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PI3-kinase p110-gamma subunit Inhibitors (IC50, Ki)

Structure
Compound Name
Standard Type
Standard Values (in nM)
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneIC501775.0 [1]
IdelalisibIC5089.0 [1]
PictilisibIC5075.0 [1]
PictilisibKi1.4 [1]
DactolisibIC5023.6 [1]
PI-103IC5048.0 [1]
4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholineIC5038.0 [1]
WortmanninIC505.0 [1], 19.0 [2], 89.0 [3], 55000.0 [4]
N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamideIC5016.0 [1], 17.0 [2]
N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamideKi7.0 [1]
2-((6-Amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-oneIC5029000.0 [1], 61000.0 [2], 70000.0 [3]
AS-252424IC5030.0 [1], 33.0 [2]
N-[6-(5-Methylsulfonylpyridin-3-Yl)-[1,2,4]triazolo[1,5-A]pyridin-2-Yl]ethanamideIC5079.43 [1], 1995.26 [2], 63095.73 [3]
(2S)-1-N-[5-(2-Tert-butylpyrimidin-4-yl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamideIC50210.0 [1], 230.0 [2], 1500.0 [3]
6-(5-(Methylsulfonyl)pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amineIC50100.0 [1], 1995.26 [2]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-tert-butylpyridine-3-sulfonamideIC5025.12 [1], 1000.0 [2], 1995.26 [3]
Chembl4126773IC50140.0 [1], 170.0 [2], 500.0 [3]
Chembl4126773Ki4.0 [1]
BuparlisibIC50262.0 [1], 372.0 [2], 778.0 [3]
AlpelisibIC50250.0 [1]
5-Quinoxalin-6-ylmethylene-thiazolidine-2,4-dioneIC508.0 [1], 9.0 [2]
DuvelisibIC502.9 [1], 12.0 [2], 100.0 [3]
Tgx-221IC501000.0 [1], 10000.0 [2]
ApitolisibIC5014.0 [1], 36.0 [2]
GedatolisibIC505.4 [1], 11.0 [2]
5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dioneIC50250.0 [1]
1-[4-(3-Ethyl-7-morpholin-4-yltriazolo[4,5-d]pyrimidin-5-yl)phenyl]-3-[4-(4-methylpiperazine-1-carbonyl)phenyl]ureaIC509.0 [1], 9.2 [2], 16.0 [3]
CID 46927938Ki179.0 [1]
(3-(9-(1-Benzylpiperidin-4-yl)-6-morpholino-9H-purin-2-yl)phenyl)methanolIC501134.0 [1]
(2S)-N1-[5-(2-Tert-butyl-4-thiazolyl)-4-methyl-2-thiazolyl]pyrrolidine-1,2-dicarboxamideIC508000.0 [1], 10000.0 [2]
2-((9H-Purin-6-ylthio)methyl)-5-chloro-3-(2-methoxyphenyl)quinazolin-4(3H)-oneIC502030.0 [1], 17000.0 [2]
3-(4-Morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol;hydrochlorideIC50660.0 [1]
2-[(1-Methyl-1h-Benzimidazol-2-Yl)methyl]-6-Morpholin-4-Ylpyrimidin-4(3h)-OneIC5010000.0 [1]
N-(5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-6-yl)pyridin-3-yl)-4-chlorobenzenesulfonamideIC506.31 [1], 1995.26 [2], 15848.93 [3]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-isopropylpyridine-3-sulfonamideIC5031.62 [1], 630.96 [2], 1584.89 [3]
N-[6-(3-Methylsulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamideIC50501.19 [1], 3981.07 [2], 12589.25 [3]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-benzylpyridine-3-sulfonamideIC50251.19 [1], 1258.93 [2], 7943.28 [3]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(cyclopropylmethyl)pyridine-3-sulfonamideIC5015.85 [1], 1584.89 [2], 1995.26 [3]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-naphthalen-1-ylpyridine-3-sulfonamideIC507.94 [1], 501.19 [2], 19952.62 [3]
CaffeineIC501000000.0 [1], 3630000.0 [2]
TheophyllineIC50800000.0 [1], 2904000.0 [2]
Ku-0063794IC5030000.0 [1]
OmipalisibIC500.6 [1], 0.61 [2]
PilaralisibIC5023.0 [1], 36.0 [2]
N-(7,8-Dimethoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamideIC5018.0 [1], 180.0 [2]
1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC501100.0 [1]
Gne-477IC5015.0 [1]
LeniolisibIC502230.0 [1], 7400.0 [2]
5-(7-(Methylsulfonyl)-2-morpholino-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amineIC5036.0 [1]
5-(2-Amino-8-fluoro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-tert-butylpyridine-3-sulfonamideIC5025.12 [1]
4-[2-[(6-Methoxypyridin-3-yl)amino]-5-[(4-methylsulfonylpiperazin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amineKi4.0 [1], 8.0 [2]
pi3K|A Inhibitor C52IC5041.0 [1], 170.0 [2]
1-[6-(5-Methoxypyridin-3-Yl)-1,3-Benzothiazol-2-Yl]-3-[2-(1-Propyl-1h-Imidazol-4-Yl)ethyl]ureaKi2.0 [1]
3-[4-Amino-1-(1-Methylethyl)-1h-Pyrazolo[3,4-D]pyrimidin-3-Yl]phenolIC501500.0 [1]
2-[[4-Amino-3-(3-fluoro-5-hydroxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-5-methyl-3-(2-methylphenyl)quinazolin-4-oneIC5033.0 [1]
5-Chloro-3-phenyl-2-[(1S)-1-(7H-purin-6-ylamino)ethyl]quinazolin-4-oneIC5012.0 [1]
(5Z)-5-[[5-(4-Hydroxyphenyl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dioneIC50380.0 [1]
4-[(4-Tert-butylphenyl)methyl]-6-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-benzoxazin-3-oneIC502.42 [1], 10.2 [2]
(2S)-1-N-[5-(3-Fluoro-4-methylsulfonylphenyl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamideIC5010000.0 [1]
(2S)-1-N-[5-(3-Fluoro-4-methylsulfonylphenyl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamideKi3060.0 [1]
3-[5-(2,4-Dioxothiazolidin-5-ylidenemethyl)furan-2-yl]benzoic acid methyl esterIC5013500.0 [1]
5-(5-Pyridin-3-ylfuran-2-ylmethylene)thiazolidine-2,4-dioneIC50950.0 [1]
5-[5-(2-Hydroxy-3-nitrophenyl)furan-2-ylmethylene]thiazolidine-2,4-dioneIC5080.0 [1]
(5Z)-5-[[5-(2-Hydroxyphenyl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dioneIC5030.0 [1]
5-[5-(2-Hydroxy-5-chlorophenyl)furan-2-ylmethylene]thiazolidine-2,4-dioneIC5043.0 [1]
3-[5-[(Z)-(2,4-Dioxo-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl]-4-hydroxybenzoic acidIC50530.0 [1]
5-(5-Pyridin-2-ylfuran-2-ylmethylene)thiazolidine-2,4-dioneIC50110.0 [1]
5-[5-(3-Hydroxyphenyl)furan-2-ylmethylene]thiazolidine-2,4-dioneIC50290.0 [1]
5-[5-(2-Hydroxy-5-methylphenyl)furan-2-ylmethylene]thiazolidine-2,4-dioneIC5039.0 [1]
5-[5-(3-Methoxyphenyl)furan-2-ylmethylene]thiazolidine-2,4-dioneIC502600.0 [1]
5-[5-(2-Hydroxy-5-trifluoromethoxyphenyl)furan-2-ylmethylene]thiazolidine-2,4-dioneIC5056.0 [1]
5-[5-(2,4-Dihydroxyphenyl)furan-2-ylmethylene]thiazolidine-2,4-dioneIC5020.0 [1]
5-[5-(5-Fluoro-2-hydroxyphenyl)furan-2-ylmethylene]thiazolidine-2,4-dioneIC5037.0 [1]
(5Z)-5-[[5-(Furan-3-yl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dioneIC50840.0 [1]
5-[5-(2-Fluoro-4-hydroxyphenyl)furan-2-ylmethylene]thiazolidine-2,4-dioneIC50260.0 [1]
(5Z)-5-[[5-(1,3-Benzodioxol-5-yl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dioneIC5020000.0 [1]
3-[5-(2,4-Dioxothiazolidin-5-ylidenemethyl)furan-2-yl]-4-hydroxybenzonitrileIC5040.0 [1]
(5Z)-5-[[5-(5-Nitrofuran-2-yl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dioneIC5020000.0 [1]
5-[5-(2,5-Dihydroxyphenyl)furan-2-ylmethylene]thiazolidine-2,4-dioneIC5020.0 [1]
8-[(3,5-Difluoro-N-methylanilino)methyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamideIC501400.0 [1]
1-[4-[4-[5-Amino-6-(benzotriazol-1-yl)pyrazin-2-yl]pyrazol-1-yl]piperidin-1-yl]-2-(dimethylamino)ethanoneIC50280.0 [1]
3-(5-((4-Oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acidIC50920.0 [1]
2-[4-(Morpholin-4-Yl)-6-Oxo-1,6-Dihydropyrimidin-2-Yl]-N-PhenylacetamideIC5010000.0 [1]
3-(6-Morpholino-9H-purin-2-yl)phenolIC502343.0 [1]
pi-103 (Hydrochloride)IC50250.0 [1]
8-(4-Fluoro-2-methylphenoxy)-2-(morpholin-4-yl)quinolin-4(1H)-oneIC5010000.0 [1], 18150.0 [2]
3-(2,4-Diaminopteridin-6-yl)phenolIC5039.9 [1], 127.0 [2]
4-[2-(3,5-Dimethylphenyl)ethyl]-6-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-benzoxazin-3-oneIC502.65 [1], 11.2 [2]
4-[2-(3-Chlorophenyl)ethyl]-6-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-benzoxazin-3-oneIC504.27 [1], 18.0 [2]
4-[2-(3-Methoxyphenyl)ethyl]-6-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-benzoxazin-3-oneIC502.66 [1], 11.22 [2]
4-[2-(4-Chlorophenyl)ethyl]-6-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-benzoxazin-3-oneIC504.76 [1], 20.1 [2]
4-[2-(4-Methoxyphenyl)ethyl]-6-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-benzoxazin-3-oneIC506.57 [1], 27.7 [2]
4-[(3,4-Dimethylphenyl)methyl]-6-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-benzoxazin-3-oneIC502.59 [1], 11.0 [2]
4-[(4-Chlorophenyl)methyl]-6-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-benzoxazin-3-oneIC507.16 [1], 30.0 [2]
4-Benzyl-6-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-benzoxazin-3-oneIC5023.0 [1], 97.0 [2]
4-[2-(4-Methylphenyl)ethyl]-6-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-benzoxazin-3-oneIC508.83 [1], 37.3 [2]
6-[(Z)-(4-Oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-4-[[4-(trifluoromethyl)phenyl]methyl]-1,4-benzoxazin-3-oneIC5027.5 [1], 116.0 [2]
6-[(Z)-(4-Oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-4-(2-phenylethyl)-1,4-benzoxazin-3-oneIC5024.5 [1], 103.4 [2]
1-Methyl-3-Naphthalen-2-Yl-1h-Pyrazolo[3,4-D]pyrimidin-4-AmineIC50570.0 [1]
1-(1-Methylethyl)-3-Quinolin-6-Yl-1h-Pyrazolo[3,4-D]pyrimidin-4-AmineIC5043.0 [1]



References

This online tool may be cited as follows

MLA

"Quest Database™ PI3-kinase p110-gamma subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc.21 Dec2024https://www.aatbio.com/data-sets/pi3-kinase-p110-gamma-subunit-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024December 21). Quest Database™ PI3-kinase p110-gamma subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/pi3-kinase-p110-gamma-subunit-inhibitors-ic50-ki.
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