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Phosphodiesterase 9A Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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1-(2-Chlorophenyl)-6-[(2R)-3,3,3-trifluoro-2-methylpropyl]-5,7a-dihydro-3aH-pyrazolo[3,4-d]pyrimidin-4-oneIC50179.0 [1]
1-(2-Chlorophenyl)-6-[(2S)-3,3,3-trifluoro-2-methylpropyl]-5,7a-dihydro-3aH-pyrazolo[3,4-d]pyrimidin-4-oneIC50471.0 [1]
SildenafilIC503400.0 [1], 3600.0 [2], 5600.0 [3], 10000.0 [4]
TadalafilIC5010000.0 [1]
1-(Oxan-4-yl)-6-[(1R)-1-(3-phenoxyazetidin-1-yl)ethyl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC5012.5 [1], 22.0 [2], 22.5 [3]
VardenafilIC50460.0 [1], 680.0 [2]
1-(2-Chlorophenyl)-6-[(2R)-3,3,3-trifluoro-2-methylpropyl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC5049.7 [1], 55.0 [2]
PF-04447943IC508.3 [1], 49.0 [2]
2-Methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrido[3,2-e]pyrazineIC505000.0 [1]
6-Benzyl-1-cyclopentyl-1,5-dihydro-4h-pyrazolo[3,4-d]pyrimidin-4-oneIC500.8 [1], 2.1 [2]
5-(3-Chlorobenzyl)-3-isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-oneIC508.0 [1], 10.0 [2]
1-Cyclopentyl-6-[(1r)-1-(3-Phenoxyazetidin-1-Yl)ethyl]-1,5-Dihydro-4h-Pyrazolo[3,4-D]pyrimidin-4-OneIC5011.0 [1], 33.2 [2]
2-Fluoro-5-[1-[1-[1-(oxan-4-yl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]ethyl]azetidin-3-yl]oxybenzonitrileIC5020.0 [1], 47.0 [2]
1-Cyclopentyl-6-[(1R)-1-(3-phenylpyrrolidin-1-yl)ethyl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC50230.0 [1], 273.0 [2]
6-[(3S,4S)-4-Methyl-1-[(2-methylpyrimidin-5-yl)methyl]pyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC504.6 [1], 36.0 [2]
6-[(3S,4S)-4-Methyl-1-[(5-methylpyrazin-2-yl)methyl]pyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC5012.0 [1], 59.0 [2]
6-[(3S,4S)-1-[(4-Fluorophenyl)methyl]-4-methylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC500.9 [1], 17.0 [2]
6-[(3S,4S)-4-Methyl-1-(pyridin-2-ylmethyl)pyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC506.3 [1], 14.0 [2]
1-Cyclopentyl-6-[(1S)-1-(3-phenoxyazetidin-1-yl)ethyl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC5010.5 [1], 986.0 [2]
2-Chloro-4-[1-[1-[1-(oxan-4-yl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]ethyl]azetidin-3-yl]oxybenzonitrileIC5013.2 [1], 19.0 [2]
2-Fluoro-4-[1-[1-[1-(oxan-4-yl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]ethyl]azetidin-3-yl]oxybenzonitrileIC5034.8 [1], 43.0 [2]
4-[1-[1-[1-(Oxan-4-yl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]ethyl]azetidin-3-yl]oxybenzonitrileIC5070.0 [1], 70.2 [2]
1-(Oxan-4-yl)-6-[1-(3-pyrimidin-2-yloxyazetidin-1-yl)ethyl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC5045.3 [1], 63.0 [2]
6-(Cyclohexylmethyl)-1-(1-ethylpropyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-oneIC50110.0 [1]
6-[(1R)-1-[3-(4-Fluorophenoxy)azetidin-1-yl]ethyl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC5010.7 [1], 12.18 [2]
1-(Oxan-4-yl)-6-[(1R)-1-(3-phenylazetidin-1-yl)ethyl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC5025.4 [1], 82.4 [2]
1-(Oxan-4-yl)-6-[1-(3-pyrazin-2-yloxyazetidin-1-yl)ethyl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC5039.9 [1], 73.5 [2]
1-(Oxan-4-yl)-6-[1-(3-quinoxalin-2-yloxyazetidin-1-yl)ethyl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC502.94 [1], 8.47 [2]
6-[(1R)-1-(3-Benzylazetidin-1-yl)ethyl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC5013.2 [1], 31.4 [2]
1-Cyclopentyl-6-[(1R)-1-[3-(4-methylphenoxy)azetidin-1-yl]ethyl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC5067.1 [1], 222.0 [2]
3-Isobutyl-1-methylxanthineIC50200000.0 [1]
RolipramIC5016000.0 [1]
ZaprinastKi35000.0 [1]
Moracin MIC50100000.0 [1]
Moracin CIC50100000.0 [1]
(2S,3R)-3-(6-Amino-9H-purin-9-yl)nonan-2-olIC5016000.0 [1]
8-[(4-Chlorophenyl)methyl]-10-thia-3,5,6,8-tetrazatetracyclo[7.7.0.02,6.011,16]hexadeca-1(9),2,4,11(16)-tetraen-7-oneIC5010000.0 [1]
4-(4-((8-(3-(Difluoromethoxy)phenyl)quinolin-6-yl)methoxy)phenyl)-2-methylbutan-2-olIC5055000.0 [1]
1-(Oxan-4-yl)-6-(pyridin-2-ylmethyl)-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC5052.0 [1]
RoflupramIC5050000.0 [1]
4-(3-(1-Acetylpiperidine-4-yl)pyrazine-2-yloxy)phenyl(1H-benzoimidazole-2-yl)methanoneIC5030000.0 [1]
Unii-7eis09YY11IC5010000.0 [1]
3-[(4-Hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC502000.0 [1]
7-(6-Methoxypyridin-3-yl)-3-(2-morpholin-4-ylethylamino)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC502000.0 [1]
PDE-9 inhibitorIC504.9 [1]
CID 46239428Ki10000.0 [1]
4-[[1-(2-Chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholineIC5010000.0 [1]
(4As,8aR)-2-cycloheptyl-4-[4-methoxy-3-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4a,5,8,8a-tetrahydrophthalazin-1-oneIC5010000.0 [1]
N-[(1S)-1-[3-Fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl]-7-methoxy-2-oxo-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamideIC5030000.0 [1]
1-Cyclopentyl-6-[(3S,4S)-4-methyl-1-(quinoxalin-6-ylmethyl)pyrrolidin-3-yl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC501.8 [1]
5-[[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxythiophene-2-carboxamideIC5010000.0 [1]
N-(12-Methoxy-5-methyl-3-propyl-2,4,8,13-tetrazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaen-7-yl)methanesulfonamideIC501000.0 [1]
6,8-Dimethoxy-3,4-dimethyl-1-(3-methylpyridin-4-yl)imidazo[1,5-a]quinoxalineIC5010000.0 [1]
6-Methoxy-3,8-Dimethyl-4-(Morpholin-4-Ylmethyl)-1h-Pyrazolo[3,4-B]quinolineKi10000.0 [1]
4-[(3-Chloro-4-methoxyphenyl)methylamino]-8-cyclopropyl-3-(hydroxymethyl)quinoline-6-carbonitrileIC5010000.0 [1]
[1-(3-{[1-(Quinolin-2-Yl)azetidin-3-Yl]oxy}pyrazin-2-Yl)piperidin-4-Yl]methanolIC5030000.0 [1]
1-(5-Butoxypyridin-3-Yl)-4-Methyl-8-(Morpholin-4-Ylmethyl)[1,2,4]triazolo[4,3-A]quinoxalineIC5010000.0 [1]
Pde2/pde10-IN-1IC5010000.0 [1]
1-Methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)pyrazolo[3,4-b]pyrazineIC5010000.0 [1]
(11R,15S)-5-Anilino-4-[[4-(6-fluoropyridin-2-yl)phenyl]methyl]-8-methyl-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-one;phosphoric acidKi17000.0 [1]
(2S,4S,5S)-4-(3,4-Dimethoxyphenyl)-5-[(E)-3-(2,6-dimethoxyphenyl)prop-2-enyl]-2-[(E)-2-(2-methoxyphenyl)ethenyl]-1,3-dioxaneIC5015000.0 [1]
(2R,4R,5R)-4-(3,4-Dimethoxyphenyl)-5-[(E)-3-(2,6-dimethoxyphenyl)prop-2-enyl]-2-[(E)-2-(2-methoxyphenyl)ethenyl]-1,3-dioxaneIC508800.0 [1]
5-Methyl-6-oxo-N-(1,3,4-thiadiazol-2-yl)-7H-furo[2,3-f]indole-7-carboxamideIC5016000.0 [1]
(7R)-7-Benzyl-2-bromo-5-ethyl-3-[(4-hydroxyphenyl)methyl]-7,8-dihydroimidazo[2,1-b]purin-4-oneIC5010000.0 [1]
2-Oxo-N-[1-[4-(trifluoromethoxy)phenyl]propyl]-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamideIC5010000.0 [1]
(3-Bromo-4-fluorophenyl)-[(5S)-3,3-difluoro-5-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanoneIC5010000.0 [1]
5,8-Dimethyl-2-(2-phenylimidazo[1,2-a]pyrimidin-7-yl)-[1,2,4]triazolo[1,5-a]pyrazineIC5010000.0 [1]
5,7-Dimethyl-2-(2-phenylimidazo[1,2-a]pyrimidin-7-yl)-[1,2,4]triazolo[1,5-a]pyrimidineIC5010000.0 [1]
5,8-Dimethyl-2-(2-pyridin-2-ylimidazo[1,2-a]pyrimidin-7-yl)-[1,2,4]triazolo[1,5-a]pyrazineIC5010000.0 [1]
2-[2-(Furan-2-yl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazineIC5010000.0 [1]
2-[2-(2-Methoxyphenyl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazineIC5010000.0 [1]
5,8-Dimethyl-2-(2-pyridin-3-yl-3H-benzimidazol-5-yl)-[1,2,4]triazolo[1,5-a]pyrazineIC5010000.0 [1]
2-[7-(5,8-Dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)imidazo[1,2-a]pyrimidin-2-yl]-1,3-thiazoleIC5010000.0 [1]
2-[2-(3-Bromophenyl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazineIC5010000.0 [1]
5,8-Dimethyl-2-(2-pyridin-2-yl-3H-benzimidazol-5-yl)-[1,2,4]triazolo[1,5-a]pyrazineIC5010000.0 [1]
2-[2-(5-Chlorothiophen-2-yl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazineIC5010000.0 [1]
2-[2-(4-Fluorophenyl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazineIC5010000.0 [1]
5-[6-(5,8-Dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-1H-benzimidazol-2-yl]-1,3-thiazoleIC5010000.0 [1]
2-[2-(2-Methoxyphenyl)imidazo[1,2-a]pyrimidin-7-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazineIC5010000.0 [1]
5,7-Dimethyl-2-(2-phenyl-3H-benzimidazol-5-yl)-[1,2,4]triazolo[1,5-a]pyrimidineIC5010000.0 [1]
2-[2-(2-Fluorophenyl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazineIC5010000.0 [1]
(2S,4S,5S)-5-[(E)-3-(2,6-Dimethoxyphenyl)prop-2-enyl]-4-(2-methoxyphenyl)-2-[(E)-2-(2-methoxyphenyl)ethenyl]-1,3-dioxaneIC5010100.0 [1]
(2S,4S,5S)-4-(2,6-Dimethoxyphenyl)-5-[(E)-3-(2,6-dimethoxyphenyl)prop-2-enyl]-2-[(E)-2-(2-methoxyphenyl)ethenyl]-1,3-dioxaneIC505600.0 [1]
(2S,4S,5S)-4-(2-Methoxyphenyl)-2-[(E)-2-(2-methoxyphenyl)ethenyl]-5-[(E)-3-(2-methoxyphenyl)prop-2-enyl]-1,3-dioxaneIC506400.0 [1]
(2R,4R,5R)-5-[(E)-3-(2,6-Dimethoxyphenyl)prop-2-enyl]-4-(2-methoxyphenyl)-2-[(E)-2-(2-methoxyphenyl)ethenyl]-1,3-dioxaneIC507700.0 [1]
(2R,4R,5R)-4-(2,6-Dimethoxyphenyl)-5-[(E)-3-(2,6-dimethoxyphenyl)prop-2-enyl]-2-[(E)-2-(2-methoxyphenyl)ethenyl]-1,3-dioxaneIC507800.0 [1]
(2R,4R,5R)-4-(2-Methoxyphenyl)-2-[(E)-2-(2-methoxyphenyl)ethenyl]-5-[(E)-3-(2-methoxyphenyl)prop-2-enyl]-1,3-dioxaneIC506700.0 [1]
(11R,15S)-5-Anilino-8-methyl-4-[(4-pyridin-2-ylphenyl)methyl]-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-oneKi6100.0 [1]
(11R,15S)-5-Anilino-8-methyl-4-[(4-phenylphenyl)methyl]-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-oneKi100000.0 [1]
(11R,15S)-5-Anilino-8-methyl-4-[[4-(trifluoromethyl)phenyl]methyl]-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-oneKi50000.0 [1]
(11R,15S)-5-Anilino-8-methyl-4-[[6-(trifluoromethyl)pyridin-3-yl]methyl]-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-oneKi100000.0 [1]
3-Cyclopentyloxy-4-(difluoromethoxy)-N-[(4-methoxyphenyl)methyl]benzamideIC50100000.0 [1]
(1R,4As,6aR,6aS,6bR,8aR,10S,11R,12aR,14bS)-11-hydroxy-10-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]oxy-1,6a,6b,9,9,12a-hexamethyl-2-methylidene-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acidIC504830.0 [1]
8-Bromo-1-(6-fluoropyridin-3-yl)-6-methoxy-3,4-dimethylimidazo[1,5-a]quinoxalineIC501000.0 [1]
1,8-Bis(6-fluoropyridin-3-yl)-6-methoxy-3,4-dimethylimidazo[1,5-a]quinoxalineIC501000.0 [1]
8-Bromo-1-(2-fluoropyridin-3-yl)-6-methoxy-3,4-dimethylimidazo[1,5-a]quinoxalineIC501000.0 [1]
6-Methoxy-3,4-dimethyl-1,8-dipyridin-3-ylimidazo[1,5-a]quinoxalineIC501000.0 [1]
8-(6-Fluoropyridin-3-yl)-6-methoxy-3,4-dimethyl-1-pyridin-4-ylimidazo[1,5-a]quinoxalineIC501000.0 [1]
8-(6-Fluoropyridin-3-yl)-6-methoxy-3,4-dimethyl-1-pyridin-3-ylimidazo[1,5-a]quinoxalineIC501000.0 [1]
1-(6-Fluoropyridin-3-yl)-6-methoxy-3,4-dimethyl-8-pyridin-4-ylimidazo[1,5-a]quinoxalineIC501000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Phosphodiesterase 9A Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/phosphodiesterase-9a-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Phosphodiesterase 9A Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/phosphodiesterase-9a-inhibitors-ic50-ki.
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