5-[(4-Chlorophenyl)methyl]-1-[(4-methoxyphenyl)methyl]-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]guanidineIC5019.0 [1]
2-[2-[[1,5-Bis[(4-methoxyphenyl)methyl]-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]guanidineIC5021.0 [1]
(3-Amino-1-methylpyrazol-4-yl)-[3-(5-chloro-3-methylpyridin-2-yl)-3-methoxypiperidin-1-yl]methanoneIC509000.0 [1]
[2-(Dimethylamino)pyridin-4-yl]-[3-(1-propan-2-ylbenzimidazol-2-yl)piperidin-1-yl]methanoneIC50320.0 [1]
(3-Amino-1-methylpyrazol-4-yl)-[3-(5-chloro-1-ethylindol-2-yl)piperidin-1-yl]methanoneIC50910.0 [1]
[6-(Methylamino)pyridazin-4-yl]-[3-(3-methyl-1H-indol-2-yl)piperidin-1-yl]methanoneIC507410.0 [1]
(1-Ethylpyrazol-4-yl)-[3-(1-propan-2-ylindol-2-yl)piperidin-1-yl]methanoneIC50330.0 [1]
2-[2-[[5-[2-(4-Methoxyphenyl)ethyl]-1-[(4-methoxyphenyl)methyl]-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]guanidineIC50461.0 [1]
2-[2-[[5-Benzyl-1-[(4-fluorophenyl)methyl]-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]guanidineIC5010000.0 [1]
2-[2-[[5-Benzyl-1-[(4-methoxyphenyl)methyl]-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]guanidineIC50336.0 [1]
2-[2-[[1-[(4-Methoxyphenyl)methyl]-4,6-dioxo-5-(2-phenylethyl)-1,3,5-triazin-2-yl]amino]ethyl]guanidineIC502500.0 [1]
2-[2-[[5-Butyl-1-[(4-methoxyphenyl)methyl]-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]guanidineIC502180.0 [1]
2-[2-[[5-[(3-Methoxyphenyl)methyl]-1-[(4-methoxyphenyl)methyl]-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]guanidineIC503690.0 [1]
2-[2-[[5-[(2-Methoxyphenyl)methyl]-1-[(4-methoxyphenyl)methyl]-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]guanidineIC5010000.0 [1]
2-[2-[[5-[(4-Methoxyphenyl)methyl]-1-[(6-methoxypyridin-3-yl)methyl]-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]guanidineIC5051.0 [1]
2-[2-[[5-[(4-Cyanophenyl)methyl]-1-[(4-methoxyphenyl)methyl]-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]guanidineIC50318.0 [1]
6-(2-Aminoethylamino)-3-[(4-ethylphenyl)methyl]-1-[(4-methoxyphenyl)methyl]-1,3,5-triazine-2,4-dioneKi440.0 [1]
6-[2-(4,5-Dihydro-1H-imidazol-2-ylamino)ethylamino]-3-[(4-ethylphenyl)methyl]-1-[(4-methoxyphenyl)methyl]-1,3,5-triazine-2,4-dioneKi4719.0 [1]
2-[2-[[5-[(4-Fluorophenyl)methyl]-1-[2-(4-methoxyphenyl)ethyl]-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]guanidineIC502860.0 [1]
2-[2-[[5-[(3,4-Dichlorophenyl)methyl]-1-hexyl-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]guanidineIC506510.0 [1]
2-[2-[[5-[(3,4-Dichlorophenyl)methyl]-1-[(4-methoxyphenyl)methyl]-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]guanidineIC5022.0 [1]
2-[2-[[1-[(4-Hydroxyphenyl)methyl]-5-[(4-methoxyphenyl)methyl]-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]guanidineIC5027.0 [1]
2-[2-[[5-[(4-Chlorophenyl)methyl]-1-(furan-3-yl)-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]guanidineIC501870.0 [1]
2-[3-[[5-[(3,4-Dichlorophenyl)methyl]-1-[(4-methoxyphenyl)methyl]-4,6-dioxo-1,3,5-triazin-2-yl]amino]propyl]guanidineIC501210.0 [1]
2-[2-[[1-[(4-Methoxycyclohexyl)methyl]-5-[(4-methoxyphenyl)methyl]-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]guanidineIC503260.0 [1]
2-[2-[[5-[(4-Hydroxyphenyl)methyl]-1-[(4-methoxyphenyl)methyl]-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]guanidineIC501160.0 [1]
2-[2-[[1-Benzyl-5-[(4-chlorophenyl)methyl]-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]guanidineIC504780.0 [1]
2-[2-[[5-[(3,4-Dichlorophenyl)methyl]-1-[[4-(difluoromethoxy)phenyl]methyl]-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]guanidineIC5047.0 [1]
2-[2-[[5-(Furan-2-yl)-1-[(4-methoxyphenyl)methyl]-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]guanidineIC502590.0 [1]
2-[2-[[5-[(4-Fluorophenyl)methyl]-1-[(4-nitrophenyl)methyl]-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]guanidineIC5010000.0 [1]
2-[2-[[5-[(3,4-Dichlorophenyl)methyl]-4,6-dioxo-1-[(4-propoxyphenyl)methyl]-1,3,5-triazin-2-yl]amino]ethyl]guanidineIC50515.0 [1]
[3-(5-Chloro-3-methylpyridin-2-yl)-3-fluoropiperidin-1-yl]-[2-(methylamino)pyridin-4-yl]methanoneIC50290.0 [1]
(2E)-2-(4-Chlorophenyl)-2-[1-[(3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl]-3-methylpiperidin-4-ylidene]acetonitrileIC50470.0 [1]
4-(2,4-Dichlorophenoxy)-1-[1,5-dimethyl-3-(trifluoromethyl)pyrazol-4-yl]sulfonylpiperidineIC501700.0 [1]
N-(3,4-Dichlorophenyl)-N-methyl-1-(1,3,5-trimethylpyrazol-4-yl)sulfonylpiperidin-4-amineIC505200.0 [1]
N-(4-Chlorophenyl)-N-methyl-1-(1,3,5-trimethylpyrazol-4-yl)sulfonylpiperidin-4-amineIC50900.0 [1]
1-((3,5-Dimethyl-1H-pyrazol-4-yl)sulfonyl)-4-(2-fluorophenoxy)piperidineIC503730.0 [1]
4-(4-Chloro-2-methoxybenzyl)-1-((1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl)piperidineIC5050.0 [1]
4-(4-Chloro-2-methoxybenzyl)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)-4-fluoropiperidineIC50170.0 [1]
4-(4-Chloro-2-methoxybenzyl)-4-fluoro-1-((1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl)piperidineIC50140.0 [1]
2-(4-Chloro-2-fluorophenyl)-2-(1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-yl)acetonitrileIC501850.0 [1]
2-(4-Chlorophenyl)-2-(1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-yl)acetonitrileIC50610.0 [1]
(4-Chlorophenyl)-[1-[(3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl]piperidin-4-yl]methanolIC501740.0 [1]
(4-Chlorophenyl)(1-((1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-yl)methanolIC50710.0 [1]
4-((4-Chlorophenyl)(methoxy)methyl)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidineIC50160.0 [1]
4-((4-Chlorophenyl)(methoxy)methyl)-1-((1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl)piperidineIC5060.0 [1]
2-(4-Chlorophenyl)-2-(1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-yl)ethanolIC509420.0 [1]
1-(4-Chlorophenyl)-1-(1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-yl)ethanolIC502380.0 [1]
4-[1-(4-Chlorophenyl)ethyl]-1-[(3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl]piperidineIC50470.0 [1]
4-(4-Chlorobenzyl)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-olIC501640.0 [1]
4-((4-Chlorophenyl)fluoromethyl)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidineIC504000.0 [1]
4-((4-Chlorophenyl)(ethoxy)methyl)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidineIC50720.0 [1]
1-((3,5-Dimethyl-1H-pyrazol-4-yl)sulfonyl)-4-(methoxy(phenyl)methyl)piperidineIC503010.0 [1]
4-(1-(4-Chlorophenyl)-2,2-difluoroethyl)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidineIC50340.0 [1]
4-(4-Chloro-2-methoxybenzyl)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)-4-methoxypiperidineIC504600.0 [1]
4-(3,4-Dichlorophenoxy)-1-((1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl)piperidineIC501400.0 [1]
4-(3,4-Dichlorophenoxy)-1-[(3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl]piperidineIC501000.0 [1]
4-[4-(Trifluoromethoxy)phenoxy]-1-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl]piperidineIC501400.0 [1]
4-(4-Methylphenoxy)-1-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl]piperidineIC50820.0 [1]
4-(4-Chlorophenoxy)-1-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl]piperidineIC50530.0 [1]
4-(3-Chlorophenoxy)-1-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl]piperidineIC502200.0 [1]
4-({1-[(1,3,5-Trimethyl-1H-pyrazol-4-yl)sulfonyl]piperidin-4-yl}oxy)benzonitrileIC507300.0 [1]
4-(4-Chlorophenoxy)-1-[(3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl]piperidineIC501450.0 [1]
1-[(1-Ethyl-3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl]-4-(4-methylphenoxy)piperidineIC502300.0 [1]
1-{[1,5-Dimethyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]sulfonyl}-4-(4-methylphenoxy)piperidineIC501700.0 [1]
1-[(5-Chloro-1,3-dimethyl-1H-pyrazol-4-yl)sulfonyl]-4-(4-methylphenoxy)piperidineIC50860.0 [1]
4-[4-(Trifluoromethyl)phenoxy]-1-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl]piperidineIC504700.0 [1]
4-(2,4-Dichlorophenoxy)-1-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl]piperidineIC50790.0 [1]
4-(4-Bromo-2-fluorophenoxy)-1-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl]piperidineIC50470.0 [1]
1-[(5-Chloro-1,3-dimethyl-1H-pyrazol-4-yl)sulfonyl]-4-(4-chlorophenoxy)piperidineIC502900.0 [1]
4-(4-Chlorophenoxy)-1-{[1,5-dimethyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]sulfonyl}piperidineIC504600.0 [1]
4-(3-Methoxyphenoxy)-1-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl]piperidineIC503600.0 [1]
4-(4-Methoxyphenoxy)-1-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl]piperidineIC507000.0 [1]
4-Phenoxy-1-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl]piperidineIC505600.0 [1]
4-(4-Fluorophenoxy)-1-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl]piperidineIC503600.0 [1]
4-(4-Chlorophenoxy)-3-methyl-1-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl]piperidineIC502100.0 [1]
4-(2,4-Dichlorophenoxy)-1-[(3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl]piperidineIC501180.0 [1]
4-(4-Chlorophenoxy)-2-methyl-1-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl]piperidineIC501500.0 [1]
4-(Naphthalen-2-yloxy)-1-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl]piperidineIC50220.0 [1]
1-[(5-Chloro-1,3-dimethyl-1H-pyrazol-4-yl)sulfonyl]-4-(2,4-dichlorophenoxy)piperidineIC501300.0 [1]
4-(2,4-Dichlorophenoxy)-1-[(1,3-dimethyl-1H-pyrazol-4-yl)sulfonyl]piperidineIC505600.0 [1]
4-(2,4-Dichlorophenoxy)-1-[(3,5-diethyl-1-methyl-1H-pyrazol-4-yl)sulfonyl]piperidineIC50320.0 [1]
4-(2,4-Dichlorophenoxy)-1-[1-(difluoromethyl)-3,5-dimethylpyrazol-4-yl]sulfonylpiperidineIC501100.0 [1]
4-(4-Chloro-2-fluorophenoxy)-1-(trimethyl-1H-pyrazole-4-sulfonyl)piperidineIC50510.0 [1]
5-Chloro-2-{[1-(trimethyl-1H-pyrazole-4-sulfonyl)piperidin-4-yl]oxy}benzonitrileIC50310.0 [1]
1-[(3,5-Dimethyl-1H-pyrazol-4-yl)sulfonyl]-4-[4-(trifluoromethoxy)phenoxy]piperidineIC503400.0 [1]
1-[(3,5-Dimethyl-1H-pyrazol-4-yl)sulfonyl]-4-(naphthalen-2-yloxy)piperidineIC50440.0 [1]
5-Chloro-2-{[1-(3,5-dimethyl-1H-pyrazole-4-sulfonyl)piperidin-4-yl]oxy}benzonitrileIC50240.0 [1]
4-(4-Chloro-2-fluorophenoxy)-1-(3,5-dimethyl-1H-pyrazole-4-sulfonyl)piperidineIC501100.0 [1]
4-(4-Chlorophenoxy)-1-(1,4-dimethyl-1H-pyrazole-5-sulfonyl)piperidineIC507400.0 [1]
4-(2,4-Dichlorophenoxy)-1-(1,4-dimethyl-1H-pyrazole-5-sulfonyl)piperidineIC501100.0 [1]
1-(3,5-Dimethyl-1H-pyrazole-4-sulfonyl)-4-(2,6-dimethylphenoxy)piperidineIC503200.0 [1]
4-[4-Chloro-2-(trifluoromethyl)phenoxy]-1-(trimethyl-1H-pyrazole-4-sulfonyl)piperidineIC50210.0 [1]
4-[4-Chloro-2-(trifluoromethyl)phenoxy]-1-(3,5-dimethyl-1H-pyrazole-4-sulfonyl)piperidineIC50210.0 [1]
1-(3,5-Dimethyl-1H-pyrazole-4-sulfonyl)-4-(3-fluoro-4-methoxyphenoxy)piperidineIC505900.0 [1]
4-(3,5-Difluoro-4-methoxyphenoxy)-1-(3,5-dimethyl-1H-pyrazole-4-sulfonyl)piperidineIC505900.0 [1]
4-(3-Fluoro-4-methoxyphenoxy)-1-(trimethyl-1H-pyrazole-4-sulfonyl)piperidineIC506300.0 [1]
4-(3,5-Difluoro-4-methoxyphenoxy)-1-(trimethyl-1H-pyrazole-4-sulfonyl)piperidineIC505100.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Prokineticin receptor 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/prokineticin-receptor-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Prokineticin receptor 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/prokineticin-receptor-1-inhibitors-ic50-ki.
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