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Plasminogen activator inhibitor-1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
TiplasininIC5010000.0 [1]
(3Z,6Z)-3-Benzylidene-6-[[5-[2-(dimethylamino)ethylsulfanyl]thiophen-2-yl]methylidene]piperazine-2,5-dioneIC503500.0 [1], 8000.0 [2], 106000.0 [3]
4-[3-[[2-[(1R,2S,5R)-5-Methyl-2-propan-2-ylcyclohexyl]oxyacetyl]amino]-4-nitrophenoxy]benzoic acidIC5010.0 [1], 380.0 [2]
8-[4-[(Z)-[(5Z)-3,6-Dioxo-5-[[4-(thiophene-2-carbonylamino)phenyl]methylidene]piperazin-2-ylidene]methyl]phenoxy]octanoic acidIC50200.0 [1], 260.0 [2], 510.0 [3]
AR-HO29953XXIC5013000.0 [1], 17800.0 [2]
2-[2-Methoxy-6-[[3-(trifluoromethyl)-4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]anilino]methyl]phenoxy]-5-nitrobenzoic acidIC50500.0 [1]
8-[4-[[3-Hydroxy-1-(4-methylphenyl)-5-oxo-2H-pyrrole-4-carbonyl]amino]phenoxy]octanoic acidIC501950.0 [1]
Methyl 8-[4-[[1-(4-chlorophenyl)-3-hydroxy-5-oxo-2H-pyrrole-4-carbonyl]amino]phenoxy]octanoateIC5050000.0 [1]
8-[4-[[1-(4-Chlorophenyl)-2-oxo-4-hydroxy-3-pyrroline-3-ylcarbonyl]amino]phenoxy]octanoic acidIC505000.0 [1]
N-[2-[(3,4-Dihydroxyphenyl)sulfonylamino]ethyl]-3,4-dihydroxybenzenesulfonamideIC50450000.0 [1], 518000.0 [2]
N-[2-[(3,4-Dihydroxyphenyl)sulfonyl-ethylamino]ethyl]-N-ethyl-3,4-dihydroxybenzenesulfonamideIC509320.0 [1], 10200.0 [2]
8-[4-[(E)-[(5Z)-3,6-Dioxo-5-[[4-(thiophene-2-carbonylamino)phenyl]methylidene]piperazin-2-ylidene]methyl]phenoxy]octanoic acidIC50200.0 [1], 510.0 [2]
4-[3-[[2-[(1R,2S,5R)-5-Methyl-2-propan-2-ylcyclohexyl]oxyacetyl]amino]-4-nitroanilino]cyclohexane-1-carboxylic acidIC50900.0 [1], 1100.0 [2]
2-[2-Methoxy-6-[[4-[[[2-[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]oxyacetyl]amino]methyl]anilino]methyl]phenoxy]-5-nitrobenzoic acidIC50100.0 [1], 1200.0 [2]
1-[3-[[2-[(1R,2S,5R)-5-Methyl-2-propan-2-ylcyclohexyl]oxyacetyl]amino]-4-nitrophenyl]piperidine-4-carboxylic acidIC5010.0 [1], 940.0 [2]
3-[3-[[2-[(1R,2S,5R)-5-Methyl-2-propan-2-ylcyclohexyl]oxyacetyl]amino]-4-nitrophenoxy]benzoic acidIC50100.0 [1], 400.0 [2]
8-[4-[[6-(1-Benzothiophen-3-yl)-4-hydroxy-2-oxo-1H-quinoline-3-carbonyl]amino]phenoxy]octanoic acidIC50510.0 [1], 940.0 [2]
3-Hydroxy-1-(4-methylphenyl)-5-oxo-N-[4-[7-(tetrazol-1-yl)heptoxy]phenyl]-2H-pyrrole-4-carboxamideIC50830.0 [1], 890.0 [2]
1-(4-Chlorophenyl)-3-hydroxy-5-oxo-N-[4-[7-(tetrazol-1-yl)heptoxy]phenyl]-2H-pyrrole-4-carboxamideIC50300.0 [1], 690.0 [2]
6-(1-Benzothiophen-2-yl)-4-hydroxy-2-oxo-N-[4-[7-(tetrazol-1-yl)heptoxy]phenyl]-1H-quinoline-3-carboxamideIC50290.0 [1], 1010.0 [2]
9-Hydroxy-3-methoxy-4,7-dimethyl-10-[[4-[[[2-[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]oxyacetyl]amino]methyl]anilino]methyl]-6-oxobenzo[b][1,4]benzodioxepine-1-carboxylic acidIC50100.0 [1], 1400.0 [2]
[4-(3,4,5-Trihydroxybenzoyl)oxycyclohexyl] 3,4,5-trihydroxybenzoateIC5050.0 [1], 332000.0 [2]
D-Glucopyranose, pentakis(3,4,5-trihydroxybenzoate)IC5010.0 [1]
Sideroxylonal CIC504700.0 [1]
TM 5275 freeIC507940.0 [1]
3-Benzylidene-6-(4'-methoxybenzylidene)piperazine-2,5-dioneIC5059400.0 [1]
5-Chloro-2-[(4-phenylbenzoyl)amino]benzoic acidIC502980.0 [1]
Euglobal IA2IC50138000.0 [1]
(1'S,2R,4R,5'R)-5,7-Dihydroxy-6',6'-dimethyl-4-(2-methylpropyl)spiro[3,4-dihydrochromene-2,2'-bicyclo[3.1.1]heptane]-6,8-dicarbaldehydeIC50152000.0 [1]
1,2-Bis[(3,4,5-Trihydroxybenzoyl)Oxy]BenzeneIC502960.0 [1]
2-[2-Methoxy-6-[[4-[[[2-[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]oxyacetyl]amino]methyl]anilino]methyl]phenoxy]pyridine-3-carboxylic acidIC50500.0 [1]
3,4,5-Trihydroxy-N-[3-[(3,4,5-trihydroxybenzoyl)amino]propyl]benzamideIC50269000.0 [1]
8-[4-[(Z)-[(5Z)-3,6-Dioxo-5-[[4-(thiophene-2-carbonylamino)phenyl]methylidene]piperazin-2-ylidene]methyl]anilino]-8-oxooctanoic acidIC50520.0 [1]
(1-Benzyl-6-phenyl-1H-indol-3-yl)(oxo)acetic AcidIC5026000.0 [1]
[1-(4-Tert-Butyl-benzyl)-6-(4-trifluoromethoxy-phenyl)-1H-indol-3-yl]-oxo-acetic acidIC5050000.0 [1]
1,2-Bis[(3,4,5-Trihydroxybenzoyl)Oxy]EthaneIC50370.0 [1]
{1-Benzyl-5-[3-(trifluoromethoxy)phenyl]-1H-indol-3-yl}(oxo)acetic AcidIC509800.0 [1]
{1-Benzyl-7-[4-(trifluoromethoxy)phenyl]-1H-indol-3-yl}(oxo)acetic AcidIC5010000.0 [1]
{1-(4-Tert-Butylbenzyl)-5-[4-(trifluoromethoxy)phenyl]-1H-indol-3-yl}(oxo)acetic AcidIC5016000.0 [1]
{1-Benzyl-4-[4-(trifluoromethoxy)phenyl]-1H-indol-3-yl}(oxo)acetic AcidIC5050000.0 [1]
AleplasininIC508600.0 [1]
{1-Benzyl-6-[4-(trifluoromethoxy)phenyl]-1H-indol-3-yl}(oxo)acetic AcidIC5017000.0 [1]
[(1S,2R)-2-(3,4,5-Trihydroxybenzoyl)oxycyclohexyl] 3,4,5-trihydroxybenzoateIC50280.0 [1]
10-[4-[(Z)-[(5Z)-3,6-Dioxo-5-[[4-(thiophene-2-carbonylamino)phenyl]methylidene]piperazin-2-ylidene]methyl]anilino]-10-oxodecanoic acidIC50390.0 [1]
[1-(4-Tert-Butyl-benzyl)-5-(3-methoxy-phenyl)-1H-indol-3-yl]-oxo-acetic acidIC5021000.0 [1]
Sideroxylonal AIC503300.0 [1]
(3Z,6Z)-3-(2-Pyridinylmethylene)-6-[4-[3-(3-pyridinyl)propoxy]benzylidene]piperazine-2,5-dioneIC50300.0 [1]
(3Z,6Z)-3-(2-Thiazolylmethylene)-6-[4-[3-(3-pyridinyl)propoxy]benzylidene]piperazine-2,5-dioneIC50600.0 [1]
9-Hydroxy-3-methoxy-4,7-dimethyl-10-[[[6-[[2-[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]oxyacetyl]amino]pyridin-3-yl]amino]methyl]-6-oxobenzo[b][1,4]benzodioxepine-1-carboxylic acidIC50530.0 [1]
3,4,5-Trihydroxy-N-[2-[(3,4,5-trihydroxybenzoyl)amino]ethyl]benzamideIC50900000.0 [1]
1-Benzyl-3-phenyl-5-(4-trifluoromethoxy-benzenesulfonylamino)-1H-indole-2-carboxylic acidIC508300.0 [1]
1-Biphenyl-4-ylmethyl-5-(4-tert-butyl-phenylamino)-3-phenyl-1H-indole-2-carboxylic acidIC5012000.0 [1]
1-Benzyl-5-(biphenyl-4-sulfonylamino)-3-phenyl-1H-indole-2-carboxylic acidIC5023000.0 [1]
1-Benzyl-5-(4-tert-butyl-benzenesulfonylamino)-3-phenyl-1H-indole-2-carboxylic acidIC5028700.0 [1]
5-Benzenesulfonylamino-1-biphenyl-4-ylmethyl-3-phenyl-1H-indole-2-carboxylic acidIC5028000.0 [1]
7-Nitro-3-{[2-(phenyloxy)phenyl]amino}-4H-1,2,4-benzothiadiazin-5-ol 1,1-dioxideIC507900.0 [1]
[(2R,3R,4S,5S,6S)-3,4,5,6-Tetrakis[(3,4,5-trihydroxybenzoyl)oxy]oxan-2-yl]methyl 3,4,5-trihydroxybenzoateIC5010.0 [1]
[(2R,3S,4S,5R,6R)-3,4,5,6-Tetrakis[(3,4,5-trihydroxybenzoyl)oxy]oxan-2-yl]methyl 3,4,5-trihydroxybenzoateIC5010.0 [1]
[(2R,3S,4S,5R,6S)-3,4,5,6-Tetrakis[(3,4,5-trihydroxybenzoyl)oxy]oxan-2-yl]methyl 3,4,5-trihydroxybenzoateIC5010.0 [1]
Euglobal IICIC50700000.0 [1]
Methyl 8-[4-[(Z)-[(5Z)-3,6-dioxo-5-[[4-(thiophene-2-carbonylamino)phenyl]methylidene]piperazin-2-ylidene]methyl]phenoxy]octanoateIC501930.0 [1]
5-Chloro-2-[(4-propan-2-yloxybenzoyl)amino]benzoic acidIC5010000.0 [1]
5-Chloro-2-[[4-(oxan-4-yl)benzoyl]amino]benzoic acidIC5021600.0 [1]
(E)-3-[3-(4-Chlorophenoxy)-5,6-bis[(2-phenylphenyl)methoxy]-1-benzothiophen-2-yl]-2-pyridin-4-ylprop-2-enoic acidIC5010800.0 [1]
CID 16770662IC505200.0 [1]
(E)-3-[3-(4-Imidazol-1-ylphenoxy)-5,6-bis[(4-phenylphenyl)methoxy]-1-benzothiophen-2-yl]-2-pyridin-4-ylprop-2-enoic acidIC502910.0 [1]
(E)-3-[3-(3-Fluorophenoxy)-5,6-bis[(4-phenylphenyl)methoxy]-1-benzothiophen-2-yl]-2-pyridin-4-ylprop-2-enoic acidIC50240.0 [1]
(E)-3-[3-(6-Chloropyridin-3-yl)oxy-5,6-bis[(4-phenylphenyl)methoxy]-1-benzothiophen-2-yl]-2-pyridin-4-ylprop-2-enoic acidIC502070.0 [1]
(E)-3-[3-(4-Chlorophenoxy)-5,6-bis[(4-phenylsulfanylphenyl)methoxy]-1-benzothiophen-2-yl]-2-pyridin-4-ylprop-2-enoic acidIC5039.0 [1]
(E)-3-[3-(4-Chlorophenoxy)-5,6-bis[(4-phenoxyphenyl)methoxy]-1-benzothiophen-2-yl]-2-pyridin-4-ylprop-2-enoic acidIC50100.0 [1]
(E)-3-[5,6-Bis[(4-benzylphenyl)methoxy]-3-(4-chlorophenoxy)-1-benzothiophen-2-yl]-2-pyridin-4-ylprop-2-enoic acidIC50270.0 [1]
2-[N-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-4-[[3,5-bis(trifluoromethyl)phenyl]sulfonyl-methylamino]anilino]-2-oxoacetic acidIC505000.0 [1]
2-[N-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-4-[[3-(trifluoromethyl)phenyl]sulfonylamino]anilino]-2-oxoacetic acidIC504500.0 [1]
2-[N-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-4-[4-(trifluoromethoxy)phenyl]anilino]-2-oxoacetic acidIC5014400.0 [1]
2-[N-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-4-[(4-methoxyphenyl)sulfonylamino]anilino]-2-oxoacetic acidIC5080000.0 [1]
2-[N-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-4-[[3-(trifluoromethoxy)phenyl]sulfonylamino]anilino]-2-oxoacetic acidIC5015400.0 [1]
2-[N-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-4-[methyl-[4-(trifluoromethoxy)phenyl]sulfonylamino]anilino]-2-oxoacetic acidIC5025000.0 [1]
2-[N-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-4-[pentyl-[4-(trifluoromethoxy)phenyl]sulfonylamino]anilino]-2-oxoacetic acidIC5014900.0 [1]
2-[N-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-4-[[4-(trifluoromethoxy)phenyl]methyl-[4-(trifluoromethoxy)phenyl]sulfonylamino]anilino]-2-oxoacetic acidIC508500.0 [1]
2-[N-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-4-[methyl-[4-(trifluoromethyl)phenyl]sulfonylamino]anilino]-2-oxoacetic acidIC5061000.0 [1]
2-[N-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-4-[[3,5-bis(trifluoromethyl)phenyl]sulfonyl-propylamino]anilino]-2-oxoacetic acidIC508400.0 [1]
2-Oxo-2-[4-[4-(trifluoromethoxy)phenyl]-N-[[3-(trifluoromethyl)phenyl]methyl]anilino]acetic acidIC5023000.0 [1]
2-[N-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-4-[(4-chlorophenyl)sulfonylamino]anilino]-2-oxoacetic acidIC5075000.0 [1]
2-[N-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-4-[(3,4-difluorophenyl)sulfonylamino]anilino]-2-oxoacetic acidIC5029900.0 [1]
2-[N-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-4-[prop-2-enyl-[3-(trifluoromethyl)phenyl]sulfonylamino]anilino]-2-oxoacetic acidIC5011000.0 [1]
2-[N-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-4-[[4-(trifluoromethoxy)phenyl]sulfonylamino]anilino]-2-oxoacetic acidIC509300.0 [1]
2-[N-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-4-[[2-(trifluoromethoxy)phenyl]sulfonylamino]anilino]-2-oxoacetic acidIC50114000.0 [1]
2-[N-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-4-[propyl-[4-(trifluoromethoxy)phenyl]sulfonylamino]anilino]-2-oxoacetic acidIC5021000.0 [1]
2-[4-[Benzyl-[4-(trifluoromethoxy)phenyl]sulfonylamino]-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]anilino]-2-oxoacetic acidIC5043000.0 [1]
2-[N-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-4-[[4-(trifluoromethyl)phenyl]sulfonylamino]anilino]-2-oxoacetic acidIC5086000.0 [1]
2-[N-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-4-[[4-(trifluoromethyl)phenyl]methyl-[3-(trifluoromethyl)phenyl]sulfonylamino]anilino]-2-oxoacetic acidIC505400.0 [1]
2-[N-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-4-[[3,5-bis(trifluoromethyl)phenyl]sulfonyl-prop-2-enylamino]anilino]-2-oxoacetic acidIC5012800.0 [1]
2-[N-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-4-[prop-2-enyl-[4-(trifluoromethoxy)phenyl]sulfonylamino]anilino]-2-oxoacetic acidIC5013300.0 [1]
4-Hydroxy-3-phenyl-2H-isoquinolin-1-oneIC5050000.0 [1]
5-Chloro-2-[[2-[[3-(furan-3-yl)phenyl]methylamino]-2-oxoacetyl]amino]benzoic acidIC503550.0 [1]
5-Chloro-2-([(2-([3-(furan-3-yl)benzyl]amino)-2-oxoethoxy)acetyl]amino)benzoic acidIC507450.0 [1]
5-Chloro-2-[[2-[3-(furan-3-yl)anilino]-2-oxoacetyl]amino]benzoic acidIC503560.0 [1]
(E)-3-[5,6-Bis[[4-(benzenesulfonyl)phenyl]methoxy]-3-(4-chlorophenoxy)-1-benzothiophen-2-yl]-2-pyridin-4-ylprop-2-enoic acidIC50770.0 [1]
Methyl (E)-3-[3-(4-chlorophenoxy)-5,6-bis(phenylmethoxy)-1-benzothiophen-2-yl]-2-pyridin-4-ylprop-2-enoateIC50470.0 [1]
(3Z,6Z)-1-Methyl-3-[4-[3-(3-pyridinyl)propoxy]benzylidene]-6-benzylidenepiperazine-2,5-dioneIC5012000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Plasminogen activator inhibitor-1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/plasminogen-activator-inhibitor-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Plasminogen activator inhibitor-1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/plasminogen-activator-inhibitor-1-inhibitors-ic50-ki.
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