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PI3K p110 beta/p85 alpha Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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DactolisibIC5016.23 [1], 35.9 [2], 421.0 [3], 478.0 [4]
CID 46927938Ki170.0 [1]
IdelalisibIC50600.0 [1], 3700.0 [2]
PictilisibIC5054.0 [1], 108.0 [2]
DuvelisibIC5049.0 [1], 1000.0 [2]
N-[4-[[4-[2-(Difluoromethyl)-4-methoxybenzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]amino]cyclohexyl]methanesulfonamideIC501000.0 [1]
BuparlisibIC50234.0 [1]
FimepinostatIC5054.0 [1]
4-[2-[(6-Methoxypyridin-3-yl)amino]-5-[(4-methylsulfonylpiperazin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amineKi5.0 [1]
4-[2-[(5-Fluoro-6-methoxypyridin-3-yl)amino]-5-[(1R)-1-(4-methylsulfonylpiperazin-1-yl)ethyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amineKi6.0 [1]
CID 91933883IC503500.0 [1]
Chembl4126445IC5019952.62 [1]
Chembl4126156IC5031622.78 [1]
4-[2-[(5-Fluoro-6-methoxypyridin-3-yl)amino]-5-[(1S)-1-(4-methylsulfonylpiperazin-1-yl)ethyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amineKi3.0 [1]
4-Amino-6-[[(1S)-1-[3-methyl-6-[3-[[4-[methyl(2-methylpropyl)amino]piperidin-1-yl]methyl]phenyl]-5-oxo-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrileIC5079.43 [1]
8-Chloro-2-phenyl-3-[1-(7H-purin-6-ylamino)ethyl]isoquinolin-1-oneIC501000.0 [1]
4-Amino-6-[[(1S)-1-(5-methyl-4-oxo-3-phenylpyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino]pyrimidine-5-carbonitrileIC50120.0 [1]
N-[2-Methoxy-5-[1-methyl-4-[(3R)-1-[(1,3,5-trimethylpyrazol-4-yl)methyl]pyrrolidin-3-yl]oxypyrazolo[3,4-b]pyridin-6-yl]pyridin-3-yl]methanesulfonamideIC50520.0 [1]
N-[(E)-(5-Cyanopyrazolo[1,5-a]pyridin-3-yl)methylideneamino]-N-(2-hydroxyethyl)-2-methyl-5-nitrobenzenesulfonamideIC5051.0 [1]
N-[3-(Dimethylamino)propyl]-6-(1H-indazol-4-yl)-8-morpholin-4-ylimidazo[1,2-a]pyrazine-2-carboxamideKi500.0 [1]
4-Amino-6-[[(1S)-1-(4-oxo-3-phenylpyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino]pyrimidine-5-carbonitrileIC50640.0 [1]
4-Amino-6-[[(1S)-1-(5-chloro-4-oxo-3-phenylquinazolin-2-yl)ethyl]amino]pyrimidine-5-carbonitrileIC5054.0 [1]
N-[4-[4-[[(1S)-1-(5-Methyl-4-oxo-3-phenylpyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-1H-indol-6-yl]methanesulfonamideIC5010.0 [1]
8-Chloro-2-[(S)-cyclopropyl-[(2,6-diamino-5-chloropyrimidin-4-yl)amino]methyl]-6-fluoro-3-(1H-pyrazol-5-yl)quinazolin-4-oneIC5028.0 [1]
2-Amino-4-[[(1S)-1-[5-chloro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]ethyl]amino]-6-(trifluoromethyl)pyrimidine-5-carbonitrileIC50671.0 [1]
2,4-Diamino-6-[[(S)-[8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]-cyclopropylmethyl]amino]pyrimidine-5-carbonitrileIC500.7 [1]
2-Amino-4-chloro-6-[[(S)-[5-chloro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]-cyclopropylmethyl]amino]pyrimidine-5-carbonitrileIC505.2 [1]
2-[(1S)-1-[(2,6-Diamino-5-chloropyrimidin-4-yl)amino]ethyl]-6-fluoro-3-(1H-pyrazol-5-yl)quinazolin-4-oneIC5042.0 [1]
4-Amino-6-[[(1S)-1-[5-chloro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]ethyl]amino]pyrimidine-5-carbonitrileIC502.5 [1]
2-Amino-4-[[(S)-[8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]-cyclopropylmethyl]amino]-6-(difluoromethyl)pyrimidine-5-carbonitrileIC504.5 [1]
PI3K-IN-6IC507.8 [1]
2-[(1S)-1-[(2,6-Diamino-5-chloropyrimidin-4-yl)amino]ethyl]-6,8-difluoro-3-(1H-pyrazol-5-yl)quinazolin-4-oneIC5017.0 [1]
2,4-Diamino-6-[[(S)-[5-chloro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]-cyclopropylmethyl]amino]pyrimidine-5-carbonitrileIC501.6 [1]
5-Chloro-2-[(1S)-1-[(2,6-diaminopyrimidin-4-yl)amino]ethyl]-3-(1H-pyrazol-5-yl)quinazolin-4-oneIC501584.0 [1]
5-Chloro-2-[(1S)-1-[(2,6-diamino-5-chloropyrimidin-4-yl)amino]ethyl]-3-(1H-pyrazol-5-yl)quinazolin-4-oneIC502.1 [1]
2-Amino-4-[[(1S)-1-[8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]ethyl]amino]-6-(difluoromethyl)pyrimidine-5-carbonitrileIC502.6 [1]
2-Amino-4-(difluoromethyl)-6-[[(1S)-1-[8-fluoro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]ethyl]amino]pyrimidine-5-carbonitrileIC5029.0 [1]
8-Chloro-2-[(1S)-1-[(2,6-diamino-5-chloropyrimidin-4-yl)amino]propyl]-6-fluoro-3-(1H-pyrazol-5-yl)quinazolin-4-oneIC50138.0 [1]
4-Amino-6-[[(1S)-1-[5-chloro-4-oxo-3-(1H-pyrazol-4-yl)quinazolin-2-yl]ethyl]amino]pyrimidine-5-carbonitrileIC5014.0 [1]
2-Amino-4-[[(S)-[5-chloro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]-cyclopropylmethyl]amino]-6-methylpyrimidine-5-carbonitrileIC501.7 [1]
5-Chloro-2-[(S)-cyclopropyl-[(2,6-diamino-5-chloropyrimidin-4-yl)amino]methyl]-3-(1H-pyrazol-5-yl)quinazolin-4-oneIC507.9 [1]
2-Amino-4-[[(S)-[5-chloro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]-cyclopropylmethyl]amino]-6-(difluoromethyl)pyrimidine-5-carbonitrileIC509.3 [1]
2-Amino-4-[[(1S)-1-[8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]propyl]amino]-6-(difluoromethyl)pyrimidine-5-carbonitrileIC5016.0 [1]
2-[(1S)-1-[(2,6-Diamino-5-chloropyrimidin-4-yl)amino]ethyl]-8-fluoro-3-(1H-pyrazol-5-yl)quinazolin-4-oneIC5034.0 [1]
2-Amino-4-(difluoromethyl)-6-[[(1S)-1-[6-fluoro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]ethyl]amino]pyrimidine-5-carbonitrileIC50121.0 [1]
2-Amino-4-(difluoromethyl)-6-[[(1S)-1-[5-fluoro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]ethyl]amino]pyrimidine-5-carbonitrileIC50109.0 [1]
2-Amino-4-(difluoromethyl)-6-[[(1S)-1-[6,8-difluoro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]ethyl]amino]pyrimidine-5-carbonitrileIC5015.0 [1]
2-[(1S)-1-[(2,6-Diamino-5-chloropyrimidin-4-yl)amino]ethyl]-5-fluoro-3-(1H-pyrazol-5-yl)quinazolin-4-oneIC5035.0 [1]
2,4-Diamino-6-[[(1S)-1-[5-chloro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]ethyl]amino]pyrimidine-5-carbonitrileIC500.7 [1]
pi3K/Mtor Inhibitor-2IC5034.0 [1]
3-(6,7-Dimethoxy-4-morpholin-4-ylquinazolin-2-yl)-5-hydroxybenzamideIC50454.0 [1]
3-(6,7-Dimethoxy-4-morpholin-4-ylquinazolin-2-yl)-5-(trifluoromethoxy)benzamideIC50128.0 [1]
pi3K/Mtor Inhibitor-1IC50376.0 [1]
5-[2-[(3S)-3-Methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]-4-(trifluoromethyl)pyridin-2-amineIC50264.0 [1]
5-[6-(1-Methylsulfonylcyclopropyl)-2-morpholin-4-ylpyrimidin-4-yl]-4-(trifluoromethyl)pyridin-2-amineIC50314.0 [1]
1-[2-(Diethylamino)ethyl]-3-[6-[5-[(4-fluorophenyl)sulfonylamino]-6-methoxypyridin-3-yl]-1,3-benzothiazol-2-yl]ureaIC5090.0 [1]
3-(Benzotriazol-1-Yl)-5-[1-Methyl-5-(1-Phenylcyclopropyl)-1,2,4-Triazol-3-Yl]pyrazin-2-AmineIC506309.57 [1]
3-(Benzotriazol-1-yl)-5-[1-methyl-5-[(1S)-1-morpholin-4-ylethyl]-1,2,4-triazol-3-yl]pyrazin-2-amineIC503981.07 [1]
5-[1-Methyl-5-(1-Phenylcyclopropyl)-1,2,4-Triazol-3-Yl]-3-(1~{h}-Pyrazol-4-Yl)pyrazin-2-AmineIC5015848.93 [1]
4-[3-Amino-6-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]pyrazin-2-yl]-N,N-dimethylpyrazole-1-sulfonamideIC502511.89 [1]
4-[3-Amino-6-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]pyrazin-2-yl]pyrazole-1-carboxamideIC5031622.78 [1]
1-[3-Amino-6-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]pyrazin-2-yl]pyrazole-4-carboxamideIC5012589.25 [1]
1-[3-Amino-6-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]pyrazin-2-yl]pyrazole-3-carboxamideIC5031622.78 [1]
4-[3-Azanyl-6-[1-Methyl-5-(1-Phenylcyclopropyl)-1,2,4-Triazol-3-Yl]pyrazin-2-Yl]benzamideIC5010000.0 [1]
Chembl4126010IC5025118.86 [1]
Chembl4127396IC5019952.62 [1]
Chembl4129600IC5025118.86 [1]
Chembl4128537IC5031622.78 [1]
N-[5-[3-[(3S)-1-(Cyclopropylmethyl)pyrrolidin-3-yl]-4-oxoquinazolin-6-yl]-2-methoxypyridin-3-yl]-4-fluorobenzenesulfonamideIC5024.0 [1]
N-[5-[3-[(3S)-1-(Cyclopropanecarbonyl)pyrrolidin-3-yl]-4-oxoquinazolin-6-yl]-2-methoxypyridin-3-yl]-4-fluorobenzenesulfonamideIC50209.0 [1]
N-[(E)-(5-Cyanopyrazolo[1,5-a]pyridin-3-yl)methylideneamino]-2-[2-(diethylamino)ethyl-methylamino]-N-methyl-5-nitrobenzenesulfonamideIC50330.0 [1]
N-[(E)-(5-Cyanopyrazolo[1,5-a]pyridin-3-yl)methylideneamino]-2-[2-imidazol-1-ylethyl(methyl)amino]-N-methyl-5-nitrobenzenesulfonamideIC50150.0 [1]
N-[(E)-(5-Cyanopyrazolo[1,5-a]pyridin-3-yl)methylideneamino]-N-methyl-2-[methyl(2-pyridin-4-ylethyl)amino]-5-nitrobenzenesulfonamideIC50160.0 [1]
N-[(E)-(5-Cyanopyrazolo[1,5-a]pyridin-3-yl)methylideneamino]-2-[2-(1H-imidazol-5-yl)ethyl-methylamino]-N-methyl-5-nitrobenzenesulfonamideIC50740.0 [1]
N-[(E)-(5-Cyanopyrazolo[1,5-a]pyridin-3-yl)methylideneamino]-N-methyl-2-[methyl(2-pyridin-3-ylethyl)amino]-5-nitrobenzenesulfonamideIC50180.0 [1]
2-[2-Aminoethyl(methyl)amino]-N-[(E)-(5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylideneamino]-N-methyl-5-nitrobenzenesulfonamideIC501000.0 [1]
N-[(E)-1-(5-Cyanopyrazolo[1,5-a]pyridin-3-yl)ethylideneamino]-N-methyl-2-[methyl(pyridin-2-ylmethyl)amino]-5-nitrobenzenesulfonamideIC509400.0 [1]
N-[(E)-(5-Bromopyrazolo[1,5-a]pyridin-3-yl)methylideneamino]-N-methyl-2-[methyl(pyridin-2-ylmethyl)amino]-5-nitrobenzenesulfonamideIC501000.0 [1]
N-[(E)-(5-Cyanopyrazolo[1,5-a]pyridin-3-yl)methylideneamino]-N-methyl-2-[methyl(2-pyridin-2-ylethyl)amino]-5-nitrobenzenesulfonamideIC50410.0 [1]
N-[(E)-(5-Cyanopyrazolo[1,5-a]pyridin-3-yl)methylideneamino]-N-methyl-2-[methyl(pyridin-4-ylmethyl)amino]-5-nitrobenzenesulfonamideIC50390.0 [1]
N-[(E)-(5-Cyanopyrazolo[1,5-a]pyridin-3-yl)methylideneamino]-2-[2-(dimethylamino)ethyl-methylamino]-N-methyl-5-nitrobenzamideIC50230.0 [1]
N-[(E)-(5-Cyanopyrazolo[1,5-a]pyridin-3-yl)methylideneamino]-2-[3-(dimethylamino)propyl-methylamino]-N-methyl-5-nitrobenzenesulfonamideIC5076.0 [1]
N-[(E)-(5-Cyanopyrazolo[1,5-a]pyridin-3-yl)methylideneamino]-N-methyl-2-[methyl(3-morpholin-4-ylpropyl)amino]-5-nitrobenzenesulfonamideIC50510.0 [1]
N-[(E)-(5-Cyanopyrazolo[1,5-a]pyridin-3-yl)methylideneamino]-N-methyl-5-nitro-2-(pyridin-2-ylmethylamino)benzenesulfonamideIC501000.0 [1]
N-[(E)-(5-Cyanopyrazolo[1,5-a]pyridin-3-yl)methylideneamino]-N-methyl-2-[methyl(pyridin-2-ylmethyl)amino]-5-nitrobenzenesulfonamideIC50450.0 [1]
N-[(E)-1-(5-Cyanopyrazolo[1,5-a]pyridin-3-yl)ethylideneamino]-2-[2-(dimethylamino)ethyl-methylamino]-N-methyl-5-nitrobenzenesulfonamideIC501000.0 [1]
5-Cyano-N-[(E)-(5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylideneamino]-N-methyl-2-[methyl(3-morpholin-4-ylpropyl)amino]benzenesulfonamideIC501000.0 [1]
N-[4-Methyl-5-(7-methyl-1-oxo-2,3-dihydroisoindol-5-yl)-1,3-thiazol-2-yl]acetamideIC501584.89 [1]
4-Amino-6-[[(1S)-1-(3-methyl-5-oxo-6-phenyl-[1,3]thiazolo[3,2-a]pyridin-7-yl)ethyl]amino]pyrimidine-5-carbonitrileIC5050.12 [1]
4-Amino-6-[[(1S)-1-[3-methyl-6-[[3-[[methyl(2-methylpropyl)amino]methyl]phenyl]methyl]-5-oxo-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrileIC50100.0 [1]
12-(2-Aminopyrimidin-5-yl)-N-[(4-fluorophenyl)methyl]-10-morpholin-4-yl-1,5,8,11-tetrazatricyclo[7.4.0.02,7]trideca-2(7),8,10,12-tetraene-5-carboxamideKi43.3 [1]
5-Chloro-2-[(1S)-1-[(2,6-diamino-5-chloropyrimidin-4-yl)amino]ethyl]-3-(1,2-oxazol-3-yl)quinazolin-4-oneIC50539.0 [1]
5-[1-Methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]-3-(1H-pyrazol-5-yl)pyrazin-2-amineIC5031622.78 [1]
5-[4-(4-Fluorophenyl)sulfonyl-10-morpholin-4-yl-1,4,8,11-tetrazatricyclo[7.4.0.02,7]trideca-2(7),8,10,12-tetraen-12-yl]pyrimidin-2-amineKi490.0 [1]
4-Amino-6-[[(1S)-1-[3-methyl-6-[[3-(methylaminomethyl)phenyl]methyl]-5-oxo-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrileIC5010.0 [1]
4-Amino-6-[[(1S)-1-[3-methyl-6-[3-[[4-(2-morpholin-4-ylethyl)piperazin-1-yl]methyl]phenyl]-5-oxo-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrileIC50100.0 [1]
4-Amino-6-[[(1S)-1-[3-methyl-5-oxo-6-[[3-[[4-(2-phenylethoxy)butylamino]methyl]phenyl]methyl]-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrileIC507.94 [1]
3-(Benzotriazol-1-yl)-5-[1-methyl-5-[1-(4-methylpiperazin-1-yl)cyclopropyl]-1,2,4-triazol-3-yl]pyrazin-2-amineIC5031622.78 [1]
3-(Benzotriazol-1-yl)-5-[1-methyl-5-[(1R)-1-morpholin-4-ylethyl]-1,2,4-triazol-3-yl]pyrazin-2-amineIC503162.28 [1]
3-Indazol-1-yl-5-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]pyrazin-2-amineIC5019952.62 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ PI3K p110 beta/p85 alpha Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/pi3k-p110-beta-p85-alpha-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ PI3K p110 beta/p85 alpha Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/pi3k-p110-beta-p85-alpha-inhibitors-ic50-ki.
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