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Platelet-derived growth factor receptor alpha Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
ImatinibIC5018.0 [1]
NintedanibIC501.9 [1], 2.3 [2], 4.0 [3], 18.0 [4], 59.0 [5]
StaurosporineIC500.1 [1], 0.43 [2], 0.45 [3], 0.6 [4]
ForetinibIC503.6 [1], 6.82 [2]
N-(1,3-Benzodioxol-5-ylmethyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carbothioamideIC50210.0 [1], 25000.0 [2], 26600.0 [3]
Imatinib mesylateIC5020000.0 [1], 24000.0 [2]
DasatinibIC509.9 [1], 63.0 [2]
NilotinibIC502.54 [1], 71.0 [2]
AmuvatinibIC502100.0 [1], 3000.0 [2]
PDGF Receptor Tyrosine Kinase Inhibitor IVIC5045.0 [1]
4-(6,7-Dimethoxy-9H-pyrimido[4,5-b]indol-4-yl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]piperazine-1-carbothioamideIC5050000.0 [1]
(4S,6Z)-18-Hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,15,17-tetraene-2,8-dioneIC5095.0 [1], 440.0 [2]
1-(2,2-Diethoxyethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrazolo[3,4-d]pyrimidin-4-amineIC5010000.0 [1], 100000.0 [2]
N-[[4-(6,7-Dimethoxyquinolin-4-yl)oxyphenyl]carbamoyl]-2-methylbenzamideIC504.0 [1], 7.6 [2]
4-(4-(5-Benzylpyrimidin-2-yl)piperazin-1-yl)quinazolineIC50295.0 [1], 316.0 [2]
Infigratinib phosphateIC502718.0 [1], 10000.0 [2]
1-[4-[3-[4-Amino-5-[2-fluoro-5-[[(2S)-oxolan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]piperazin-1-yl]ethanoneIC505300.0 [1], 10000.0 [2]
N-(1,3-Benzodioxol-5-ylmethyl)-4-(6,7-dimethoxy-9H-pyrimido[4,5-b]indol-4-yl)piperazine-1-carbothioamideIC5015500.0 [1], 16000.0 [2]
N-(1,3-Benzodioxol-5-ylmethyl)-4-(8-thia-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-6-yl)piperazine-1-carbothioamideIC5050000.0 [1]
Amuvatinib hydrochlorideIC5040.0 [1], 81.0 [2]
N-[4-(Pyrimidin-2-ylsulfamoyl)phenyl]-4-(8-thia-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-6-yl)piperazine-1-carbothioamideIC5050000.0 [1]
4-(6,7-Dimethoxyquinazolin-4-yl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]piperazine-1-carbothioamideIC5050000.0 [1]
SunitinibIC50130.0 [1]
LapatinibIC5020000.0 [1]
CrizotinibIC501000.0 [1]
PazopanibIC5071.0 [1]
Nintedanib esylateIC5059.0 [1]
SemaxanibIC50200.0 [1]
CabozantinibIC5010000.0 [1]
PonatinibIC502.6 [1]
CeritinibIC501140.0 [1]
SaracatinibIC5010000.0 [1]
DoramapimodIC5030000.0 [1]
ElliptiniumIC50700.0 [1]
Nvp-aew541IC50800.0 [1]
9-HydroxyellipticineIC50600.0 [1]
LinifanibIC5015.0 [1]
TivozanibIC502.26 [1]
4-[[9-Chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acidIC50794.33 [1]
Bms-777607IC5028.0 [1]
1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)ureaIC5010.0 [1]
BemcentinibIC5020.0 [1]
9H-Purine-2,6-diamine, N2-(2-aminocyclohexyl)-N6-(3-chlorophenyl)-9-ethyl-, cis-IC5020000.0 [1]
1-(Tert-Butyl)-3-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC50657.0 [1]
(E)-N-(5-Methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amineIC5056.0 [1]
VEGF receptor tyrosine kinase inhibitor IIIIC50970.0 [1]
Tak-285IC5010000.0 [1]
1-(2,4-Difluorophenyl)-3-(4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl)ureaIC5067.0 [1]
3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamideIC503120.0 [1]
MK-2461IC50100.0 [1]
CID 44219749IC5050000.0 [1]
(4S,6Z,9S,10S)-9,10,18-Trihydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,15,17-tetraene-2,8-dioneIC502.38 [1]
IlorasertibKi0.79 [1]
Tak-593IC504.3 [1]
CID 53246941IC50956.0 [1]
PDGF Receptor Tyrosine Kinase Inhibitor IIIIC5050.0 [1]
3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dioneIC50943.0 [1]
MivavotinibIC5045.0 [1]
1-[2-Fluoro-4-(5-methylpyrrolo[3,2-d]pyrimidin-4-yl)oxyphenyl]-3-[3-(trifluoromethyl)phenyl]ureaIC5035.0 [1]
Flt3-IN-1IC5010000.0 [1]
Cep-11981IC50246.0 [1]
CID 44814409IC5010000.0 [1]
3-((4-(6-Methylpyridin-2-yl)-5-(quinolin-6-yl)-1H-imidazol-2-yl)methyl)benzamideIC503000.0 [1]
1-[4-(6,7-Dimethoxy-quinazolin-4-yloxy)-phenyl]-3-(4-methoxy-phenyl)-ureaIC503.6 [1]
(E)-1-(4-((6-Amino-5-((methoxyimino)methyl)pyrimidin-4-yl)oxy)-2-chlorophenyl)-3-ethylureaIC501110.0 [1]
4-[5-(6-Methoxynaphthalen-2-yl)-1-methyl-2-(2-methyl-4-methylsulfinylphenyl)imidazol-4-yl]pyridineIC5030000.0 [1]
(5-Hydroxy-1H-indol-2-yl)-(1H-indol-2-yl)methanoneIC501000.0 [1]
N-[4-[(5-Tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]-5-(1-ethyl-2,2,6,6-tetramethylpiperidin-4-yl)oxypyridine-2-carboxamideIC507.7 [1]
4-(6,7-Dimethoxy-4-quinazolinyl)-N-(4-nitrophenyl)-1-piperazinecarboxamideIC50890.0 [1]
4-(Chloromethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamideIC50139.0 [1]
N-({4-[(6,7-Dimethoxyquinolin-4-Yl)oxy]phenyl}carbamothioyl)-2-PhenylacetamideIC5028.0 [1]
1-Cyclohexyl-3-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]ureaIC507.0 [1]
N-Benzyl-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carbothioamideIC50240.0 [1]
6,6-Dimethyl-8-[1-(oxan-4-ylmethyl)piperidin-4-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrileIC50402.0 [1]
1-[4-[4-Amino-7-(1-methylpyrazol-4-yl)thieno[3,2-c]pyridin-3-yl]phenyl]-3-(3-fluorophenyl)ureaKi50.12 [1]
Glycine, N,N-dimethyl-, 2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl esterIC50100.0 [1]
cis-3-[4-Amino-7-(3-azetidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-phenolIC50900.0 [1]
7-[3-(Azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2S)-oxolan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-4-amineIC5010000.0 [1]
2-Amino-N-[3-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]phenyl]acetamideIC501000.0 [1]
4-(6,7-Dimethoxy-quinoxalin-2-ylamino)-cyclohexanolIC50299.0 [1]
N-(4-Bromophenyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxamideIC50710.0 [1]
N-(4-Cyanophenyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxamideIC50770.0 [1]
4-(6,7-Dimethoxyquinazolin-4-yl)-N-(4-propan-2-ylphenyl)piperazine-1-carboxamideIC5090.0 [1]
1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinolin-4-yloxy)-3-fluoro-phenyl]-ureaIC5017.0 [1]
1-[4-[4-Amino-7-[3-(methylamino)prop-1-ynyl]thieno[3,2-c]pyridin-3-yl]phenyl]-3-(3-methylphenyl)ureaKi2.51 [1]
Tert-butyl N-[4-[4-amino-1-[2-[4-(dimethylamino)piperidin-1-yl]ethyl]pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]carbamateIC5010000.0 [1]
1-[5-Amino-4-(3,4-dichlorophenyl)-3-methylpyrazol-1-yl]ethanoneIC50100000.0 [1]
N-Ethyl-2-hydroxy-N-methyl-3-[C-phenyl-N-[4-(piperidin-1-ylmethyl)phenyl]carbonimidoyl]-1H-indole-6-carboxamideIC50890.0 [1]
VegfrecineIC503200.0 [1]
3-{[(1R)-1-Phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dioneIC5040500.0 [1]
(13R,15S)-13-Methyl-16-oxa-8,9,12,22,24-pentazahexacyclo[15.6.2.16,9.112,15.02,7.021,25]heptacosa-1(24),2,4,6,17,19,21(25)-heptaene-23,27-dioneIC501000.0 [1]
N-Propyl-4-({4-[(2,2,2-trifluoroethyl)amino]-1H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)benzamideIC504310.0 [1]
1-[4-[4-Amino-7-(3-amino-3-methylbut-1-ynyl)thieno[3,2-c]pyridin-3-yl]phenyl]-3-(3-methylphenyl)ureaKi10000.0 [1]
N-(1,3-Dimethylpyrazol-4-yl)-2-[2-methoxy-4-(7-methoxyquinolin-4-yl)oxyphenyl]acetamideIC503.0 [1]
CID 25207521IC5011100.0 [1]
6H-Pyrido(4,3-b)carbazol-9-ol, 1-((3-(diethylamino)propyl)amino)-5,6,11-trimethyl-, hydrateIC502000.0 [1]
6-[2-[2-(Dimethylamino)ethylamino]ethylamino]-2-octylbenzo[de]isoquinoline-1,3-dioneIC50100000.0 [1]
6-[2-[2-(Dimethylamino)ethylamino]ethylamino]-2-dodecylbenzo[de]isoquinoline-1,3-dioneIC5026170.0 [1]
CID 46864270IC501.3 [1]
3-[7-[4-[(1S,4S)-5-Methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]phenyl]-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-3-yl]phenolIC506560.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Platelet-derived growth factor receptor alpha Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/platelet-derived-growth-factor-receptor-alpha-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Platelet-derived growth factor receptor alpha Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/platelet-derived-growth-factor-receptor-alpha-inhibitors-ic50-ki.
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