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PI4-kinase alpha subunit Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
IdelalisibIC5010000.0 [1]
PictilisibIC5010000.0 [1]
Torin 1IC5010000.0 [1]
ApitolisibIC5010000.0 [1]
Torin 2IC5010000.0 [1]
N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamideIC501100.0 [1]
4-[2-[(6-Methoxypyridin-3-yl)amino]-5-[(4-methylsulfonylpiperazin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amineIC5010000.0 [1]
Chmfl-PI3KD-317IC50574.1 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC505888.44 [1]
6-(6-Methoxypyridin-3-yl)benzo[d]thiazol-2-amineIC50630.96 [1]
6-Phenylbenzo[d]thiazol-2-amineIC502511.89 [1]
6-(Pyridin-4-yl)benzo[d]thiazol-2-amineIC502511.89 [1]
N-[5-(2-Amino-4-oxo-3-phenylquinazolin-6-yl)-2-methoxypyridin-3-yl]-2,4-difluorobenzenesulfonamideIC501.58 [1]
N-[2-Amino-5-(2-amino-4-oxo-3-phenylquinazolin-6-yl)pyridin-3-yl]-2,4-difluorobenzenesulfonamideIC500.79 [1]
2,4-Difluoro-N-[2-methoxy-5-(4-morpholin-4-ylquinazolin-6-yl)pyridin-3-yl]benzenesulfonamideIC501.58 [1]
N-[5-(2-Amino-3-phenylquinolin-6-yl)-2-methoxypyridin-3-yl]-2,4-difluorobenzenesulfonamideIC50100.0 [1]
N-[5-[2-Amino-3-(4-morpholin-4-ylphenyl)quinolin-6-yl]-2-methoxypyridin-3-yl]-2,4-difluorobenzenesulfonamideIC5039.81 [1]
N-[5-(2-Amino-4-oxo-3-phenylquinazolin-6-yl)-2-methoxypyridin-3-yl]-2,4-difluoro-N-methylbenzenesulfonamideIC503981.07 [1]
N-[5-(2-Amino-4-oxo-3-phenylquinazolin-6-yl)-2-methoxyphenyl]-2,4-difluorobenzenesulfonamideIC50316.23 [1]
N-[5-(7-Amino-6-phenyl-1,8-naphthyridin-3-yl)-2-methoxypyridin-3-yl]-2,4-difluorobenzenesulfonamideIC50630.96 [1]
N-[5-(6-Amino-7-phenyl-1,5-naphthyridin-2-yl)-2-methoxypyridin-3-yl]-2,4-difluorobenzenesulfonamideIC507943.28 [1]
N-[5-(2-Amino-3-phenylquinoxalin-6-yl)-2-methoxypyridin-3-yl]-2,4-difluorobenzenesulfonamideIC505.01 [1]
N-[5-(2-Amino-3-phenyl-1,7-naphthyridin-6-yl)-2-methoxypyridin-3-yl]-2,4-difluorobenzenesulfonamideIC50199.53 [1]
N-[2-[[6-Chloro-3-[3-(dimethylsulfamoyl)phenyl]-2-methylimidazo[1,2-b]pyridazin-8-yl]amino]ethyl]acetamideIC50100000.0 [1]
6-(6-Ethoxypyridin-3-yl)-1,3-benzothiazol-2-amineIC50158.49 [1]
6-(6-Ethylsulfanylpyridin-3-yl)-1,3-benzothiazol-2-amineIC50100.0 [1]
6-[6-(Methoxymethyl)pyridin-3-yl]-1,3-benzothiazol-2-amineIC501000.0 [1]
6-[6-(Methylaminomethyl)pyridin-3-yl]-1,3-benzothiazol-2-amineIC502511.89 [1]
6-(6-Propan-2-yloxypyridin-3-yl)-1,3-benzothiazol-2-amineIC5079.43 [1]
6-[6-(Ethylamino)pyridin-3-yl]-1,3-benzothiazol-2-amineIC50630.96 [1]
6-[6-[Ethyl(methyl)amino]pyridin-3-yl]-1,3-benzothiazol-2-amineIC50630.96 [1]
[5-(2-Amino-1,3-benzothiazol-6-yl)pyridin-2-yl]methanolIC501584.89 [1]
6-(6-Methylpyridin-3-yl)-1,3-benzothiazol-2-amineIC501584.89 [1]
6-[6-(Trifluoromethyl)pyridin-3-yl]-1,3-benzothiazol-2-amineIC5015848.93 [1]
6-(6-Methylsulfonylpyridin-3-yl)-1,3-benzothiazol-2-amineIC5025118.86 [1]
2-[5-(2-Amino-1,3-benzothiazol-6-yl)pyridin-2-yl]oxyethanolIC50316.23 [1]
6-[6-(2-Methoxyethoxy)pyridin-3-yl]-1,3-benzothiazol-2-amineIC50316.23 [1]
5-(2-Amino-1,3-benzothiazol-6-yl)-N-methylpyridine-2-carboxamideIC503162.28 [1]
5-(2-Amino-1,3-benzothiazol-6-yl)-N,N-dimethylpyridine-2-carboxamideIC501258.93 [1]
6-(5-Propan-2-yloxypyridin-3-yl)-1,3-benzothiazol-2-amineIC501000.0 [1]
6-Pyridin-2-yl-1,3-benzothiazol-2-amineIC5010000.0 [1]
6-Pyrimidin-2-yl-1,3-benzothiazol-2-amineIC5015848.93 [1]
6-Pyrazin-2-yl-1,3-benzothiazol-2-amineIC507943.28 [1]
5-(2-Amino-1,3-benzothiazol-6-yl)-1H-pyridin-2-oneIC503162.28 [1]
4-(2-Amino-1,3-benzothiazol-6-yl)-1H-pyridin-2-oneIC50316.23 [1]
6-(1-Methylpyrazol-3-yl)-1,3-benzothiazol-2-amineIC502511.89 [1]
6-(2-Methylpyrazol-3-yl)-1,3-benzothiazol-2-amineIC5012589.25 [1]
6-(1-Ethylpyrazol-4-yl)-1,3-benzothiazol-2-amineIC503162.28 [1]
6-(1-Propylpyrazol-4-yl)-1,3-benzothiazol-2-amineIC501584.89 [1]
6-(1-Propan-2-ylpyrazol-4-yl)-1,3-benzothiazol-2-amineIC5025118.86 [1]
6-(1-Cyclopropylpyrazol-4-yl)-1,3-benzothiazol-2-amineIC507943.28 [1]
6-[1-(Cyclopropylmethyl)pyrazol-4-yl]-1,3-benzothiazol-2-amineIC50630.96 [1]
6-(1-Benzylpyrazol-4-yl)-1,3-benzothiazol-2-amineIC50158.49 [1]
4-(2-Amino-1,3-benzothiazol-6-yl)-1-methylpyridin-2-oneIC50501.19 [1]
4-(2-Amino-1,3-benzothiazol-6-yl)-1-ethylpyridin-2-oneIC50316.23 [1]
4-(2-Amino-1,3-benzothiazol-6-yl)-1-(2-methoxyethoxy)pyridin-2-oneIC50630.96 [1]
1-(Cyclopropylmethyl)-4-[2-(oxan-4-ylmethylamino)-1,3-benzothiazol-6-yl]pyridin-2-oneIC505.01 [1]
1-(Cyclopropylmethyl)-4-[2-[[(1R)-1-(oxan-4-yl)ethyl]amino]-1,3-benzothiazol-6-yl]pyridin-2-oneIC507.94 [1]
1-(Cyclopropylmethyl)-4-[2-[[(1S)-1-(oxan-4-yl)ethyl]amino]-1,3-benzothiazol-6-yl]pyridin-2-oneIC5039.81 [1]
1-(Cyclopropylmethyl)-4-[2-[(1,1-dioxothian-4-yl)methylamino]-1,3-benzothiazol-6-yl]pyridin-2-oneIC502.0 [1]
4-[[[6-[1-(Cyclopropylmethyl)-2-oxopyridin-4-yl]-1,3-benzothiazol-2-yl]amino]methyl]cyclohexane-1-carboxylic acidIC501.0 [1]
N-[2-[[6-Chloro-3-(4-methoxy-3-morpholin-4-ylsulfonylphenyl)-2-methylimidazo[1,2-b]pyridazin-8-yl]amino]ethyl]acetamideIC5048000.0 [1]
N-[2-[[6-Chloro-3-[3-[4-(hydroxymethyl)piperidin-1-yl]sulfonyl-4-methoxyphenyl]-2-methylimidazo[1,2-b]pyridazin-8-yl]amino]ethyl]acetamideIC508190.0 [1]
N-[2-[[3-[3-[(4-Aminocyclohexyl)sulfamoyl]-4-methoxyphenyl]-6-chloro-2-methylimidazo[1,2-b]pyridazin-8-yl]amino]ethyl]acetamideIC50660.0 [1]
N-[2-[[6-Chloro-3-[3-(1-hydroxybutan-2-ylsulfamoyl)-4-methoxyphenyl]-2-methylimidazo[1,2-b]pyridazin-8-yl]amino]ethyl]acetamideIC5012280.0 [1]
N-[2-[[6-Chloro-3-[4-methoxy-3-[2-(methylamino)ethylsulfamoyl]phenyl]-2-methylimidazo[1,2-b]pyridazin-8-yl]amino]ethyl]acetamideIC5017070.0 [1]
N-(4-Aminocyclohexyl)-5-[6-chloro-8-[(2-ethylpyridin-4-yl)methylamino]-2-methylimidazo[1,2-b]pyridazin-3-yl]-2-methoxybenzenesulfonamideIC50553.0 [1]
N-[2-[[6-Chloro-3-[3-[2-(dimethylamino)ethylsulfamoyl]-4-methoxyphenyl]-2-methylimidazo[1,2-b]pyridazin-8-yl]amino]ethyl]acetamideIC504860.0 [1]
5-[6-Chloro-8-[(2-ethylpyridin-4-yl)methylamino]-2-methylimidazo[1,2-b]pyridazin-3-yl]-N-(2-hydroxyethyl)-2-methoxybenzenesulfonamideIC5013400.0 [1]
5-[6-Chloro-8-[(2-ethylpyridin-4-yl)methylamino]-2-methylimidazo[1,2-b]pyridazin-3-yl]-N-[2-(dimethylamino)ethyl]-2-methoxybenzenesulfonamideIC501128.0 [1]
(2S)-2-Amino-N-[5-[6-chloro-5-[(4-methylphenyl)sulfonylamino]pyridin-3-yl]-4-methyl-1,3-thiazol-2-yl]-3-methylbutanamideIC50163.7 [1]
(2S)-2-Amino-N-[5-[6-chloro-5-[(2-methylphenyl)sulfonylamino]pyridin-3-yl]-4-methyl-1,3-thiazol-2-yl]-3-methylbutanamideIC50130.6 [1]
6-(1-Methylpyrazol-4-yl)-1,3-benzothiazol-2-amineIC502511.89 [1]
SureCN6875931IC5010000.0 [1]
N-[5-(2-Amino-4-oxo-3-phenylquinazolin-6-yl)-2-methoxypyridin-3-yl]benzenesulfonamideIC502.51 [1]
N-[5-(2-Amino-4-oxo-3-phenylquinazolin-6-yl)-2-methoxypyridin-3-yl]-2-methylbenzenesulfonamideIC501.0 [1]
N-[5-(2-Amino-4-oxo-3-phenylquinazolin-6-yl)-2-methoxypyridin-3-yl]-3-methylbenzenesulfonamideIC503.98 [1]
N-[5-(2-Amino-4-oxo-3-phenylquinazolin-6-yl)-2-methoxypyridin-3-yl]-4-cyanobenzenesulfonamideIC501.0 [1]
N-[5-(2-Amino-4-oxo-3-phenylquinazolin-6-yl)-2-methoxypyridin-3-yl]methanesulfonamideIC5019.95 [1]
N-[5-(2-Amino-4-oxo-3-phenylquinazolin-6-yl)-2-methoxypyridin-3-yl]propane-2-sulfonamideIC50125.89 [1]
N-[5-(2-Amino-4-oxo-3-phenylquinazolin-6-yl)-2-methoxypyridin-3-yl]pyridine-3-sulfonamideIC500.32 [1]
5-[2-Amino-4-oxo-3-[2-(trifluoromethyl)phenyl]quinazolin-6-yl]-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamideIC5015.85 [1]
CID 58441401IC501000.0 [1]
5-[2-Amino-4-oxo-3-(2-propan-2-ylphenyl)quinazolin-6-yl]-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamideIC5031.62 [1]
5-[2-Amino-3-(2-methylphenyl)-4-oxoquinazolin-6-yl]-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamideIC5010.0 [1]
5-[2-Amino-4-oxo-3-[4-(trifluoromethyl)phenyl]quinazolin-6-yl]-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamideIC5050.12 [1]
N-[5-(2-Amino-4-oxo-3-phenylquinazolin-6-yl)-2-methoxypyridin-3-yl]-4-methylbenzenesulfonamideIC5015.85 [1]
5-[2-Amino-4-oxo-3-[3-(trifluoromethyl)phenyl]quinazolin-6-yl]-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamideIC5050.12 [1]
5-(2-Amino-4-oxo-3-phenylquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamideIC506.31 [1]
5-(2-Amino-3-ethyl-4-oxoquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamideIC5039.81 [1]
5-[2-Amino-3-(oxan-4-yl)-4-oxoquinazolin-6-yl]-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamideIC5010.0 [1]
Tert-butyl 3-[[8-(2-chlorophenyl)-4,5-dihydro-[1,3]thiazolo[4,5-h]quinazolin-2-yl]carbamoylamino]propanoateIC50450.0 [1]
6-(Pyridin-3-yl)benzo[d]thiazol-2-amineIC501584.89 [1]
1-(Cyclopropylmethyl)-4-(2-aminobenzothiazole-6-yl)pyridine-2(1H)-oneIC506.31 [1]
6-(5-Methylsulfonylpyridin-3-yl)-1,3-benzothiazol-2-amineIC50398.11 [1]
Items per page: 1 - 10 of 95
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References

This online tool may be cited as follows

MLA

"Quest Database™ PI4-kinase alpha subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/pi4-kinase-alpha-subunit-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ PI4-kinase alpha subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/pi4-kinase-alpha-subunit-inhibitors-ic50-ki.
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