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Pregnane X receptor Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
HyperforinKi27.0 [1]
N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamideIC5039.81 [1]
CoumestrolIC5012000.0 [1]
3-(3-(N-(2-Chloro-3-trifluoromethylbenzyl)(2,2-diphenylethyl)amino)propoxy)phenylacetic acidKi2000.0 [1]
E-GuggulsteroneIC502.4 [1]
GuggulsteroneIC502.4 [1]
2-(2-Chloro-4-fluorobenzyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazoleIC501770.0 [1]
S-(4-Methylphenyl) 3-methyl-5-(5-methyl-1,2-oxazol-3-yl)-1,2-oxazole-4-carbothioateIC50850.0 [1]
2-(4-(2-(4-(2,2-Dimethylbutyl)-1H-imidazol-2-yl)ethyl)phenyl)pyridineIC503500.0 [1]
S-Phenyl 3-methyl-5-(5-methyl-1,2-oxazol-3-yl)-1,2-oxazole-4-carbothioateIC50850.0 [1]
(6R,7S,8S)-6-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-7-(4-fluorophenyl)-1,2,5,6,7,8-hexahydropyrrolizin-3-oneIC504800.0 [1]
3-Methyl-4-[4-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-pyrimidin-4-yl-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acidIC5030000.0 [1]
RGX-104 (free Acid)Ki10000.0 [1]
(6R,7S,8R)-1-Amino-6-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-7-(4-fluorophenyl)-1,2,5,6,7,8-hexahydropyrrolizin-3-oneIC5025000.0 [1]
(6R,7S,8S)-2-Amino-6-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-7-(4-fluorophenyl)-1,2,5,6,7,8-hexahydropyrrolizin-3-oneIC5025000.0 [1]
CID 24776335IC507943.28 [1]
N-(4-Acetylphenyl)-N-(2,2,2-trifluoroethyl)benzenesulfonamideIC501584.89 [1]
1-(2',4'-Bis(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-5-methyl-1H-pyrazole-3-carboxamideIC5025000.0 [1]
[4-[(3R)-4-[5-(Hydroxymethyl)-4-(trifluoromethyl)pyrimidin-2-yl]-3-propan-2-ylpiperazin-1-yl]-2-methylsulfonylphenyl]methanolIC5010000.0 [1]
2-[3-[(2R)-4-[[2-Chloro-3-(trifluoromethyl)phenyl]methyl-(2,2-diphenylethyl)amino]butan-2-yl]oxyphenyl]acetic acidKi10000.0 [1]
2-(2-Oxo-1-(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)indolin-5-yl)acetic acidIC5010000.0 [1]
8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1-methyl-6-oxopyridazin-3-yl)-2,8-diazaspiro[4.5]decan-1-oneIC5030000.0 [1]
8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-3-(4-phenylphenyl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC5050000.0 [1]
2-[3-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]-3,9-diazaspiro[5.5]undecan-9-yl]acetic acidIC5030000.0 [1]
CID 16072077IC5025.12 [1]
(1S,2R)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-7-(1-tert-butyl-3,6-dihydro-2H-pyridin-4-yl)-1-(4-fluorophenyl)-2,3,8,8a-tetrahydro-1H-indolizin-5-oneIC5030000.0 [1]
N-(2,2,2-Trifluoroethyl)-N-[4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl]benzenesulfonamideIC5010000.0 [1]
N-(2,2,2-Trifluoroethyl)-N-[4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl]benzenesulfonamideIC503981.07 [1]
N-(2,2,2-Trifluoroethyl)-N-[4-(1,1,1-trifluoro-2-hydroxypentan-2-yl)phenyl]benzenesulfonamideIC50316.23 [1]
CID 24776336IC502511.89 [1]
N-(2,2,2-Trifluoroethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-phenylethyl)phenyl]benzenesulfonamideIC5063.1 [1]
N-(2,2,2-Trifluoroethyl)-N-[4-(1,1,1-trifluoro-2-hydroxy-4-phenylbut-3-yn-2-yl)phenyl]benzenesulfonamideIC50630.96 [1]
CID 24776340IC5019.95 [1]
3-(4-Fluorophenyl)-2-[(2-fluorophenyl)methyl]-7-(trifluoromethyl)-2H-indazoleIC502160.0 [1]
N-[4-(1,1,1,4,4,4-Hexafluoro-2-hydroxybutan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamideIC50251.19 [1]
(1S,2R,5As,7S,8aR,8bS)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-1-(4-fluorophenyl)-7-hydroxy-7-methyl-1,2,3,5a,6,8,8a,8b-octahydrocyclopenta[a]pyrrolizin-5-oneIC508400.0 [1]
8-[(3-Methylpyridin-2-yl)methyl]-1-(2-oxo-1H-pyrimidin-6-yl)-3-(4-phenylphenyl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC5050000.0 [1]
3-Methyl-4-[4-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-pyrazin-2-yl-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acidIC5030000.0 [1]
8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyridazin-3-yl)-3-(4-phenylphenyl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC5050000.0 [1]
1-[3-[2,5-Bis(trifluoromethyl)phenyl]phenyl]pyrazole-3,5-dicarboxamideIC5025000.0 [1]
(1S,2R,5As,7R,8aR,8bS)-7-(benzylamino)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-1-(4-fluorophenyl)-2,3,5a,6,7,8,8a,8b-octahydro-1H-cyclopenta[a]pyrrolizin-5-oneIC5025000.0 [1]
(1S,2R,5As,7R,8aR,8bS)-7-amino-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-1-(4-fluorophenyl)-2,3,5a,6,7,8,8a,8b-octahydro-1H-cyclopenta[a]pyrrolizin-5-oneIC5025000.0 [1]
(1S,2R,5As,7S,8aR,8bS)-7-(benzylamino)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-1-(4-fluorophenyl)-2,3,5a,6,7,8,8a,8b-octahydro-1H-cyclopenta[a]pyrrolizin-5-oneIC5025000.0 [1]
(1S,2R,5As,7S,8aR,8bS)-7-amino-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-1-(4-fluorophenyl)-2,3,5a,6,7,8,8a,8b-octahydro-1H-cyclopenta[a]pyrrolizin-5-oneIC5025000.0 [1]
(1S,2R,5As,7S,8aR,8bS)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-7-ethyl-1-(4-fluorophenyl)-7-hydroxy-1,2,3,5a,6,8,8a,8b-octahydrocyclopenta[a]pyrrolizin-5-oneIC503300.0 [1]
(1S,2R,5As,7S,8aR,8bS)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-1-(4-fluorophenyl)-7-hydroxy-2,3,5a,6,7,8,8a,8b-octahydro-1H-cyclopenta[a]pyrrolizin-5-oneIC504500.0 [1]
9-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]-1-oxa-9-azaspiro[5.5]undecane-3-carboxylic acidIC5030000.0 [1]
2-[3-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]-3-azaspiro[5.5]undecan-9-yl]acetic acidIC5030000.0 [1]
2-[8-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]-1-oxa-8-azaspiro[4.5]decan-3-yl]acetic acidIC5030000.0 [1]
2-[(3S)-8-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]-1-oxa-8-azaspiro[4.5]decan-3-yl]acetic acidIC5030000.0 [1]
2-[(3R)-8-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]-1-oxa-8-azaspiro[4.5]decan-3-yl]acetic acidIC5030000.0 [1]
2-[9-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]-1-oxa-9-azaspiro[5.5]undecan-3-yl]acetic acidIC5030000.0 [1]
2-[8-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]-1-oxa-8-azaspiro[4.5]decan-2-yl]acetic acidIC5030000.0 [1]
8-[(3-Methylpyridin-2-yl)methyl]-1-(4-oxo-1H-pyridin-2-yl)-3-(4-phenylphenyl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC5050000.0 [1]
2-[9-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]-1-oxa-9-azaspiro[5.5]undecan-4-yl]acetic acidIC5030000.0 [1]
2-[4-[(1R,2R)-2-[(2-Fluoro-4-methylsulfonylphenyl)methoxymethyl]cyclopropyl]piperidin-1-yl]-5-(methoxymethyl)pyrimidineIC5030000.0 [1]
2-[[2-[(3R)-3-Aminopiperidin-1-yl]-5-methyl-6,9-dioxo-7H-imidazo[1,2-a]purin-1-yl]methyl]-4-fluorobenzonitrileIC5030000.0 [1]
Items per page: 1 - 10 of 57
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References

This online tool may be cited as follows

MLA

"Quest Database™ Pregnane X receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/pregnane-x-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Pregnane X receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/pregnane-x-receptor-inhibitors-ic50-ki.
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