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Platelet activating factor receptor Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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ApafantIC5040.0 [1], 50.0 [2], 200.0 [3]
2-[3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]sulfonylethanolIC506.0 [1]
2-[3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]sulfonylethanolKi3.2 [1], 6.0 [2], 6.1 [3], 6.3 [4]
(2R,5R)-2-(3-Methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5-trimethoxyphenyl)oxolaneIC5013.0 [1]
(2R,5R)-2-(3-Methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5-trimethoxyphenyl)oxolaneKi9.0 [1], 14.3 [2]
5-(4-Methoxyphenyl)-N-(1-methyl-4-(3-pyridinyl)butyl)-2,4-decadienamideIC5040.0 [1]
LoratadineIC5050000.0 [1], 135000.0 [2]
Modipafant racemateIC5013.0 [1], 31.3 [2]
RespatadineIC50610.0 [1], 840.0 [2]
5-[4-[2-(3,4,5-Trimethoxyphenyl)ethyl]phenyl]-2,3-dihydroimidazo[2,1-a]isoquinolineIC5040.0 [1], 60.0 [2]
(2R,5R)-2,5-Bis(3,4,5-trimethoxyphenyl)oxolaneIC501500.0 [1]
(2R,5R)-2,5-Bis(3,4,5-trimethoxyphenyl)oxolaneKi103.0 [1]
2-[3-Methoxy-2-propoxy-5-[5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]sulfonylethanolKi59.0 [1], 116.0 [2]
4-(2-Chlorophenyl)-2-iodo-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepineIC50370.0 [1]
1-IphtfKi1.85 [1], 2.9 [2]
Potassium;3-[3-(2-oxopropylsulfonyl)-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenoxy]propyl hydrogen phosphateKi110.0 [1], 174.0 [2]
(4R)-5-[3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]sulfonyl-4-methylpentan-1-olKi3.72 [1], 5.26 [2]
(4S)-5-[3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]sulfonyl-4-methylpentan-1-olKi2.86 [1], 3.7 [2]
N-Cyclohexyl-N-methyl-4-[(2-methylbenzimidazol-1-yl)methyl]benzenesulfonamideIC50300.0 [1]
(5S)-2-[4-[2-(Benzenesulfonyl)ethoxy]-3-methoxy-5-propylsulfonylphenyl]-5-(3,4,5-trimethoxyphenyl)oxolaneIC501.0 [1]
(5S)-2-[4-[2-(Benzenesulfonyl)ethoxy]-3-methoxy-5-propylsulfonylphenyl]-5-(3,4,5-trimethoxyphenyl)oxolaneKi1.0 [1]
ClotrimazoleKi22635.0 [1]
ChlorpheniramineIC5050000.0 [1]
Ginkgolide-BIC50128.0 [1]
BrotizolamIC50300.0 [1]
CilostamideKi1917.0 [1]
RupatadineIC503700.0 [1]
AzatadineIC5050000.0 [1]
LexipafantKi0.38 [1]
5-[3-[7-(2-Chlorophenyl)-13-methyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-4-yl]prop-2-ynyl]phenanthridin-6-oneIC5013.0 [1]
TulopafantumIC5011.0 [1]
OrvepitantKi2270.0 [1]
(2r)-2-(Acetyloxy)-3-(Hexadecyloxy)propyl 2-(Trimethylammonio)ethyl PhosphateIC500.28 [1]
3-[[2-[2-(4-Chlorophenyl)sulfanylethoxy]-3-methoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]methyl]-1-hydroxy-1-methylureaIC5010.0 [1]
[4-(3-Phenylpropyl)piperazin-1-yl]-[(4R)-2-pyridin-3-yl-1,3-thiazolidin-4-yl]methanoneIC502.3 [1]
CID 46897162IC505000.0 [1]
1-[4-(13-Chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidin-1-yl]butan-1-oneIC5033000.0 [1]
1-[4-(13-Chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidin-1-yl]propan-1-oneIC502400.0 [1]
N-(4-1H-Imidazol-1-yl)butyl-2-(1-methylethyl)-11-oxo-11H-pyrido(2,1b)quinazoline-8-carboxamideIC503500.0 [1]
ABT-491 free baseKi0.57 [1]
(2R,3R,4R,5S)-2,5-Bis-(3,4-dimethoxy-phenyl)-3,4-dimethyl-tetrahydro-furanKi1000.0 [1]
N-[(2S)-1-Ethoxy-4-methylpentan-2-yl]-4-[(2-methylimidazo[4,5-c]pyridin-1-yl)methyl]benzenesulfonamideIC500.01 [1]
5-(2-Fluoro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinolineIC505700.0 [1]
11-Oxo-2-propan-2-yl-N-(4-pyridin-3-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamideIC50350.0 [1]
2-Methyl-11-oxo-N-(4-pyridin-3-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamideIC50500.0 [1]
2-Methoxy-11-oxo-N-(4-pyridin-3-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamideIC501000.0 [1]
11-Oxo-2-propan-2-yloxy-N-(4-pyridin-3-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamideIC50600.0 [1]
11-Oxo-N-(4-pyridin-3-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamideIC501800.0 [1]
2-Bromo-11-oxo-N-(4-pyridin-3-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamideIC50700.0 [1]
2-Hydroxy-11-oxo-N-(4-pyridin-3-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamideIC501200.0 [1]
11-Oxo-2-propan-2-yl-N-(4-pyridin-2-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamideIC505000.0 [1]
11-Oxo-2-propan-2-yl-N-(7-pyridin-3-ylheptyl)pyrido[2,1-b]quinazoline-8-carboxamideIC501000.0 [1]
11-Oxo-2-propan-2-yl-N-(4-pyrimidin-5-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamideIC50450.0 [1]
3-Methoxy-11-oxo-N-(4-pyridin-3-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamideIC50370.0 [1]
3-Chloro-11-oxo-N-(4-pyridin-3-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamideIC501000.0 [1]
N-(2-Methyl-5-pyridin-3-ylpentan-2-yl)-11-oxo-2-propan-2-ylpyrido[2,1-b]quinazoline-8-carboxamideIC501200.0 [1]
N-Formyl DesloratadineIC5013000.0 [1]
1-[4-(13-Methoxy-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidin-1-yl]ethanoneIC503400.0 [1]
1-[4-(2-Tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)piperidin-1-yl]ethanoneIC5041000.0 [1]
2,5-Bis-(3,4,5-trimethoxy-phenyl)-tetrahydro-furanIC50180.0 [1]
1-(2,2-Dimethylpropyl)-5-[5-(2-hydroxypropan-2-yl)-2-methylphenyl]-3-methylimidazo[4,5-b]pyridin-2-oneKi2000.0 [1]
SDZ-62-434 freeIC507500.0 [1]
N-[4,6-Dimethoxy-2-(3-morpholin-4-ylpropylamino)pyrimidin-5-yl]-5-[(3,3,6-trimethyl-1,2-dihydroinden-5-yl)oxy]furan-2-carboxamideKi1060.0 [1]
(E)-3-(1-Butyl-4-methoxynaphthalen-2-yl)-N-[(2S)-5-pyridin-3-ylpentan-2-yl]prop-2-enamideIC501.0 [1]
5-p-Tolyl-2,3-dihydro-imidazo[2,1-a]isoquinolineIC505400.0 [1]
Diallyl-[4-(2,3-dihydro-imidazo[2,1-a]isoquinolin-5-yl)-benzyl]-amineIC509200.0 [1]
4-[[4-(2,3-Dihydroimidazo[2,1-a]isoquinolin-5-yl)phenyl]methyl]thiomorpholineIC501100.0 [1]
1-[3-(3-Morpholin-4-ylpropoxy)-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]sulfonylpropan-2-oneKi2.5 [1]
5-(4-Pyrrolidin-1-ylmethyl-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinolineIC5059400.0 [1]
Dicyclohexyl-[4-(2,3-dihydro-imidazo[2,1-a]isoquinolin-5-yl)-benzyl]-amineIC5013100.0 [1]
5-Phenyl-2,3-dihydroimidazo[2,1-a]isoquinolineIC5011200.0 [1]
5-Pyridin-4-yl-2,3-dihydro-imidazo[2,1-a]isoquinolineIC5047900.0 [1]
5-Thiophen-2-yl-2,3-dihydro-imidazo[2,1-a]isoquinolineIC5015200.0 [1]
5-(3,4-Dimethoxy-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinolineIC5022000.0 [1]
5-(4-Tert-Butylphenyl)-2,3-dihydroimidazo[2,1-a]isoquinolineIC50900.0 [1]
5-(4-Morpholin-4-ylmethyl-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinolineIC502800.0 [1]
5-Furan-2-yl-2,3-dihydro-imidazo[2,1-a]isoquinolineIC50100000.0 [1]
5-(4-Fluoro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinolineIC5014200.0 [1]
5-(3,4,5-Trimethoxy-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinolineIC50100000.0 [1]
5-(4-Chloro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinolineIC5037200.0 [1]
5-Biphenyl-4-yl-2,3-dihydro-imidazo[2,1-a]isoquinolineIC503400.0 [1]
5-(2-Chloro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinolineIC508100.0 [1]
5-(3-Chloro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinolineIC505400.0 [1]
5-(4-Tert-butylphenyl)-9-methyl-2,3-dihydroimidazo[2,1-a]isoquinolineIC5031800.0 [1]
1-[3-(3-Imidazol-1-ylpropoxy)-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]sulfonylpropan-2-oneKi3.0 [1]
5-(4-Ethyl-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinolineIC506300.0 [1]
5-(4-Tert-butylphenyl)-9-chloro-2,3-dihydroimidazo[2,1-a]isoquinolineIC5040400.0 [1]
5-Pyridin-3-yl-2,3-dihydro-imidazo[2,1-a]isoquinolineIC50100000.0 [1]
5-(3,4-Dichloro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinolineIC5017000.0 [1]
5-(3-Trifluoromethyl-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinolineIC5019200.0 [1]
3-[2-[2-(3-Bromophenyl)sulfanylethoxy]-3-methoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]-1-butyl-1-hydroxyureaIC5022.0 [1]
3-[2-[2-(4-Bromophenyl)sulfanylethoxy]-3-methoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]-1-butyl-1-hydroxyureaIC5021.0 [1]
1-Butyl-1-hydroxy-3-[3-methoxy-2-[2-(2,3,5,6-tetrafluorophenyl)sulfanylethoxy]-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]ureaIC502.0 [1]
4-[2-(4-Butylphenyl)ethyl]-7-(2-chlorophenyl)-13-methyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaeneIC5010.0 [1]
3-[2-[2-(2-Bromophenyl)sulfanylethoxy]-3-methoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]-1-butyl-1-hydroxyureaIC5023.0 [1]
1-Butyl-1-hydroxy-3-[3-methoxy-2-[2-(2,3,5,6-tetrafluorophenyl)sulfonylethoxy]-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]ureaIC50285.0 [1]
1-Butyl-3-[[2-[2-(4-chlorophenyl)sulfanylethoxy]-3-methoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]methyl]-1-hydroxyureaIC50167.0 [1]
7-(2-Chlorophenyl)-13-methyl-4-[2-[4-(2-methylpropyl)phenyl]ethyl]-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaeneIC5030.0 [1]
3-[2-[2-(4-Bromophenyl)sulfonylethoxy]-3-methoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]-1-butyl-1-hydroxyureaIC5038.0 [1]
1-Butyl-3-[2-[2-(3,4-dichlorophenyl)sulfanylethoxy]-3-methoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]-1-hydroxyureaIC5045.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Platelet activating factor receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/platelet-activating-factor-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Platelet activating factor receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/platelet-activating-factor-receptor-inhibitors-ic50-ki.
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