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Probable protein-cysteine N-palmitoyltransferase porcupine Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
2-(2',3-Dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamideIC500.4 [1]
2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamideIC500.07 [1], 1.0 [2]
2-[5-Methyl-6-(6-methylpyridin-3-yl)pyridin-3-yl]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamideIC500.38 [1], 0.57 [2]
CID 2155128IC50157.0 [1]
N-[2-[(6-Methoxy-1,3-benzothiazol-2-yl)amino]-2-oxoethyl]-3-(4-methoxyphenyl)-4-oxophthalazine-1-carboxamideIC5060.0 [1]
2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(6-phenylpyridazin-3-yl)acetamideIC502.9 [1]
(2R)-1-(4-Imidazol-1-ylphenyl)-N-(4-phenylphenyl)pyrrolidine-2-carboxamideIC5033000.0 [1]
2-[4-(1,3-Oxazol-5-yl)phenoxy]-N-(4-phenylphenyl)acetamideIC5042.0 [1]
N-(4-Phenylphenyl)-2-[4-(1H-pyrazol-5-yl)phenoxy]acetamideIC5050000.0 [1]
(2S)-1-(4-Imidazol-1-ylphenyl)-N-(4-phenylphenyl)pyrrolidine-2-carboxamideIC5040.0 [1]
(2S)-2-[[6-(2-Methylpyrazol-3-yl)pyridin-3-yl]amino]-N-(6-pyridin-3-ylpyridin-3-yl)propanamideIC5010.0 [1]
2-[4-(2-Methylpyrazol-3-yl)phenoxy]-N-(4-phenylphenyl)acetamideIC504.0 [1]
2-(6-Cyclopropyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)-N-[6-(6-methylpyridin-3-yl)pyridazin-3-yl]acetamideIC5012.0 [1]
2-(6-Methyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)-N-[6-(6-methylpyridin-3-yl)pyridazin-3-yl]acetamideIC5029.0 [1]
2-(6-Methyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)-N-(4-phenylphenyl)acetamideIC5012.0 [1]
2-(6-Methyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)-N-(5-phenylpyridin-2-yl)acetamideIC501.0 [1]
2-(6-Methyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)-N-(4-pyridin-2-ylphenyl)acetamideIC5067.0 [1]
2-(6-Methyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)-N-(4-pyridin-3-ylphenyl)acetamideIC508.0 [1]
2-(6-Methyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)-N-(6-pyridin-3-ylpyridazin-3-yl)acetamideIC5029.0 [1]
2-(6-Methyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)-N-[4-(1,3-thiazol-2-yl)phenyl]acetamideIC5015.0 [1]
2-(6-Methyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)-N-(6-phenylpyridazin-3-yl)acetamideIC501.0 [1]
2-(6-Methyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)-N-(4-pyridin-4-ylphenyl)acetamideIC5072.0 [1]
2-(6-Methyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)-N-(6-pyridin-3-ylpyridin-3-yl)acetamideIC5011.0 [1]
2-(6-Cyclopropyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)-N-[6-(5-fluoropyridin-3-yl)pyridazin-3-yl]acetamideIC5011.0 [1]
N-[6-(5-Fluoropyridin-3-yl)pyridazin-3-yl]-2-(6-methyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)acetamideIC509.0 [1]
[4-(2-Methylpyridin-4-yl)phenyl] N-(4-phenylphenyl)carbamateIC505.0 [1]
[4-(2-Methylpyridin-4-yl)phenyl] N-(4-pyridin-3-ylphenyl)carbamateIC502.2 [1]
[4-(2-Methylpyridin-4-yl)phenyl] N-(5-pyrazin-2-ylpyridin-2-yl)carbamateIC500.23 [1]
2-[3-(2-Methylpyridin-4-yl)phenoxy]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamideIC50188.0 [1]
2-[3-(2-Methylpyridin-4-yl)anilino]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamideIC50164.0 [1]
2-[3-(2-Methylpyridin-4-yl)phenyl]sulfanyl-N-(5-pyrazin-2-ylpyridin-2-yl)acetamideIC5040.0 [1]
2-Isoquinolin-7-yloxy-N-(5-pyrazin-2-ylpyridin-2-yl)acetamideIC5030.0 [1]
2-Naphthalen-2-yloxy-N-(5-pyrazin-2-ylpyridin-2-yl)acetamideIC501000.0 [1]
2-(1H-Indazol-5-yloxy)-N-(5-pyrazin-2-ylpyridin-2-yl)acetamideIC501000.0 [1]
2-(1H-Indazol-5-ylamino)-N-(5-pyrazin-2-ylpyridin-2-yl)acetamideIC501000.0 [1]
2-(1-Methylindazol-5-yl)oxy-N-(5-pyrazin-2-ylpyridin-2-yl)acetamideIC501000.0 [1]
2-[(1-Methylindazol-5-yl)amino]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamideIC501000.0 [1]
2-[(3-Amino-1,2-benzoxazol-5-yl)oxy]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamideIC501000.0 [1]
2-(6-Methoxynaphthalen-2-yl)oxy-N-(5-pyrazin-2-ylpyridin-2-yl)acetamideIC501000.0 [1]
2-(6-Cyanonaphthalen-2-yl)oxy-N-(5-pyrazin-2-ylpyridin-2-yl)acetamideIC502.7 [1]
2-(4-Cyanophenoxy)-N-(5-pyrazin-2-ylpyridin-2-yl)acetamideIC50485.0 [1]
2-[(2-Acetyl-3,4-dihydro-1H-isoquinolin-7-yl)oxy]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamideIC5024.0 [1]
2-[4-(4-Acetylpiperazin-1-yl)phenoxy]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamideIC50483.0 [1]
2-[4-(2-Methylpyridin-4-yl)anilino]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamideIC500.96 [1]
2-[N-Methyl-4-(2-methylpyridin-4-yl)anilino]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamideIC500.67 [1]
2-[4-(2-Methylpyridin-4-yl)phenyl]sulfanyl-N-(5-pyrazin-2-ylpyridin-2-yl)acetamideIC500.53 [1]
3-[4-(2-Methylpyridin-4-yl)phenyl]-N-(5-pyrazin-2-ylpyridin-2-yl)propanamideIC500.19 [1]
2-[4-(2-Methylpyridin-4-yl)phenoxy]-N-(5-pyrazin-2-ylpyridin-2-yl)propanamideIC500.11 [1]
2-[[3-(4-Fluoro-2-methoxyphenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-(6-methyl-1,3-benzothiazol-2-yl)acetamideIC5027.0 [1]
2-[(8S)-2,4-Dimethyl-1,3-dioxo-7,8-dihydro-6H-purino[7,8-a]pyrrol-8-yl]-N-(6-phenylpyridazin-3-yl)acetamideIC505.0 [1]
(2R)-2-(4-Imidazol-1-ylphenoxy)-N-(4-phenylphenyl)propanamideIC50130.0 [1]
(2S)-2-(4-Imidazol-1-ylanilino)-N-(5-phenylpyridin-2-yl)propanamideIC505.0 [1]
(2R)-2-(4-Imidazol-1-ylanilino)-N-(5-phenylpyridin-2-yl)propanamideIC50689.0 [1]
(2S)-2-(4-Imidazol-1-ylphenoxy)-N-(4-phenylphenyl)propanamideIC507.0 [1]
(2S)-2-[[6-(2-Methylpyrazol-3-yl)pyridin-3-yl]amino]-N-(5-phenylpyridin-2-yl)propanamideIC501.0 [1]
2-(6-Methyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)-N-(6-phenylpyridin-3-yl)acetamideIC506.0 [1]
2-(2-Methyl-1,3-dioxoisoindol-4-yl)-N-[4-(1,3-thiazol-2-yl)phenyl]acetamideIC5015.0 [1]
N-(6-Methoxy-1,3-benzothiazol-2-yl)-2-[[3-(4-methoxyphenyl)-4-oxophthalazin-1-yl]methylamino]acetamideIC5060.0 [1]
2-(4-Imidazol-1-ylanilino)-N-(4-phenylphenyl)acetamideIC5030.0 [1]
2,4-Dimethyl-1,3-dioxo-N-[4-(1,3-thiazol-2-yl)phenyl]-7,8-dihydro-6H-purino[7,8-a]pyrrole-8-carboxamideIC5042.0 [1]
2-[[3-[(4-Methoxyphenyl)methyl]-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-[6-(trifluoromethyl)-1,3-benzothiazol-2-yl]acetamideIC50710.0 [1]
N-{[1,1'-Biphenyl]-4-yl}-2-[4-(1H-imidazol-1-yl)phenoxy]acetamideIC5015.0 [1]
(2S)-2-[[6-(2-Methylpyrazol-3-yl)pyridin-3-yl]amino]-N-(5-pyridin-3-ylpyridin-2-yl)propanamideIC501.0 [1]
2-[4-(2-Methylimidazol-1-yl)phenoxy]-N-(4-phenylphenyl)acetamideIC502.0 [1]
N-(4-Phenylphenyl)-2-(4-pyrrol-1-ylphenoxy)acetamideIC5050000.0 [1]
(2R)-2-(1,3-Dimethyl-2,6-dioxopurin-7-yl)-N-(4-thiophen-3-ylphenyl)propanamideIC505400.0 [1]
2-(1,3-Dimethyl-2,6-dioxopurin-7-yl)-N-(4-thiophen-3-ylphenyl)acetamideIC500.4 [1]
2-(1,3-Dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-yl)-N-[4-(1,3-thiazol-2-yl)phenyl]acetamideIC5024.0 [1]
2-(6-Cyclopropyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)-N-(6-pyridin-3-ylpyridazin-3-yl)acetamideIC5012.0 [1]
Items per page: 1 - 10 of 69
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References

This online tool may be cited as follows

MLA

"Quest Database™ Probable protein-cysteine N-palmitoyltransferase porcupine Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Dec. 2024, https://www.aatbio.com/data-sets/probable-protein-cysteine-n-palmitoyltransferase-porcupine-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 22). Quest Database™ Probable protein-cysteine N-palmitoyltransferase porcupine Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/probable-protein-cysteine-n-palmitoyltransferase-porcupine-inhibitors-ic50-ki.
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