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Platelet-derived growth factor receptor Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
ImatinibIC5050.0 [1], 400.0 [2]
4-(6,7-Dimethoxy-quinoxalin-2-ylamino)-cyclohexanolIC5068.0 [1], 76.0 [2]
4-Methyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideIC5010.0 [1]
3-(3-Thienyl)-6,7-dimethoxyquinolineIC5020.0 [1], 461.0 [2]
N-[3-(4-Pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideIC505000.0 [1]
4-(6,7-Dimethoxyquinoxaline-2-ylamino)cyclohexanecarboxylic acid methyl esterIC5028.0 [1], 49.0 [2], 345.0 [3]
6-(2,6-Dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl]amino}-8-methylpyrido[2,3-D]pyrimidin-7(8H)-oneIC5045.0 [1], 139.0 [2]
N-[4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamideIC50100.0 [1]
Pyrido(2,3-d)pyrimidin-7(8H)-one, 6-(2,6-dichlorophenyl)-2-((4-fluorophenyl)amino)-8-methyl-IC5047.0 [1], 1250.0 [2]
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamineIC5010000.0 [1]
2-(3-Methylcyclohexylamino)-6,7-dimethoxyquinoxalineIC5041.0 [1]
2-Cyclohexylamino-6,7-dimethoxyquinoxalineIC50124.0 [1]
5,7-Dimethoxy-3-(4-pyridinyl)quinolineIC5080.0 [1]
5,7-Dimethoxy-3-(4-pyridinyl)quinolineKi14.0 [1]
N-[4-Methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-acetamideIC5050000.0 [1]
2-(Phenylamino)-6,7-dimethoxyquinoxalineIC506.0 [1]
2-Methoxy-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideIC50300.0 [1]
N-[4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]naphthalene-2-carboxamideIC5050.0 [1]
4-Chloro-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideIC5010.0 [1]
StaurosporineIC502.0 [1]
SunitinibIC5080.0 [1]
N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amineIC5010000.0 [1]
N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amineIC5010000.0 [1]
CanertinibIC5050000.0 [1]
Lfm-a13IC50500000.0 [1]
6,7-Dimethyl-2-phenylquinoxalineIC500.0 [1]
Pyridone 6IC501490.0 [1]
6-(2,6-Dichlorophenyl)-8-methyl-2-((3-(methylthio)phenyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-oneIC501660.0 [1]
6-(2,6-Dichlorophenyl)-2-[(4-Fluoro-3-Methylphenyl)amino]-8-Methylpyrido[2,3-D]pyrimidin-7(8h)-OneIC501430.0 [1]
Unii-NA856793UTIC5050000.0 [1]
7-[cis-4-(4-Methylpiperazin-1-Yl)cyclohexyl]-5-(4-Phenoxyphenyl)-7h-Pyrrolo[2,3-D]pyrimidin-4-AmineIC5020000.0 [1]
CID 6918852Ki5000.0 [1]
6-(2,6-Dichlorophenyl)-8-methyl-2-(4-morpholin-4-ylanilino)pyrido[2,3-d]pyrimidin-7-oneIC50636.0 [1]
9-Hydroxy-4-phenyl-6H-pyrrolo[3,4-C]carbazole-1,3-dioneIC5050000.0 [1]
(Z)-3-(3,4-Dimethoxy-phenyl)-2-pyridin-3-yl-acrylonitrileIC503000.0 [1]
3-(4-{4-Aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[2-fluoro-5-(trifluoromethyl)phenyl]ureaIC5027.54 [1]
PDGF Receptor Tyrosine Kinase Inhibitor IIIIC5080.0 [1]
PDGF Receptor Tyrosine Kinase Inhibitor IIIC501100.0 [1]
VEGF Receptor 2 Kinase Inhibitor IIC50100000.0 [1]
1-[4-(4-Aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-3-(3-methylphenyl)ureaIC5048.0 [1]
2-[2-[4-[4-(4-Tert-butylanilino)phenoxy]-6-methoxyquinolin-7-yl]oxyethylamino]ethanolIC50480.0 [1]
1-[2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylureaIC501250.0 [1]
N-(3-Cyclopropyl-1H-pyrazol-5-YL)-2-(2-naphthyl)acetamideIC5010000.0 [1]
3-(3-Chlorophenyl)-5,7-dimethoxychromen-4-oneIC5010000.0 [1]
(5-Hydroxy-1H-indol-2-yl)-(1H-indol-2-yl)methanoneIC50200.0 [1]
4-(6,7-Dimethoxy-4-quinazolinyl)-N-(4-nitrophenyl)-1-piperazinecarboxamideIC50700.0 [1]
N-(4-Chlorophenyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxamideIC501100.0 [1]
N-Benzyl-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carbothioamideIC50550.0 [1]
4-[(4-Methyl-1-piperazinyl)methyl]-N-[3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamideIC50200.0 [1]
1,3-Diphenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC5010000.0 [1]
6-Acetyl-8-cyclopentyl-5-methyl-2-(4-piperazin-1-yl-phenylamino)-8H-pyrido[2,3-d]pyrimidin-7-oneIC502460.0 [1]
3-[[5-[6-[(3-Chlorophenyl)amino]pyrazinyl]-3-pyridinyl]amino]-1-propanolIC50360.0 [1]
Glycine, N,N-dimethyl-, 2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl esterIC50100.0 [1]
Thienopyrimidine deriv. 28IC5060.0 [1]
N-(1,3-Benzodioxol-5-ylmethyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carbothioamideIC50140.0 [1]
[4-[(2S)-2-Acetamido-3-[[(2S)-1-[[(2S)-1-(dibutylamino)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphateIC5077.0 [1]
20-Ethyl-17,23-dioxa-4,14,20,26-tetrazahexacyclo[24.6.1.17,14.02,6.08,13.027,32]tetratriaconta-1(33),2(6),7(34),8,10,12,27,29,31-nonaene-3,5-dioneIC504400.0 [1]
3-(1H-Indol-3-yl)quinolineIC508000.0 [1]
2-(3-Aminophenylamino)-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-oneIC5024.0 [1]
N-(4-Bromophenyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxamideIC50530.0 [1]
N-(4-Tert-butylphenyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxamideIC5030.0 [1]
4-(6,7-Dimethoxyquinazolin-4-yl)-N-(4-propan-2-ylphenyl)piperazine-1-carboxamideIC5080.0 [1]
N-(4-Chlorophenyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carbothioamideIC50790.0 [1]
[3-(2-Imidazol-1-yl-ethoxy)-phenyl]-(4-pyridin-3-yl-pyrimidin-2-yl)-amineIC5010000.0 [1]
3-[5-[3-(2-Methoxyethoxy)prop-1-ynyl]thiophen-3-yl]-7-(1,2,4-triazol-1-ylmethyl)-1,4-dihydroindeno[1,2-c]pyrazoleIC5084.0 [1]
(3-Imidazol-1-yl-phenyl)-(4-pyridin-3-yl-pyrimidin-2-yl)-amineIC5018000.0 [1]
(3-Chloro-phenyl)-(4-pyridin-3-yl-pyrimidin-2-yl)-amineIC5010000.0 [1]
2-(Phenylamino)quinoxalineIC505100.0 [1]
4-(Benzothiazol-6-ylamino)-6-(benzyl-isopropyl-amino)-[1,3,5]triazin-2-olIC5012500.0 [1]
6-[(4-Methylpiperazin-1-yl)methyl]-3-[5-(3-phenoxyprop-1-ynyl)thiophen-3-yl]-1,4-dihydroindeno[1,2-c]pyrazoleIC5058.0 [1]
[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamateIC5050000.0 [1]
7-((1H-Imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazoleIC5050000.0 [1]
7-[(4-Methylpiperazin-1-yl)methyl]-3-thiophen-3-yl-1,4-dihydroindeno[1,2-c]pyrazoleIC5050000.0 [1]
2-Aminopyrido[2,3-d]pyrimidin-7(8H)-one 46IC50500.0 [1]
2-Aminopyrido[2,3-d]pyrimidin-7(8H)-one 50IC5076.0 [1]
2-Aminopyrido[2,3-d]pyrimidin-7(8H)-one 51IC5082.0 [1]
1-[2-Amino-6-(2,6-dimethylphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylureaIC50340.0 [1]
1-[2-Amino-6-(2,3,5,6-tetramethylphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylureaIC5050000.0 [1]
1-(2-Amino-6-phenylpyrido[2,3-d]pyrimidin-7-yl)-3-tert-butylureaIC5013240.0 [1]
PD089828 analog 12IC5050000.0 [1]
1-[2-Amino-6-(3,5-diethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylureaIC5050000.0 [1]
PD089828 analog 31IC5050000.0 [1]
Bis(1H-2-indolyl)methanone 11IC50300.0 [1]
Bis(1H-2-indolyl)methanone 12IC50300.0 [1]
Acetic acid, methoxy-, 2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl esterIC50200.0 [1]
3-[[4-[4-[(3-Chlorophenyl)amino]-1,3,5-triazin-2-yl]-2-pyridinyl]amino]-1-PropanolIC5010000.0 [1]
N-(4-Pyridin-4-yl-pyrimidin-2-yl)-benzene-1,3-diamineIC5010000.0 [1]
N-(4-Pyridin-3-yl-pyrimidin-2-yl)-benzene-1,3-diamineIC50100000.0 [1]
2-Chloro-N-[4-(4,5-dichloro-2-fluoro-phenylamino)-quinazolin-6-yl]-acetamideIC501000.0 [1]
6-(2,6-Dichlorophenyl)-8-methyl-2-[4-(4-methylpiperazine-1-carbonyl)anilino]pyrido[2,3-d]pyrimidin-7-oneIC5014.0 [1]
6,7-Dimethoxy-3-((E)-styryl)-quinolineIC505.0 [1]
6,7-Dimethoxy-3-(4-methoxy-3-methyl-phenyl)-quinolineIC50400.0 [1]
6-(2,6-Dichlorophenyl)-2-(4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-oneIC50203.0 [1]
3-(4-Fluoro-phenyl)-6,7-dimethoxy-quinolineIC5060.0 [1]
3-[[4-(3-Pyridinyl)-2-pyrimidinyl]amino]benzoic acidIC5010000.0 [1]
3-(2-Cyclohexyl-ethyl)-6,7-dimethoxy-quinolineIC50500.0 [1]
3-(1H-Indol-3-yl)-7,8-dimethoxy-quinolineIC5050000.0 [1]
3-(2,4-Dimethoxy-phenyl)-6,7-dimethoxy-quinolineIC5050000.0 [1]
4-(6,7-Dimethoxy-quinolin-3-yl)-benzoic acid ethyl esterIC50200.0 [1]
3-Hydroxy-6,7-dimethoxyquinolineIC5020000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Platelet-derived growth factor receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/platelet-derived-growth-factor-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Platelet-derived growth factor receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/platelet-derived-growth-factor-receptor-inhibitors-ic50-ki.
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