Poly [ADP-ribose] polymerase 3 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Olaparib	IC50	46.0 [1], 230.0 [2], 320.0 [3]
	3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one	IC50	831.76 [1], 10000.0 [2]
	Niraparib	IC50	296.0 [1], 1300.0 [2]
	N~2~,N~2~-Dimethyl-N~1~-(6-oxo-5,6-dihydrophenanthridin-2-YL)glycinamide	IC50	1430.0 [1]
	Veliparib	IC50	2040.0 [1]
	Rucaparib	IC50	512.0 [1]
	Bmn-673 8R,9S	IC50	62.8 [1]
	4-Methoxybenzamide	IC50	100000.0 [1]
	3-(4-Oxo-3,4-Dihydroquinazolin-2-Yl)-N-[(1s)-1-Phenylethyl]propanamide	IC50	900.0 [1]
	4,4'-Oxydibenzamide	IC50	100000.0 [1]
	4-[[3-[(6S)-3-(1,1-Difluoroethyl)-6-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl]phenyl]-difluoromethyl]-2H-phthalazin-1-one	IC50	2800.0 [1]
	5-(2-Oxo-2-phenylethoxy)isoquinolin-1(2H)-one	IC50	1300.0 [1]
	4-Quinazolinol, 5,6,7,8-tetrahydro-2-(4-methyl-1-piperazinyl)-	IC50	91000.0 [1]
	2-(4-Tert-Butylphenyl)-2,3-dihydroquinazoline-4(1H)-one	IC50	34000.0 [1]
	4-(4-Carbamoylphenoxy)benzoic acid	IC50	100000.0 [1]
	4-[(2-Fluorophenyl)methoxy]benzamide	IC50	100000.0 [1]
	2-[4-[3-[(4-Oxo-3H-phthalazin-1-yl)methyl]benzoyl]piperazin-1-yl]pyridine-3-carbonitrile	IC50	46.0 [1]
	N-{4-[(2-Chlorophenyl)(Pyrimidin-4-Yl)carbamoyl]phenyl}-4-Methoxybenzamide	IC50	100000.0 [1]
	1-[3-[4-(2-Chlorophenyl)-5-pyrimidin-4-yl-1,2,4-triazol-3-yl]cyclobutyl]-2-oxo-3H-benzimidazole-5-carbonitrile	IC50	100000.0 [1]
	Pamiparib	IC50	185.0 [1]
	3-(4-Oxo-3,4-Dihydroquinazolin-2-Yl)-N-[(1s)-1-(Pyridin-2-Yl)ethyl]propanamide	IC50	1300.0 [1]
	3-(4-Oxo-3,4-Dihydroquinazolin-2-Yl)-N-[(1r)-1-(Pyridin-2-Yl)ethyl]propanamide	IC50	100000.0 [1]
	3-(4-Oxo-3,4-Dihydroquinazolin-2-Yl)-N-[(1s)-1-Phenylpropyl]propanamide	IC50	2200.0 [1]
	N-[(2s)-1-Hydroxy-3-Phenylpropan-2-Yl]-3-(4-Oxo-3,4-Dihydroquinazolin-2-Yl)propanamide	IC50	1000.0 [1]
	N-[(2s)-1-Hydroxybutan-2-Yl]-3-(4-Oxo-3,4-Dihydroquinazolin-2-Yl)propanamide	IC50	9600.0 [1]
	Methyl N-[3-(4-Oxo-3,4-Dihydroquinazolin-2-Yl)propanoyl]-L-Phenylalaninate	IC50	2200.0 [1]
	2-(4-((Pyridin-4-Yl)methyl)piperazin-1-Yl)-3,4,5,6,7,8-Hexahydroquinazolin-4-One	IC50	13000.0 [1]
	4-[3-(4-Oxo-3H-quinazolin-2-yl)propanoylamino]-N-quinolin-8-ylbenzamide	IC50	40000.0 [1]
	4-[3-(8-Methyl-4-oxo-3H-quinazolin-2-yl)propanoylamino]-N-quinolin-8-ylbenzamide	IC50	45000.0 [1]
	N-[1-(4-Imidazol-1-ylphenyl)ethyl]-3-(4-oxo-3H-quinazolin-2-yl)propanamide	IC50	13200.0 [1]
	3-(4-Oxo-3,4-dihydroquinazolin-2-yl)-N-[1-(4-sulfamoylphenyl)ethyl]propanamide	IC50	14400.0 [1]
	N-[(1R)-2,3-Dihydro-1H-inden-1-yl]-3-(4-oxo-3H-quinazolin-2-yl)propanamide	IC50	100000.0 [1]
	N-[(1S)-2,3-Dihydro-1H-inden-1-yl]-3-(4-oxo-3H-quinazolin-2-yl)propanamide	IC50	100000.0 [1]
	3-(4-Oxo-3H-quinazolin-2-yl)-N-[(1R)-1-phenylethyl]propanamide	IC50	15200.0 [1]
	(2S)-2-[3-(4-Oxo-3H-quinazolin-2-yl)propanoylamino]-3-phenylpropanamide	IC50	3800.0 [1]
	N-[(2S)-1-Hydroxypropan-2-yl]-3-(4-oxo-3H-quinazolin-2-yl)propanamide	IC50	11100.0 [1]
	2-(3-Pyrazin-2-ylpropanoyl)-2,11-diazatricyclo[7.3.1.05,13]trideca-5(13),6,8-trien-10-one	IC50	70.0 [1]
	2-(2-Pyridin-3-ylacetyl)-2,11-diazatricyclo[7.3.1.05,13]trideca-5(13),6,8-trien-10-one	IC50	50.0 [1]
	4-(4-Formyl-phenoxy)-benzamide	IC50	86000.0 [1]
	1,2-Dihydro-2-(4-isopropylphenyl)-4(3H)-quinazolinone	IC50	50000.0 [1]
	4-[(4s)-5,5-Dimethyl-2-Oxo-4-Phenyl-1,3-Oxazolidin-3-Yl]-N-(Quinolin-8-Yl)benzamide	IC50	10000.0 [1]
	7-(2-Fluorophenyl)-4-Methylquinolin-2(1h)-One	IC50	10000.0 [1]
	N-[3-Chloranyl-4-[[4-(4-Methoxyphenyl)oxan-4-Yl]methylcarbamoyl]phenyl]furan-2-Carboxamide	IC50	100000.0 [1]
	6,7,16-Triazatetracyclo[11.2.1.05,15.09,14]hexadeca-1(15),5,9(14),10,12-pentaen-8-one	IC50	199.0 [1]
	11-Fluoro-3,3-dimethyl-6,7,16-triazatetracyclo[11.2.1.05,15.09,14]hexadeca-1(15),5,9(14),10,12-pentaen-8-one	IC50	136.0 [1]
	3-Propan-2-yl-3,6,7,16-tetrazatetracyclo[11.2.1.05,15.09,14]hexadeca-1(15),5,9(14),10,12-pentaen-8-one	IC50	760.0 [1]
	3-(Cyclopropanecarbonyl)-3,6,7,16-tetrazatetracyclo[11.2.1.05,15.09,14]hexadeca-1(15),5,9(14),10,12-pentaen-8-one	IC50	180.0 [1]
	3-(2,2-Dimethylpropanoyl)-3,6,7,16-tetrazatetracyclo[11.2.1.05,15.09,14]hexadeca-1(15),5,9(14),10,12-pentaen-8-one	IC50	660.0 [1]
	3-(2-Amino-2-methylpropanoyl)-3,6,7,16-tetrazatetracyclo[11.2.1.05,15.09,14]hexadeca-1(15),5,9(14),10,12-pentaen-8-one	IC50	18.0 [1]
	3,3-Dimethyl-16-(2-piperidin-1-ylethyl)-6,7,16-triazatetracyclo[11.2.1.05,15.09,14]hexadeca-1(15),5,9(14),10,12-pentaen-8-one	IC50	20000.0 [1]
	16-[2-(Diethylamino)ethyl]-3,3-dimethyl-6,7,16-triazatetracyclo[11.2.1.05,15.09,14]hexadeca-1(15),5,9(14),10,12-pentaen-8-one	IC50	11000.0 [1]
	3,3-Dimethyl-16-(oxiran-2-ylmethyl)-6,7,16-triazatetracyclo[11.2.1.05,15.09,14]hexadeca-1(15),5,9(14),10,12-pentaen-8-one	IC50	1000.0 [1]
	4-[[4-Fluoro-3-[5-methyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl]phenyl]methyl]-2H-phthalazin-1-one	IC50	66.9 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 53 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Poly [ADP-ribose] polymerase 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/poly-adp-ribose-polymerase-3-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, November 21). Quest Database™ Poly [ADP-ribose] polymerase 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/poly-adp-ribose-polymerase-3-inhibitors-ic50-ki.
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