![](https://images.aatbio.com/dataset/ic50/presenilin-1_a0d8652959c9bfd68f6495b79d14f752.svg) | CID 25164607 | IC50 | 1.3 [1], 4.0 [2], 46.0 [3] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_8646475472fc05098102b971f2b3260c.svg) | DL-alpha-Tocopherol | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_476e114a55875bab4f5f6e9c4385a0e1.svg) | (4S,4As,10bS)-10b-(4-chlorophenyl)sulfonyl-4-(2-ethylsulfonylethyl)-7,10-difluoro-2,4,4a,5-tetrahydro-1H-pyrano[3,4-c]chromene | IC50 | 3.0 [1], 5.0 [2] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_bdc8e44f2b68acb7be3d2f14b77fb1e6.svg) | (4S,4As,10bS)-10b-(4-chlorophenyl)sulfonyl-7,10-difluoro-4-(2-propan-2-ylsulfonylethyl)-2,4,4a,5-tetrahydro-1H-pyrano[3,4-c]chromene | IC50 | 24.0 [1], 26.0 [2] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_2d8b68227d849f31bc547a0eadb125b1.svg) | 2-[[2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl]oxy]acetic acid | IC50 | 12000.0 [1], 26000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_5fc2e258b8bd4dedf852af5519e5dfde.svg) | Methyl 2-[[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl]oxy]acetate | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_2c96c0ddc90bfd5fd98ebd7536fc2971.svg) | 2-[(4S,4As,10bS)-10b-(4-chlorophenyl)sulfonyl-7,10-difluoro-2,4,4a,5-tetrahydro-1H-pyrano[3,4-c]chromen-4-yl]ethanol | IC50 | 18.0 [1], 20.0 [2] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_bc9ff67b9ea057e4bf8283a776909996.svg) | 2-[(4S,4As,10bS)-10b-(4-chlorophenyl)sulfonyl-7,10-difluoro-2,4,4a,5-tetrahydro-1H-pyrano[3,4-c]chromen-4-yl]ethyl N-methylcarbamate | IC50 | 8.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_171180c55770116147ce2620229b123c.svg) | 3-[(4S,4As,10bS)-10b-(4-chlorophenyl)sulfonyl-7,10-difluoro-2,4,4a,5-tetrahydro-1H-pyrano[3,4-c]chromen-4-yl]propanenitrile | IC50 | 22.0 [1], 37.0 [2] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_05b72c01a3a1796958bbc7c789df5153.svg) | 2-[(4S,4As,10bS)-10b-(4-chlorophenyl)sulfonyl-7,10-difluoro-2,4,4a,5-tetrahydro-1H-pyrano[3,4-c]chromen-4-yl]ethyl N-ethylcarbamate | IC50 | 24.0 [1], 48.0 [2] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_5744120e75da700e297dad129473f10d.svg) | 2-[6-Chloro-9-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]carbazol-2-yl]propanoic acid | IC50 | 26000.0 [1], 31622.78 [2] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_393a0dfc9e636c66fc9d0036511d0d2e.svg) | 2-[6-Chloro-9-[(E,7R,11R)-3,7,11,15-tetramethylhexadec-2-enyl]carbazol-2-yl]propanoic acid | IC50 | 23000.0 [1], 50000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_47f28efeca5c23de9f760b5a410832bd.svg) | 2,5,7,8-Tetramethyl-6-octoxy-3,4-dihydrochromene-2-carboxylic acid | IC50 | 50000.0 [1], 57000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_4738a924c2a04f83189bc8dff3216f04.svg) | 2,5,7,8-Tetramethyl-6-undecoxy-3,4-dihydrochromene-2-carboxylic acid | IC50 | 28000.0 [1], 50000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_4caf5eda5361853a465e8c37b26cf811.svg) | 2,5,7,8-Tetramethyl-6-tetradecoxy-3,4-dihydrochromene-2-carboxylic acid | IC50 | 14000.0 [1], 29000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_2f390e487a9fa3402780c3302e18f97c.svg) | 2,5,7,8-Tetramethyl-6-[(E,7R,11R)-3,7,11,15-tetramethylhexadec-2-enoxy]-3,4-dihydrochromene-2-carboxylic acid | IC50 | 26000.0 [1], 42000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_f1898c91c6d08fd419a000b20939b854.svg) | 2,5,7,8-Tetramethyl-6-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienoxy]-3,4-dihydrochromene-2-carboxylic acid | IC50 | 28000.0 [1], 39000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_5d0112715853084208307c801f5b0e9b.svg) | 2-[(2,5,7,8-Tetramethyl-2-octoxycarbonyl-3,4-dihydrochromen-6-yl)oxy]acetic acid | IC50 | 35000.0 [1], 42000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_5eebaba8541525cbc1697744f9f7a331.svg) | 2-[(2,5,7,8-Tetramethyl-2-undecoxycarbonyl-3,4-dihydrochromen-6-yl)oxy]acetic acid | IC50 | 12000.0 [1], 23000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_5c89f26becb4f5c187b3b7c48db630ac.svg) | 2-[(2,5,7,8-Tetramethyl-2-tetradecoxycarbonyl-3,4-dihydrochromen-6-yl)oxy]acetic acid | IC50 | 22000.0 [1], 34000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_1c77d6eb8dbd6f75e0ecb56c7416d006.svg) | 2-[[2,5,7,8-Tetramethyl-2-[(E,7R,11R)-3,7,11,15-tetramethylhexadec-2-enoxy]carbonyl-3,4-dihydrochromen-6-yl]oxy]acetic acid | IC50 | 24000.0 [1], 36000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_e1a631d4782ad840e88714df7d9050a9.svg) | 2-[[2,5,7,8-Tetramethyl-2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienoxy]carbonyl-3,4-dihydrochromen-6-yl]oxy]acetic acid | IC50 | 25000.0 [1], 27000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_e05c54b12c8a2c6f8e1943920e489a2f.svg) | 2-[[2,5,7,8-Tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl]oxy]acetic acid | IC50 | 11000.0 [1], 24000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_704a62662812eaabf9e9944a27942eba.svg) | 2-(4,6-Diphenethoxypyrimidin-2-ylthio)hexanoic acid | IC50 | 22800.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_2136725d770dbaeb49b944cea654d22f.svg) | 2-(4,6-Bis(2-cyclohexylethoxy)pyrimidin-2-ylthio)hexanoic acid | IC50 | 5100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_5277dc821e528581cabf4cec919fbac9.svg) | (2E)-2-[[2,5-Bis[[4-(trifluoromethyl)phenyl]methoxy]phenyl]methylidene]hexanoic acid | IC50 | 1200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_b4060163eedffd08271e0a21a444f9c4.svg) | (2E)-2-[[5-Phenyl-2-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]methylidene]hexanoic acid | IC50 | 11900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_863dee1a393bd34937a7356a6dfad5fb.svg) | (2E)-2-[[5-Phenoxy-2-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]methylidene]hexanoic acid | IC50 | 14900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_4ced57cc661ea53ecdbb23520eb3ac2e.svg) | (2E)-2-[[5-Phenylmethoxy-2-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]methylidene]hexanoic acid | IC50 | 19300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_4c87efe1ffeda39e35b1355191a52c37.svg) | (2E)-2-[[5-[(E)-3-Phenylprop-2-enoxy]-2-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]methylidene]hexanoic acid | IC50 | 4100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_10fa4881c1e8c573709977e6e238d7de.svg) | (2E)-2-[[5-[(4-Butylphenyl)methoxy]-2-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]methylidene]hexanoic acid | IC50 | 4900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_589efee3ef7cb53bad7903f4e443204b.svg) | (2E)-2-[[5-[(4-Phenylphenyl)methoxy]-2-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]methylidene]hexanoic acid | IC50 | 11900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_97f2d9a4c28cfd57b0ad025b8afd0d40.svg) | (2E)-2-[[5-[(4-Phenylmethoxyphenyl)methoxy]-2-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]methylidene]hexanoic acid | IC50 | 8500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_ae96faf73a8be7c072e77c26973034da.svg) | (2E)-2-[[5-[(4-Fluorophenyl)methoxy]-2-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]methylidene]hexanoic acid | IC50 | 7000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_ef973da991d11b63116793e1a2c847d9.svg) | (2E)-2-[[5-[(3,4-Dichlorophenyl)methoxy]-2-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]methylidene]hexanoic acid | IC50 | 2000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_d034d91ae4d7c564ee41d3d3f92c6fde.svg) | (2E)-2-[[5-[[3,5-Bis(trifluoromethyl)phenyl]methoxy]-2-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]methylidene]hexanoic acid | IC50 | 790.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_41ad21309a38bc87cdea54c795cb17a5.svg) | (2E)-2-[[5-(Pyridin-3-ylmethoxy)-2-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]methylidene]hexanoic acid | IC50 | 32100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_648a80315b6ab93c4754cb4297a94d0e.svg) | (2E)-2-[[5-(1-Benzothiophen-2-ylmethoxy)-2-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]methylidene]hexanoic acid | IC50 | 4600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_4faddda3032425252b9db1e9132babb8.svg) | (2E)-2-[[2-[[4-(Trifluoromethyl)phenyl]methoxy]-5-[[2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl]methoxy]phenyl]methylidene]hexanoic acid | IC50 | 2300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_995c46a626bfa15037eb6119d8e54b9a.svg) | (2E)-2-[[5-[[4-Methoxy-2-(trifluoromethyl)quinolin-6-yl]methoxy]-2-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]methylidene]hexanoic acid | IC50 | 630.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_c85c5321f11f570e0d3245e70aed8cba.svg) | (2E)-2-[[5-[[4-(2-Methyl-1,3-thiazol-4-yl)phenyl]methoxy]-2-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]methylidene]hexanoic acid | IC50 | 20200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_4c82931dd5d2861d6c73e210b8b0d809.svg) | (2E)-2-[[5-[(4-Pyridin-2-yloxyphenyl)methoxy]-2-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]methylidene]hexanoic acid | IC50 | 5000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_6ad7d226c4d38caf170186e279aed617.svg) | (2E)-2-[[5-[[4-(2-Morpholin-4-ylethoxy)phenyl]methoxy]-2-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]methylidene]hexanoic acid | IC50 | 2200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_679e9918c1f7b474655899f47b062091.svg) | (2E)-2-[[5-Hydroxy-2-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]methylidene]hexanoic acid | IC50 | 40000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_eb2dd636bca84a50c5b1abcf9682b5b4.svg) | (2E)-2-[[5-(2,2-Diphenylethoxy)-2-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]methylidene]hexanoic acid | IC50 | 11400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_7a89192c504a52a8f33ba33c6a287d00.svg) | (2E)-2-[[5-[[4-(Trifluoromethyl)cyclohexyl]methoxy]-2-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]methylidene]hexanoic acid | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_bdd487403405384765a864f685e17a9d.svg) | (2E)-2-[[5-[2-[4-(Trifluoromethyl)phenyl]ethoxy]-2-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]methylidene]hexanoic acid | IC50 | 1500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_0ae517ce636fa5c162747cca156fdfd5.svg) | 2-[(4R,4Ar,10bR)-10b-(4-chlorophenyl)sulfonyl-7,10-difluoro-2,4,4a,5-tetrahydro-1H-pyrano[3,4-c]chromen-4-yl]ethanol | IC50 | 320.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_498fcaa5673df19fb0c8e68f1718f80b.svg) | (4R,4Ar,10bR)-10b-(4-chlorophenyl)sulfonyl-7,10-difluoro-4-(2-methylsulfonylethyl)-2,4,4a,5-tetrahydro-1H-pyrano[3,4-c]chromene | IC50 | 377.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_4506f07f22ca497963ee531ac2da7b71.svg) | 2-[(1S)-1-[(2S,5R)-5-[4-Chloro-2-(trifluoromethyl)phenyl]oxolan-2-yl]ethyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 9.1 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_8cd1aa3fa91c82f746a3b3f69e922aee.svg) | 2-[(1S)-1-[(2S,5R)-5-[4-Chloro-5-fluoro-2-(trifluoromethyl)phenyl]oxolan-2-yl]ethyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 7.84 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_4938ce09fc3203946a76df0c71f9f62f.svg) | 2-[[3-(4-Chlorophenyl)cyclohexyl]methyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 98.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_6937289556ddc9d0418128cdba5fc1c0.svg) | 2-[(1R,2R)-2-(3,5-Difluorophenyl)cyclopentyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 563.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_b7a6a4114d9aace0df3ece5f38725ed2.svg) | 2-[(1R,2R)-2-[(3,5-Difluorophenyl)methyl]cyclopentyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 561.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_ce9c1698397bb9f1fdf770110d602333.svg) | 2-[3-[[4-Fluoro-2-(trifluoromethyl)phenoxy]methyl]cyclobutyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 303.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_4d06125c085dee30c609bb1a78fe6270.svg) | 7-(4-Methylimidazol-1-yl)-2-[(1R,2R)-2-naphthalen-1-yloxycyclobutyl]-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 164.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_8981701f890fb7714d5a161f0db3ffce.svg) | 2-[(1S)-1-[(2S,5R)-5-(4-Chloro-2,5-difluorophenyl)oxolan-2-yl]ethyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 11.4 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_0e0bf890e2fa9ad86b97535badd3687b.svg) | 2-[(1S)-1-[(2S,5R)-5-(4-Chloro-5-fluoro-2-methoxyphenyl)oxolan-2-yl]ethyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 11.1 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_a91cd299011209c3434a8dd026332f8b.svg) | 7-(4-Methylimidazol-1-yl)-2-[[(2R,5S)-5-[4-(1,1,2,2,2-pentafluoroethyl)phenyl]oxolan-2-yl]methyl]-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 157.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_e42ad7b22f10431737e1de5819005ab3.svg) | 7-(4-Methylimidazol-1-yl)-2-[[(2S,5R)-5-[2-(trifluoromethyl)phenyl]oxolan-2-yl]methyl]-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 73.3 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_8cccfe127be335173c9e86552bf4ac28.svg) | 7-(4-Methylimidazol-1-yl)-2-[[(2S,4R,5R)-4-methyl-5-[4-(trifluoromethyl)phenyl]oxolan-2-yl]methyl]-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 73.5 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_b868d7e58909be8fbd24d57c433c1867.svg) | 2-[(1S)-1-[(2S,5R)-5-(3,4-Dichloro-5-fluorophenyl)oxolan-2-yl]ethyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 5.78 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_93a7df49425e46e072f58604773465ee.svg) | (3R)-3-Methyl-7-(4-methylimidazol-1-yl)-2-[[(2R,5S)-5-[4-(trifluoromethyl)phenyl]oxolan-2-yl]methyl]-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 46.4 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_abc953bc3aae43c8f170054bbdf03ca4.svg) | (3S)-3-Methyl-7-(4-methylimidazol-1-yl)-2-[[(2R,5S)-5-[4-(trifluoromethyl)phenyl]oxolan-2-yl]methyl]-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 19.8 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_cc8951756f9ad6d55ed0c913f53f77fd.svg) | 2-[(1S)-1-[(2S,5R)-5-[3,5-Difluoro-4-(trifluoromethyl)phenyl]oxolan-2-yl]ethyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 3.34 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_911c3a2dee24130f132478ed8c21a190.svg) | 7-(4-Methylimidazol-1-yl)-2-[(1S)-1-[(2S,5R)-5-[4-(trifluoromethyl)phenyl]oxolan-2-yl]ethyl]-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 14.3 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_f06aa4dc3bdd57ae1b7a667af2bf0b3e.svg) | 2-[(1S)-1-[(2S,5R)-5-(4-Chloro-3,5-difluorophenyl)oxolan-2-yl]ethyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 5.48 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_ebd723c3c61e6e65a589b6a14914f8e3.svg) | 2-[(1S)-1-[(2S,5R)-5-[4,5-Difluoro-2-(trifluoromethyl)phenyl]oxolan-2-yl]ethyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 33.5 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_f776b6f504579243d80cf24ae145099c.svg) | 2-[(1S)-1-[(2S,5R)-5-[4-Chloro-3-fluoro-2-(trifluoromethyl)phenyl]oxolan-2-yl]ethyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_b4a67225c60226834a5708d7b1069a7e.svg) | 2-[(1S)-1-[(2S,5R)-5-[4-Fluoro-2-(trifluoromethyl)phenyl]oxolan-2-yl]ethyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 24.2 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_c80fd496921c99f8f872edb51efd4548.svg) | 2-[(1S)-1-[(2S,5R)-5-[3-Fluoro-4-(trifluoromethyl)phenyl]oxolan-2-yl]ethyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 8.35 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_340ae4bf4c148de8f4c397c4098a2ec9.svg) | 2-[(1R,2R)-2-(3-Chloro-4-fluoro-2-methylphenoxy)cyclobutyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 146.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_7bd8cf6605a1b2e2716234da0cc8b9d2.svg) | 7-(4-Methylimidazol-1-yl)-2-[[(2S,4S,5R)-4-methyl-5-[4-(trifluoromethyl)phenyl]oxolan-2-yl]methyl]-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 38.4 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_ed848a30eefd52cba3877a0d76d88eea.svg) | 7-(4-Methylimidazol-1-yl)-2-[[(2R,6S)-6-[4-(trifluoromethyl)phenyl]oxan-2-yl]methyl]-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 96.6 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_4d9714078686acc0243a8ab4051eb57f.svg) | 7-(4-Methylimidazol-1-yl)-2-[[(2S,3S,5R)-3-methyl-5-[4-(trifluoromethyl)phenyl]oxolan-2-yl]methyl]-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 25.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_4880ce68cdf5b9773f513065dadb758b.svg) | 2-[(1R,2R)-2-[(7-Fluoro-2,3-dihydro-1H-inden-4-yl)oxy]cyclobutyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 162.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_f6ce39247f6b13cf6c99261bc8bd34d7.svg) | 7-(4-Methylimidazol-1-yl)-2-[(1S)-1-[(2S,5R)-5-[5-(trifluoromethyl)thiophen-2-yl]oxolan-2-yl]ethyl]-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 52.4 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_83a2ec315631f58c3bc6fa2dbcbe51e3.svg) | 2-[[(2S,5R)-5-(4-Chloro-2-methoxyphenyl)oxolan-2-yl]methyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 21.6 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_3c960a8e1fc61bf7a46401629358f858.svg) | 7-(4-Methylimidazol-1-yl)-2-[[(2S,5R)-5-[4-(trifluoromethyl)phenyl]oxolan-2-yl]methyl]-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 27.6 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_3e281619ff956461c98652cbce34f272.svg) | 7-(4-Methylimidazol-1-yl)-2-[(1R,2S)-2-[2-(trifluoromethyl)phenoxy]cyclobutyl]-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 469.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_3b411185037ee904a924bf7f4acf529b.svg) | 7-(4-Methylimidazol-1-yl)-2-[[2-methyl-5-[4-(trifluoromethyl)phenyl]oxolan-2-yl]methyl]-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 1040.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_a63a467f1bff868164ebddf96a4837df.svg) | 7-(4-Methylimidazol-1-yl)-2-[3-[2-(trifluoromethyl)phenoxy]cyclobutyl]-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 789.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_91cfac6da31a99949a60ccf56295b746.svg) | 2-[[3-[2-Chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-1,2-oxazol-5-yl]methyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 711.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_e878cfec5c03e5e5a02f8092d7bc1d9e.svg) | 2-[(1R,2R)-2-(6,7-Difluoronaphthalen-1-yl)oxycyclobutyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 60.6 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_8c55ce735a9acc6faa52d991db51a0d7.svg) | 2-[(1S)-1-[(2S,5R)-5-[2-Methoxy-4-(trifluoromethyl)phenyl]oxolan-2-yl]ethyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 15.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_b242fec9285432469c6bcee49f108067.svg) | 2-[[5-(3,4-Dichlorophenyl)oxolan-2-yl]methyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 117.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_f61a74f1707f99cd401d7e3e756c8597.svg) | 2-[(1R,2R)-2-(4-Chloro-3-propan-2-ylphenoxy)cyclobutyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 158.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_f24c40933ae8ab485af6b985dd60964e.svg) | 2-[[3-[2-Chloro-3-(trifluoromethyl)phenyl]-4,5-dihydro-1,2-oxazol-5-yl]methyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 429.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_daea5bbd7c2e3de7f148ba3feec5975c.svg) | 2-[[3-[4-Chloro-3-(trifluoromethyl)phenyl]-4,5-dihydro-1,2-oxazol-5-yl]methyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 483.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_db8c0bb89e41fd1c80b18cb55c5e1f75.svg) | 7-(4-Methylimidazol-1-yl)-2-[(1R,2R)-2-[3-(trifluoromethyl)phenoxy]cyclobutyl]-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 217.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_4d59ec36cfbd4df081fbc93615de6bb6.svg) | 2-[[(2S,5R)-5-[3-Fluoro-4-(trifluoromethyl)phenyl]oxolan-2-yl]methyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 15.7 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_0237dbafd816d00e566cefcab3231c95.svg) | 7-(4-Methylimidazol-1-yl)-2-[[(2S,5R)-5-[4-(trifluoromethoxy)phenyl]oxolan-2-yl]methyl]-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 60.3 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_619f9ddd52c997f627178854e8652610.svg) | 2-[2-(4-Chlorophenoxy)cyclohexyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 591.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_343bb22f7db2e8295a21f2630ff42ca6.svg) | 2-[(1R,2S)-2-[4-Fluoro-2-(trifluoromethyl)phenoxy]cyclopentyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 140.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_3e9f7b1f52882999ce43af426834b1a9.svg) | 2-[[(2S,5R)-5-(4-Cyclopropylphenyl)oxolan-2-yl]methyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 63.8 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_832e85a9cec8bcf4fe2fe61ad51ef901.svg) | 7-(4-Methylimidazol-1-yl)-2-[[(2R,6R)-6-[4-(trifluoromethyl)phenyl]oxan-2-yl]methyl]-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 29.9 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_4a639a33cc1fb640c8b0ed9636a9e4b8.svg) | 7-(4-Methylimidazol-1-yl)-2-[(1R,2R)-2-[2-(trifluoromethyl)phenoxy]cyclopentyl]-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_62c9c14aff3789b89472029724046b33.svg) | 2-[[(2S,5R)-5-[4-(1,1-Difluoroethyl)phenyl]oxolan-2-yl]methyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 73.3 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_271219e5c084efe10e0a6ab74cfece9a.svg) | 2-[(1S)-1-[(2S,5R)-5-[4-Chloro-2-(trifluoromethoxy)phenyl]oxolan-2-yl]ethyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 14.5 [1] |
![](https://images.aatbio.com/dataset/ic50/presenilin-1_995a18066c53e99d1e4249fd07d6d30e.svg) | 2-[[(1R,3S)-3-(4-Chlorophenyl)cyclohexyl]methyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione | IC50 | 80.0 [1] |