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Platelet-derived growth factor receptor beta Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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SunitinibIC5083.1 [1]
SunitinibKi8.0 [1]
SemaxanibIC502400.0 [1]
3-(4-(Dimethylamino)benzylidene)-1,3-dihydro-2H-indol-2-oneIC503750.0 [1]
ErlotinibIC5012200.0 [1]
StaurosporineIC500.6 [1], 0.76 [2], 4.3 [3], 4.7 [4], 204.7 [5]
SorafenibIC5010.0 [1], 18.4 [2], 37.0 [3], 57.0 [4]
NintedanibIC501.8 [1], 2.0 [2], 3.5 [3], 3.7 [4], 65.0 [5]
OrantinibIC5050.0 [1], 60.0 [2], 100.0 [3], 16500.0 [4]
ImatinibIC5072.0 [1], 240.0 [2], 386.0 [3]
3-[(3-(2-Carboxyethyl)-4-methylpyrrol-2-YL)methylene]-2-indolinoneIC50510.0 [1], 28400.0 [2], 60900.0 [3]
6,7-Dimethyl-2-phenylquinoxalineIC506200.0 [1], 6500.0 [2]
PDGF Receptor Tyrosine Kinase Inhibitor IIIIC5080.0 [1], 130.0 [2]
4-N-(3-Bromophenyl)-6-[(2-methylphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamineIC5050000.0 [1]
4-N-(3-Bromophenyl)-6-[(2,5-dimethoxyphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamineIC508900.0 [1], 8920.0 [2], 300000.0 [3]
(5-Hydroxy-1H-indol-2-yl)-(1H-indol-2-yl)methanoneIC5090.0 [1], 200.0 [2], 600.0 [3], 3200.0 [4]
4-(6,7-Dimethoxy-4-quinazolinyl)-N-(4-nitrophenyl)-1-piperazinecarboxamideIC50240.0 [1], 700.0 [2]
Glycine, N,N-dimethyl-, 2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl esterIC50100.0 [1], 1300.0 [2], 3500.0 [3]
CrizotinibIC501000.0 [1], 10000.0 [2]
VatalanibIC50490.0 [1], 600.0 [2]
TandutinibIC5026.0 [1], 36.0 [2], 200.0 [3]
LinifanibIC5060.0 [1], 66.0 [2]
PDGF Receptor Tyrosine Kinase Inhibitor IVIC503.0 [1], 4.2 [2]
5-[(Z)-(5-Chloro-2-oxo-1H-indol-3-ylidene)methyl]-N-[2-(diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamideIC503.0 [1], 3000.0 [2]
7-(2,6-Dichlorophenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amineIC5015.0 [1]
7-(2,6-Dichlorophenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amineKi2090.0 [1]
3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dioneIC50680.0 [1], 1867.0 [2]
N4-(3-Bromophenyl)-6-(naphthalen-1-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamineIC5050000.0 [1], 300000.0 [2]
2-Benzyl-N4-(3-bromophenyl)-1H-indole-4,6-diamineIC5050000.0 [1]
4-[6-Methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]-N-(4-phenoxyphenyl)piperazine-1-carboxamideIC5010.0 [1], 40.0 [2], 525.0 [3]
N-(4-Cyanophenyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxamideIC50450.0 [1], 850.0 [2]
Acetic acid, methoxy-, 2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl esterIC5020.0 [1], 100.0 [2], 4200.0 [3]
4-[6-Methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamideIC50200.0 [1], 216.0 [2], 420.0 [3]
4-[6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[(6-methylpyridin-3-yl)methyl]piperazine-1-carbothioamideIC5090.0 [1], 140.0 [2]
N-(4-Cyanophenyl)-4-[6-methoxy-7-[3-(2-methylpiperidin-1-yl)propoxy]quinazolin-4-yl]piperazine-1-carboxamideIC504.0 [1], 29.0 [2], 150.0 [3]
4-[6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[(5-methylpyrazin-2-yl)methyl]piperazine-1-carbothioamideIC5050.0 [1], 140.0 [2], 1350.0 [3]
N-[(6-Chloropyridin-3-yl)methyl]-4-[6-methoxy-7-(2-piperidin-1-ylethoxy)quinazolin-4-yl]piperazine-1-carbothioamideIC5050.0 [1], 80.0 [2], 1010.0 [3]
N-(4-Isopropoxyphenyl)-4-(6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-yl)piperazine-1-carboxamideIC5020.0 [1], 60.0 [2], 100.0 [3]
4-[6-Methoxy-7-[3-(4-methylpiperidin-1-yl)propoxy]quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamideIC504.0 [1], 39.0 [2], 51.0 [3]
N-(4-Cyanophenyl)-4-[6-methoxy-7-[3-(4-methylpiperidin-1-yl)propoxy]quinazolin-4-yl]piperazine-1-carboxamideIC504.0 [1], 22.0 [2], 73.0 [3]
4-[6-Methoxy-7-[3-(2-methylpiperidin-1-yl)propoxy]quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamideIC504.0 [1], 35.0 [2], 74.0 [3]
4-[6-Methoxy-7-(2-piperidin-1-ylethoxy)quinazolin-4-yl]-N-pyridin-4-ylpiperazine-1-carbothioamideIC50240.0 [1], 400.0 [2], 980.0 [3]
4-[6-Methoxy-7-(2-piperidin-1-ylethoxy)quinazolin-4-yl]-N-[[6-(trifluoromethyl)pyridin-3-yl]methyl]piperazine-1-carbothioamideIC5090.0 [1], 150.0 [2], 1030.0 [3]
4-[3-Cyano-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinolin-4-yl]-N-[[6-(trifluoromethyl)pyridin-3-yl]methyl]piperazine-1-carbothioamideIC503.0 [1], 10.0 [2]
N-[[2-Chloro-6-(trifluoromethyl)pyridin-3-yl]methyl]-4-[6-methoxy-7-(2-piperidin-1-ylethoxy)quinazolin-4-yl]piperazine-1-carbothioamideIC50100.0 [1], 1130.0 [2], 1400.0 [3]
N-(6-Chloropyridin-3-yl)-4-[6-methoxy-7-(2-piperidin-1-ylethoxy)quinazolin-4-yl]piperazine-1-carbothioamideIC50360.0 [1], 510.0 [2], 890.0 [3]
4-[6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(6-phenylpyridin-3-yl)piperazine-1-carbothioamideIC50100.0 [1], 270.0 [2], 360.0 [3]
4-[6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[(5-methylfuran-2-yl)methyl]piperazine-1-carbothioamideIC5080.0 [1], 90.0 [2]
4-[6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-pyridin-4-ylpiperazine-1-carbothioamideIC5060.0 [1], 220.0 [2], 580.0 [3]
N-(Furan-2-ylmethyl)-4-[6-methoxy-7-(2-pyrrolidin-1-ylethoxy)quinazolin-4-yl]piperazine-1-carbothioamideIC50160.0 [1], 290.0 [2], 310.0 [3]
Bis(1H-2-indolyl)methanone deriv. 50IC5070.0 [1], 300.0 [2], 4900.0 [3]
4-[6-Methoxy-7-(2-piperidin-1-ylethoxy)quinazolin-4-yl]-N-[(5-methylpyrazin-2-yl)methyl]piperazine-1-carbothioamideIC5050.0 [1], 60.0 [2], 250.0 [3]
4-[6-Methoxy-7-(2-piperidin-1-ylethoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamideIC50170.0 [1], 250.0 [2], 1250.0 [3]
N-(1,3-Benzodioxol-5-ylmethyl)-4-[6-methoxy-7-(2-piperidin-1-ylethoxy)quinazolin-4-yl]piperazine-1-carbothioamideIC5020.0 [1], 40.0 [2], 120.0 [3]
4-[6-Methoxy-7-(2-piperidin-1-ylethoxy)quinazolin-4-yl]-N-(4-pyridin-2-ylphenyl)piperazine-1-carbothioamideIC5070.0 [1], 150.0 [2], 180.0 [3]
LapatinibIC508500.0 [1], 200000.0 [2]
NilotinibIC5060.11 [1], 71.0 [2]
PazopanibIC5083.0 [1], 84.0 [2]
VandetanibIC50477.0 [1], 1100.0 [2]
DovitinibIC501.0 [1], 5.0 [2]
ForetinibIC509.6 [1]
(3Z)-3-(1H-Imidazol-5-ylmethylene)-5-methoxy-1H-indol-2(3H)-oneIC5010000.0 [1], 18000.0 [2]
3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamideIC501860.0 [1], 2636.67 [2]
4-Chloro-3-(5-methyl-3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)benzo[e][1,2,4]triazin-7-yl)phenolIC501.1 [1]
VEGF Receptor 2 Kinase Inhibitor IIC504000.0 [1], 100000.0 [2]
2-(4-((6,7-Dimethoxyquinazolin-4-yl)oxy)phenyl)-N-(1-isopropyl-1H-pyrazol-4-yl)acetamideIC504.0 [1]
7-(2,6-Dimethylphenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amineIC505.9 [1], 6.0 [2]
(Z)-3-(2,4-Dimethyl-5-((2-oxo-6-phenylindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acidIC5010.0 [1], 110.0 [2]
N-(4-Chlorophenyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxamideIC501100.0 [1]
N-Benzyl-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carbothioamideIC5090.0 [1], 550.0 [2]
6-(2-Phenylethyl)-4-N-[3-(trifluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamineIC50500000.0 [1]
2-(2-Chlorobenzyl)-N4-(3-bromophenyl)-1H-indole-4,6-diamineIC5050000.0 [1]
N-(4-Methoxyphenyl)-N,2,6-trimethylfuro[2,3-d]pyrimidin-4-amineIC5022.8 [1]
2-[4-[(6,7-Dimethoxyquinazolin-4-yl)amino]phenyl]-N-(1-propan-2-ylpyrazol-4-yl)acetamideIC5020.0 [1]
N-(1,3-Benzodioxol-5-ylmethyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carbothioamideIC5090.0 [1]
4-(7-Ethoxy-6-methoxyquinazolin-4-yl)-N-(4-phenoxyphenyl)piperazine-1-carboxamideIC5010.0 [1]
4-N-(3-Bromo-4-fluorophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamineIC50500000.0 [1]
N-(4-Bromophenyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxamideIC50270.0 [1], 530.0 [2]
4-(6,7-Dimethoxyquinazolin-4-yl)-N-(4-propan-2-ylphenyl)piperazine-1-carboxamideIC5020.0 [1], 80.0 [2]
N-Benzyl-4-(7-ethoxy-6-methoxyquinazolin-4-yl)piperazine-1-carbothioamideIC50150.0 [1]
4-(6-Ethoxy-7-methoxyquinazolin-4-yl)-N-(4-phenoxyphenyl)piperazine-1-carboxamideIC5040.0 [1]
4-(6,7-Dimethoxy-2-methylquinazolin-4-yl)-N-(4-phenoxyphenyl)piperazine-1-carboxamideIC5030000.0 [1]
4-[6-Amino-7-(ethylamino)quinazolin-4-yl]-N-benzylpiperazine-1-carbothioamideIC501440.0 [1]
4-(2-Chloro-6,7-dimethoxyquinazolin-4-yl)-N-(4-phenoxyphenyl)piperazine-1-carboxamideIC5030000.0 [1]
N-Benzyl-4-quinazolin-4-ylpiperazine-1-carbothioamideIC5030000.0 [1]
4-[7-(Ethylamino)-6-nitroquinazolin-4-yl]-N-(4-phenoxyphenyl)piperazine-1-carboxamideIC50200.0 [1]
N-(4-Phenoxyphenyl)-4-(6,7,8-trimethoxyquinazolin-4-yl)piperazine-1-carboxamideIC5030000.0 [1]
N-Benzyl-4-(6-ethoxy-7-methoxyquinazolin-4-yl)piperazine-1-carbothioamideIC50620.0 [1]
N-Benzyl-4-[7-(ethylamino)-6-nitroquinazolin-4-yl]piperazine-1-carbothioamideIC5030000.0 [1]
4-(7,8-Dimethoxyquinazolin-4-yl)-N-(4-phenoxyphenyl)piperazine-1-carboxamideIC5030000.0 [1]
N-(4-Phenoxyphenyl)-4-quinazolin-4-ylpiperazine-1-carboxamideIC50380.0 [1]
4-(6,7-Dimethoxy-2-morpholin-4-ylquinazolin-4-yl)-N-(4-phenoxyphenyl)piperazine-1-carboxamideIC5030000.0 [1]
(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)-phenyl amineIC509.0 [1], 23.0 [2]
(5-Methoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamineIC5054.0 [1], 487.0 [2]
4-Chloro-3-(5-methyl-3-(4-(piperidin-4-ylsulfonyl)phenylamino)benzo[e][1,2,4]triazin-7-yl)phenolIC502.8 [1]
4-[[7-(2-Chloro-5-hydroxyphenyl)-5-methyl-1,2,4-benzotriazin-3-yl]amino]-N-(2-pyrrolidin-1-ylethyl)benzenesulfonamideIC501.7 [1]
(7-Methoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamineIC509.0 [1], 18.0 [2]
4-(6,8-Dimethoxyquinazolin-4-yl)-N-(4-phenoxyphenyl)piperazine-1-carboxamideIC5010900.0 [1]
4-N-[4-Fluoro-3-(trifluoromethyl)phenyl]-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamineIC5090000.0 [1]
4-N-(3-Bromophenyl)-6-[(2,4-dichlorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamineIC5017000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Platelet-derived growth factor receptor beta Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/platelet-derived-growth-factor-receptor-beta-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Platelet-derived growth factor receptor beta Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/platelet-derived-growth-factor-receptor-beta-inhibitors-ic50-ki.
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