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Progesterone receptor Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
MifepristoneIC500.2 [1]
MifepristoneKi0.25 [1], 0.64 [2]
DexamethasoneIC502000.0 [1]
DexamethasoneKi561.0 [1], 778.0 [2]
PrednisoloneIC502000.0 [1], 2080.0 [2], 27000.0 [3]
Medroxyprogesterone acetateIC5010.8 [1], 10000.0 [2]
OnapristoneIC501.6 [1], 3.3 [2]
OnapristoneKi18.0 [1]
2,2,4-Trimethyl-6-(3-nitrophenyl)-1,2-dihydroquinolineIC5041.0 [1], 42.0 [2]
2,2,4-Trimethyl-6-(3-nitrophenyl)-1,2-dihydroquinolineKi19.95 [1], 20.0 [2]
3-Fluoro-5-(2,2,4-trimethyl-1,2-dihydroquinolin-6-yl)benzonitrileIC5030.0 [1], 37.0 [2]
3-Fluoro-5-(2,2,4-trimethyl-1,2-dihydroquinolin-6-yl)benzonitrileKi10.0 [1]
SpironolactoneIC50650.0 [1], 1400.0 [2], 4000.0 [3], 10000.0 [4]
SpironolactoneKi399.7 [1]
EplerenoneIC5010000.0 [1], 20000.0 [2]
1,2-Dihydro-2,2,4-trimethyl-5-(4-chlorophenyl)-5H-1-aza-6-oxachryseneIC50600.0 [1]
1,2-Dihydro-2,2,4-trimethyl-5-(4-chlorophenyl)-5H-1-aza-6-oxachryseneKi0.7 [1]
1,2-Dihydro-2,2,4-trimethyl-6-phenylquinolineIC50783.0 [1]
1,2-Dihydro-2,2,4-trimethyl-6-phenylquinolineKi131.83 [1], 133.0 [2]
(E)-3-[3,5-Difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-1,3,4,9-tetrahydropyrido[3,4-b]indol-1-yl]phenyl]prop-2-enoic acidIC500.28 [1], 11.22 [2], 540.0 [3], 3162.28 [4]
2,2,4,9-Tetramethyl-2,5-dihydro-1H-chromeno[3,4-f]quinolineIC50100.0 [1]
2,2,4,9-Tetramethyl-2,5-dihydro-1H-chromeno[3,4-f]quinolineKi44.67 [1], 45.0 [2], 50.2 [3]
9-Fluoro-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinolineIC50335.0 [1]
9-Fluoro-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinolineKi6.1 [1], 19.3 [2], 19.5 [3]
2,2,4-Trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinolineIC50138.0 [1]
2,2,4-Trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinolineKi83.18 [1], 84.0 [2]
4-Methyl-5-(2,2,4,4-tetramethyl-3-oxo-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carbonitrileIC5010.0 [1]
4-Methyl-5-(2,2,4,4-tetramethyl-3-oxo-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carbonitrileKi3.89 [1], 3.9 [2]
1-Methyl-5-(2-oxochromen-6-yl)pyrrole-2-carbonitrileIC5065.0 [1], 123.0 [2], 15200.0 [3]
3-(2-Oxospiro[1H-indole-3,1'-cyclohexane]-5-yl)benzonitrileIC506.6 [1], 14.7 [2], 15.0 [3], 25.0 [4]
3-(4,4-Dimethyl-2-oxo-2,4-dihydro-1H-benzo[d][1,3]oxazin-6-yl)-5-fluorobenzonitrileIC5015.9 [1], 16.0 [2], 90.0 [3]
5-(4,4-Dimethyl-2-oxo-2,4-dihydro-1H-benzo[d][1,3]oxazin-6-yl)-2-fluorobenzonitrileIC5015.0 [1], 15.1 [2], 55.0 [3]
6-(3-Nitro-phenyl)-3H-benzothiazol-2-oneIC5083.8 [1], 84.0 [2], 326.0 [3]
6-(3-Nitro-phenyl)-3H-benzothiazol-2-oneKi332.0 [1]
6-(5-Cyano-3-thienyl)-1,2-dihydro-2,2,4-trimethylquinolineIC5024.0 [1], 106.0 [2]
6-(5-Cyano-3-thienyl)-1,2-dihydro-2,2,4-trimethylquinolineKi3.47 [1], 3.5 [2]
2,2,4-Trimethyl-6-(3-methyl-2-thienyl)-1,2-dihydroquinolineIC50105.0 [1], 232.0 [2]
2,2,4-Trimethyl-6-(3-methyl-2-thienyl)-1,2-dihydroquinolineKi25.0 [1], 25.12 [2]
2,2,4-Trimethyl-6-(5-chloro-2-thienyl)-1,2-dihydroquinolineIC5043.0 [1], 151.0 [2]
2,2,4-Trimethyl-6-(5-chloro-2-thienyl)-1,2-dihydroquinolineKi12.0 [1], 12.02 [2]
2,2,4-Trimethyl-6-(5-nitro-2-thienyl)-1,2-dihydroquinolineIC5031.0 [1], 70.0 [2]
2,2,4-Trimethyl-6-(5-nitro-2-thienyl)-1,2-dihydroquinolineKi2.57 [1], 2.6 [2]
5-(2,2,4-Trimethyl-1,2-dihydroquinolin-6-yl)thiophene-2-carbonitrileIC5027.0 [1], 80.0 [2]
5-(2,2,4-Trimethyl-1,2-dihydroquinolin-6-yl)thiophene-2-carbonitrileKi54.95 [1], 55.0 [2]
6-(3-Chloro-phenyl)-1-isopropyl-1,3-dihydro-benzoimidazol-2-oneIC5073.0 [1], 112.8 [2], 412.0 [3]
6-(3-Chloro-phenyl)-1-isopropyl-1,3-dihydro-benzoimidazol-2-oneKi525.0 [1]
2,2,4-Trimethyl-6-(4-bromo-2-thienyl)-1,2-dihydroquinolineIC50105.0 [1], 190.0 [2]
2,2,4-Trimethyl-6-(4-bromo-2-thienyl)-1,2-dihydroquinolineKi32.0 [1], 32.36 [2]
2,2,4-Trimethyl-6-(5-bromo-2-thienyl)-1,2-dihydroquinolineIC5065.0 [1], 71.0 [2]
2,2,4-Trimethyl-6-(5-bromo-2-thienyl)-1,2-dihydroquinolineKi30.9 [1], 31.0 [2]
4-(2,2,4-Trimethyl-1,2-dihydroquinoline-6-yl)-3,5-dimethylthiophene-2-carbonitrileIC50124.0 [1], 150.0 [2]
4-(2,2,4-Trimethyl-1,2-dihydroquinoline-6-yl)-3,5-dimethylthiophene-2-carbonitrileKi36.0 [1], 36.31 [2]
4-(2,2,4-Trimethyl-1,2-dihydroquinoline-6-yl)thiophene-2-carbaldehydeIC50102.0 [1], 245.0 [2]
4-(2,2,4-Trimethyl-1,2-dihydroquinoline-6-yl)thiophene-2-carbaldehydeKi37.0 [1], 37.15 [2]
4-(2,2,4-Trimethyl-1,2-dihydroquinoline-6-yl)-5-methylthiophene-2-carbonitrileIC50109.0 [1], 120.0 [2]
4-(2,2,4-Trimethyl-1,2-dihydroquinoline-6-yl)-5-methylthiophene-2-carbonitrileKi30.9 [1], 31.0 [2]
4-Methyl-5-(2,2,4-trimethyl-1,2-dihydroquinolin-6-yl)thiophene-2-carbonitrileIC5033.0 [1], 123.0 [2]
4-Methyl-5-(2,2,4-trimethyl-1,2-dihydroquinolin-6-yl)thiophene-2-carbonitrileKi25.7 [1], 26.0 [2]
3-Bromo-5-(2,2,4-trimethyl-1,2-dihydroquinolin-6-yl)thiophene-2-carbonitrileIC50242.0 [1], 250.0 [2]
3-Bromo-5-(2,2,4-trimethyl-1,2-dihydroquinolin-6-yl)thiophene-2-carbonitrileKi249.0 [1], 251.19 [2]
2,2,4-Trimethyl-6-(2-thienyl)-1,2-dihydroquinolineIC50416.0 [1], 700.0 [2]
2,2,4-Trimethyl-6-(2-thienyl)-1,2-dihydroquinolineKi234.42 [1], 237.0 [2]
5-(2,2,4-Trimethyl-1,2-dihydroquinoline-6-yl)thiophene-2-carbaldehydeIC5078.0 [1], 729.0 [2]
5-(2,2,4-Trimethyl-1,2-dihydroquinoline-6-yl)thiophene-2-carbaldehydeKi79.43 [1], 80.0 [2]
4-Bromo-5-(2,2,4-trimethyl-1,2-dihydroquinolin-6-yl)thiophene-2-carbonitrileIC5052.0 [1], 120.0 [2]
4-Bromo-5-(2,2,4-trimethyl-1,2-dihydroquinolin-6-yl)thiophene-2-carbonitrileKi433.0 [1], 436.52 [2]
7-(Diethylamino)-6-phenylchromen-2-oneIC50500.0 [1], 1420.0 [2]
6-(3-Chloro-4-fluorophenyl)-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-oneIC5023.0 [1], 37.0 [2]
4-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]oxazin-6-yl)-furan-2-carbonitrileIC508.0 [1], 40.2 [2]
AsoprisnilIC500.2 [1], 0.3 [2]
DesmethylmifepristoneIC500.07 [1], 0.17 [2]
5-Bromo-2-[[(1S,3R)-3-bromo-2,2-dimethyl-6-methylidenecyclohexyl]methyl]-4-methoxyphenolIC50354.0 [1], 549.0 [2]
5-Bromo-2-[[(1S,3R)-3-bromo-2,2-dimethyl-6-methylidenecyclohexyl]methyl]-4-methoxyphenolKi490.0 [1]
5-(3-Chloro-phenyl)-9-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chryseneKi0.32 [1]
4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)-2-(trifluoromethyl)pentanamideIC5012.59 [1], 22.0 [2]
N-(4-Phenoxyphenyl)-3-trifluoromethylbenzenesulfonamideIC5033.0 [1], 40.0 [2], 107.0 [3]
9-Chloro-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinolineKi3.6 [1], 12.88 [2], 12.9 [3]
6-(1-(4-Fluoro-2-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)-2H-benzo[b][1,4]oxazin-3(4H)-oneIC501800.0 [1], 1900.0 [2]
3-(2,2,4-Trimethyl-1,2-dihydroquinolin-6-yl)benzonitrileIC5038.0 [1]
3-(2,2,4-Trimethyl-1,2-dihydroquinolin-6-yl)benzonitrileKi19.0 [1], 19.05 [2]
(5Z)-2,2,4-Trimethyl-5-[(2-methylphenyl)methylidene]-1H-chromeno[3,4-f]quinolineKi0.66 [1]
7-Fluoro-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline-9-carbonitrileIC50149.0 [1]
7-Fluoro-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline-9-carbonitrileKi4.47 [1], 4.5 [2]
5-Phenyl-2,2,4-trimethyl-1,2-dihydro-5H-1-aza-6-oxachryseneIC50290.0 [1]
5-Phenyl-2,2,4-trimethyl-1,2-dihydro-5H-1-aza-6-oxachryseneKi3.6 [1]
2,2,4-Trimethyl-6-(3,5-difluorophenyl)-1,2-dihydroquinolineIC5079.0 [1]
2,2,4-Trimethyl-6-(3,5-difluorophenyl)-1,2-dihydroquinolineKi10.0 [1]
2,2,4-Trimethyl-6-(3-nitro-5-fluorophenyl)-1,2-dihydroquinolineIC5070.0 [1]
2,2,4-Trimethyl-6-(3-nitro-5-fluorophenyl)-1,2-dihydroquinolineKi5.0 [1], 5.01 [2]
2,2,4-Trimethyl-6-(3-fluorophenyl)-1,2-dihydroquinolineIC50750.0 [1]
2,2,4-Trimethyl-6-(3-fluorophenyl)-1,2-dihydroquinolineKi181.97 [1], 182.0 [2]
5-(3-Cyclopentyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrileIC505.6 [1], 26.2 [2]
5-(3-Chlorophenyl)spiro[1H-indole-3,1'-cyclohexane]-2-oneIC5056.0 [1], 477.0 [2]
1,3,3-Trimethyl-4,11-dihydro-3H-indeno[2,1-f]quinolineIC50549.0 [1]
1,3,3-Trimethyl-4,11-dihydro-3H-indeno[2,1-f]quinolineKi12.88 [1], 13.0 [2]
9-Bromo-1,3,3-trimethyl-4,11-dihydro-3H-indeno[2,1-f]quinolineIC502330.0 [1]
Items per page: 1 - 10 of 96
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References

This online tool may be cited as follows

MLA

"Quest Database™ Progesterone receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/progesterone-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Progesterone receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/progesterone-receptor-inhibitors-ic50-ki.
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