Phosphodiesterase, PDE1/PDE5 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	CI-1018	IC50	73400.0 [1], 100000.0 [2]
	N-[(11R)-6-Methoxy-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]isoquinoline-3-carboxamide	IC50	65300.0 [1]
	4-Amino-3,5-dichloro-N-[(11R)-6-methyl-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]benzamide	IC50	100000.0 [1]
	N-[(11R)-6-Methyl-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]isoquinoline-3-carboxamide	IC50	100000.0 [1]
	2-Methoxy-N-[(11R)-6-methyl-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]benzamide	IC50	50600.0 [1], 71700.0 [2]
	N-[(11R)-12-Oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]isoquinoline-3-carboxamide	IC50	100000.0 [1]
	4,7-Dimethyl-N-[(11R)-6-methyl-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyrazolo[5,1-c][1,2,4]triazine-3-carboxamide	IC50	100000.0 [1]
	Rolipram	IC50	94900.0 [1]
	CI-1044	IC50	100000.0 [1]
	N-[(11R)-6-Amino-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyridine-4-carboxamide	IC50	100000.0 [1]
	N-[(11R)-6-Methoxy-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyridine-4-carboxamide	IC50	16100.0 [1]
	N-[(11R)-12-Oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]-1H-indole-2-carboxamide	IC50	100000.0 [1]
	N-[(11R)-6-Amino-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]-3,5-dichloropyridine-4-carboxamide	IC50	100000.0 [1]
	4-Amino-N-[(11R)-6-amino-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]benzamide	IC50	93200.0 [1]
	N-[(11R)-6-Amino-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]-2-methoxybenzamide	IC50	93200.0 [1]
	N-[(11R)-12-Oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyridine-3-carboxamide	IC50	100000.0 [1]
	N-[(11R)-6-Methoxy-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]-4,7-dimethylpyrazolo[5,1-c][1,2,4]triazine-3-carboxamide	IC50	14100.0 [1]
	N-[(11R)-6-Acetamido-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]-4-amino-3,5-dichlorobenzamide	IC50	3500.0 [1]
	4-Amino-3,5-dichloro-N-[(11R)-12-oxo-9-phenyl-6-pyrrolidin-1-yl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]benzamide	IC50	39200.0 [1]
	3-Amino-N-[(11R)-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyridine-4-carboxamide	IC50	100000.0 [1]
	N-[(11R)-6-Acetamido-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyridine-4-carboxamide	IC50	30100.0 [1]
	Tert-butyl N-[4-[[(11R)-6-amino-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]carbamoyl]pyridin-3-yl]carbamate	IC50	67700.0 [1]
	3,5-Dichloro-N-[(11R)-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyridine-4-carboxamide	IC50	100000.0 [1]
	Tert-butyl N-[4-[[(11R)-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]carbamoyl]pyridin-3-yl]carbamate	IC50	53300.0 [1]
	4-Amino-3,5-dichloro-N-[(11R)-6-(dimethylamino)-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]benzamide	IC50	5300.0 [1]
	N-[(11R)-12-Oxo-9-phenyl-6-pyrrolidin-1-yl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyridine-4-carboxamide	IC50	34000.0 [1]
	4,7-Dimethyl-N-[(11R)-12-oxo-9-phenyl-6-pyrrolidin-1-yl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyrazolo[5,1-c][1,2,4]triazine-3-carboxamide	IC50	100000.0 [1]
	3-Amino-N-[(11R)-6-amino-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyridine-4-carboxamide	IC50	100000.0 [1]
	N-[(11R)-6-Amino-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]quinoline-3-carboxamide	IC50	90700.0 [1]
	N-[(11R)-6-Amino-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]-4,7-dimethylpyrazolo[5,1-c][1,2,4]triazine-3-carboxamide	IC50	72000.0 [1]
	N-[(11R)-12-Oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyridine-4-carboxamide	IC50	100000.0 [1]
	N-[(11R)-6-Amino-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]isoquinoline-3-carboxamide	IC50	100000.0 [1]
	N-[(11S)-12-Oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]-1H-indole-2-carboxamide	IC50	100000.0 [1]
	N-[(11R)-6-Methoxy-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]quinoline-3-carboxamide	IC50	16100.0 [1]
	3,5-Dichloro-N-[(11R)-6-methyl-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyridine-4-carboxamide	IC50	38000.0 [1]
	N-[(11R)-6-Hydroxy-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]isoquinoline-3-carboxamide	IC50	100000.0 [1]
	N-(13-Oxo-10-phenyl-1,11-diazatricyclo[7.4.1.05,14]tetradeca-5(14),6,8,10-tetraen-12-yl)-1H-indole-2-carboxamide	IC50	100000.0 [1]
	4-Chloro-N-[(11R)-6-methoxy-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]benzamide	IC50	40000.0 [1]
	4-Chloro-N-[(11R)-6-methyl-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]benzamide	IC50	100000.0 [1]
	4-Amino-3,5-dichloro-N-[(11R)-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]benzamide	IC50	100000.0 [1]
	2,4-Dichloro-N-[(11R)-6-methyl-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]benzamide	IC50	100000.0 [1]
	3,5-Dichloro-N-[(11R)-6-methyl-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]benzamide	IC50	100000.0 [1]
	N-[(11R)-6-Methoxy-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]-1H-indole-2-carboxamide	IC50	100000.0 [1]
	4-Amino-N-[(11R)-6-amino-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]-3,5-dichlorobenzamide	IC50	100000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 44 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Phosphodiesterase, PDE1/PDE5 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/phosphodiesterase-pde1-pde5-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Phosphodiesterase, PDE1/PDE5 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/phosphodiesterase-pde1-pde5-inhibitors-ic50-ki.
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