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Plasminogen Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
Tranexamic acidIC5012000.0 [1]
Tranexamic acidKi40000000.0 [1]
RazaxabanKi15000.0 [1]
5-(4-Piperidyl)isoxazol-3-olIC50800.0 [1], 2800.0 [2]
6-(N-Phenylcarbamyl)-2-naphthalenecarboxamidineIC5022000.0 [1]
6-(N-Phenylcarbamyl)-2-naphthalenecarboxamidineKi1950.0 [1], 2000.0 [2]
EfegatranIC5025.0 [1], 230.0 [2], 670.0 [3]
Tert-butyloxy carbonyl-D-Phe-pro-Arg-HIC50190.0 [1], 950.0 [2]
Wx-uk1 free baseKi390.0 [1]
Tert-butyl N-[(1R)-2-[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]carbamateIC5098.0 [1], 8700.0 [2]
(2S)-N-[(2S)-5-(Diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(2R)-2-(methylamino)-2-phenylacetyl]pyrrolidine-2-carboxamideIC50490.0 [1], 500.0 [2], 42000.0 [3]
4-(Aminomethyl)-N-[(2S)-1-(hexylamino)-1-oxo-3-[4-(pyridin-3-ylmethoxy)phenyl]propan-2-yl]benzamideIC502900.0 [1], 4500.0 [2]
4-(Aminomethyl)-N-[(2S)-1-(hexylamino)-1-oxo-3-[4-(pyridin-3-ylmethoxy)phenyl]propan-2-yl]benzamideKi2900.0 [1]
Aminocaproic acidIC5040000.0 [1], 105000.0 [2]
ArgatrobanIC50800000.0 [1]
ArgatrobanKi257000.0 [1]
NafamostatIC50240.0 [1], 2900.0 [2]
MelagatranIC503060.0 [1]
MelagatranKi1800.0 [1]
Bis(5-amidino-2-benzimidazolyl)methaneIC5026000.0 [1]
Bis(5-amidino-2-benzimidazolyl)methaneKi2650.0 [1]
Naphthalene-2-carboximidamideKi51000.0 [1], 51300.0 [2]
1-[n-(Naphthalen-2-Ylsulfonyl)glycyl-4-Carbamimidoyl-D-Phenylalanyl]piperidineKi30000.0 [1]
2-[3-(Aminomethyl)phenyl]-N-[2-fluoro-4-(2-methylsulfonylphenyl)phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide;hydrochlorideKi35000.0 [1]
1-(4-Chlorophenyl)guanidineKi50000.0 [1], 10000000.0 [2]
2-{5-[Amino(iminio)methyl]-1H-benzimidazol-2-YL}benzenolateKi46000.0 [1]
2-(2-Hydroxyphenyl)-1H-indole-5-carboxamidineKi12000.0 [1]
2-{5-[Amino(iminio)methyl]-1H-indol-2-YL}-6-bromo-4-methylbenzenolateKi600.0 [1], 1200.0 [2]
[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[[4-(diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carboxylateKi494000.0 [1]
Ethyl N-[(2S)-6-amino-1-oxo-1-[5-[[4-(2-phenylethoxy)phenyl]methyl]-1,2,4-oxadiazol-3-yl]hexan-2-yl]carbamateKi430.0 [1]
4-[(E)-(5-Oxo-2-phenyl-1,3-oxazol-4-ylidene)methyl]benzenecarboximidamideIC50340.0 [1], 100000.0 [2]
1-Piperazino-2-[(2-naphthyl)sulfonylamino]-3-(3-amidinophenyl)-1-propanoneKi10200.0 [1]
6-[N-(4-(Aminomethyl)phenyl)carbamyl]-2-naphthalenecarboxamidineIC5062000.0 [1]
6-[N-(4-(Aminomethyl)phenyl)carbamyl]-2-naphthalenecarboxamidineKi16000.0 [1]
3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-piperidin-1-yl-propyl]-benzamidineKi7000.0 [1]
Diphenyl N-(benzyloxycarbonyl)amino(4-amidinophenyl)methanephosphonateIC502500.0 [1], 3600.0 [2]
2-[(3S)-3-(Benzylsulfonylamino)-2-oxopiperidin-1-yl]-N-[(3S)-1-carbamimidoyl-2-hydroxypiperidin-3-yl]acetamideIC502500.0 [1]
(2S)-3-(7-Carbamimidoylnaphthalen-2-yl)-2-[4-[(3S)-1-ethanimidoylpyrrolidin-3-yl]oxyphenyl]propanoic acid;hydrochlorideKi11000.0 [1], 23000.0 [2]
1-[2-(4-Amidinophenoxy)-4-methyl-7-quinolinyl]cyclopentane-1-carboxylic acid ethyl esterIC505800.0 [1]
Tert-butyl N-[(1R)-2-[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-(4-hydroxyphenyl)-2-oxoethyl]carbamateIC5094.0 [1], 16000.0 [2]
Tert-butyl N-[(1R)-1-cyclohexyl-2-[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]carbamateIC5081.0 [1], 2300.0 [2]
Tert-butyl N-[(1R)-2-[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-(4-fluorophenyl)-2-oxoethyl]carbamateIC5085.0 [1], 18000.0 [2]
(2S)-1-[(2R)-2-Amino-2-phenylacetyl]-N-[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pyrrolidine-2-carboxamideIC50910.0 [1], 39000.0 [2]
6-Carbamimidoyl-4-(furan-3-yl)-N-phenylnaphthalene-2-carboxamideKi320.0 [1], 321.0 [2]
6-Carbamimidoyl-N-phenyl-4-(pyrimidin-2-ylamino)naphthalene-2-carboxamideKi90.0 [1]
3(2H)-Isoxazolone, 4-methyl-5-(4-piperidinyl)-IC502000.0 [1], 5700.0 [2]
Benzyl N-[(2R)-1-[[(2S)-1-[[4-(diaminomethylideneamino)-1-diphenoxyphosphorylbutyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]carbamateIC5010800.0 [1]
3-Amino-N-[3-[[(2S)-3-(3-carbamimidoylphenyl)-1-[4-[2-(diaminomethylideneamino)ethyl]piperidin-1-yl]-1-oxopropan-2-yl]sulfamoyl]phenyl]propanamideKi5000.0 [1]
3-Amino-N-[3-[[(2S)-1-[4-(2-aminoethyl)piperidin-1-yl]-3-(3-carbamimidoylphenyl)-1-oxopropan-2-yl]sulfamoyl]phenyl]propanamideKi2400.0 [1]
N-[(1S)-5-Amino-1-cyanopentyl]-2-[[3-(4-fluorophenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-3-methylbenzimidazole-5-carboxamideIC50100000.0 [1]
(2R)-2-(Benzylsulfonylamino)-N-[(2S)-1-[[2-[4-(diaminomethylideneamino)phenyl]-1-diphenoxyphosphorylethyl]amino]-1-oxopropan-2-yl]-3-hydroxypropanamideIC5037.0 [1]
[5-[4-[(4-Carbamimidoylphenyl)methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[(4-carbamimidoylphenyl)methylcarbamoyl]piperazine-1-carboxylateKi134000.0 [1]
4-(1H-Tetrazol-5-YL)piperidineIC50100000.0 [1]
2-[2-(4-Amidinophenoxy)-4-methyl-7-quinolinyl]isobutyric acid ethyl esterIC5020000.0 [1]
[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(benzylcarbamoyl)piperazine-1-carboxylateKi1000000.0 [1]
[5-[4-(Benzylcarbamoyl)piperazine-1-carbonyl]oxycyclooctyl] 4-(benzylcarbamoyl)piperazine-1-carboxylateKi1000000.0 [1]
3-[3-(4-Methylsulfonylpiperazin-1-yl)-3-oxo-2-[[2,4,6-tri(propan-2-yl)phenyl]sulfonylamino]propyl]benzenecarboximidamideKi6400.0 [1], 8000.0 [2]
Bis-triazole derivative 10Ki0.77 [1]
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-(4-phenoxyphenyl)imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamideIC5014000.0 [1], 51000.0 [2]
N-[(1S)-1-[4-(3-Amino-1H-indazol-6-yl)pyridin-2-yl]-2-phenylethyl]-4-(aminomethyl)cyclohexane-1-carboxamideKi22100.0 [1]
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(4-fluorophenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamideIC5043000.0 [1], 130000.0 [2]
N-(Benzylsulfonyl)-D-Seryl-N-{4-[amino(Imino)methyl]benzyl}-L-AlaninamideKi540.0 [1]
2-(6-Chloronaphthalen-2-yl)-5-methyl-N-[4-(2-sulfamoylphenyl)phenyl]pyrazole-3-carboxamideIC5011000.0 [1]
2-(2-Hydroxy-3-phenyl-5-methylphenyl)-1H-indole-5-carboxamidineKi250.0 [1], 1500.0 [2]
Benzyl N-[(2R)-1-[[(2S)-1-[[2-[4-(diaminomethylideneamino)phenyl]-1-diphenoxyphosphorylethyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]carbamateIC502000.0 [1], 22000.0 [2]
Tert-butyl N-[(1S)-2-[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-(4-fluorophenyl)-2-oxoethyl]carbamateIC50770.0 [1], 91000.0 [2]
(2S)-N-[(2S)-5-(Diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(3R)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl]pyrrolidine-2-carboxamideIC50370.0 [1], 90000.0 [2]
Tert-butyl N-[(1R)-2-[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxo-1-thiophen-3-ylethyl]carbamateIC50150.0 [1], 13000.0 [2]
(2S)-N-[(2S)-5-(Diaminomethylideneamino)-1-oxopentan-2-yl]-1-(1,2,3,4-tetrahydroquinoline-2-carbonyl)pyrrolidine-2-carboxamideIC5015000.0 [1], 660000.0 [2]
Benzyl N-[2-[4-(diaminomethylideneamino)phenyl]-1-diphenoxyphosphorylethyl]carbamateIC503000.0 [1]
5-Methyl-2-(3-methylsulfonylnaphthalen-2-yl)-N-[4-(2-sulfamoylphenyl)phenyl]pyrazole-3-carboxamideIC5011000.0 [1]
5-Methyl-2-(3-sulfamoylnaphthalen-2-yl)-N-[4-(2-sulfamoylphenyl)phenyl]pyrazole-3-carboxamideIC5011000.0 [1]
Methyl 3-[3-methyl-5-[[4-(2-sulfamoylphenyl)phenyl]carbamoyl]pyrazol-1-yl]naphthalene-2-carboxylateIC5011000.0 [1]
2-(3-Bromonaphthalen-2-yl)-5-methyl-N-[4-(2-sulfamoylphenyl)phenyl]pyrazole-3-carboxamideIC5011000.0 [1]
2-(3-Carbamoylnaphthalen-2-yl)-5-methyl-N-[4-(2-sulfamoylphenyl)phenyl]pyrazole-3-carboxamideIC5011000.0 [1]
2-(3-Hydroxynaphthalen-2-yl)-5-methyl-N-[4-(2-sulfamoylphenyl)phenyl]pyrazole-3-carboxamideIC5011000.0 [1]
2-[3-(Hydroxymethyl)naphthalen-2-yl]-5-methyl-N-[4-(2-sulfamoylphenyl)phenyl]pyrazole-3-carboxamideIC5011000.0 [1]
2-[3-(N,N-Dimethylcarbamimidoyl)naphthalen-2-yl]-5-methyl-N-[4-(2-sulfamoylphenyl)phenyl]pyrazole-3-carboxamideIC5011000.0 [1]
Benzyl N-[3-(4-carbamimidoylphenyl)-1-diphenoxyphosphorylpropyl]carbamateIC506200.0 [1]
Benzyl N-[(2S)-1-[(2S)-2-[[2,2-dimethyl-1-[(2S,6R)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3,3-diphenylpropan-2-yl]carbamateKi17.0 [1], 71.0 [2]
2-(3-Carbamimidoylnaphthalen-2-yl)-5-methyl-N-[4-(2-sulfamoylphenyl)phenyl]pyrazole-3-carboxamideIC5011000.0 [1]
2-[3-(4,5-Dihydro-1H-imidazol-2-yl)naphthalen-2-yl]-5-methyl-N-[4-(2-sulfamoylphenyl)phenyl]pyrazole-3-carboxamideIC5011000.0 [1]
[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[(4-aminocyclohexyl)methylcarbamoyl]piperazine-1-carboxylateKi1000000.0 [1]
Tert-butyl N-[(1R)-2-[(2S)-2-[[5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-naphthalen-2-yl-2-oxoethyl]carbamateIC5055.0 [1], 12000.0 [2]
Tert-butyl N-[2-[(2S)-2-[[5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl]carbamateIC50130.0 [1], 15000.0 [2]
(2S)-N-[5-(Diaminomethylideneamino)-1-oxopentan-2-yl]-1-(1H-indole-2-carbonyl)pyrrolidine-2-carboxamideIC5018000.0 [1], 420000.0 [2]
Tert-butyl N-[(1R)-2-[(2S)-2-[[5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-naphthalen-1-yl-2-oxoethyl]carbamateIC50620.0 [1], 20000.0 [2]
Tert-butyl N-[2-[(2S)-2-[[5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-(3,4-dichlorophenyl)-2-oxoethyl]carbamateIC50180.0 [1], 31000.0 [2]
(2S)-N-[5-(Diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(2S)-2-methoxy-2-phenylacetyl]pyrrolidine-2-carboxamideIC5015000.0 [1], 860000.0 [2]
(2S)-N-[5-(Diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(2S)-2-phenylbutanoyl]pyrrolidine-2-carboxamideIC5021000.0 [1], 100000.0 [2]
(2S)-N-[5-(Diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(2S)-2-phenylpropanoyl]pyrrolidine-2-carboxamideIC5010000.0 [1], 18000.0 [2]
Benzyl N-[4-(diaminomethylideneamino)-1-diphenoxyphosphorylbutyl]carbamateIC5030000.0 [1]
5-((2S,4S)-2-Benzylpiperidin-4-yl)isoxazol-3(2H)-oneIC50580.0 [1], 2900.0 [2]
5-[(2r,4s)-2-(Phenylmethyl)piperidin-4-Yl]-1,2-Oxazol-3-OneIC50280.0 [1], 950.0 [2]
(12S,15R)-15-(Benzylsulfonylamino)-N-[(4-carbamimidoylphenyl)methyl]-3,14,24-trioxo-4,13,23-triazatetracyclo[24.2.2.16,10.117,21]dotriaconta-1(29),6,8,10(32),17(31),18,20,26(30),27-nonaene-12-carboxamideKi6.9 [1]
(12S,15R)-15-(Benzylsulfonylamino)-N-[(4-carbamimidoylphenyl)methyl]-3,14,24-trioxo-1,4,13,23,26-pentazatetracyclo[24.2.2.16,10.117,21]dotriaconta-6,8,10(32),17(31),18,20-hexaene-12-carboxamideKi4.1 [1], 4.9 [2]
(13S,16R)-16-(Benzylsulfonylamino)-N-[(4-carbamimidoylphenyl)methyl]-15-oxo-2,7-dioxa-14-azatricyclo[16.2.2.28,11]tetracosa-1(21),8,10,18(22),19,23-hexaene-13-carboxamideKi1.1 [1], 1.9 [2]
(7S,10R)-10-(Benzylsulfonylamino)-N-[(4-carbamimidoylphenyl)methyl]-4,9,13-trioxo-3,8,14-triazabicyclo[14.3.1]icosa-1(19),16(20),17-triene-7-carboxamideKi431.0 [1]
(19S,22R)-22-(Benzylsulfonylamino)-N-[(4-carbamimidoylphenyl)methyl]-4,11,21-trioxo-3,12,20-triazatetracyclo[22.2.2.26,9.214,17]dotriaconta-1(27),6,8,14(30),15,17(29),24(28),25,31-nonaene-19-carboxamideKi9.4 [1]
(19S,22R)-22-(Benzylsulfonylamino)-N-[(4-carbamimidoylphenyl)methyl]-4,11,21-trioxo-3,6,9,12,20-pentazatetracyclo[22.2.2.26,9.214,17]dotriaconta-1(27),14(30),15,17(29),24(28),25-hexaene-19-carboxamideKi9.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Plasminogen Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/plasminogen-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Plasminogen Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/plasminogen-inhibitors-ic50-ki.
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