PI3-kinase p110-gamma subunit Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	IC50	1775.0 [1]
	Idelalisib	IC50	89.0 [1]
	Pictilisib	IC50	75.0 [1]
	Pictilisib	Ki	1.4 [1]
	Dactolisib	IC50	23.6 [1]
	PI-103	IC50	48.0 [1]
	4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine	IC50	38.0 [1]
	Wortmannin	IC50	5.0 [1], 19.0 [2], 89.0 [3], 55000.0 [4]
	N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamide	IC50	16.0 [1], 17.0 [2]
	N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamide	Ki	7.0 [1]
	2-((6-Amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one	IC50	29000.0 [1], 61000.0 [2], 70000.0 [3]
	AS-252424	IC50	30.0 [1], 33.0 [2]
	N-[6-(5-Methylsulfonylpyridin-3-Yl)-[1,2,4]triazolo[1,5-A]pyridin-2-Yl]ethanamide	IC50	79.43 [1], 1995.26 [2], 63095.73 [3]
	(2S)-1-N-[5-(2-Tert-butylpyrimidin-4-yl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide	IC50	210.0 [1], 230.0 [2], 1500.0 [3]
	6-(5-(Methylsulfonyl)pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine	IC50	100.0 [1], 1995.26 [2]
	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-tert-butylpyridine-3-sulfonamide	IC50	25.12 [1], 1000.0 [2], 1995.26 [3]
	Chembl4126773	IC50	140.0 [1], 170.0 [2], 500.0 [3]
	Chembl4126773	Ki	4.0 [1]
	Buparlisib	IC50	262.0 [1], 372.0 [2], 778.0 [3]
	Alpelisib	IC50	250.0 [1]
	5-Quinoxalin-6-ylmethylene-thiazolidine-2,4-dione	IC50	8.0 [1], 9.0 [2]
	Duvelisib	IC50	2.9 [1], 12.0 [2], 100.0 [3]
	Tgx-221	IC50	1000.0 [1], 10000.0 [2]
	Apitolisib	IC50	14.0 [1], 36.0 [2]
	Gedatolisib	IC50	5.4 [1], 11.0 [2]
	5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione	IC50	250.0 [1]
	1-[4-(3-Ethyl-7-morpholin-4-yltriazolo[4,5-d]pyrimidin-5-yl)phenyl]-3-[4-(4-methylpiperazine-1-carbonyl)phenyl]urea	IC50	9.0 [1], 9.2 [2], 16.0 [3]
	CID 46927938	Ki	179.0 [1]
	(3-(9-(1-Benzylpiperidin-4-yl)-6-morpholino-9H-purin-2-yl)phenyl)methanol	IC50	1134.0 [1]
	(2S)-N1-[5-(2-Tert-butyl-4-thiazolyl)-4-methyl-2-thiazolyl]pyrrolidine-1,2-dicarboxamide	IC50	8000.0 [1], 10000.0 [2]
	2-((9H-Purin-6-ylthio)methyl)-5-chloro-3-(2-methoxyphenyl)quinazolin-4(3H)-one	IC50	2030.0 [1], 17000.0 [2]
	3-(4-Morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol;hydrochloride	IC50	660.0 [1]
	2-[(1-Methyl-1h-Benzimidazol-2-Yl)methyl]-6-Morpholin-4-Ylpyrimidin-4(3h)-One	IC50	10000.0 [1]
	N-(5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-6-yl)pyridin-3-yl)-4-chlorobenzenesulfonamide	IC50	6.31 [1], 1995.26 [2], 15848.93 [3]
	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-isopropylpyridine-3-sulfonamide	IC50	31.62 [1], 630.96 [2], 1584.89 [3]
	N-[6-(3-Methylsulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide	IC50	501.19 [1], 3981.07 [2], 12589.25 [3]
	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-benzylpyridine-3-sulfonamide	IC50	251.19 [1], 1258.93 [2], 7943.28 [3]
	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(cyclopropylmethyl)pyridine-3-sulfonamide	IC50	15.85 [1], 1584.89 [2], 1995.26 [3]
	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-naphthalen-1-ylpyridine-3-sulfonamide	IC50	7.94 [1], 501.19 [2], 19952.62 [3]
	Caffeine	IC50	1000000.0 [1], 3630000.0 [2]
	Theophylline	IC50	800000.0 [1], 2904000.0 [2]
	Ku-0063794	IC50	30000.0 [1]
	Omipalisib	IC50	0.6 [1], 0.61 [2]
	Pilaralisib	IC50	23.0 [1], 36.0 [2]
	N-(7,8-Dimethoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide	IC50	18.0 [1], 180.0 [2]
	1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	IC50	1100.0 [1]
	Gne-477	IC50	15.0 [1]
	Leniolisib	IC50	2230.0 [1], 7400.0 [2]
	5-(7-(Methylsulfonyl)-2-morpholino-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine	IC50	36.0 [1]
	5-(2-Amino-8-fluoro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-tert-butylpyridine-3-sulfonamide	IC50	25.12 [1]
	4-[2-[(6-Methoxypyridin-3-yl)amino]-5-[(4-methylsulfonylpiperazin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine	Ki	4.0 [1], 8.0 [2]
	pi3K|A Inhibitor C52	IC50	41.0 [1], 170.0 [2]
	1-[6-(5-Methoxypyridin-3-Yl)-1,3-Benzothiazol-2-Yl]-3-[2-(1-Propyl-1h-Imidazol-4-Yl)ethyl]urea	Ki	2.0 [1]
	3-[4-Amino-1-(1-Methylethyl)-1h-Pyrazolo[3,4-D]pyrimidin-3-Yl]phenol	IC50	1500.0 [1]
	2-[[4-Amino-3-(3-fluoro-5-hydroxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-5-methyl-3-(2-methylphenyl)quinazolin-4-one	IC50	33.0 [1]
	5-Chloro-3-phenyl-2-[(1S)-1-(7H-purin-6-ylamino)ethyl]quinazolin-4-one	IC50	12.0 [1]
	(5Z)-5-[[5-(4-Hydroxyphenyl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	380.0 [1]
	4-[(4-Tert-butylphenyl)methyl]-6-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-benzoxazin-3-one	IC50	2.42 [1], 10.2 [2]
	(2S)-1-N-[5-(3-Fluoro-4-methylsulfonylphenyl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide	IC50	10000.0 [1]
	(2S)-1-N-[5-(3-Fluoro-4-methylsulfonylphenyl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide	Ki	3060.0 [1]
	3-[5-(2,4-Dioxothiazolidin-5-ylidenemethyl)furan-2-yl]benzoic acid methyl ester	IC50	13500.0 [1]
	5-(5-Pyridin-3-ylfuran-2-ylmethylene)thiazolidine-2,4-dione	IC50	950.0 [1]
	5-[5-(2-Hydroxy-3-nitrophenyl)furan-2-ylmethylene]thiazolidine-2,4-dione	IC50	80.0 [1]
	(5Z)-5-[[5-(2-Hydroxyphenyl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	30.0 [1]
	5-[5-(2-Hydroxy-5-chlorophenyl)furan-2-ylmethylene]thiazolidine-2,4-dione	IC50	43.0 [1]
	3-[5-[(Z)-(2,4-Dioxo-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl]-4-hydroxybenzoic acid	IC50	530.0 [1]
	5-(5-Pyridin-2-ylfuran-2-ylmethylene)thiazolidine-2,4-dione	IC50	110.0 [1]
	5-[5-(3-Hydroxyphenyl)furan-2-ylmethylene]thiazolidine-2,4-dione	IC50	290.0 [1]
	5-[5-(2-Hydroxy-5-methylphenyl)furan-2-ylmethylene]thiazolidine-2,4-dione	IC50	39.0 [1]
	5-[5-(3-Methoxyphenyl)furan-2-ylmethylene]thiazolidine-2,4-dione	IC50	2600.0 [1]
	5-[5-(2-Hydroxy-5-trifluoromethoxyphenyl)furan-2-ylmethylene]thiazolidine-2,4-dione	IC50	56.0 [1]
	5-[5-(2,4-Dihydroxyphenyl)furan-2-ylmethylene]thiazolidine-2,4-dione	IC50	20.0 [1]
	5-[5-(5-Fluoro-2-hydroxyphenyl)furan-2-ylmethylene]thiazolidine-2,4-dione	IC50	37.0 [1]
	(5Z)-5-[[5-(Furan-3-yl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	840.0 [1]
	5-[5-(2-Fluoro-4-hydroxyphenyl)furan-2-ylmethylene]thiazolidine-2,4-dione	IC50	260.0 [1]
	(5Z)-5-[[5-(1,3-Benzodioxol-5-yl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	20000.0 [1]
	3-[5-(2,4-Dioxothiazolidin-5-ylidenemethyl)furan-2-yl]-4-hydroxybenzonitrile	IC50	40.0 [1]
	(5Z)-5-[[5-(5-Nitrofuran-2-yl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	20000.0 [1]
	5-[5-(2,5-Dihydroxyphenyl)furan-2-ylmethylene]thiazolidine-2,4-dione	IC50	20.0 [1]
	8-[(3,5-Difluoro-N-methylanilino)methyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide	IC50	1400.0 [1]
	1-[4-[4-[5-Amino-6-(benzotriazol-1-yl)pyrazin-2-yl]pyrazol-1-yl]piperidin-1-yl]-2-(dimethylamino)ethanone	IC50	280.0 [1]
	3-(5-((4-Oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid	IC50	920.0 [1]
	2-[4-(Morpholin-4-Yl)-6-Oxo-1,6-Dihydropyrimidin-2-Yl]-N-Phenylacetamide	IC50	10000.0 [1]
	3-(6-Morpholino-9H-purin-2-yl)phenol	IC50	2343.0 [1]
	pi-103 (Hydrochloride)	IC50	250.0 [1]
	8-(4-Fluoro-2-methylphenoxy)-2-(morpholin-4-yl)quinolin-4(1H)-one	IC50	10000.0 [1], 18150.0 [2]
	3-(2,4-Diaminopteridin-6-yl)phenol	IC50	39.9 [1], 127.0 [2]
	4-[2-(3,5-Dimethylphenyl)ethyl]-6-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-benzoxazin-3-one	IC50	2.65 [1], 11.2 [2]
	4-[2-(3-Chlorophenyl)ethyl]-6-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-benzoxazin-3-one	IC50	4.27 [1], 18.0 [2]
	4-[2-(3-Methoxyphenyl)ethyl]-6-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-benzoxazin-3-one	IC50	2.66 [1], 11.22 [2]
	4-[2-(4-Chlorophenyl)ethyl]-6-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-benzoxazin-3-one	IC50	4.76 [1], 20.1 [2]
	4-[2-(4-Methoxyphenyl)ethyl]-6-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-benzoxazin-3-one	IC50	6.57 [1], 27.7 [2]
	4-[(3,4-Dimethylphenyl)methyl]-6-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-benzoxazin-3-one	IC50	2.59 [1], 11.0 [2]
	4-[(4-Chlorophenyl)methyl]-6-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-benzoxazin-3-one	IC50	7.16 [1], 30.0 [2]
	4-Benzyl-6-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-benzoxazin-3-one	IC50	23.0 [1], 97.0 [2]
	4-[2-(4-Methylphenyl)ethyl]-6-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-benzoxazin-3-one	IC50	8.83 [1], 37.3 [2]
	6-[(Z)-(4-Oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-4-[[4-(trifluoromethyl)phenyl]methyl]-1,4-benzoxazin-3-one	IC50	27.5 [1], 116.0 [2]
	6-[(Z)-(4-Oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-4-(2-phenylethyl)-1,4-benzoxazin-3-one	IC50	24.5 [1], 103.4 [2]
	1-Methyl-3-Naphthalen-2-Yl-1h-Pyrazolo[3,4-D]pyrimidin-4-Amine	IC50	570.0 [1]
	1-(1-Methylethyl)-3-Quinolin-6-Yl-1h-Pyrazolo[3,4-D]pyrimidin-4-Amine	IC50	43.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ PI3-kinase p110-gamma subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/pi3-kinase-p110-gamma-subunit-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, November 20). Quest Database™ PI3-kinase p110-gamma subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/pi3-kinase-p110-gamma-subunit-inhibitors-ic50-ki.
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