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Poly [ADP-ribose] polymerase 2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-oneIC50106.0 [1]
OlaparibIC503.0 [1]
VeliparibIC5017.5 [1], 70.0 [2], 137.0 [3]
VeliparibKi5.0 [1]
IWR-1-endoIC5018700.0 [1], 25000.0 [2], 35000.0 [3], 170000.0 [4]
N~2~,N~2~-Dimethyl-N~1~-(6-oxo-5,6-dihydrophenanthridin-2-YL)glycinamideIC5033.5 [1], 382.0 [2]
RucaparibIC5028.2 [1], 138.0 [2]
NiraparibIC502.1 [1], 15.3 [2]
Nvp-tnks656IC5019000.0 [1], 32000.0 [2]
4,4'-OxydibenzamideIC50100000.0 [1]
2-(Azetidin-3-yl)-1H-benzimidazole-4-carboxamideKi11.0 [1]
2-[4-(4-Fluorobenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-(thiophen-2-ylmethyl)acetamideIC5019000.0 [1]
2-[4-(4-Fluorobenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-propylacetamideIC5019000.0 [1]
N-[(4-Oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-3-phenyl-N-(thiophen-2-ylmethyl)propanamideIC5019000.0 [1], 56400.0 [2]
3-(3-Hydroxyphenyl)-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-(thiophen-2-ylmethyl)propanamideIC5019000.0 [1]
N-[(4-Oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-3-phenyl-N-(thiophen-3-ylmethyl)propanamideIC5010400.0 [1]
2-[4-(4-Fluorobenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]acetamideIC503100.0 [1], 3150.0 [2]
2-[4-(4-Fluorobenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-(pyridin-2-ylmethyl)acetamideIC5019000.0 [1]
2-[4-(4-Fluorobenzoyl)piperidin-1-yl]-N-(2-methylpropyl)-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]acetamideIC5019000.0 [1]
N-Benzyl-2-[4-(4-fluorobenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]acetamideIC5019000.0 [1]
TalazoparibKi0.85 [1]
Bmn-673 8R,9SIC504.1 [1]
4-MethoxybenzamideIC5077000.0 [1]
2-(4-Nitrophenyl)quinazolin-4-olIC502064.0 [1]
2-(4-Chlorophenyl)quinazolin-4-olIC502600.0 [1]
2-(4-Bromophenyl)-3,4-Dihydroquinazolin-4-OneIC50100000.0 [1]
3-(4-Oxo-3,4-dihydroquinazolin-2-yl)propanoic acidIC50125.0 [1]
2-(4-Fluorophenyl)quinazolin-4-olIC504688.0 [1]
2-(4-Methylphenyl)-4H-chromen-4-oneIC5027800.0 [1]
1H-Benzimidazole-7-carboxamide, 2-(1-propyl-4-piperidinyl)-Ki5.0 [1]
5-[[4-(4-Methoxyphenyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanylmethyl]-3-(4-methylphenyl)-1,2,4-oxadiazoleIC5019000.0 [1]
2-[2-Fluoro-4-[(2S)-2-pyrrolidinyl]phenyl]-1H-benzimidazole-7-carboxamideKi1.5 [1]
4-[[3-[(6S)-3-(1,1-Difluoroethyl)-6-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl]phenyl]-difluoromethyl]-2H-phthalazin-1-oneIC5030.0 [1]
8-Chloro-2-{3-[4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridin-1-yl]propyl}-3,4-dihydroquinazolin-4-oneIC50500.0 [1]
CID 16665853Ki3.0 [1]
5-(2-Oxo-2-phenylethoxy)isoquinolin-1(2H)-oneIC501000.0 [1]
1H-Benzimidazole-7-carboxamide, 2-[4-(2-pyridinyl)phenyl]-Ki2.0 [1]
2-(4-Nitrophenyl)-4H-chromen-4-oneIC508300.0 [1]
4-Quinazolinol, 5,6,7,8-tetrahydro-2-(4-methyl-1-piperazinyl)-IC503600.0 [1]
8-Methoxy-2-(4-nitro-phenyl)-3H-quinazolin-4-oneIC50928.0 [1]
8-Methoxy-2-phenyl-quinazolin-4-olIC501539.0 [1]
8-Methyl-2-[4-(Trifluoromethyl)phenyl]-3h-Quinazolin-4-OneIC503098.0 [1]
8-Methoxy-2-[4-(Trifluoromethyl)phenyl]-3,4-Dihydroquinazolin-4-OneIC50570.0 [1]
Morpholin-4-Yl[4-(Tetrazolo[1,5-A]quinoxalin-4-Ylamino)phenyl]methanoneIC505011.87 [1]
3-(4-Cyanophenyl)quinoxaline-5-carboxamideIC508.0 [1]
4'-IsopropylflavoneIC5034900.0 [1]
2-(4-Pyridine-3-ylphenyl)-1H-benzimidazole-4-carboxamideKi8.0 [1]
2-(4-Tert-Butylphenyl)-2,3-dihydroquinazoline-4(1H)-oneIC50100000.0 [1]
4-[(3Ar,4r,7s,7as)-1,3-Dioxooctahydro-2h-4,7-Methanoisoindol-2-Yl]-N-(Quinolin-8-Yl)benzamideIC50100000.0 [1]
3H-Pyridazino(3,4,5-de)quinazolin-3-one, 8-((1,3-dihydro-2H-isoindol-2-yl)methyl)-1,2-dihydro-IC501.0 [1]
N-(2-Methoxyphenyl)-4-{[3-(4-Oxo-3,4-Dihydroquinazolin-2-Yl)propanoyl]amino}benzamideIC50931.0 [1]
2-[4-(Trifluoromethyl)phenyl]-3h-Quinazolin-4-OneIC5010000.0 [1]
2-[4-[6-[(3R,5S)-3,5-Dimethylpiperazin-1-yl]-4-methylpyridin-3-yl]phenyl]-7-methyl-3H-pyrrolo[2,3-d]pyrimidin-4-oneIC50990.0 [1]
2-(4-Chlorophenyl)-8-methyl-3H-quinazolin-4-oneIC506350.0 [1]
2-(4-Fluorophenyl)-8-methyl-3H-quinazolin-4-oneIC50683.0 [1]
Benzyl N-[[4-(8-methyl-4-oxo-3H-quinazolin-2-yl)phenyl]methyl]carbamateIC50100000.0 [1]
2-(4-Bromophenyl)-8-methyl-3H-quinazolin-4-oneIC5010529.0 [1]
2-(4-Chlorophenyl)-8-methoxy-3H-quinazolin-4-oneIC506022.0 [1]
2-[4-(Trifluoromethyl)phenyl]-3,5,6,8-tetrahydrothiopyrano[3,4-d]pyrimidin-4-oneIC50479.0 [1]
3-(4-Methoxyphenyl)-5-[[4-(4-methoxyphenyl)-5-methyl-1,2,4-triazol-3-yl]sulfanylmethyl]-1,2,4-oxadiazoleIC5019000.0 [1]
3-(3,4-Dimethoxyphenyl)-5-[[4-(4-methoxyphenyl)-5-methyl-1,2,4-triazol-3-yl]sulfanylmethyl]-1,2,4-oxadiazoleIC5019000.0 [1]
4-Tert-Butyl-N-(5,6-Dihydro[1,3]thiazolo[2,3-C][1,2,4]triazol-3-Yl)benzamideIC5019000.0 [1]
4-(4-Carbamoylphenoxy)benzoic acidIC50100000.0 [1]
2-(4-(Pyridin-4-yl)phenyl)-1H-benzimidazole-4-carboxamideKi1.0 [1]
4-[(2-Fluorophenyl)methoxy]benzamideIC50100000.0 [1]
2-[4-[3-[(4-Oxo-3H-phthalazin-1-yl)methyl]benzoyl]piperazin-1-yl]pyridine-3-carbonitrileIC501.0 [1]
N-{4-[(2-Chlorophenyl)(Pyrimidin-4-Yl)carbamoyl]phenyl}-4-MethoxybenzamideIC50100000.0 [1]
2-[(2s)-2-Methylpyrrolidin-2-Yl]-1h-Benzimidazole-7-CarboxamideKi2.0 [1]
2-(3-Methylpyrrolidin-3-yl)-1H-1,3-benzodiazole-4-carboxamideKi2.0 [1]
6-Fluoro-2-[(2R)-2-methylpyrrolidin-2-yl]-1H-1,3-benzodiazole-4-carboxamideKi4.0 [1]
1-[3-[4-(2-Chlorophenyl)-5-pyrimidin-4-yl-1,2,4-triazol-3-yl]cyclobutyl]-2-oxo-3H-benzimidazole-5-carbonitrileIC50100000.0 [1]
Tert-butyl (3S)-3-[[5-[(2,4-dioxoquinazolin-1-yl)methyl]-2-fluoropyridin-3-yl]carbamoyl]pyrrolidine-1-carboxylateIC508.6 [1]
Parp-2-IN-1IC5011.5 [1]
(3S)-N-[5-[(2,4-Dioxoquinazolin-1-yl)methyl]-2-fluoropyridin-3-yl]-1-phenylpyrrolidine-3-carboxamideIC504.1 [1]
(E)-3-[4-[[4-[2-Fluoro-5-[(4-oxo-3H-phthalazin-1-yl)methyl]benzoyl]piperazin-1-yl]methyl]phenyl]-N-hydroxyprop-2-enamideIC502.53 [1]
4-[[4-[2-Fluoro-5-[(4-oxo-3H-phthalazin-1-yl)methyl]benzoyl]piperazin-1-yl]methyl]-N-hydroxybenzamideIC5031.52 [1]
6-Fluoro-2-(4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-yl)-1H-benzimidazole-4-carboxamideIC50144.0 [1]
2-(4-Fluorophenyl)-8-methoxyquinazolin-4(3H)-oneIC501562.0 [1]
PamiparibIC500.5 [1]
3-[(4-Oxo-3H-quinazolin-2-yl)sulfanyl]-N-[4-(5-phenyl-1,3,4-oxadiazol-2-yl)cyclohexyl]propanamideIC502450.0 [1]
N-[trans-4-(4-Cyanophenoxy)cyclohexyl]-3-[(4-Oxo-3,4-Dihydroquinazolin-2-Yl)sulfanyl]propanamideIC501760.0 [1]
Benzyl N-{[4-(4-Oxo-3,4-Dihydroquinazolin-2-Yl)phenyl]methyl}carbamateIC5010000.0 [1]
2-(4-((Pyridin-4-Yl)methyl)piperazin-1-Yl)-3,4,5,6,7,8-Hexahydroquinazolin-4-OneIC504200.0 [1]
4-[3-(4-Oxo-3H-quinazolin-2-yl)propanoylamino]-N-quinolin-8-ylbenzamideIC506900.0 [1]
4-[3-(8-Methyl-4-oxo-3H-quinazolin-2-yl)propanoylamino]-N-quinolin-8-ylbenzamideIC5011600.0 [1]
2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-3H-thiopyrano[3,2-D]pyrimidin-4(6H)-oneIC504080.0 [1]
N-(Cyclopropylmethyl)-2-[4-(4-fluorobenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]acetamideIC5019000.0 [1]
N-Ethyl-2-[4-(4-fluorobenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]acetamideIC5019000.0 [1]
3-(8-Methyl-4-oxo-3H-quinazolin-2-yl)propanoic acidIC50145.0 [1]
2-(4-Bromophenyl)-8-methoxy-3H-quinazolin-4-oneIC50259.0 [1]
6-Fluoro-2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)-1H-benzimidazole-4-carboxamideIC5073.0 [1]
6-Fluoro-2-(4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-1H-benzimidazole-4-carboxamideIC50124.0 [1]
(3S)-1-(2-Cyclopropylethyl)-N-[5-[(2,4-dioxoquinazolin-1-yl)methyl]-2-fluoropyridin-3-yl]pyrrolidine-3-carboxamideIC501.0 [1]
Tert-butyl (3S)-3-[[2-chloro-5-[(2,4-dioxoquinazolin-1-yl)methyl]pyridin-3-yl]carbamoyl]pyrrolidine-1-carboxylateIC5012.2 [1]
Tert-butyl (3S)-3-[[5-[(2,4-dioxoquinazolin-1-yl)methyl]pyridin-3-yl]carbamoyl]pyrrolidine-1-carboxylateIC50100.0 [1]
(3S)-1-(Cyclopropylmethyl)-N-[5-[(2,4-dioxoquinazolin-1-yl)methyl]-2-fluoropyridin-3-yl]pyrrolidine-3-carboxamideIC503.6 [1]
(3S)-N-[2-Chloro-5-[(2,4-dioxoquinazolin-1-yl)methyl]phenyl]pyrrolidine-3-carboxamide;2,2,2-trifluoroacetic acidIC50100.0 [1]
2-[4-(Trifluoromethyl)phenyl]-7,8-dihydro-3H-thiopyrano[4,3-d]pyrimidine-4,5-dioneIC50141.0 [1]
2-[3-(Propylamino)pyrrolidine-1-carbonyl]-1H-benzimidazole-4-carboxamideIC5075.0 [1]
(3S)-1-(Cyclopropanecarbonyl)-N-[5-[(2,4-dioxoquinazolin-1-yl)methyl]-2-fluoropyridin-3-yl]pyrrolidine-3-carboxamideIC504.5 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Poly [ADP-ribose] polymerase 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/poly-adp-ribose-polymerase-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ Poly [ADP-ribose] polymerase 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/poly-adp-ribose-polymerase-2-inhibitors-ic50-ki.
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