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PI3-kinase p110-beta subunit Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneIC50420.0 [1]
Tgx-221IC5022.0 [1]
IdelalisibIC50562.0 [1]
4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholineIC5015.2 [1]
PI-103IC5012.0 [1]
DactolisibIC5035.9 [1]
PictilisibIC5033.0 [1]
(2S)-1-N-[5-(2-Tert-butylpyrimidin-4-yl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamideIC502010.0 [1]
2-[(1-Methyl-1h-Benzimidazol-2-Yl)methyl]-6-Morpholin-4-Ylpyrimidin-4(3h)-OneIC5086.0 [1]
AlpelisibIC501200.0 [1], 2200.0 [2]
8-[(3,5-Difluoro-N-methylanilino)methyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamideIC507.0 [1], 10.0 [2], 35.0 [3]
2-Methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-7-morpholin-4-ylimidazo[1,2-a]pyrimidin-5-oneIC501.0 [1], 1.3 [2], 78.0 [3], 29000.0 [4]
2-((6-Amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-oneIC5016000.0 [1], 75000.0 [2], 200000.0 [3]
2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acidIC5010.0 [1], 40.0 [2]
1-[4-[4-[5-Amino-6-(benzotriazol-1-yl)pyrazin-2-yl]pyrazol-1-yl]piperidin-1-yl]-2-(dimethylamino)ethanoneIC50900.0 [1], 13000.0 [2]
1-[4-[3-[6-(6-Methoxypyridin-3-yl)quinazolin-4-yl]benzoyl]piperazin-1-yl]ethanoneIC503570.0 [1], 4840.0 [2]
5-{4-[3-(4-Acetylpiperazine-1-Carbonyl)phenyl]quinazolin-6-Yl}-2-Methoxypyridine-3-CarbonitrileIC501650.0 [1], 6530.0 [2]
8-(1-Anilinoethyl)-6-methyl-2-morpholin-4-ylchromen-4-oneIC503.0 [1], 28.0 [2], 57.0 [3]
WortmanninIC5010.0 [1], 14.0 [2], 15.0 [3]
(S)-2-(2-(2-Methylindolin-1-yl)-2-oxoethyl)-6-morpholinopyrimidin-4(3H)-oneIC5023.0 [1], 49.0 [2], 60.0 [3]
(2S)-N1-[5-(2-Tert-butyl-4-thiazolyl)-4-methyl-2-thiazolyl]pyrrolidine-1,2-dicarboxamideIC506500.0 [1], 10000.0 [2]
3-(4-Morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol;hydrochlorideIC5016.0 [1]
9-(1-Anilinoethyl)-N,N-dimethyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamideIC5011.0 [1], 68.0 [2], 156.0 [3]
9-(1-Anilinoethyl)-N-[2-(dimethylamino)ethyl]-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamideIC508.0 [1], 35.0 [2]
2-N-[2-Chloro-4-(dimethylcarbamoyl)phenyl]-2-N,8-N-dimethyl-4,5-dihydrothieno[3,2-d][1]benzoxepine-2,8-dicarboxamideIC5022.0 [1], 60.0 [2]
2-N-[2-Chloro-4-(dimethylcarbamoyl)phenyl]-2-N,8-N-dimethyl-4,5-dihydrothieno[3,2-d][1]benzoxepine-2,8-dicarboxamideKi19.0 [1]
(2S)-2-Amino-1-[4-[4-[2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]piperazin-1-yl]-3-phenylpropan-1-oneIC5063.0 [1], 74.0 [2], 6000.0 [3]
(2S)-2-Amino-1-[4-[4-[2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]piperazin-1-yl]propan-1-oneIC5031.0 [1], 62.0 [2], 890.0 [3]
8-[(6-Fluoro-2,3-dihydro-1,4-benzoxazin-4-yl)methyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamideIC509.0 [1], 10.0 [2], 37.0 [3]
8-[(8-Fluoro-2,3-dihydro-1,4-benzoxazin-4-yl)methyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamideIC508.0 [1], 10.0 [2], 12.0 [3]
8-[(6-Fluoro-2,3-dihydro-1,4-benzoxazin-4-yl)methyl]-N,N-dimethyl-2-[(2R)-2-methylmorpholin-4-yl]-4-oxochromene-6-carboxamideIC503.0 [1], 7.0 [2], 10.0 [3]
8-[(8-Fluoro-2,3-dihydro-1,4-benzoxazin-4-yl)methyl]-N,N-dimethyl-2-[(2R)-2-methylmorpholin-4-yl]-4-oxochromene-6-carboxamideIC502.0 [1], 7.0 [2], 10.0 [3]
8-[(6,8-Difluoro-2,3-dihydro-1,4-benzoxazin-4-yl)methyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamideIC506.0 [1], 9.0 [2], 10.0 [3]
8-[(3,5-Difluoro-N-methylanilino)methyl]-N,N-dimethyl-2-[(2R)-2-methylmorpholin-4-yl]-4-oxochromene-6-carboxamideIC502.0 [1], 7.0 [2], 10.0 [3]
8-[(6,8-Difluoro-2,3-dihydro-1,4-benzoxazin-4-yl)methyl]-N,N-dimethyl-2-[(2R)-2-methylmorpholin-4-yl]-4-oxochromene-6-carboxamideIC503.0 [1], 6.0 [2], 10.0 [3]
2-[(5-Fluoro-1H-benzimidazol-2-yl)methyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-oneIC5030.0 [1], 41.0 [2], 100.0 [3]
8-[1-(3-Fluoro-5-methylanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamideIC505.0 [1], 15.0 [2], 49.0 [3]
8-[1-(3-Chloro-4-fluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamideIC506.0 [1], 12.0 [2], 16.0 [3]
8-[1-(2,5-Difluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamideIC5010.0 [1], 19.0 [2], 60.0 [3]
8-[1-(3,5-Difluoroanilino)ethyl]-6-(4-hydroxypiperidine-1-carbonyl)-2-morpholin-4-ylchromen-4-oneIC503.0 [1], 11.0 [2], 17.0 [3]
8-[1-(3,5-Difluoroanilino)ethyl]-2-morpholin-4-yl-6-(piperidine-1-carbonyl)chromen-4-oneIC505.0 [1], 12.0 [2], 14.0 [3]
8-[1-(3,5-Difluoroanilino)ethyl]-N-ethyl-N-methyl-2-morpholin-4-yl-4-oxochromene-6-carboxamideIC502.0 [1], 7.0 [2], 8.0 [3]
8-[1-(3-Fluoro-5-methoxyanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamideIC504.0 [1], 10.0 [2], 15.0 [3]
8-[1-(2,3-Difluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamideIC504.0 [1], 13.0 [2], 24.0 [3]
8-[1-(3,5-Difluoroanilino)ethyl]-N-ethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamideIC505.0 [1], 9.0 [2], 14.0 [3]
8-[1-(3,5-Difluoroanilino)ethyl]-N-(2-methoxyethyl)-N-methyl-2-morpholin-4-yl-4-oxochromene-6-carboxamideIC504.0 [1], 11.0 [2], 17.0 [3]
8-[1-(3,5-Dichloroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamideIC505.0 [1], 10.0 [2], 17.0 [3]
8-[1-(3,5-Difluoro-N-methylanilino)ethyl]-2-morpholin-4-yl-6-(pyrrolidine-1-carbonyl)chromen-4-oneIC505.0 [1], 13.0 [2], 100.0 [3]
8-[1-(3-Chloroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamideIC504.0 [1], 9.0 [2], 10.0 [3]
8-(1-(3,5-Difluorophenylamino)ethyl)-6-(morpholine-4-carbonyl)-2-morpholino-4H-chromen-4-oneIC505.0 [1], 11.0 [2], 33.0 [3]
8-[1-(3,5-Difluoroanilino)ethyl]-N-(2-methoxyethyl)-2-morpholin-4-yl-4-oxochromene-6-carboxamideIC504.0 [1], 9.0 [2], 31.0 [3]
8-[1-(3,5-Difluoroanilino)ethyl]-N-(2-hydroxyethyl)-N-methyl-2-morpholin-4-yl-4-oxochromene-6-carboxamideIC504.0 [1], 10.0 [2], 15.0 [3]
8-[1-(3,5-Difluoroanilino)ethyl]-N,N-diethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamideIC504.0 [1], 10.0 [2], 16.0 [3]
8-[1-(3,5-Difluoroanilino)ethyl]-2-morpholin-4-yl-6-(pyrrolidine-1-carbonyl)chromen-4-oneIC502.0 [1], 4.0 [2], 9.0 [3]
8-[1-(4-Fluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamideIC507.0 [1], 18.0 [2], 128.0 [3]
8-[1-(3-Fluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamideIC505.0 [1], 12.0 [2], 32.0 [3]
2-Methyl-5-(2-methylmorpholin-4-yl)-3-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-oneIC500.3 [1], 0.5 [2], 2500.0 [3]
(2S,3S)-2-Amino-1-[4-[4-[2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]piperazin-1-yl]-3-methylpentan-1-oneIC5067.0 [1], 140.0 [2], 1400.0 [3]
BuparlisibIC50166.0 [1], 607.0 [2]
Nvp-aew541IC509000.0 [1], 9100.0 [2]
ApitolisibIC5027.0 [1]
Ku-0063794IC5030000.0 [1]
OmipalisibIC501.2 [1]
AS-252424IC5020000.0 [1]
Azd-8186IC503.0 [1], 4.0 [2]
1-[4-(3-Ethyl-7-morpholin-4-yltriazolo[4,5-d]pyrimidin-5-yl)phenyl]-3-[4-(4-methylpiperazine-1-carbonyl)phenyl]ureaIC507.0 [1]
N-(7,8-Dimethoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamideIC50350.0 [1]
1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC501400.0 [1]
Gne-477IC5086.0 [1]
LeniolisibIC50424.0 [1], 2250.0 [2]
5-(7-(Methylsulfonyl)-2-morpholino-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amineIC50120.0 [1]
5-(2-Amino-8-fluoro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-tert-butylpyridine-3-sulfonamideIC501000.0 [1], 1258.93 [2]
DNA-PK Inhibitor VIC503700.0 [1]
2-((9H-Purin-6-ylthio)methyl)-5-chloro-3-(2-methoxyphenyl)quinazolin-4(3H)-oneIC5011000.0 [1]
3-[4-Amino-1-(1-Methylethyl)-1h-Pyrazolo[3,4-D]pyrimidin-3-Yl]phenolIC508600.0 [1]
cis-3-[4-Amino-7-(3-azetidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-phenolIC50230.0 [1]
7-[3-(Azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2S)-oxolan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-4-amineIC509000.0 [1], 9100.0 [2]
5-Chloro-3-phenyl-2-[(1S)-1-(7H-purin-6-ylamino)ethyl]quinazolin-4-oneIC5077.0 [1]
(2S)-1-N-[5-(3-Fluoro-4-methylsulfonylphenyl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamideIC509100.0 [1]
(2S)-1-N-[5-(3-Fluoro-4-methylsulfonylphenyl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamideKi10000.0 [1]
4-[4-(2-Methylbenzimidazol-1-yl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholineIC50289.0 [1], 523.0 [2]
2-[4-(Morpholin-4-Yl)-6-Oxo-1,6-Dihydropyrimidin-2-Yl]-N-PhenylacetamideIC5042.0 [1]
2-[2-(2-Methyl-2,3-dihydroindol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-oneIC504.0 [1], 6.0 [2]
pi-103 (Hydrochloride)IC503.0 [1]
8-(4-Fluoro-2-methylphenoxy)-2-(morpholin-4-yl)quinolin-4(1H)-oneIC5032.0 [1], 72.0 [2]
1-Methyl-3-Naphthalen-2-Yl-1h-Pyrazolo[3,4-D]pyrimidin-4-AmineIC5016000.0 [1]
1-(1-Methylethyl)-3-Quinolin-6-Yl-1h-Pyrazolo[3,4-D]pyrimidin-4-AmineIC50240.0 [1]
1-Cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC50130.0 [1]
(2R)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-oneIC5027.0 [1], 145.0 [2]
N-[(E)-(5-Cyanopyrazolo[1,5-a]pyridin-3-yl)methylideneamino]-N,2-dimethyl-5-nitrobenzenesulfonamideIC5046.0 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC50489.78 [1], 50118723.36 [2]
1-(4-Amino-6-Methyl-1,3,5-Triazin-2-Yl)-N-(1h-Pyrazol-3-Yl)-1h-Benzimidazol-2-AmineIC50870.0 [1], 875.0 [2]
5-Methyl-4-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-2-morpholin-4-yl-[1,3]thiazolo[4,5-d]pyrimidin-7-oneIC500.6 [1], 0.63 [2]
[(4-{2-[(3-Hydroxyphenyl)amino]-1h-Benzimidazol-1-Yl}-1,3,5-Triazin-2-Yl)amino]acetonitrileIC50380.0 [1]
[(4-{2-[(3-Hydroxyphenyl)amino]-1h-Benzimidazol-1-Yl}-1,3,5-Triazin-2-Yl)amino]acetonitrileKi190.0 [1]
6-(6-Methoxypyridin-3-yl)benzo[d]thiazol-2-amineIC501584.89 [1], 3600.0 [2]
2-N-[2-Chloro-5-(dimethylcarbamoyl)phenyl]-2-N,8-N-dimethyl-4,5-dihydrothieno[3,2-d][1]benzoxepine-2,8-dicarboxamideIC50204.0 [1]
2-N-[2-Chloro-5-(dimethylcarbamoyl)phenyl]-2-N,8-N-dimethyl-4,5-dihydrothieno[3,2-d][1]benzoxepine-2,8-dicarboxamideKi204.0 [1]
[(3S)-3-[[6-(6-Methoxy-5-methylpyridin-3-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]oxy]pyrrolidin-1-yl]-(oxan-4-yl)methanoneIC504150.0 [1], 6790.0 [2]
N-{5-[3-Fluoro-4-(methanesulfonyl)phenyl]-4-methyl-1,3-thiazol-2-yl}acetamideIC501600.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ PI3-kinase p110-beta subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/pi3-kinase-p110-beta-subunit-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ PI3-kinase p110-beta subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/pi3-kinase-p110-beta-subunit-inhibitors-ic50-ki.
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