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PI3-kinase p85-alpha subunit Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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QuercetinIC503800.0 [1]
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneIC501400.0 [1]
2-(Morpholin-4-yl)-benzo[h]chromen-4-oneIC5013000.0 [1]
4-[3-Hydroxyanilino]-6,7-dimethoxyquinazolineIC502.0 [1]
2-[[4-Amino-3-(3-hydroxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-5-ethynyl-3-[(3-methoxyphenyl)methyl]quinazolin-4-oneIC501966.0 [1]
8-[(2R)-1-(3,5-Difluorophenyl)pyrrolidin-2-yl]-6-(morpholine-4-carbonyl)-2-morpholino-chromen-4-oneIC5050000.0 [1]
1-[3-(Difluoromethoxy)phenyl]-3-[4-[6-ethyl-8,8-dimethyl-2-[(3S)-3-methylmorpholin-4-yl]-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]ureaIC50468.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]-3-(6-methoxypyridazin-3-yl)ureaIC5010000.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-methylphenyl]-3-(6-methoxypyridin-3-yl)ureaIC5010000.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(4-oxa-7-azatricyclo[3.2.1.01,3]octan-7-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-pyridin-4-ylureaIC501710.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(4-oxa-7-azatricyclo[3.2.1.01,3]octan-7-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-(2-methylpyridin-4-yl)ureaIC503230.0 [1]
1-(2,6-Dimethylpyridin-4-yl)-3-[4-[6-ethyl-8,8-dimethyl-2-(4-oxa-7-azatricyclo[3.2.1.01,3]octan-7-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]ureaIC509470.0 [1]
1-(1H-Benzimidazol-2-yl)-3-[4-[6-ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]ureaIC505040.0 [1]
N-[2-(Dimethylamino)ethyl]-4-[[4-[6-ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]carbamoylamino]-N-methylbenzamideIC50100.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]-3-[4-(piperidin-1-ylmethyl)phenyl]ureaIC509610.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-methylureaIC5010000.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-[(3S)-3-methylmorpholin-4-yl]-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-[3-(1-fluoroethoxy)phenyl]ureaIC501540.0 [1]
1-[3-(1-Fluoroethoxy)phenyl]-3-[2-fluoro-4-[6-(2-methoxyethyl)-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]ureaIC501860.0 [1]
[(2S)-1-Hydroxypropan-2-yl] N-[4-[6,8,8-trimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]carbamateIC5010000.0 [1]
[4-(8-Oxa-3-azabicyclo[3.2.1]octan-3-yl)phenyl] N-[2-fluoro-4-[6,8,8-trimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]carbamateIC5010000.0 [1]
2-[[4-Amino-3-(4-hydroxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-3-[(2-chlorophenyl)methyl]-5-(6-morpholin-4-yl-6-oxohex-1-ynyl)quinazolin-4-oneIC5020.0 [1]
6-[2-[[4-Amino-3-(4-hydroxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-3-[(2-chlorophenyl)methyl]-4-oxoquinazolin-5-yl]-N-propan-2-ylhex-5-ynamideIC5027.0 [1]
2-[[4-Amino-3-(4-hydroxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-3-[(2-chlorophenyl)methyl]-5-(6-oxo-6-pyrrolidin-1-ylhex-1-ynyl)quinazolin-4-oneIC501486.0 [1]
6-[2-[[4-Amino-3-(4-hydroxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-3-[(2-chlorophenyl)methyl]-4-oxoquinazolin-5-yl]hex-5-ynoic acidIC5017.0 [1]
2-[[4-Amino-3-(3-hydroxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-5-(3-methoxyprop-1-ynyl)-3-[[3-(trifluoromethyl)phenyl]methyl]quinazolin-4-oneIC50474.0 [1]
N-[2-Chloro-5-[4-(oxan-4-yloxy)pyrido[3,2-d]pyrimidin-6-yl]pyridin-3-yl]-2,4-difluorobenzenesulfonamideIC501000.0 [1]
N-[5-[4-(Oxan-4-yloxy)pyrido[3,2-d]pyrimidin-6-yl]pyridin-3-yl]benzenesulfonamideIC5010000.0 [1]
N-[2-Chloro-5-[4-(1-methylpiperidin-4-yl)oxypyrido[3,2-d]pyrimidin-6-yl]pyridin-3-yl]-2,4-difluorobenzenesulfonamideIC501000.0 [1]
N-[5-[4-(1-Methylpiperidin-4-yl)oxypyrido[3,2-d]pyrimidin-6-yl]pyridin-3-yl]benzenesulfonamideIC5010000.0 [1]
N-[5-(4-Pyridin-3-yloxypyrido[3,2-d]pyrimidin-6-yl)pyridin-3-yl]benzenesulfonamideIC5010000.0 [1]
N-[2-Chloro-5-[4-(oxan-4-ylamino)pyrido[3,2-d]pyrimidin-6-yl]pyridin-3-yl]-2,4-difluorobenzenesulfonamideIC5010000.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]-3-pyridin-3-ylureaIC502660.0 [1]
1-Ethyl-3-[4-[6-ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]ureaIC5010000.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]-3-(5-methyl-1,2-oxazol-3-yl)ureaIC504310.0 [1]
1-Cyclopropyl-3-[4-[6-ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]ureaIC5010000.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-(1,2-oxazol-3-yl)ureaIC506525.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-(6-methoxypyridin-3-yl)ureaIC5010000.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-[(3S)-3-methylmorpholin-4-yl]-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-(6-methoxypyridin-3-yl)ureaIC50598.0 [1]
1-Cyclopropyl-3-[4-[6-ethyl-8,8-dimethyl-2-[(3S)-3-methylmorpholin-4-yl]-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]ureaIC505800.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-[(3S)-3-methylmorpholin-4-yl]-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-(1,2-oxazol-3-yl)ureaIC50561.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-[(3S)-3-methylmorpholin-4-yl]-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-(6-methylpyridin-3-yl)ureaIC50321.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-[(3S)-3-methylmorpholin-4-yl]-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]-3-(5-methylpyridin-2-yl)ureaIC501450.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-[(3S)-3-methylmorpholin-4-yl]-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]ureaIC50308.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-[(3S)-3-methylmorpholin-4-yl]-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]-3-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]ureaIC50326.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-(6-methylpyridin-3-yl)ureaIC505680.0 [1]
2-Hydroxyethyl N-[4-[6-ethyl-8,8-dimethyl-2-[(3S)-3-methylmorpholin-4-yl]-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]carbamateIC503940.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-[(3S)-3-methylmorpholin-4-yl]-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-(6-morpholin-4-ylpyridin-3-yl)ureaIC50472.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]ureaIC506800.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-methylureaIC508841.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-[(3S)-3-methylmorpholin-4-yl]-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-methylureaIC50547.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-[(3S)-3-methylmorpholin-4-yl]-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-(2-methylpyridin-4-yl)ureaIC50174.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-(6-morpholin-4-ylpyridin-3-yl)ureaIC5010000.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-[(3S)-3-methylmorpholin-4-yl]-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]-3-(2-fluorophenyl)ureaIC50213.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]-3-[4-(4-methylpiperazin-1-yl)phenyl]ureaIC503740.0 [1]
1-Ethyl-3-[4-[6-ethyl-8,8-dimethyl-2-[(3S)-3-methylmorpholin-4-yl]-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]ureaIC502110.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-[4-(4-methylpiperazin-1-yl)phenyl]ureaIC506470.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-methylureaIC5010000.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-[(3S)-3-methylmorpholin-4-yl]-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]-3-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]ureaIC501060.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-[(3S)-3-methylmorpholin-4-yl]-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]-3-pyridin-2-ylureaIC50372.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-pyridin-3-ylureaIC502070.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-[6-(1-methylpiperidin-4-yl)oxypyridin-3-yl]ureaIC503070.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-[6-[(3R)-3-methylmorpholin-4-yl]pyridin-3-yl]ureaIC5010000.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-[6-[(3S)-3-methylmorpholin-4-yl]pyridin-3-yl]ureaIC5010000.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-(6-piperidin-1-ylpyridin-3-yl)ureaIC5010000.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-[(3S)-3-methylmorpholin-4-yl]-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-(4-morpholin-4-ylphenyl)ureaIC50484.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-(6-methylpyridin-3-yl)ureaIC5010000.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-[(3S)-3-methylmorpholin-4-yl]-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-pyridin-4-ylureaIC50103.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-[4-(4-methylsulfonylpiperazin-1-yl)phenyl]ureaIC507200.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]-3-(4-methoxypyridin-2-yl)ureaIC5010000.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-(6-pyrrolidin-1-ylpyridin-3-yl)ureaIC5010000.0 [1]
1-[4-[6-Ethyl-2-[(3S)-3-ethylmorpholin-4-yl]-8,8-dimethyl-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-(6-methylpyridin-3-yl)ureaIC508630.0 [1]
Methyl 4-[4-[[4-[6-ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]carbamoylamino]phenyl]piperazine-1-carboxylateIC507200.0 [1]
1-[4-(1,1-Dioxo-1,4-thiazinan-4-yl)phenyl]-3-[4-[6-ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]ureaIC507200.0 [1]
1-(2,6-Dimethylpyridin-4-yl)-3-[4-[6-ethyl-8,8-dimethyl-2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]ureaIC5010000.0 [1]
2-Hydroxyethyl N-[4-[6-ethyl-8,8-dimethyl-2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-3-fluorophenyl]carbamateIC503870.0 [1]
1-Methyl-3-[4-[6,8,8-trimethyl-2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]ureaIC504730.0 [1]
1-[2-Fluoro-4-[6,8,8-trimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]-3-methylureaIC504000.0 [1]
1-[2-Fluoro-4-[6,8,8-trimethyl-2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]-3-methylureaIC508880.0 [1]
1-(5-Methoxypyridin-2-yl)-3-[4-[6,8,8-trimethyl-2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]ureaIC5010000.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-pyridin-3-ylureaIC502870.0 [1]
1-(6-Cyanopyridin-3-yl)-3-[4-[6-ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]ureaIC507200.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-[(3S)-3-methylmorpholin-4-yl]-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-[6-[(3S)-3-ethylmorpholin-4-yl]pyridin-3-yl]ureaIC5010000.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]-3-[5-(2-methoxyethoxy)pyridin-2-yl]ureaIC5010000.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-pyridin-4-ylureaIC501900.0 [1]
1-(5-Methoxypyridin-2-yl)-3-[4-[6,8,8-trimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]ureaIC503000.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-(2-methylpyridin-4-yl)ureaIC504810.0 [1]
1-[2-Fluoro-4-[6,8,8-trimethyl-2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]-3-(2-methylpyridin-4-yl)ureaIC504200.0 [1]
1-Cyclopropyl-3-[4-[6-ethyl-8,8-dimethyl-2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]ureaIC5010000.0 [1]
1-Ethyl-3-[4-[6-ethyl-8,8-dimethyl-2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]ureaIC5010000.0 [1]
1-[6-(3,3-Dimethylmorpholin-4-yl)pyridin-3-yl]-3-[4-[6-ethyl-8,8-dimethyl-2-[(3S)-3-methylmorpholin-4-yl]-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]ureaIC50199.0 [1]
1-[5-(Dimethylamino)pyridin-2-yl]-3-[4-[6-ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]ureaIC5010000.0 [1]
1-[2-Fluoro-4-[6,8,8-trimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]-3-(6-methylpyridin-3-yl)ureaIC502950.0 [1]
1-[2-Fluoro-4-[6,8,8-trimethyl-2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]-3-(6-methylpyridin-3-yl)ureaIC5010000.0 [1]
1-Pyridin-4-yl-3-[4-[6,8,8-trimethyl-2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]ureaIC501360.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-[(3S)-3-methylmorpholin-4-yl]-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-[6-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)pyridin-3-yl]ureaIC502940.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-2-fluorophenyl]-3-[2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)pyridin-4-yl]ureaIC5010000.0 [1]
1-(4-Methoxypyridin-2-yl)-3-[4-[6,8,8-trimethyl-2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]ureaIC5010000.0 [1]
1-[4-[6-Ethyl-8,8-dimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]-3-fluorophenyl]-3-pyridin-4-ylureaIC5010000.0 [1]
1-[2-Fluoro-4-[6,8,8-trimethyl-2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]-3-[6-[(3S)-3-methylmorpholin-4-yl]pyridin-3-yl]ureaIC5010000.0 [1]
1-[2-Fluoro-4-[6,8,8-trimethyl-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-4-yl]phenyl]-3-[6-[(3S)-3-methylmorpholin-4-yl]pyridin-3-yl]ureaIC505910.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ PI3-kinase p85-alpha subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/pi3-kinase-p85-alpha-subunit-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ PI3-kinase p85-alpha subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/pi3-kinase-p85-alpha-subunit-inhibitors-ic50-ki.
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