![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_98871935c6dbd53bec1df41a5db7ba4b.svg) | Dactolisib | IC50 | 4.0 [1], 16.4 [2], 35.15 [3], 49.0 [4], 89.0 [5] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_6a128ea299a9f7657caade2822bdee2e.svg) | CID 46927938 | IC50 | 2.3 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_6a128ea299a9f7657caade2822bdee2e.svg) | CID 46927938 | Ki | 2.3 [1], 2.34 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_12ff920cef706e53faae74d41615486f.svg) | [3-[4-(2-Aminopyrimidin-5-yl)-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl] N-methylsulfamate | Ki | 0.08 [1], 0.23 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_cb085b9c40d9ca2c9f2f96e81812bd3a.svg) | 4-[4-(2-Aminopyrimidin-5-yl)-7-[3-[methyl(methylsulfamoyl)amino]cyclobutyl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-2-yl]morpholine | Ki | 0.19 [1], 0.32 [2], 0.41 [3], 0.47 [4] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_ac9222422aa3967de001af41e8ffd43b.svg) | Wortmannin | IC50 | 1.2 [1], 11.9 [2], 1610.0 [3] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_80f534f1ba1e8231071ce6b7de9f8a21.svg) | Idelalisib | IC50 | 825.0 [1], 2000.0 [2], 7500.0 [3] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_160a29879cd73d7dd09660bb28cdf816.svg) | Pictilisib | IC50 | 4.8 [1], 18.0 [2], 19.0 [3] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_2370402f8a6e3bb628c80ef4783fd95f.svg) | Buparlisib | IC50 | 11.0 [1], 29.0 [2], 40.0 [3] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_45132d864d2b45c655e5656779f071a3.svg) | PI-103 | IC50 | 2.0 [1], 8.0 [2], 40.0 [3] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_7c5bca176faf398f529ca1ccbde3c3ee.svg) | pi3K/Mtor Inhibitor-1 | IC50 | 10.0 [1], 11.0 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_59dfbce99ef8fc13c9ba7170ef992633.svg) | N-[3-[4-(2-Aminopyrimidin-5-yl)-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]methanesulfonamide | Ki | 0.16 [1], 0.28 [2], 1.39 [3] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_6cd6b7ce24b0d6aa9a4952a1fa156bcd.svg) | Duvelisib | IC50 | 400.0 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_c4d3aa6d99807cc348ed21510235dff7.svg) | Fimepinostat | IC50 | 19.0 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_5e57b4a6c01b7d72b98bb8264ab3d8a1.svg) | 4-[2-[(5-Fluoro-6-methoxypyridin-3-yl)amino]-5-[(1R)-1-(4-methylsulfonylpiperazin-1-yl)ethyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine | Ki | 4.0 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_5090904d3c9cd3ca24dd6d3095f977ef.svg) | N-[3-(Dimethylamino)propyl]-6-(1H-indazol-4-yl)-8-morpholin-4-ylimidazo[1,2-a]pyrazine-2-carboxamide | IC50 | 35.0 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_5090904d3c9cd3ca24dd6d3095f977ef.svg) | N-[3-(Dimethylamino)propyl]-6-(1H-indazol-4-yl)-8-morpholin-4-ylimidazo[1,2-a]pyrazine-2-carboxamide | Ki | 44.0 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_cb1ca64754c452d699feab697d6e79ee.svg) | 12-(2-Aminopyrimidin-5-yl)-N-[(4-fluorophenyl)methyl]-10-morpholin-4-yl-1,5,8,11-tetrazatricyclo[7.4.0.02,7]trideca-2(7),8,10,12-tetraene-5-carboxamide | IC50 | 1.2 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_cb1ca64754c452d699feab697d6e79ee.svg) | 12-(2-Aminopyrimidin-5-yl)-N-[(4-fluorophenyl)methyl]-10-morpholin-4-yl-1,5,8,11-tetrazatricyclo[7.4.0.02,7]trideca-2(7),8,10,12-tetraene-5-carboxamide | Ki | 9.2 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_a8efcdf51c2069c58524f0c6c4b3b497.svg) | 5-[4-(4-Fluorophenyl)sulfonyl-10-morpholin-4-yl-1,4,8,11-tetrazatricyclo[7.4.0.02,7]trideca-2(7),8,10,12-tetraen-12-yl]pyrimidin-2-amine | IC50 | 1.1 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_a8efcdf51c2069c58524f0c6c4b3b497.svg) | 5-[4-(4-Fluorophenyl)sulfonyl-10-morpholin-4-yl-1,4,8,11-tetrazatricyclo[7.4.0.02,7]trideca-2(7),8,10,12-tetraen-12-yl]pyrimidin-2-amine | Ki | 2.55 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_6a86fb57f569bf1408e6b1ac720f4080.svg) | 5-[5-[2-(4-Fluorophenyl)ethyl]-10-morpholin-4-yl-1,5,8,11-tetrazatricyclo[7.4.0.02,7]trideca-2(7),8,10,12-tetraen-12-yl]pyrimidin-2-amine | IC50 | 8.0 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_6a86fb57f569bf1408e6b1ac720f4080.svg) | 5-[5-[2-(4-Fluorophenyl)ethyl]-10-morpholin-4-yl-1,5,8,11-tetrazatricyclo[7.4.0.02,7]trideca-2(7),8,10,12-tetraen-12-yl]pyrimidin-2-amine | Ki | 5.9 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_afbf54a39edd86c779920a246d6ef342.svg) | 5-[5-(4-Fluorophenyl)-10-morpholin-4-yl-1,5,8,11-tetrazatricyclo[7.4.0.02,7]trideca-2(7),8,10,12-tetraen-12-yl]pyrimidin-2-amine | IC50 | 0.5 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_afbf54a39edd86c779920a246d6ef342.svg) | 5-[5-(4-Fluorophenyl)-10-morpholin-4-yl-1,5,8,11-tetrazatricyclo[7.4.0.02,7]trideca-2(7),8,10,12-tetraen-12-yl]pyrimidin-2-amine | Ki | 3.3 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_31ad17e97f5360b2a9721b6dd6bdd727.svg) | 12-(2-Aminopyrimidin-5-yl)-N-cyclohexyl-10-morpholin-4-yl-1,5,8,11-tetrazatricyclo[7.4.0.02,7]trideca-2(7),8,10,12-tetraene-5-carboxamide | IC50 | 9.6 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_31ad17e97f5360b2a9721b6dd6bdd727.svg) | 12-(2-Aminopyrimidin-5-yl)-N-cyclohexyl-10-morpholin-4-yl-1,5,8,11-tetrazatricyclo[7.4.0.02,7]trideca-2(7),8,10,12-tetraene-5-carboxamide | Ki | 3.1 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_298ac66588e46a3c127d1fb88539c9a0.svg) | N-[4-[[4-[2-(Difluoromethyl)-4-methoxybenzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]amino]cyclohexyl]methanesulfonamide | IC50 | 6.1 [1], 8.0 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_7fb1e49362ee2a0fffe57abaa95d6671.svg) | 5-(4-Cyclopropylsulfonyl-10-morpholin-4-yl-1,4,8,11-tetrazatricyclo[7.4.0.02,7]trideca-2(7),8,10,12-tetraen-12-yl)pyrimidin-2-amine | IC50 | 26.1 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_7fb1e49362ee2a0fffe57abaa95d6671.svg) | 5-(4-Cyclopropylsulfonyl-10-morpholin-4-yl-1,4,8,11-tetrazatricyclo[7.4.0.02,7]trideca-2(7),8,10,12-tetraen-12-yl)pyrimidin-2-amine | Ki | 7.65 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_5acc2ee206f3be772a52c693af0ff78e.svg) | N-[2-[12-(2-Aminopyrimidin-5-yl)-10-morpholin-4-yl-1,5,8,11-tetrazatricyclo[7.4.0.02,7]trideca-2(7),8,10,12-tetraen-5-yl]ethyl]methanesulfonamide | IC50 | 8.1 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_5acc2ee206f3be772a52c693af0ff78e.svg) | N-[2-[12-(2-Aminopyrimidin-5-yl)-10-morpholin-4-yl-1,5,8,11-tetrazatricyclo[7.4.0.02,7]trideca-2(7),8,10,12-tetraen-5-yl]ethyl]methanesulfonamide | Ki | 9.9 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_62619df4971829e5b308e22c3acf5b7f.svg) | 5-(5-Methylsulfonyl-10-morpholin-4-yl-1,5,8,11-tetrazatricyclo[7.4.0.02,7]trideca-2(7),8,10,12-tetraen-12-yl)pyrimidin-2-amine | IC50 | 29.3 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_62619df4971829e5b308e22c3acf5b7f.svg) | 5-(5-Methylsulfonyl-10-morpholin-4-yl-1,5,8,11-tetrazatricyclo[7.4.0.02,7]trideca-2(7),8,10,12-tetraen-12-yl)pyrimidin-2-amine | Ki | 3.11 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_07c3d3a1c2fcd98ce7fcca55f1218575.svg) | 4-[6-(1H-Indazol-4-yl)-2-[(4-methylsulfonylpiperazin-1-yl)methyl]imidazo[1,2-a]pyrazin-8-yl]morpholine | IC50 | 95.0 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_07c3d3a1c2fcd98ce7fcca55f1218575.svg) | 4-[6-(1H-Indazol-4-yl)-2-[(4-methylsulfonylpiperazin-1-yl)methyl]imidazo[1,2-a]pyrazin-8-yl]morpholine | Ki | 181.0 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_ada38593848977feca5bba658473116d.svg) | 6-(1H-Indazol-4-yl)-N-methyl-8-morpholin-4-ylimidazo[1,2-a]pyrazine-2-carboxamide | IC50 | 110.0 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_ada38593848977feca5bba658473116d.svg) | 6-(1H-Indazol-4-yl)-N-methyl-8-morpholin-4-ylimidazo[1,2-a]pyrazine-2-carboxamide | Ki | 102.0 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_65b1d44bcb0ac644944c32c93d2a8907.svg) | 6-(1H-Indazol-4-yl)-N-(3-methoxypropyl)-8-morpholin-4-ylimidazo[1,2-a]pyrazine-2-carboxamide | IC50 | 31.0 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_65b1d44bcb0ac644944c32c93d2a8907.svg) | 6-(1H-Indazol-4-yl)-N-(3-methoxypropyl)-8-morpholin-4-ylimidazo[1,2-a]pyrazine-2-carboxamide | Ki | 60.0 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_5651fa4d60c00eb1d9c1baf4c02aae9c.svg) | 4-[5-Chloro-6-(1H-indazol-4-yl)-2-[(4-methylsulfonylpiperazin-1-yl)methyl]imidazo[1,2-a]pyrazin-8-yl]morpholine | IC50 | 145.0 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_5651fa4d60c00eb1d9c1baf4c02aae9c.svg) | 4-[5-Chloro-6-(1H-indazol-4-yl)-2-[(4-methylsulfonylpiperazin-1-yl)methyl]imidazo[1,2-a]pyrazin-8-yl]morpholine | Ki | 210.0 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_80dea8d1e8c0bcb3274677d29b39225b.svg) | 4-[3-Bromo-6-(1H-indazol-4-yl)-2-[(4-methylsulfonylpiperazin-1-yl)methyl]imidazo[1,2-a]pyrazin-8-yl]morpholine | IC50 | 47.0 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_80dea8d1e8c0bcb3274677d29b39225b.svg) | 4-[3-Bromo-6-(1H-indazol-4-yl)-2-[(4-methylsulfonylpiperazin-1-yl)methyl]imidazo[1,2-a]pyrazin-8-yl]morpholine | Ki | 86.0 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_aba9f8c2d5d6654996f93d173c760ad9.svg) | 6-(1H-Indazol-4-yl)-8-morpholin-4-yl-N-(2-morpholin-4-ylethyl)imidazo[1,2-a]pyrazine-2-carboxamide | IC50 | 38.0 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_aba9f8c2d5d6654996f93d173c760ad9.svg) | 6-(1H-Indazol-4-yl)-8-morpholin-4-yl-N-(2-morpholin-4-ylethyl)imidazo[1,2-a]pyrazine-2-carboxamide | Ki | 65.0 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_865bd0403631236073f8bc54dacb76cf.svg) | 6-(1H-Indazol-4-yl)-2-[(4-methylsulfonylpiperazin-1-yl)methyl]-8-morpholin-4-ylimidazo[1,2-a]pyrazine-5-carbonitrile | IC50 | 194.0 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_865bd0403631236073f8bc54dacb76cf.svg) | 6-(1H-Indazol-4-yl)-2-[(4-methylsulfonylpiperazin-1-yl)methyl]-8-morpholin-4-ylimidazo[1,2-a]pyrazine-5-carbonitrile | Ki | 410.0 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_d223dbfe2f155a6a6a7fdf14d94b89e5.svg) | 5-[7-(3-Aminocyclobutyl)-2-[(3S)-3-methylmorpholin-4-yl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine | Ki | 0.94 [1], 1.35 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_628c90260e884648623484b3e60edbde.svg) | 5-[2-[(3S)-3-Methylmorpholin-4-yl]-7-(1-propan-2-ylsulfonylazetidin-3-yl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine | Ki | 0.23 [1], 2.3 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_524064951cb173ba2dcd4e97a6715ab6.svg) | 5-[7-[3-(Methylamino)cyclobutyl]-2-[(3S)-3-methylmorpholin-4-yl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine | Ki | 0.99 [1], 2.12 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_a69e23aa28987669b58c284280a1df6e.svg) | 5-[7-(3,3-Difluorocyclobutyl)-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine | Ki | 0.21 [1], 0.31 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_0c9d87f824f4a70187c06563e36da4d6.svg) | N-[3-[4-(2-Aminopyrimidin-5-yl)-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]-N-methylmethanesulfonamide | Ki | 0.23 [1], 0.72 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_7ac922217b379b894cd95292d38f59dc.svg) | 5-[7-[(3S)-1-Methylsulfonylpyrrolidin-3-yl]-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine | Ki | 0.15 [1], 1.25 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_955038ad36393f195f8ff0684dcfe54c.svg) | N-[3-[4-(2-Aminopyrimidin-5-yl)-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]-N-methylacetamide | Ki | 5.39 [1], 9.03 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_5766411bc7b5c396621029f9471123e0.svg) | 5-[7-[(1S)-3,3-Difluorocyclopentyl]-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine | Ki | 0.31 [1], 0.39 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_a22787f740115f5febcb527834599954.svg) | 5-[7-[(1R)-3,3-Difluorocyclopentyl]-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine | Ki | 0.31 [1], 0.39 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_ff158ac2649ac75b9b9bdbf5a690cfe6.svg) | N-[3-[4-(2-Aminopyrimidin-5-yl)-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]acetamide | Ki | 5.83 [1], 9.7 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_90d2db206c0e7f988ab956f4af4717ad.svg) | (3S)-3-[4-(2-Aminopyrimidin-5-yl)-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]-N-methylpyrrolidine-1-sulfonamide | Ki | 0.12 [1], 0.79 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_6918f33ec3cf290fe9f3244158be3c54.svg) | 3-[4-(2-Aminopyrimidin-5-yl)-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]-1-methylcyclobutan-1-ol | Ki | 0.74 [1], 1.97 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_695dc062aad1d77d7b744b77ab1d28df.svg) | N-[3-[4-(2-Aminopyrimidin-5-yl)-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]-2,2,4,4-tetramethylcyclobutyl]acetamide | Ki | 1.14 [1], 7.68 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_cea8a3ebc628058ebd6eb64805bff351.svg) | Methyl 3-[4-(2-aminopyrimidin-5-yl)-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]azetidine-1-carboxylate | Ki | 0.23 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_e1a9ac9004b5f244baf4976975c2ea13.svg) | 3-[4-(2-Aminopyrimidin-5-yl)-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]cyclobutane-1-carbonitrile | Ki | 0.12 [1], 0.23 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_40fe2418f341a88c595beb2d8e470491.svg) | 5-[7-(3-Fluorocyclobutyl)-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine | Ki | 0.23 [1], 0.51 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_3b307a61287d1028dd5870c35dba2884.svg) | 5-[2-[(3S)-3-Methylmorpholin-4-yl]-7-[(3S)-1-methylsulfonylpyrrolidin-3-yl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine | Ki | 0.23 [1], 0.26 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_3fc042f060ee718518ef4204d61cb384.svg) | 1-[(3S,4R)-3-[4-(2-Aminopyrimidin-5-yl)-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]-4-fluoropyrrolidin-1-yl]ethanone | Ki | 2.44 [1], 5.08 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_05c67294b6249496535d5882acee1047.svg) | 5-[7-(1-Methylsulfonylazetidin-3-yl)-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine | Ki | 0.3 [1], 0.35 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_9ef101c2a556f31514b205e4d02a3e1c.svg) | 3-[4-(2-Aminopyrimidin-5-yl)-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]azetidine-1-sulfonamide | Ki | 0.13 [1], 0.23 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_f715c41c9638d7cb5320be3711ebc9c4.svg) | (3S)-3-[4-(2-Aminopyrimidin-5-yl)-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]-N,N-dimethylpyrrolidine-1-sulfonamide | Ki | 0.1 [1], 0.24 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_ac890efe1fae6aec80bf95d3261499e9.svg) | 5-[7-[(3R)-1-Methylsulfonylpiperidin-3-yl]-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine | Ki | 0.51 [1], 0.6 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_4a676075d9c3e1c39736e4a943ee8b2d.svg) | (3R)-3-[4-(2-Aminopyrimidin-5-yl)-2-[(3S)-3-methylmorpholin-4-yl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]-N-methylpyrrolidine-1-sulfonamide | Ki | 0.47 [1], 3.25 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_792d6e0dcaa65e43584a5716ff688d35.svg) | Tert-butyl (3S)-3-[4-(2-aminopyrimidin-5-yl)-2-[(3S)-3-methylmorpholin-4-yl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]pyrrolidine-1-carboxylate | Ki | 0.18 [1], 0.36 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_6e4d61ba240cd72126b5725192f09c3e.svg) | (3S)-3-[4-(2-Aminopyrimidin-5-yl)-2-[(3S)-3-methylmorpholin-4-yl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]pyrrolidine-1-sulfonamide | Ki | 0.13 [1], 0.23 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_a47b1dde72088460f919fc6e5e608a56.svg) | 5-[7-[(3S)-1-Ethylsulfonylpyrrolidin-3-yl]-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine | Ki | 0.09 [1], 0.49 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_49b758a9355bd8eea6ad2443279e520e.svg) | 5-[7-[(3S)-1-Cyclopropylsulfonylpyrrolidin-3-yl]-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine | Ki | 0.07 [1], 0.23 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_9395d2480e13d5d2008f1098cc479bc2.svg) | 5-[2-Morpholin-4-yl-7-[(3S)-1-propan-2-ylsulfonylpyrrolidin-3-yl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine | Ki | 0.15 [1], 0.23 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_0f0feea8e9211856be6d6b2906c0dcdd.svg) | 5-[7-(1-Ethylsulfonylazetidin-3-yl)-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine | Ki | 0.12 [1], 0.23 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_b4378c430a018e7ba8f09292584bad1d.svg) | 5-[2-Morpholin-4-yl-7-[(3R)-1-propan-2-ylsulfonylpyrrolidin-3-yl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine | Ki | 0.15 [1], 0.23 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_0ba52f225b12029d1544a3a304b38348.svg) | 5-[7-(1-Cyclopropylsulfonylazetidin-3-yl)-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine | Ki | 0.12 [1], 0.23 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_78636d2c0d2f8546d691e69735649348.svg) | 5-[7-[(3S)-1-Ethylsulfonylpyrrolidin-3-yl]-2-[(3S)-3-methylmorpholin-4-yl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine | Ki | 0.06 [1], 0.23 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_ff5761c2c8fac8d0956710fd80a89139.svg) | 5-[2-[(3S)-3-Methylmorpholin-4-yl]-7-(1-methylsulfonylazetidin-3-yl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine | Ki | 0.23 [1], 0.29 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_bbd7b330d6365e1d38ce3746d590b5cf.svg) | 3-[4-(2-Aminopyrimidin-5-yl)-2-[(3S)-3-methylmorpholin-4-yl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]-N,N-dimethylazetidine-1-sulfonamide | Ki | 0.03 [1], 0.23 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_55542cd18fb68b42a9206905dbab6451.svg) | 5-[7-[(3S)-1-Cyclopropylsulfonylpyrrolidin-3-yl]-2-[(3S)-3-methylmorpholin-4-yl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine | Ki | 0.06 [1], 0.23 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_b52a1d7cf12bdab38bfeaf69f229fa75.svg) | 5-[7-(1-Ethylsulfonylazetidin-3-yl)-2-[(3S)-3-methylmorpholin-4-yl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine | Ki | 0.1 [1], 0.23 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_50fdbb89862edea728ec76f1c9ea78b7.svg) | (3R,4R)-3-[4-(2-Aminopyrimidin-5-yl)-2-[(3S)-3-methylmorpholin-4-yl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]-4-methoxy-N-methylpyrrolidine-1-sulfonamide | Ki | 0.18 [1], 0.26 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_5112ac8a1dfe4c71f2af404b7d2b73f7.svg) | Ethyl (3S)-3-[4-(2-aminopyrimidin-5-yl)-2-[(3S)-3-methylmorpholin-4-yl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]pyrrolidine-1-carboxylate | Ki | 0.09 [1], 0.23 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_d1ee2fae863e70e8b92afbc6aa6b609e.svg) | 5-[7-(1-Cyclopropylsulfonylazetidin-3-yl)-2-[(3S)-3-methylmorpholin-4-yl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine | Ki | 0.03 [1], 0.23 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_bbf30486cae669db52688251218d3804.svg) | (3R,4R)-3-[4-(2-Aminopyrimidin-5-yl)-2-[(3S)-3-methylmorpholin-4-yl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]-4-hydroxy-N-methylpyrrolidine-1-sulfonamide | Ki | 0.13 [1], 0.23 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_82a703b13e046ae1f5e5a465ac767ac8.svg) | 3-[4-(2-Aminopyrimidin-5-yl)-2-[(3S)-3-methylmorpholin-4-yl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]-N-methylazetidine-1-sulfonamide | Ki | 0.06 [1], 0.23 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_5902f736a34b5073738213322b65501a.svg) | 3-[4-(2-Aminopyrimidin-5-yl)-2-[(3S)-3-methylmorpholin-4-yl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]azetidine-1-sulfonamide | Ki | 0.22 [1], 0.23 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_f903f5c6c255258787a2f5995371e680.svg) | Methyl (3S)-3-[4-(2-aminopyrimidin-5-yl)-2-[(3S)-3-methylmorpholin-4-yl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]pyrrolidine-1-carboxylate | Ki | 0.07 [1], 0.23 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_b5d284e33bf7b06f2f2844abe3514401.svg) | 5-[2-[(3S)-3-Methylmorpholin-4-yl]-7-[(3S)-1-propan-2-ylsulfonylpyrrolidin-3-yl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine | Ki | 0.04 [1], 0.23 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_ce4365d97fa8e4d6055ff4f7c29abdb3.svg) | 5-(7-Tert-butyl-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine | Ki | 0.15 [1], 0.23 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_9de121864e0485a03a3c928c51f65b43.svg) | (1-Acetylazetidin-3-yl) (3R)-3-[4-(2-aminopyrimidin-5-yl)-2-[(3S)-3-methylmorpholin-4-yl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]pyrrolidine-1-carboxylate | Ki | 0.1 [1], 0.23 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_8abb68add51c3a1cefa1b33999a55894.svg) | 5-[7-(3-Methyl-1-methylsulfonylpyrrolidin-3-yl)-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine | Ki | 0.01 [1], 0.23 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_e8abe19fb8278076d889255e6d29448f.svg) | Tert-butyl N-[3-[4-(2-aminopyrimidin-5-yl)-2-[(3S)-3-methylmorpholin-4-yl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]carbamate | Ki | 0.43 [1], 0.64 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_66286e7f95c1ef7daacb255556e73180.svg) | Tert-butyl N-[3-[4-(2-aminopyrimidin-5-yl)-2-[(3S)-3-methylmorpholin-4-yl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]-N-methylcarbamate | Ki | 0.29 [1], 0.69 [2] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_403b832729a4c215a5195e14911a88aa.svg) | Vorinostat | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_a04ee8c579b4787488913d763482cc53.svg) | [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol | IC50 | 5577.0 [1] |
![](https://images.aatbio.com/dataset/ic50/pi3-kinase-p110-alpha-p85-alpha_5f1eec00976779acb7107f5298587de7.svg) | Torin 1 | IC50 | 250.0 [1] |