Poly [ADP-ribose] polymerase-1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Olaparib	IC50	6.0 [1]
	Veliparib	IC50	10.0 [1]
	Veliparib	Ki	5.0 [1]
	3-Aminobenzamide	IC50	30000.0 [1]
	3-Aminobenzamide	Ki	3100.0 [1]
	3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one	IC50	1200.0 [1]
	N~2~,N~2~-Dimethyl-N~1~-(6-oxo-5,6-dihydrophenanthridin-2-YL)glycinamide	IC50	110.0 [1]
	Rucaparib	IC50	26.0 [1]
	Rucaparib	Ki	1.4 [1]
	Niraparib	IC50	16.7 [1]
	6(5H)-Phenanthridinone	IC50	350.0 [1]
	Nicotinamide	IC50	210000.0 [1]
	5-Aminoisoquinolin-1(2H)-one	IC50	300.0 [1], 1000.0 [2], 1600.0 [3], 1800.0 [4]
	9,19-Diazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),2(6),7(11),13,15,17-hexaene-8,10-dione	IC50	36.0 [1]
	1H-Benzimidazole-4-carboxamide	IC50	240.0 [1]
	1H-Benzimidazole-4-carboxamide	Ki	95.0 [1], 240.0 [2]
	2-Phenylbenzimidazole-4-carboxamide	Ki	15.0 [1], 17.0 [2]
	8-Chloro-2-{3-[4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridin-1-yl]propyl}-3,4-dihydroquinazolin-4-one	IC50	13.0 [1]
	4-{[3-(Piperazine-1-carbonyl)phenyl]methyl}phthalazin-1(2H)-one	IC50	2.0 [1], 16.0 [2], 30.5 [3]
	Benzamide	IC50	5400.0 [1], 20000.0 [2], 22000.0 [3]
	Talazoparib	IC50	0.6 [1], 7.2 [2]
	Talazoparib	Ki	1.2 [1]
	4-[3-(1,4-Diazepan-1-ylcarbonyl)-4-fluorobenzyl]phthalazin-1(2H)-one	IC50	3.4 [1], 7.0 [2]
	4-Benzyl-1(2H)-phthalazinone	IC50	770.0 [1]
	IWR-1-endo	IC50	18700.0 [1], 85000.0 [2], 100000.0 [3]
	4,4'-Oxydibenzamide	IC50	100000.0 [1]
	5-Chloro-2-(3-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)propyl)quinazolin-4(3H)-one	IC50	65.0 [1], 682.0 [2]
	1H-Benzimidazole-7-carboxamide, 2-[4-(2-pyridinyl)phenyl]-	IC50	83.0 [1]
	1H-Benzimidazole-7-carboxamide, 2-[4-(2-pyridinyl)phenyl]-	Ki	1.9 [1], 2.0 [2]
	2-Methyl-1H-benzo[d]imidazole-4-carboxamide	IC50	1000.0 [1]
	2-Methyl-1H-benzo[d]imidazole-4-carboxamide	Ki	99.0 [1]
	2-{3-[4-Phenyl-3,6-dihydro-1(2H)-pyridinyl]propyl}-4(3H)-quinazolinone	IC50	16.0 [1], 21.0 [2]
	2-(3-(4-(4-Fluorophenyl)-5,6-dihydropyridin-1(2H)-yl)propyl)quinazolin-4(3H)-one	IC50	8.9 [1], 16.0 [2], 304.0 [3]
	2-(3-(4-Phenylpiperidin-1-yl)propyl)quinazolin-4(3H)-one	IC50	46.0 [1], 79.0 [2]
	2-(3-(4-(4-Chlorophenyl)-5,6-dihydropyridin-1(2H)-yl)propyl)quinazolin-4(3H)-one	IC50	8.9 [1], 23.0 [2]
	N-Ethyl-3-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzamide	IC50	50.0 [1]
	N-{3-[(4-Oxo-3,4-dihydrophthalazin-1-yl)methyl]phenyl}propanamide	IC50	20.0 [1]
	2-(4-Pyridine-3-ylphenyl)-1H-benzimidazole-4-carboxamide	IC50	22.0 [1]
	2-(4-Pyridine-3-ylphenyl)-1H-benzimidazole-4-carboxamide	Ki	0.95 [1], 1.0 [2]
	2-Phenyl-2H-indazole-7-carboxamide	IC50	24.0 [1], 25.0 [2]
	2-(4-((Methylamino)methyl)phenyl)-2H-indazole-7-carboxamide	IC50	3.8 [1], 5.0 [2]
	INO-1001 free base	IC50	1.0 [1], 40.0 [2]
	4-[[4-Fluoro-3-[4-(4-iodobenzoyl)piperazine-1-carbonyl]phenyl]methyl]-2H-phthalazin-1-one	IC50	3.3 [1], 7.0 [2], 7.4 [3]
	4-[[4-Fluoro-3-[5-methyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl]phenyl]methyl]-2H-phthalazin-1-one	IC50	0.74 [1], 10.0 [2], 17.33 [3]
	4-Hydroxyquinazoline	IC50	9500.0 [1], 15800.0 [2]
	4-Amino-1,8-naphthalimide	IC50	26.0 [1], 180.0 [2]
	Bmn-673 8R,9S	IC50	1.1 [1], 144.0 [2]
	1-Hydroxyisoquinoline	IC50	9.0 [1], 7000.0 [2]
	2-(4-(Piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide	IC50	3.2 [1]
	3,4-Dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone	IC50	53.2 [1], 10820.0 [2]
	5-Methyl-3,4-dihydroisoquinolin-1(2H)-one	IC50	160.0 [1]
	5-Methyl-3,4-dihydroisoquinolin-1(2H)-one	Ki	70.0 [1]
	3-(4-Oxo-3,4-Dihydroquinazolin-2-Yl)-N-[(1s)-1-Phenylethyl]propanamide	IC50	3700.0 [1], 6300.0 [2]
	Nvp-tnks656	IC50	19000.0 [1]
	2-(4-Methylphenyl)-4H-chromen-4-one	IC50	7100.0 [1], 25000.0 [2]
	1H-Benzimidazole-7-carboxamide, 2-(1-propyl-4-piperidinyl)-	Ki	8.0 [1]
	2-(4-Hydroxyphenyl)-1h-Benzimidazole-4-Carboxamide	Ki	6.0 [1]
	2-(4-Methoxyphenyl)-1H-benzimidazole-4-carboxamide	IC50	60.0 [1]
	2-(4-Methoxyphenyl)-1H-benzimidazole-4-carboxamide	Ki	6.8 [1]
	1-[2-Fluoro-5-[(4-oxo-3H-phthalazin-1-yl)methyl]phenyl]pyrrolidine-2,5-dione	IC50	5.0 [1]
	(S)-8-Chloro-2-(3-(4-phenylpiperidin-1-yl)cyclopent-1-enyl)quinazolin-4(3H)-one	IC50	8.7 [1]
	5-Chloro-2-methyl-3H-quinazolin-4-one	IC50	1200.0 [1]
	3-(4-Cyanophenyl)quinoxaline-5-carboxamide	IC50	101.0 [1]
	9,19-Diazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),2(6),7(11),13,15,17-hexaen-10-one	IC50	10000.0 [1]
	9,19-Diazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),2(6),7(11),13,15,17-hexaen-8-one	IC50	56.0 [1], 90.0 [2]
	2-(4-((Methylamino)methyl)phenyl)-1H-benzo[d]imidazole-4-carboxamide	Ki	3.2 [1], 4.0 [2]
	2-(3-(4-Phenyl-5,6-dihydropyridin-1(2H)-yl)propyl)phenanthridin-6(5H)-one	IC50	46.0 [1], 119.0 [2]
	2-Phenyl-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraen-9-one	Ki	6.0 [1]
	4-(4-(4-Phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)phthalazin-1(2H)-one	IC50	64.0 [1]
	Benzo[c][1,7]naphthyridin-6(5H)-one	IC50	169.0 [1]
	Benzo[c][1,5]naphthyridin-6(5H)-one	IC50	116.0 [1]
	2-(4-Aminophenyl)-1H-benzo[d]imidazole-4-carboxamide	IC50	30.0 [1]
	2-(4-Aminophenyl)-1H-benzo[d]imidazole-4-carboxamide	Ki	11.0 [1]
	2-[4-[(Dimethylamino)methyl]phenyl]-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraen-9-one	IC50	5.0 [1]
	2-[4-[(Dimethylamino)methyl]phenyl]-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraen-9-one	Ki	5.0 [1]
	3-[(E)-N-Hydroxy-C-methylcarbonimidoyl]-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-9-one	Ki	39.0 [1]
	3-[(E)-Methoxyiminomethyl]-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-9-one	Ki	809.0 [1]
	2-(4-Fluorophenyl)-3-[(E)-hydroxyiminomethyl]-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-9-one	Ki	6.0 [1]
	3-[(E)-Hydroxyiminomethyl]-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-9-one	Ki	9.4 [1]
	3-(Hydroxymethyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-9-one	Ki	79.0 [1]
	3-[(Z)-Methoxyiminomethyl]-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-9-one	Ki	121.0 [1]
	1-[2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)phenyl]-3-phenylpyrrolidine-2,5-dione	IC50	6.8 [1]
	1-(2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)phenyl)piperidine-2,6-dione	IC50	4.1 [1]
	4-(4-Fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one	IC50	5.0 [1], 6.9 [2]
	2-(4-Chlorophenyl)-3-[(E)-hydroxyiminomethyl]-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-9-one	Ki	7.5 [1]
	2-{3-[4-(4-Fluorophenyl)-3,6-dihydro-1(2H)-pyridinyl]propyl}-8-methyl-4(3H)-quinazolinone	IC50	8.0 [1], 16.0 [2]
	8-Chloro-2-[3-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)propyl]-3,4-dihydroquinazolin-4-one	IC50	26.0 [1]
	3H-Pyridazino(3,4,5-de)quinazolin-3-one, 8-((1,3-dihydro-2H-isoindol-2-yl)methyl)-1,2-dihydro-	IC50	2.0 [1], 12.0 [2]
	5H-Benzo[c][1,6]naphthyridin-6-one	IC50	128.0 [1]
	2-Nitro-6(5H)-phenanthridinone	IC50	156.0 [1], 350.0 [2]
	3-Aminobenzo[c][1,5]naphthyridin-6(5H)-one	IC50	180.0 [1]
	2-[1-(Propan-2-yl)pyrrolidin-3-yl]-1H-1,3-benzodiazole-4-carboxamide	Ki	9.0 [1]
	2-(Pyrrolidin-3-yl)-1H-1,3-benzodiazole-4-carboxamide	Ki	4.0 [1]
	1-[2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)phenyl]-3-methylpyrrolidine-2,5-dione	IC50	3.8 [1]
	4-(3-(2-Oxopyrrolidin-1-yl)benzyl)phthalazin-1(2H)-one	IC50	120.0 [1]
	3,4-Dihydropyrrolo(3,2,1-jk)(1,4)benzodiazepin-1(2H)-one	Ki	105.0 [1]
	(R)-2-(4-(Piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide	IC50	2.4 [1]
	2-(Azetidin-3-yl)-1H-benzimidazole-4-carboxamide	Ki	6.0 [1]
	2-[(2r)-Pyrrolidin-2-yl]-1h-benzimidazole-4-carboxamide	Ki	7.0 [1]
	2-[(2s)-Pyrrolidin-2-yl]-1h-benzimidazole-4-carboxamide	Ki	30.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Poly [ADP-ribose] polymerase-1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/poly-adp-ribose-polymerase-1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, December 21). Quest Database™ Poly [ADP-ribose] polymerase-1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/poly-adp-ribose-polymerase-1-inhibitors-ic50-ki.
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