PI3-kinase p110-delta/p85-alpha Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Dactolisib	IC50	22.0 [1], 78.4 [2], 138.0 [3], 204.0 [4]
	Idelalisib	IC50	2.7 [1], 17.0 [2], 18.0 [3], 25.0 [4]
	Pictilisib	IC50	3.3 [1], 39.0 [2], 163.0 [3]
	CID 46927938	Ki	14.2 [1]
	4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine	IC50	3.9 [1], 6.0 [2]
	2-((6-Amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one	IC50	130.0 [1]
	2-((6-Amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one	Ki	19.95 [1]
	Duvelisib	IC50	2.3 [1], 100.0 [2]
	Fimepinostat	IC50	39.0 [1]
	4-Amino-6-[[(1S)-1-(5-methyl-4-oxo-3-phenylpyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile	IC50	1.0 [1], 1.1 [2]
	4-Amino-6-[[(1S)-1-(4-oxo-3-phenylpyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile	IC50	3.9 [1], 4.3 [2]
	4-Amino-6-[[(1S)-1-(5-chloro-4-oxo-3-phenylquinazolin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile	IC50	0.34 [1], 0.4 [2]
	N-[4-[[4-[2-(Difluoromethyl)-4-methoxybenzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]amino]cyclohexyl]methanesulfonamide	IC50	78.0 [1], 111.0 [2]
	Panobinostat	IC50	10000.0 [1]
	Buparlisib	IC50	125.0 [1]
	Torin 1	IC50	564.0 [1]
	Torin 2	IC50	17.5 [1]
	Ethyl 6-(5-(phenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxylate	IC50	87.0 [1]
	4-[2-[(6-Methoxypyridin-3-yl)amino]-5-[(4-methylsulfonylpiperazin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine	Ki	4.0 [1]
	4-[2-[(5-Fluoro-6-methoxypyridin-3-yl)amino]-5-[(1R)-1-(4-methylsulfonylpiperazin-1-yl)ethyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine	Ki	2.0 [1]
	N-Benzyl-6-bromo-N-methylquinazolin-4-amine	IC50	6918.31 [1]
	CID 91933883	IC50	8400.0 [1]
	Chembl4126445	IC50	199.53 [1]
	Chembl4126156	IC50	316.23 [1]
	4-[2-[(5-Fluoro-6-methoxypyridin-3-yl)amino]-5-[(1S)-1-(4-methylsulfonylpiperazin-1-yl)ethyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine	Ki	1.0 [1]
	4-Amino-6-[[(1S)-1-[3-methyl-6-[3-[[4-[methyl(2-methylpropyl)amino]piperidin-1-yl]methyl]phenyl]-5-oxo-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile	IC50	0.63 [1]
	8-Chloro-2-phenyl-3-[1-(7H-purin-6-ylamino)ethyl]isoquinolin-1-one	IC50	100.0 [1]
	5-Chloro-3-phenyl-2-[(1S)-1-(7H-purin-6-ylamino)ethyl]quinazolin-4-one	IC50	1.0 [1]
	2-(2-Difluoromethylbenzimidazol-1-yl)-4-morpholino-6-(piperazin-1-yl)-1,3,5-triazine	IC50	142.0 [1]
	N-[2-[2-[2-[2-[4-[4-[2-(Difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]piperazin-1-yl]ethoxy]ethoxy]ethoxy]ethoxy]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide	IC50	942.0 [1]
	N-[2-Methoxy-5-[1-methyl-4-[(3R)-1-[(1,3,5-trimethylpyrazol-4-yl)methyl]pyrrolidin-3-yl]oxypyrazolo[3,4-b]pyridin-6-yl]pyridin-3-yl]methanesulfonamide	IC50	4.5 [1]
	N-[2-Methoxy-5-[1-methyl-4-[(3R)-1-(oxane-4-carbonyl)pyrrolidin-3-yl]oxypyrazolo[3,4-b]pyridin-6-yl]pyridin-3-yl]methanesulfonamide	IC50	5.3 [1]
	N-[3-(Dimethylamino)propyl]-6-(1H-indazol-4-yl)-8-morpholin-4-ylimidazo[1,2-a]pyrazine-2-carboxamide	Ki	3.6 [1]
	2-Anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-one	IC50	10000.0 [1]
	4-(6-Chloro-2-methylimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-amine	IC50	2570.4 [1]
	Cyclohex-3-en-1-yl-[3-(2H-pyrazolo[3,4-b]pyridin-3-yl)piperidin-1-yl]methanone	IC50	8511.38 [1]
	3-[3-(1-Methylindol-5-yl)imidazo[1,2-a]pyrazin-6-yl]benzamide	IC50	426.58 [1]
	2-Amino-N-[(1S)-1-[1-oxo-2-phenyl-8-[(E)-prop-1-enyl]isoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	IC50	10000.0 [1]
	2-Amino-N-[(1S)-1-[1-oxo-2-phenyl-8-(2-pyridin-3-ylethynyl)isoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	IC50	6000.0 [1]
	2-Amino-N-[(1S)-1-[1-oxo-2-phenyl-8-[2-(1,3-thiazol-4-yl)ethynyl]isoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	IC50	4800.0 [1]
	2-Amino-N-[(1S)-1-[1-oxo-2-phenyl-8-[2-(1,3-thiazol-2-yl)ethynyl]isoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	IC50	10000.0 [1]
	2-Amino-N-[(1S)-1-[8-[2-(1-methylpyrazol-3-yl)ethynyl]-1-oxo-2-phenylisoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	IC50	9000.0 [1]
	2-Amino-N-[(1S)-1-[1-oxo-2-phenyl-8-(2-pyridin-2-ylethynyl)isoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	IC50	9600.0 [1]
	2-Amino-N-[(1S)-1-[1-oxo-2-phenyl-8-(2-pyridin-4-ylethynyl)isoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	IC50	9000.0 [1]
	2-Amino-N-[(1S)-1-[1-oxo-2-phenyl-8-[2-(1,3-thiazol-5-yl)ethynyl]isoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	IC50	8000.0 [1]
	2-Amino-N-[(1S)-1-[1-oxo-2-phenyl-8-(2-phenylethynyl)isoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	IC50	140.0 [1]
	N-[4-[4-[[(1S)-1-(5-Methyl-4-oxo-3-phenylpyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-1H-indol-6-yl]methanesulfonamide	IC50	0.5 [1]
	2-Amino-4-[[(1S)-1-(5-chloro-4-oxo-3-phenylquinazolin-2-yl)ethyl]amino]-6-methylpyrimidine-5-carbonitrile	IC50	0.13 [1]
	2-[(1S)-1-[(6-Aminopyrimidin-4-yl)amino]ethyl]-5-chloro-3-phenylquinazolin-4-one	IC50	99.0 [1]
	8-Chloro-2-[(S)-cyclopropyl-[(2,6-diamino-5-chloropyrimidin-4-yl)amino]methyl]-6-fluoro-3-(1H-pyrazol-5-yl)quinazolin-4-one	IC50	15.0 [1]
	2-Amino-4-[[(1S)-1-[5-chloro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]ethyl]amino]-6-(trifluoromethyl)pyrimidine-5-carbonitrile	IC50	309.0 [1]
	2,4-Diamino-6-[[(S)-[8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]-cyclopropylmethyl]amino]pyrimidine-5-carbonitrile	IC50	0.6 [1]
	2-Amino-4-chloro-6-[[(S)-[5-chloro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]-cyclopropylmethyl]amino]pyrimidine-5-carbonitrile	IC50	5.9 [1]
	2-[(1S)-1-[(2,6-Diamino-5-chloropyrimidin-4-yl)amino]ethyl]-6-fluoro-3-(1H-pyrazol-5-yl)quinazolin-4-one	IC50	9.8 [1]
	4-Amino-6-[[(1S)-1-[5-chloro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]ethyl]amino]pyrimidine-5-carbonitrile	IC50	0.6 [1]
	2-Amino-4-[[(S)-[8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]-cyclopropylmethyl]amino]-6-(difluoromethyl)pyrimidine-5-carbonitrile	IC50	7.2 [1]
	PI3K-IN-6	IC50	5.3 [1]
	2-[(1S)-1-[(2,6-Diamino-5-chloropyrimidin-4-yl)amino]ethyl]-6,8-difluoro-3-(1H-pyrazol-5-yl)quinazolin-4-one	IC50	3.0 [1]
	2,4-Diamino-6-[[(S)-[5-chloro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]-cyclopropylmethyl]amino]pyrimidine-5-carbonitrile	IC50	0.6 [1]
	5-Chloro-2-[(1S)-1-[(2,6-diaminopyrimidin-4-yl)amino]ethyl]-3-(1H-pyrazol-5-yl)quinazolin-4-one	IC50	317.0 [1]
	5-Chloro-2-[(1S)-1-[(2,6-diamino-5-chloropyrimidin-4-yl)amino]ethyl]-3-(1H-pyrazol-5-yl)quinazolin-4-one	IC50	2.1 [1]
	2-Amino-4-[[(1S)-1-[8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]ethyl]amino]-6-(difluoromethyl)pyrimidine-5-carbonitrile	IC50	3.3 [1]
	2-Amino-4-(difluoromethyl)-6-[[(1S)-1-[8-fluoro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]ethyl]amino]pyrimidine-5-carbonitrile	IC50	9.5 [1]
	8-Chloro-2-[(1S)-1-[(2,6-diamino-5-chloropyrimidin-4-yl)amino]propyl]-6-fluoro-3-(1H-pyrazol-5-yl)quinazolin-4-one	IC50	132.0 [1]
	4-Amino-6-[[(1S)-1-[5-chloro-4-oxo-3-(1H-pyrazol-4-yl)quinazolin-2-yl]ethyl]amino]pyrimidine-5-carbonitrile	IC50	3.2 [1]
	2-Amino-4-[[(S)-[5-chloro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]-cyclopropylmethyl]amino]-6-methylpyrimidine-5-carbonitrile	IC50	0.8 [1]
	5-Chloro-2-[(S)-cyclopropyl-[(2,6-diamino-5-chloropyrimidin-4-yl)amino]methyl]-3-(1H-pyrazol-5-yl)quinazolin-4-one	IC50	5.2 [1]
	2-Amino-4-[[(S)-[5-chloro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]-cyclopropylmethyl]amino]-6-(difluoromethyl)pyrimidine-5-carbonitrile	IC50	13.0 [1]
	2-Amino-4-[[(1S)-1-[8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]propyl]amino]-6-(difluoromethyl)pyrimidine-5-carbonitrile	IC50	13.0 [1]
	2-[(1S)-1-[(2,6-Diamino-5-chloropyrimidin-4-yl)amino]ethyl]-8-fluoro-3-(1H-pyrazol-5-yl)quinazolin-4-one	IC50	12.0 [1]
	2-Amino-4-(difluoromethyl)-6-[[(1S)-1-[6-fluoro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]ethyl]amino]pyrimidine-5-carbonitrile	IC50	26.0 [1]
	2-Amino-4-(difluoromethyl)-6-[[(1S)-1-[5-fluoro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]ethyl]amino]pyrimidine-5-carbonitrile	IC50	51.0 [1]
	2-Amino-4-(difluoromethyl)-6-[[(1S)-1-[6,8-difluoro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]ethyl]amino]pyrimidine-5-carbonitrile	IC50	6.2 [1]
	2-[(1S)-1-[(2,6-Diamino-5-chloropyrimidin-4-yl)amino]ethyl]-5-fluoro-3-(1H-pyrazol-5-yl)quinazolin-4-one	IC50	21.0 [1]
	2,4-Diamino-6-[[(1S)-1-[5-chloro-4-oxo-3-(1H-pyrazol-5-yl)quinazolin-2-yl]ethyl]amino]pyrimidine-5-carbonitrile	IC50	0.2 [1]
	pi3K/Mtor Inhibitor-2	IC50	16.0 [1]
	2-Amino-4-chloro-6-[[(1S)-1-(5-chloro-4-oxo-3-phenylquinazolin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile	IC50	1.0 [1]
	4-Amino-2-chloro-6-[[(1S)-1-(5-chloro-4-oxo-3-phenylquinazolin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile	IC50	4.3 [1]
	3-(6,7-Dimethoxy-4-morpholin-4-ylquinazolin-2-yl)-5-hydroxybenzamide	IC50	260.0 [1]
	3-(6,7-Dimethoxy-4-morpholin-4-ylquinazolin-2-yl)-5-(trifluoromethoxy)benzamide	IC50	330.0 [1]
	Chembl4125884	IC50	2.9 [1]
	pi3K/Mtor Inhibitor-1	IC50	46.0 [1]
	5-[2-[(3S)-3-Methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]-4-(trifluoromethyl)pyridin-2-amine	IC50	197.0 [1]
	5-[6-(1-Methylsulfonylcyclopropyl)-2-morpholin-4-ylpyrimidin-4-yl]-4-(trifluoromethyl)pyridin-2-amine	IC50	240.0 [1]
	1-[2-(Diethylamino)ethyl]-3-[6-[5-[(4-fluorophenyl)sulfonylamino]-6-methoxypyridin-3-yl]-1,3-benzothiazol-2-yl]urea	IC50	148.0 [1]
	N-Hydroxy-2-[[2-(4-methoxyphenyl)-9-methyl-6-morpholin-4-ylpurin-8-yl]methyl-methylamino]pyrimidine-5-carboxamide	IC50	10000.0 [1]
	2-[[2-(4-Aminophenyl)-9-methyl-6-morpholin-4-ylpurin-8-yl]methyl-methylamino]-N-hydroxypyrimidine-5-carboxamide	IC50	10000.0 [1]
	N-Hydroxy-2-[[2-(6-methoxypyridin-3-yl)-9-methyl-6-morpholin-4-ylpurin-8-yl]methyl-methylamino]pyrimidine-5-carboxamide	IC50	493.0 [1]
	2-[[2-(2-Aminopyrimidin-5-yl)-9-methyl-6-morpholin-4-ylpurin-8-yl]methyl-methylamino]-N-hydroxypyrimidine-5-carboxamide	IC50	15.0 [1]
	N-Hydroxy-2-[methyl-[(9-methyl-6-morpholin-4-yl-2-pyridin-4-ylpurin-8-yl)methyl]amino]pyrimidine-5-carboxamide	IC50	10000.0 [1]
	9-Methyl-7-phenyl-5,6-dihydropyrazolo[3,4-h]quinazolin-2-amine	IC50	8128.31 [1]
	3-(Benzotriazol-1-Yl)-5-[1-Methyl-5-(1-Phenylcyclopropyl)-1,2,4-Triazol-3-Yl]pyrazin-2-Amine	IC50	4.0 [1]
	3-(Benzotriazol-1-yl)-5-[1-methyl-5-[(1S)-1-morpholin-4-ylethyl]-1,2,4-triazol-3-yl]pyrazin-2-amine	IC50	79.43 [1]
	5-[1-Methyl-5-(1-Phenylcyclopropyl)-1,2,4-Triazol-3-Yl]-3-(1~{h}-Pyrazol-4-Yl)pyrazin-2-Amine	IC50	5.0 [1]
	4-[3-Amino-6-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]pyrazin-2-yl]-N,N-dimethylpyrazole-1-sulfonamide	IC50	0.8 [1]
	4-[3-Amino-6-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]pyrazin-2-yl]pyrazole-1-carboxamide	IC50	7.94 [1]
	1-[3-Amino-6-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]pyrazin-2-yl]pyrazole-4-carboxamide	IC50	2.0 [1]
	1-[3-Amino-6-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]pyrazin-2-yl]pyrazole-3-carboxamide	IC50	63.1 [1]
	4-[3-Azanyl-6-[1-Methyl-5-(1-Phenylcyclopropyl)-1,2,4-Triazol-3-Yl]pyrazin-2-Yl]benzamide	IC50	0.6 [1]
	2-[(1S)-1-[(6-Amino-5-methylpyrimidin-4-yl)amino]ethyl]-5-chloro-3-phenylquinazolin-4-one	IC50	14.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ PI3-kinase p110-delta/p85-alpha Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/pi3-kinase-p110-delta-p85-alpha-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, December 21). Quest Database™ PI3-kinase p110-delta/p85-alpha Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/pi3-kinase-p110-delta-p85-alpha-inhibitors-ic50-ki.
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