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PI3-kinase class I Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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(5,5-Dioxo-1-phenyl-4,9b-dihydrothiochromeno[4,3-c]pyrazol-1-ium-3-yl)-morpholin-4-ylmethanoneIC502740.0 [1]
(1-Methyl-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl)-morpholin-4-ylmethanoneIC501753.0 [1]
[6-Fluoro-1-[1-[2-(oxan-4-yl)ethyl]piperidin-3-yl]-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC5022.0 [1]
[8-(2-Methoxyethylamino)-5,5-dioxo-1-phenyl-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC50902.0 [1]
[1-(4,4-Difluorocyclohexyl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC50386.0 [1]
[1-[3-(Dimethylamino)phenyl]-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC504720.0 [1]
[1-(3,3-Dimethylcyclohexyl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC50498.0 [1]
[1-(3-Fluorophenyl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC50739.0 [1]
[1-[3-[(Dimethylamino)methyl]phenyl]-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC501112.0 [1]
[1-[3-(2-Aminopyrimidin-5-yl)phenyl]-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC50454.0 [1]
[5,5-Dioxo-1-(3-pyrrolidin-1-ylphenyl)-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC504949.0 [1]
[1-[3-(5-Methyl-1,3,4-thiadiazol-2-yl)phenyl]-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC50661.0 [1]
[5,5-Dioxo-1-(3-pyridin-4-ylphenyl)-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC50193.0 [1]
N-[3-[3-(Morpholine-4-carbonyl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-1-yl]phenyl]methanesulfonamideIC501780.0 [1]
[1-[3-(5-Methyl-1,3,4-oxadiazol-2-yl)phenyl]-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC501201.0 [1]
[1-[3-(3,5-Dimethyl-1,2-oxazol-4-yl)phenyl]-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC50300.0 [1]
Morpholin-4-yl-[1-[3-[1-(2-morpholin-4-ylethyl)pyrazol-4-yl]phenyl]-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]methanoneIC50338.0 [1]
[5,5-Dioxo-1-[3-(1,3-thiazol-2-yl)phenyl]-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC504219.0 [1]
1-[4-[[3-(Morpholine-4-carbonyl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-1-yl]methyl]piperidin-1-yl]ethanoneIC502825.0 [1]
6-Methoxy-3-(morpholin-4-ylcarbonyl)-1-phenyl-1,4-dihydrothiochromeno[4,3-c]pyrazole 5,5-dioxideIC50459.0 [1]
(6-Methoxy-1-methyl-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl)-morpholin-4-ylmethanoneIC501730.0 [1]
3-(Morpholin-4-ylcarbonyl)-2,4-dihydrothiochromeno[4,3-c]pyrazole 5,5-dioxideIC502881.0 [1]
[1-[[1-(2-Methoxyethyl)piperidin-4-yl]methyl]-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC50681.0 [1]
(8,8-Dioxo-3-phenyl-8lambda6,10-dithia-3,4-diazatricyclo[7.3.0.02,6]dodeca-1(9),2(6),4,11-tetraen-5-yl)-morpholin-4-ylmethanoneIC501699.0 [1]
[1-[3-(3-Methyl-1,2,4-oxadiazol-5-yl)phenyl]-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC502694.0 [1]
[1-[3-(Furan-3-yl)phenyl]-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC50826.0 [1]
(7-Methoxy-1-methyl-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl)-morpholin-4-ylmethanoneIC50422.0 [1]
(7-Methoxy-5,5-dioxo-1-phenyl-4H-thiochromeno[4,3-c]pyrazol-3-yl)-morpholin-4-ylmethanoneIC50349.0 [1]
(5,5-Dioxo-1-pyridin-2-yl-4H-thiochromeno[4,3-c]pyrazol-3-yl)-morpholin-4-ylmethanoneIC501595.0 [1]
(1-Cyclohexyl-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl)-morpholin-4-ylmethanoneIC50136.0 [1]
1-Methyl-3-(morpholin-4-ylcarbonyl)-8-nitro-1,4-dihydrothiochromeno[4,3-c]pyrazole 5,5-dioxideIC502770.0 [1]
[1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC50670.0 [1]
[1-(1H-Indazol-5-yl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC501636.0 [1]
(8,8-Dioxo-3-phenyl-8lambda6-thia-1,3,4,10-tetrazatricyclo[7.3.0.02,6]dodeca-2(6),4,9,11-tetraen-5-yl)-morpholin-4-ylmethanoneIC50477.0 [1]
(4-Methyl-5,5-dioxo-1-phenylpyrazolo[4,3-c][1,2]benzothiazin-3-yl)-morpholin-4-ylmethanoneIC503460.0 [1]
[1-(2-Methyl-1,3-benzothiazol-6-yl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC50662.0 [1]
[5,5-Dioxo-1-(4-propan-2-ylphenyl)-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC501472.0 [1]
Morpholin-4-yl-[1-(oxan-4-yl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]methanoneIC50223.0 [1]
[1-[(4-Methoxyphenyl)methyl]-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC50459.0 [1]
[1-(3-Methoxypropyl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC50907.0 [1]
[5,5-Dioxo-1-(pyridin-2-ylmethyl)-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC503955.0 [1]
[1-[2-(Dimethylamino)ethyl]-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC501505.0 [1]
Tert-butyl 4-[[3-(morpholine-4-carbonyl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-1-yl]methyl]piperidine-1-carboxylateIC50495.0 [1]
[5,5-Dioxo-1-(oxolan-2-ylmethyl)-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC501560.0 [1]
[1-(Cyclopentylmethyl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC50247.0 [1]
Morpholin-4-yl-[1-(oxan-4-ylmethyl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]methanoneIC50789.0 [1]
4-Benzyl-3-(morpholin-4-ylcarbonyl)-1-phenyl-1,4-dihydrothiochromeno[4,3-c]pyrazole 5,5-dioxideIC502475.0 [1]
[1-(Cyclohexylmethyl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC50509.0 [1]
[5,5-Dioxo-1-(piperidin-4-ylmethyl)-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC50531.0 [1]
[4-(Cyclopropylmethyl)-5,5-dioxo-1-phenyl-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC503900.0 [1]
3-[3-(Morpholine-4-carbonyl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-1-yl]benzamideIC50957.0 [1]
N-[[4-[3-(Morpholine-4-carbonyl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-1-yl]phenyl]methyl]methanesulfonamideIC50421.0 [1]
[1-[(1-Methylpiperidin-3-yl)methyl]-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC506051.0 [1]
[1-[2-(1-Methylpyrrolidin-2-yl)ethyl]-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC501233.0 [1]
(1-Cycloheptyl-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl)-morpholin-4-ylmethanoneIC50469.0 [1]
(1-Cyclopentyl-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl)-morpholin-4-ylmethanoneIC50205.0 [1]
(3-Cyclohexyl-8,8-dioxo-8lambda6-thia-3,4,10-triazatricyclo[7.4.0.02,6]trideca-1(9),2(6),4,10,12-pentaen-5-yl)-morpholin-4-ylmethanoneIC50437.0 [1]
[5,5-Dioxo-1-(oxolan-3-yl)-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC50890.0 [1]
[1-(Azepan-4-yl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC501900.0 [1]
(5,5-Dioxo-1-pyrrolidin-3-yl-4H-thiochromeno[4,3-c]pyrazol-3-yl)-morpholin-4-ylmethanoneIC504640.0 [1]
(8-Methoxy-5,5-dioxo-1-phenyl-4H-thiochromeno[4,3-c]pyrazol-3-yl)-morpholin-4-ylmethanoneIC503350.0 [1]
N-[3-(Morpholine-4-carbonyl)-5,5-dioxo-1-phenyl-4H-thiochromeno[4,3-c]pyrazol-8-yl]acetamideIC50876.0 [1]
(4-Methylpiperazin-1-yl)-[3-(morpholine-4-carbonyl)-5,5-dioxo-1-phenyl-4H-thiochromeno[4,3-c]pyrazol-8-yl]methanoneIC504275.0 [1]
N,N-Dimethyl-3-(morpholine-4-carbonyl)-5,5-dioxo-1-phenyl-4H-thiochromeno[4,3-c]pyrazole-8-carboxamideIC503728.0 [1]
[3-(Morpholine-4-carbonyl)-5,5-dioxo-1-phenyl-4H-thiochromeno[4,3-c]pyrazol-8-yl]-piperidin-1-ylmethanoneIC503412.0 [1]
[1-[1-(2-Hydroxyethyl)piperidin-4-yl]-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC501755.0 [1]
N-[3-(Morpholine-4-carbonyl)-5,5-dioxo-1-phenyl-4H-thiochromeno[4,3-c]pyrazol-8-yl]methanesulfonamideIC501312.0 [1]
[3-(Morpholine-4-carbonyl)-5,5-dioxo-1-phenyl-4H-thiochromeno[4,3-c]pyrazol-8-yl]-morpholin-4-ylmethanoneIC503030.0 [1]
[1-(1-Methylsulfonylpiperidin-4-yl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC502100.0 [1]
7-Bromo-3-(morpholin-4-ylcarbonyl)-1-phenyl-1,4-dihydrothiochromeno[4,3-c]pyrazole 5,5-dioxideIC50904.0 [1]
[1-(1-Methylsulfonylpiperidin-3-yl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC50994.0 [1]
Morpholin-4-yl-[1-[4-(morpholin-4-ylmethyl)phenyl]-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]methanoneIC50170.0 [1]
Morpholin-4-yl-[1-[3-(morpholin-4-ylmethyl)phenyl]-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]methanoneIC501300.0 [1]
[1-(3-Methylsulfonylphenyl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC502564.0 [1]
{3-[3-(Morpholin-4-ylcarbonyl)-5,5-dioxidothiochromeno[4,3-c]pyrazol-1(4H)-yl]phenyl}methanolIC502252.0 [1]
(3-Hydroxypiperidin-1-yl)-[3-[3-(morpholine-4-carbonyl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-1-yl]phenyl]methanoneIC50348.0 [1]
3-[3-(Morpholine-4-carbonyl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-1-yl]-N-pyridin-3-ylbenzamideIC50926.0 [1]
(4-Methoxypiperidin-1-yl)-[3-[3-(morpholine-4-carbonyl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-1-yl]phenyl]methanoneIC50302.0 [1]
(1,1-Dioxo-1,4-thiazinan-4-yl)-[3-[3-(morpholine-4-carbonyl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-1-yl]phenyl]methanoneIC50319.0 [1]
(8,8-Dioxo-3-phenyl-8lambda6-thia-3,4,12-triazatricyclo[7.4.0.02,6]trideca-1(9),2(6),4,10,12-pentaen-5-yl)-morpholin-4-ylmethanoneIC503050.0 [1]
[7-(Dimethylamino)-5,5-dioxo-1-phenyl-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC505020.0 [1]
[5,5-Dioxo-1-phenyl-7-(trifluoromethyl)-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC503059.0 [1]
1-Biphenyl-3-yl-3-(morpholin-4-ylcarbonyl)-1,4-dihydrothiochromeno[4,3-c]pyrazole 5,5-dioxideIC50764.0 [1]
[1-(2-Methylpropyl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC50960.0 [1]
(1-Benzyl-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl)-morpholin-4-ylmethanoneIC501189.0 [1]
[1-[4-(Hydroxymethyl)phenyl]-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC501064.0 [1]
1-(3-Bromophenyl)-3-(morpholin-4-ylcarbonyl)-1,4-dihydrothiochromeno[4,3-c]pyrazole 5,5-dioxideIC50616.0 [1]
[1-(2-Methoxyethyl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC501290.0 [1]
[1-(4-Methylpyridin-3-yl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC504045.0 [1]
[1-[3-(2-Methoxyethoxy)phenyl]-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC50726.0 [1]
3-(Morpholin-4-ylcarbonyl)-1-[piperidin-3-yl]-1,4-dihydrothiochromeno[4,3-c]pyrazole 5,5-dioxideIC503008.0 [1]
[1-(2-Methylphenyl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC502285.0 [1]
3-(Morpholin-4-ylcarbonyl)-1-piperidin-4-yl-1,4-dihydrothiochromeno[4,3-c]pyrazole 5,5-dioxideIC501515.0 [1]
(8-Amino-5,5-dioxo-1-phenyl-4H-thiochromeno[4,3-c]pyrazol-3-yl)-morpholin-4-ylmethanoneIC50368.0 [1]
[1-(4-Bromophenyl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC501123.0 [1]
[1-(2-Hydroxyethyl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC50661.0 [1]
[1-(2-Chlorophenyl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC504020.0 [1]
[1-(4-Methoxyphenyl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC50749.0 [1]
[1-(4-Chlorophenyl)-5,5-dioxo-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC50895.0 [1]
[4-(3-Methoxypropyl)-5,5-dioxo-1-phenyl-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-ylmethanoneIC505070.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ PI3-kinase class I Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/pi3-kinase-class-i-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ PI3-kinase class I Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/pi3-kinase-class-i-inhibitors-ic50-ki.
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