Phosphodiesterase; PDE3 & PDE4 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Indolidan	IC50	130.0 [1]
	Indolidan	Ki	80.0 [1]
	3,3-Dimethyl-5-(4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl)-1H-indol-2-one	IC50	13.0 [1], 240.0 [2]
	3-Isobutyl-1-methylxanthine	IC50	6900.0 [1]
	Papaverine	IC50	6600.0 [1]
	Milrinone	IC50	1100.0 [1]
	Amrinone	IC50	4800.0 [1]
	Zaprinast	IC50	230000.0 [1]
	Enoximone	IC50	2700.0 [1]
	4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone	IC50	9100.0 [1]
	Imazodan	IC50	460.0 [1]
	4,5-Dihydro-6-(4-(imidazol-1-yl)phenyl)-5-methyl-3(2H)-pyridazinone	IC50	120.0 [1]
	Griseolic acid	IC50	160.0 [1]
	Adibendan	IC50	520.0 [1]
	3-Amino-6-methyl-5-phenyl-2(1H)-pyridinone	IC50	18000.0 [1]
	Bufrolin	IC50	280000.0 [1]
	4-Ethyl-1,3-dihydro-5-(4-(2-methyl-1H-imidazol-1-yl)benzoyl)-2H-imidazol-2-one	IC50	37000.0 [1]
	Deoxygriseolic Acid	IC50	160.0 [1]
	5-(3-Methyl-3-methylthio-2-oxo-1H-indol-5-yl)-3,6-dihydro-1,3,4-thiadiazin-2-one	IC50	1200.0 [1]
	5-(6-Oxo-4,5-dihydro-1H-pyridazin-3-yl)spiro[1H-indole-3,1'-cyclopentane]-2-one	IC50	930.0 [1]
	5-(6-Oxo-4,5-dihydro-1H-pyridazin-3-yl)spiro[1H-indole-3,1'-cyclobutane]-2-one	IC50	290.0 [1]
	5-(3,3-Dimethyl-2-oxo-1H-indol-5-yl)-6-methyl-3,6-dihydro-1,3,4-thiadiazin-2-one	IC50	330.0 [1]
	5-(3,3-Dimethyl-2-oxo-1H-indol-5-yl)-6,6-dimethyl-3H-1,3,4-thiadiazin-2-one	IC50	66000.0 [1]
	6-Methyl-5-(3,3,6-trimethyl-2-oxo-1H-indol-5-yl)-3,6-dihydro-1,3,4-thiadiazin-2-one	IC50	3300.0 [1]
	5-(6-Methyl-2-oxo-3,6-dihydro-1,3,4-thiadiazin-5-yl)spiro[1H-indole-3,2'-thiolane]-2-one	IC50	1400.0 [1]
	5-(3,3-Dimethyl-2-oxo-1H-indol-5-yl)-6-methyl-3,6-dihydro-1,3,4-oxadiazin-2-one	IC50	960.0 [1]
	3,3-Dimethyl-5-(5-methyl-3-oxo-4,5-dihydro-2H-1,2,4-triazin-6-yl)-1H-indol-2-one	IC50	170.0 [1]
	5-(3,3-Dimethyl-2-oxo-1H-indol-5-yl)-6-methyl-3,6-dihydro-1,3,4-selenadiazin-2-one	IC50	540.0 [1]
	6-Methyl-5-(2-oxospiro[1H-indole-3,1'-cyclopentane]-5-yl)-3,6-dihydro-1,3,4-thiadiazin-2-one	IC50	1100.0 [1]
	6-Methyl-5-(2-oxospiro[1H-indole-3,1'-cyclohexane]-5-yl)-3,6-dihydro-1,3,4-thiadiazin-2-one	IC50	1300.0 [1]
	3-[2-(4-Methoxyphenyl)-2,3-dihydro-1H-benzimidazol-5-yl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one	IC50	560.0 [1]
	3,3-Dimethyl-5-(6-oxo-4,5-dihydro-1H-pyridazin-3-yl)-1H-indol-2-one;hydrate	IC50	73.0 [1]
	6-Methyl-5-(2-oxospiro[1H-indole-3,1'-cyclopropane]-5-yl)-3,6-dihydro-1,3,4-thiadiazin-2-one	IC50	36.0 [1]
	(2R,3R,3As,5S,6aR)-2-(6-aminopurin-9-yl)-5-(carboxymethyl)-3-hydroxy-3,3a,6,6a-tetrahydro-2H-furo[3,2-b]furan-5-carboxylic acid	IC50	120.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 34 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Phosphodiesterase; PDE3 & PDE4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/phosphodiesterase-pde3-pde4-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, November 20). Quest Database™ Phosphodiesterase; PDE3 & PDE4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/phosphodiesterase-pde3-pde4-inhibitors-ic50-ki.
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