PI3-kinase p110-alpha subunit Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	PI-103	IC50	8.7 [1]
	Pictilisib	IC50	3.0 [1]
	Pictilisib	Ki	2.6 [1], 10.2 [2]
	2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	IC50	600.0 [1]
	2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	Ki	6000.0 [1]
	4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine	IC50	16.0 [1]
	Dactolisib	IC50	16.4 [1]
	Idelalisib	IC50	800.0 [1]
	Buparlisib	IC50	30.0 [1]
	Buparlisib	Ki	20.0 [1]
	Wortmannin	IC50	12.0 [1]
	Wortmannin	Ki	120.0 [1]
	Alpelisib	IC50	5.0 [1]
	Tgx-221	IC50	5700.0 [1]
	(2S)-1-N-[5-(2-Tert-butylpyrimidin-4-yl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide	IC50	20.0 [1]
	N-[(E)-(5-Cyanopyrazolo[1,5-a]pyridin-3-yl)methylideneamino]-N,2-dimethyl-5-nitrobenzenesulfonamide	IC50	0.9 [1]
	6-(2-Aminopyrimidin-5-yl)-N-(2-methoxyethyl)-3-methyl-8-morpholin-4-ylimidazo[1,2-a]pyrazine-2-carboxamide	IC50	0.9 [1], 13.0 [2]
	6-(2-Aminopyrimidin-5-yl)-N-(2-methoxyethyl)-3-methyl-8-morpholin-4-ylimidazo[1,2-a]pyrazine-2-carboxamide	Ki	1.9 [1], 2.3 [2], 2.4 [3], 3.1 [4]
	PF-04691502	IC50	3.3 [1], 4.85 [2], 8.33 [3]
	PF-04691502	Ki	0.57 [1]
	Gedatolisib	IC50	0.4 [1], 0.6 [2]
	Taselisib	IC50	0.7 [1], 4.0 [2], 31.0 [3]
	Taselisib	Ki	0.29 [1], 0.3 [2]
	(2S)-N1-[5-(2-Tert-butyl-4-thiazolyl)-4-methyl-2-thiazolyl]pyrrolidine-1,2-dicarboxamide	IC50	15.0 [1], 32.0 [2], 200.0 [3]
	N-[(E)-(5-Cyanopyrazolo[1,5-a]pyridin-3-yl)methylideneamino]-N-(2-hydroxyethyl)-2-methyl-5-nitrobenzenesulfonamide	IC50	0.8 [1], 1.3 [2], 49.0 [3], 82.0 [4]
	N-{6-[6-Amino-5-(Trifluoromethyl)pyridin-3-Yl]imidazo[1,2-A]pyridin-2-Yl}acetamide	IC50	3.6 [1], 4.0 [2], 5.9 [3], 12.0 [4]
	2-(Difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)benzimidazol-4-ol	IC50	0.12 [1], 0.53 [2], 0.83 [3], 1.3 [4], 2.9 [5]
	2-(Difluoromethyl)-3-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-7-methoxybenzimidazol-5-amine	IC50	0.95 [1], 1.0 [2], 3.1 [3], 4.8 [4], 8.8 [5]
	4-[4-[4-(Difluoromethoxy)-2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine	IC50	3.0 [1], 4.7 [2], 8.5 [3], 418.0 [4], 427.0 [5]
	2-(Difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-5-methoxybenzimidazol-4-ol	IC50	49.0 [1], 70.0 [2], 158.0 [3], 378.0 [4], 583.0 [5]
	2-((6-Amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one	IC50	100000.0 [1], 200000.0 [2], 255000.0 [3]
	Omipalisib	IC50	0.04 [1], 0.55 [2], 0.63 [3], 1.1 [4]
	N-[6-[6-Chloro-5-[[(4-fluorophenyl)sulfonyl]amino]-3-pyridinyl]-1,3-benzothiazol-2-yl]acetamide	IC50	6.3 [1]
	N-[6-[6-Chloro-5-[[(4-fluorophenyl)sulfonyl]amino]-3-pyridinyl]-1,3-benzothiazol-2-yl]acetamide	Ki	1.2 [1]
	CID 46927938	IC50	8.3 [1]
	CID 46927938	Ki	1.77 [1], 1.89 [2], 2.33 [3]
	(3-(9-(1-Benzylpiperidin-4-yl)-6-morpholino-9H-purin-2-yl)phenyl)methanol	IC50	45.0 [1], 63.0 [2]
	N-(2-Chlorophenyl)-N-methyl-4,5-dihydrothieno[3,2-d][1]benzoxepine-2-carboxamide	IC50	16.0 [1], 1000.0 [2]
	N-(2-Chlorophenyl)-N-methyl-4,5-dihydrothieno[3,2-d][1]benzoxepine-2-carboxamide	Ki	16.0 [1], 16.3 [2]
	8-[(3,5-Difluoro-N-methylanilino)methyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide	IC50	10.0 [1], 25.0 [2], 850.0 [3]
	[(3S)-3-[[6-(6-Methoxy-5-methylpyridin-3-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]oxy]pyrrolidin-1-yl]-(oxan-4-yl)methanone	IC50	1940.0 [1], 2037.8 [2], 2038.0 [3], 6490.0 [4]
	2-[4-[2-(2-Propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazol-8-yl]pyrazol-1-yl]ethanol	IC50	0.5 [1], 16.0 [2], 24.0 [3]
	2-[4-[2-(2-Propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazol-8-yl]pyrazol-1-yl]ethanol	Ki	0.27 [1]
	2-[1-(Propan-2-Yl)-1h-1,2,4-Triazol-5-Yl]-4,5-Dihydrothieno[3,2-D][1]benzoxepine-8-Carboxamide	IC50	4.0 [1], 155.0 [2]
	1-[4-[3-[6-(6-Methoxypyridin-3-yl)quinazolin-4-yl]benzoyl]piperazin-1-yl]ethanone	IC50	418.0 [1], 2120.0 [2]
	5-{4-[3-(4-Acetylpiperazine-1-Carbonyl)phenyl]quinazolin-6-Yl}-2-Methoxypyridine-3-Carbonitrile	IC50	262.0 [1], 3440.0 [2]
	5-[5-Chloro-2-[(4-methylsulfonylpiperazin-1-yl)methyl]-8-morpholin-4-ylimidazo[1,2-a]pyrazin-6-yl]pyrimidin-2-amine	IC50	5.2 [1]
	5-[5-Chloro-2-[(4-methylsulfonylpiperazin-1-yl)methyl]-8-morpholin-4-ylimidazo[1,2-a]pyrazin-6-yl]pyrimidin-2-amine	Ki	1.73 [1], 2.77 [2], 3.07 [3]
	5-(6-Morpholin-4-yl-8-oxa-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-4-yl)benzene-1,3-diol	IC50	5.9 [1], 53.4 [2], 61.3 [3], 139.8 [4]
	2-(Morpholin-4-yl)-benzo[h]chromen-4-one	IC50	13000.0 [1]
	8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one	IC50	130.0 [1], 5000.0 [2]
	Apitolisib	IC50	4.8 [1], 5.0 [2]
	Apitolisib	Ki	5.0 [1]
	Pik-75	IC50	0.5 [1], 7.8 [2]
	1-[4-(3-Ethyl-7-morpholin-4-yltriazolo[4,5-d]pyrimidin-5-yl)phenyl]-3-[4-(4-methylpiperazine-1-carbonyl)phenyl]urea	IC50	1.0 [1], 1.4 [2], 2.0 [3]
	N-(7,8-Dimethoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide	IC50	11.0 [1]
	1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	IC50	52.0 [1]
	Leniolisib	IC50	244.0 [1], 262.0 [2], 1670.0 [3]
	CID 118502708	IC50	320.0 [1], 1400.0 [2], 1410.0 [3]
	CID 46244454	IC50	13000.0 [1], 30000.0 [2]
	5-(2-Morpholin-4-Yl-7-Pyridin-3-Yl-6,7-Dihydro-5h-Pyrrolo[2,3-D]pyrimidin-4-Yl)-Pyrimidin-2-Ylamine	IC50	33.0 [1]
	3-(4-Morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol	IC50	2.0 [1], 8.0 [2], 41.0 [3]
	1-Methyl-3-[4-[4-morpholin-4-yl-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]urea	IC50	41.0 [1]
	Methyl 4-[6-[4-(methylcarbamoylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate	IC50	100.0 [1]
	5-[6-[(4-Methylsulfonylpiperazin-1-yl)methyl]-4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl]pyrimidin-2-amine	IC50	2.0 [1]
	N-[5-(2-Amino-4-methylpyrido[2,3-d]pyrimidin-6-yl)-2-methoxypyridin-3-yl]-2,4-difluorobenzenesulfonamide	IC50	2.0 [1], 3.59 [2]
	9-(1-Anilinoethyl)-N,N-dimethyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamide	IC50	560.0 [1], 2500.0 [2], 9600.0 [3]
	9-(1-Anilinoethyl)-N-[2-(dimethylamino)ethyl]-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamide	IC50	370.0 [1], 2200.0 [2], 2300.0 [3]
	1-[4-[4-[5-Amino-6-(benzotriazol-1-yl)pyrazin-2-yl]pyrazol-1-yl]piperidin-1-yl]-2-(dimethylamino)ethanone	IC50	16.0 [1], 58.0 [2]
	2-[(1-Methyl-1h-Benzimidazol-2-Yl)methyl]-6-Morpholin-4-Ylpyrimidin-4(3h)-One	IC50	10000.0 [1]
	2-N-(2-Chlorophenyl)-2-N-methyl-4,5-dihydrothieno[3,2-d][1]benzoxepine-2,8-dicarboxamide	IC50	1.5 [1], 100.0 [2]
	2-N-(2-Chlorophenyl)-2-N-methyl-4,5-dihydrothieno[3,2-d][1]benzoxepine-2,8-dicarboxamide	Ki	1.2 [1]
	6-(1H-Indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)phenoxy)-1H-pyrazolo[3,4-b]pyridine	IC50	6.8 [1], 7.0 [2], 187.0 [3]
	2-N-[2-Chloro-4-(dimethylcarbamoyl)phenyl]-2-N,8-N-dimethyl-4,5-dihydrothieno[3,2-d][1]benzoxepine-2,8-dicarboxamide	IC50	2.0 [1], 4.6 [2]
	2-N-[2-Chloro-4-(dimethylcarbamoyl)phenyl]-2-N,8-N-dimethyl-4,5-dihydrothieno[3,2-d][1]benzoxepine-2,8-dicarboxamide	Ki	2.0 [1]
	N-[5-(1,3-Benzothiazol-6-yl)-2-chloropyridin-3-yl]-4-fluorobenzenesulfonamide	IC50	769.0 [1]
	N-[5-(1,3-Benzothiazol-6-yl)-2-chloropyridin-3-yl]-4-fluorobenzenesulfonamide	Ki	12.9 [1], 13.0 [2]
	N-[5-(2-Amino-1,3-benzothiazol-6-yl)-2-chloropyridin-3-yl]-4-fluorobenzenesulfonamide	IC50	44.0 [1]
	N-[5-(2-Amino-1,3-benzothiazol-6-yl)-2-chloropyridin-3-yl]-4-fluorobenzenesulfonamide	Ki	5.6 [1]
	5,5-Dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benzothiazol-7(4H)-one	IC50	975.0 [1], 1333.0 [2], 2939.0 [3]
	(2S)-2-Amino-1-[4-[4-[2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]piperazin-1-yl]-3-phenylpropan-1-one	IC50	4700.0 [1], 8100.0 [2], 12000.0 [3]
	(2S)-2-Amino-1-[4-[4-[2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]piperazin-1-yl]propan-1-one	IC50	2300.0 [1], 3500.0 [2], 8200.0 [3]
	2-[(3S)-3-(1H-Indol-3-ylmethyl)morpholin-4-yl]-7,7-dimethyl-6,8-dihydro-5H-[1,3]thiazolo[5,4-c]azepin-4-one	IC50	59.0 [1], 199.0 [2], 1412.0 [3]
	[(3S)-3-[[6-[6-Methoxy-5-(trifluoromethyl)pyridin-3-yl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]oxy]pyrrolidin-1-yl]-(oxan-4-yl)methanone	IC50	589.0 [1], 590.0 [2], 3550.0 [3]
	1-[(3S)-3-[[6-[6-Methoxy-5-(trifluoromethyl)pyridin-3-yl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]oxy]pyrrolidin-1-yl]propan-1-one	IC50	791.0 [1], 792.0 [2], 2600.0 [3]
	1-[(3S)-3-[[6-(6-Methoxy-5-methylpyridin-3-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]pyrrolidin-1-yl]propan-1-one	IC50	651.0 [1], 7410.0 [2]
	[(3S)-3-[[6-(6-Methoxy-5-methylpyridin-3-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]pyrrolidin-1-yl]-(oxan-4-yl)methanone	IC50	373.0 [1], 432.0 [2], 6190.0 [3]
	[(3S)-3-[[6-[6-Methoxy-5-(trifluoromethyl)pyridin-3-yl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]pyrrolidin-1-yl]-(oxan-4-yl)methanone	IC50	43.0 [1], 44.0 [2], 2150.0 [3]
	(2S,3S)-2-Amino-1-[4-[4-[2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]piperazin-1-yl]-3-methylpentan-1-one	IC50	2800.0 [1], 6300.0 [2], 9200.0 [3]
	Benzoin	IC50	2120000.0 [1]
	Nvp-aew541	IC50	9000.0 [1], 9100.0 [2]
	Ku-0063794	IC50	8900.0 [1]
	Copanlisib	IC50	0.5 [1], 0.7 [2]
	BGT-226 free base	IC50	4.0 [1], 41.91 [2]
	2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid	IC50	870.0 [1]
	AS-252424	IC50	940.0 [1]
	Azd-8186	IC50	35.0 [1], 752.0 [2]
	CID 44219749	IC50	1026.0 [1]
	Liphagal	IC50	100.0 [1]
	Gne-477	IC50	4.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ PI3-kinase p110-alpha subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/pi3-kinase-p110-alpha-subunit-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 21). Quest Database™ PI3-kinase p110-alpha subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/pi3-kinase-p110-alpha-subunit-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan