![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_fe3f92a2cc3d499742993c6ba3abb5e6.svg) | Rolipram | IC50 | 16000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_7ad97befb4c1dd57e9f2fd44275c5b12.svg) | (2S,3R)-3-(6-Amino-9H-purin-9-yl)nonan-2-ol | IC50 | 16000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_bb61b6c2e25195544b03e3a63df18225.svg) | PF-04447943 | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_e6ca044946a4d12c3099afd6e3fdefaa.svg) | 3-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 2000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_b892462b277acb6c79a58e69517da542.svg) | Unii-7eis09YY11 | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_6577747cd13a8cfc2779bc430d84b6be.svg) | 3-[(4-Hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 2000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_f31101e5d11c371914b8aff9a279bf1e.svg) | 7-(6-Methoxypyridin-3-yl)-3-(2-morpholin-4-ylethylamino)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 2000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_e08e3d5d067ce17bc18c4729515013a5.svg) | (4As,8aR)-2-cycloheptyl-4-[4-methoxy-3-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4a,5,8,8a-tetrahydrophthalazin-1-one | IC50 | 3981.07 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_f75c6abd61e3db1fb600998373bb17be.svg) | 1-Cyclopentyl-6-[(3S,4S)-4-methyl-1-(quinoxalin-6-ylmethyl)pyrrolidin-3-yl]-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_a92987c05c9abd3aa2365ce8b02b0ce3.svg) | 1-Methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)pyrazolo[3,4-b]pyrazine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_872f9da3a4fa90887131aa199694f632.svg) | 5-Methyl-6-oxo-N-(1,3,4-thiadiazol-2-yl)-7H-furo[2,3-f]indole-7-carboxamide | IC50 | 16000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_6e6f5372a9b65fbf4ad1f0806abab247.svg) | 3-Isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_2394629c929d877d873cd7be1c96675b.svg) | 3-Propan-2-yl-5-[[(1S,2R)-2-(pyrimidin-2-ylamino)cyclohexyl]methyl]-2,6-dihydropyrazolo[4,3-d]pyrimidin-7-one | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_dca654c5d156e3ddadab9bbd175bb22b.svg) | 2-[[(1R,2S)-2-[(7-Oxo-3-propan-2-yl-2,6-dihydropyrazolo[4,3-d]pyrimidin-5-yl)methyl]cyclohexyl]amino]-4-(trifluoromethyl)pyrimidine-5-carboxylic acid | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_de9b72444a5e638f05b5ea3b1d500e3f.svg) | 2-[(7-Amino-5-cyclopropyltriazolo[4,5-d]pyrimidin-3-yl)methyl]-3H-quinazolin-4-one | IC50 | 43.9 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_d96e87b02f8c9adef2f0f370df042903.svg) | (R)-2-(4-Fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)nicotinamide | IC50 | 16000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_1c711493335a94716bc575393feec9e3.svg) | 3-[(4-Benzylmorpholin-2-yl)methyl]-5-cyclopropyltriazolo[4,5-d]pyrimidin-7-amine | IC50 | 41.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_f73045d5ce95f3c97a9706502a78cb9d.svg) | 3-[[(2R)-4-(Pyridin-2-ylmethyl)morpholin-2-yl]methyl]-5-(trifluoromethyl)triazolo[4,5-d]pyrimidin-7-amine | IC50 | 1.6 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_08425ece7ecf71bbf18c104364774468.svg) | 5-Cyclopropyl-3-[[(2R)-4-(1,3-thiazol-2-ylmethyl)morpholin-2-yl]methyl]triazolo[4,5-d]pyrimidin-7-amine | IC50 | 0.9 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_49a118e7b66efb9ac8d88f0260b9a519.svg) | 5-Methyl-3-[[(2R)-4-(1,3-thiazol-2-ylmethyl)morpholin-2-yl]methyl]triazolo[4,5-d]pyrimidin-7-amine | IC50 | 1.3 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_7292df1a43269df102775b6d0fcdf27f.svg) | 3-[[(2R)-4-[(4-Ethyl-1,3-thiazol-2-yl)methyl]morpholin-2-yl]methyl]-5-methyltriazolo[4,5-d]pyrimidin-7-amine | IC50 | 4.2 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_2a56bda650d7a949b2c81511d04ae2f2.svg) | 3-[[(2R)-4-[(3,5-Difluorophenyl)methyl]morpholin-2-yl]methyl]-5-methyltriazolo[4,5-d]pyrimidin-7-amine | IC50 | 19.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_4d68768f0c8d0dc1ef6eec2f8f27162e.svg) | (3R,5S)-1-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]-5-phenylpiperidine-3-carboxamide | IC50 | 0.9 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_9310ba457d473b2fe52235466f974cd4.svg) | (3R,5S)-N-[(6-Aminopyridin-2-yl)methyl]-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-5-phenylpiperidine-3-carboxamide | IC50 | 0.12 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_2900651e5b5945313d7f0123cc05410e.svg) | (3R,5R)-5-(Methoxymethyl)-1-[(5-methyl-2-morpholin-4-yl-1,3-oxazol-4-yl)methyl]-N-[[(2R)-oxolan-2-yl]methyl]piperidine-3-carboxamide | IC50 | 65.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_5dfdde7682ebf9b947b24484dfe381f4.svg) | (3R,5R)-5-Methyl-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamide | IC50 | 40.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_10c827f03a21d180ea3635f4e15ab84e.svg) | (3R,5R)-1-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]-5-propylpiperidine-3-carboxamide | IC50 | 6.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_08b15ae63f956de17b4b09d600766c14.svg) | (3R,5S)-5-(Methoxymethyl)-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamide | IC50 | 2000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_b556d6a02772774ed08a7362cc216b8d.svg) | (3R,5R)-5-Ethyl-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[[(2R)-oxolan-2-yl]methyl]piperidine-3-carboxamide | IC50 | 2.91 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_fcee8f34f768613a22f412719bc3a385.svg) | (3R,5R)-5-Hydroxy-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamide | IC50 | 2700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_874e07616aa74358a60fbc7b41b37993.svg) | (3R)-1-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[[(2R)-oxolan-2-yl]methyl]piperidine-3-carboxamide | IC50 | 166.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_1c80e324a7ddc1cd40d37dd7e835b7a7.svg) | (3R,5R)-5-(5-Methyl-1,3,4-oxadiazol-2-yl)-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamide | IC50 | 66.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_cc0ff99a7bb7b1502fa87ab877ec979f.svg) | (3S,5S)-5-(Methoxymethyl)-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamide | IC50 | 4.3 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_16a29b51d99dbdb0cf216b01171f2e0d.svg) | (3R,5S)-5-Ethyl-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[[(2R)-oxolan-2-yl]methyl]piperidine-3-carboxamide | IC50 | 675.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_8a1b71ba970cab3362ddd82286f038d7.svg) | 4-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]-1,1-dioxo-1,4-thiazinane-2-carboxamide | IC50 | 2400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_6afe13352881f9f14a2a5eb4581f63a0.svg) | [(3R,5R)-1-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-5-[(6-methylpyridin-2-yl)methylcarbamoyl]piperidin-3-yl] acetate | IC50 | 7.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_64d81408edcd81129ef764bbc88dcf0b.svg) | (3S,5S)-5-(3-Methyl-1,2,4-oxadiazol-5-yl)-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamide | IC50 | 3.86 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_919855bd38906c11d23b8027c1e3f319.svg) | (3R,5R)-5-Ethyl-1-[(5-methyl-2-morpholin-4-yl-1,3-oxazol-4-yl)methyl]-N-(oxan-4-ylmethyl)piperidine-3-carboxamide | IC50 | 168.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_0b3d166febe5c1fb0791426e32354932.svg) | (3R)-1-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[[(2S)-oxolan-2-yl]methyl]piperidine-3-carboxamide | IC50 | 284.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_8c07a51340e4e698cb65380bc641f68f.svg) | 1-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamide | IC50 | 240.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_f4b19d5759f86f985f56349b3a9cf573.svg) | (3R,4R)-1-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]-4-(trifluoromethyl)pyrrolidine-3-carboxamide | IC50 | 1700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_80f4b12c0e188091c4c9dddedee60631.svg) | (3R,5R)-5-Butyl-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamide | IC50 | 15.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_dde043d5fbd58bee9935c2908b903e4f.svg) | (3R,5R)-N-[(6-Aminopyridin-2-yl)methyl]-5-ethyl-1-[(5-methyl-2-morpholin-4-yl-1,3-oxazol-4-yl)methyl]piperidine-3-carboxamide | IC50 | 16.5 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_dccd004ffc3a2c36de993de7c0357bd4.svg) | 1-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-(oxan-4-ylmethyl)piperidine-3-carboxamide | IC50 | 516.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_091e8e5984c93b2190298582aed93f95.svg) | (3R,5R)-5-Ethyl-1-[(5-methyl-2-pyrimidin-4-yl-1H-imidazol-4-yl)methyl]-N-[[(2S)-oxolan-2-yl]methyl]piperidine-3-carboxamide | IC50 | 26.2 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_6436e0b29f40e41407587fe707486a86.svg) | (3R,5R)-5-Ethyl-1-[(5-methyl-2-morpholin-4-yl-1,3-oxazol-4-yl)methyl]-N-[[(2S)-oxolan-2-yl]methyl]piperidine-3-carboxamide | IC50 | 707.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_21a1107c1fda96255c290435cbe5cd1b.svg) | (3R,5S)-N-[(6-Aminopyridin-2-yl)methyl]-5-ethyl-1-[(5-methyl-2-morpholin-4-yl-1,3-oxazol-4-yl)methyl]piperidine-3-carboxamide | IC50 | 2000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_13d3ab3327ac2097a5b3b416a10af5af.svg) | (3R,5S)-5-Ethyl-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-(oxan-4-ylmethyl)piperidine-3-carboxamide | IC50 | 2000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_c359b12099a477e67ca43c08d78bf6d9.svg) | (3R,5R)-5-(Methoxymethyl)-1-[(5-methyl-2-morpholin-4-yl-1,3-oxazol-4-yl)methyl]-N-(oxan-4-ylmethyl)piperidine-3-carboxamide | IC50 | 44.1 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_ca8ff043aa259c0aaba5dc3f52bb490c.svg) | 4-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]morpholine-2-carboxamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_89aa75452f73604cb8d5ae47d60233c5.svg) | (3R)-1-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]pyrrolidine-3-carboxamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_cd327c83df4d24e19309b80d1320f10d.svg) | (3R,5R)-5-Ethyl-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamide | IC50 | 6.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_dc60de81267b4d3f15a4defbdba102e7.svg) | (3R,5R)-5-Ethyl-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-(oxan-4-ylmethyl)piperidine-3-carboxamide | IC50 | 7.3 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_c867cb7cc91b00f27443d0e950eb92c6.svg) | (3S,5S)-5-Ethyl-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamide | IC50 | 0.95 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_4742188d94f536c0b3e305a8f36bf948.svg) | (3R,5S)-5-Ethyl-1-[(5-methyl-2-morpholin-4-yl-1,3-oxazol-4-yl)methyl]-N-(oxan-4-ylmethyl)piperidine-3-carboxamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_248935fed60b7ebd54bdbcd949f727fb.svg) | 4-Fluoro-2-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]-1,3-dihydroisoquinoline-4-carboxamide | IC50 | 370.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_70d16e59d3c9e637a940e92a7d204cf4.svg) | (3R,5R)-5-(Methoxymethyl)-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-(oxan-4-ylmethyl)piperidine-3-carboxamide | IC50 | 1.96 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_700c79cabb48fcedc4b5ce225f3c1d55.svg) | (3R,5R)-5-(Methoxymethyl)-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[[(2R)-oxolan-2-yl]methyl]piperidine-3-carboxamide | IC50 | 4.36 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_791eaa66f0da77a8f6f9fce06644ab64.svg) | (3R,5S)-5-(Methoxymethyl)-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[[(2R)-oxolan-2-yl]methyl]piperidine-3-carboxamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_8ca88953c0c7f0c464fc7fdcceebf887.svg) | (3R,5R)-N-[(6-Aminopyridin-2-yl)methyl]-5-ethyl-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]piperidine-3-carboxamide | IC50 | 4.42 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_4078a6d4127894de73bc34907245caec.svg) | (3R,5S)-5-(Methoxymethyl)-1-[(5-methyl-2-pyrimidin-4-yl-1H-imidazol-4-yl)methyl]-N-(oxan-4-ylmethyl)piperidine-3-carboxamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_00e3f966903b62400575c8e72659b028.svg) | (3R,5R)-5-(Methoxymethyl)-1-[(5-methyl-2-pyrimidin-4-yl-1H-imidazol-4-yl)methyl]-N-(oxan-4-ylmethyl)piperidine-3-carboxamide | IC50 | 13.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_07d4217d55acda47efe69ebd3101eea4.svg) | (3R,5R)-5-(3-Methyl-1,2,4-oxadiazol-5-yl)-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamide | IC50 | 3.9 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_ff115db9dbec713906e0514c0b83b1eb.svg) | (3R,5R)-5-Ethyl-1-[(5-methyl-2-pyrimidin-4-yl-1H-imidazol-4-yl)methyl]-N-[[(2R)-oxolan-2-yl]methyl]piperidine-3-carboxamide | IC50 | 26.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_04ecd563edb49077e383e2e161e0d382.svg) | (3R)-N-[(6-Aminopyridin-2-yl)methyl]-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]piperidine-3-carboxamide | IC50 | 58.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_a2a75c3238f006117b8a19d021bf1372.svg) | (3R,5S)-5-Ethyl-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamide | IC50 | 2000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_e1b103c6cceb4cd11f732d2db1893797.svg) | (3R,5R)-5-Ethyl-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[[(2S)-oxolan-2-yl]methyl]piperidine-3-carboxamide | IC50 | 19.6 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_8f53befaf75e59c47c066cc51d30177f.svg) | (3R,5S)-5-(Methoxymethyl)-1-[(5-methyl-2-morpholin-4-yl-1,3-oxazol-4-yl)methyl]-N-[[(2R)-oxolan-2-yl]methyl]piperidine-3-carboxamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_df146ff8c07450bb67727fecbcc9caff.svg) | (3R,5S)-5-Ethyl-1-[(5-methyl-2-morpholin-4-yl-1,3-oxazol-4-yl)methyl]-N-[[(2S)-oxolan-2-yl]methyl]piperidine-3-carboxamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_088b79dd847a6890ce36c960046bf442.svg) | (3R,5S)-5-(Methoxymethyl)-1-[(5-methyl-2-morpholin-4-yl-1,3-oxazol-4-yl)methyl]-N-(oxan-4-ylmethyl)piperidine-3-carboxamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_f26e78815dfc471bdeee30c7b95ce175.svg) | 5-(Methoxymethyl)-1-[(5-methyl-2-morpholin-4-yl-1,3-oxazol-4-yl)methyl]-N-[[(2R)-oxolan-2-yl]methyl]piperidine-3-carboxamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_7ab957c2294c58436c9562155c5b4e11.svg) | 2-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]-3,4-dihydro-1H-isoquinoline-4-carboxamide | IC50 | 5.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_d592c52ba72a725b168150072c28643a.svg) | (3R,5R)-5-(Methoxymethyl)-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamide | IC50 | 3.2 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_a98b76dc3343f6c4438ed89a84253bf2.svg) | [(3R,5R)-1-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-5-[(6-methylpyridin-2-yl)methylcarbamoyl]piperidin-3-yl] N-ethylcarbamate | IC50 | 120.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_3046fa5e3c48cf7a9380d8fa3a7eaad0.svg) | (3S,5S)-5-(5-Methyl-1,3,4-oxadiazol-2-yl)-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamide | IC50 | 65.9 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_1b30829892d0d748473cbbef38673b9d.svg) | (3R,5R)-5-(3-Methyl-1,2,4-oxadiazol-5-yl)-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[[(2S)-oxolan-2-yl]methyl]piperidine-3-carboxamide | IC50 | 35.2 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_271c868945625ab7f1dd5a14b94b53ba.svg) | 8-[(4-Hydroxycyclohexyl)amino]-3-(6-methoxypyridin-3-yl)-5-(2-propoxyethyl)pyrimido[5,4-c]pyridazin-6-one | IC50 | 2000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_32a4398f6f5597474a3fda1d2b4d37b6.svg) | 3-[(4-Chlorophenyl)methyl]-5-cyclopropyltriazolo[4,5-d]pyrimidin-7-amine | IC50 | 86.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_04575e85839da96309935390fb288c42.svg) | 5-Cyclopropyl-3-[(2-ethyl-1,3-thiazol-4-yl)methyl]triazolo[4,5-d]pyrimidin-7-amine | IC50 | 93.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_adec9b28c8cfa63de690a5301ea7faab.svg) | 5-Cyclopropyl-3-[[(3R)-1-(1,3-thiazol-2-ylmethyl)pyrrolidin-3-yl]methyl]triazolo[4,5-d]pyrimidin-7-amine | IC50 | 206.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_1bf77851dae4f83cf6e7c120189f977a.svg) | 3-(Oxan-2-ylmethyl)-N-(oxolan-2-ylmethyl)-5-(trifluoromethyl)triazolo[4,5-d]pyrimidin-7-amine | IC50 | 4030.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_ef50481c2f43d130c7be8a79d9247a48.svg) | N-(Oxolan-2-ylmethyl)-3-[[(2R)-oxolan-2-yl]methyl]-5-(trifluoromethyl)triazolo[4,5-d]pyrimidin-7-amine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_1f93f93e11d1c3cf782b5178b39658a1.svg) | 5-(5-Methyl-1,2-oxazol-3-yl)-3-(oxan-2-ylmethyl)triazolo[4,5-d]pyrimidin-7-amine | IC50 | 388.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_0e86a92da96f374cd36ed6fc712b98a7.svg) | 5-Cyclopropyl-3-[(8-methylimidazo[1,2-a]pyridin-2-yl)methyl]triazolo[4,5-d]pyrimidin-7-amine | IC50 | 53.8 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_b14287429b28efde7e03d45a0de97583.svg) | 3-[(3-Tert-butyl-1H-pyrazol-5-yl)methyl]-5-cyclopropyltriazolo[4,5-d]pyrimidin-7-amine | IC50 | 6.79 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_f0c01ec3c81f7b34584e420c997ff80f.svg) | 5-Cyclopropyl-3-(oxan-4-ylmethyl)triazolo[4,5-d]pyrimidin-7-amine | IC50 | 925.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_4018841997c3c81af5468838c5136959.svg) | 5-Cyclopropyl-3-[(3-cyclopropyl-1H-pyrazol-5-yl)methyl]triazolo[4,5-d]pyrimidin-7-amine | IC50 | 6.8 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_92749ec6930025eb8b9fbf6baac780e2.svg) | 5-Cyclopropyl-3-[[(2R)-4-(pyrimidin-2-ylmethyl)morpholin-2-yl]methyl]triazolo[4,5-d]pyrimidin-7-amine | IC50 | 23.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_82fdc7facb51bb972ac3d67544f45bae.svg) | N-(1-Methoxypropan-2-yl)-3-[[(2R)-oxolan-2-yl]methyl]-5-(trifluoromethyl)triazolo[4,5-d]pyrimidin-7-amine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_071fe752f7ccb4674faafd0d56c02b05.svg) | N-Cyclopropyl-3-[[(2R)-oxolan-2-yl]methyl]-5-(trifluoromethyl)triazolo[4,5-d]pyrimidin-7-amine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_666cc77c1d4c5d970eaa875e97e9b3f0.svg) | N',N'-Dimethyl-N-[3-[[(2R)-oxolan-2-yl]methyl]-5-(trifluoromethyl)triazolo[4,5-d]pyrimidin-7-yl]propane-1,3-diamine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_36ba74492fcb5d16407969c436ed3744.svg) | 5-Butyl-3-(oxan-2-ylmethyl)triazolo[4,5-d]pyrimidin-7-amine | IC50 | 228.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_fbdd72c4aea602e3c1677e1f9e0d5881.svg) | 5-(2-Methyl-1,3-thiazol-4-yl)-3-(oxan-2-ylmethyl)triazolo[4,5-d]pyrimidin-7-amine | IC50 | 13.1 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_82efa544923a7e03ca8eab9c85549854.svg) | 5-[(3-Fluorophenoxy)methyl]-3-(oxolan-2-ylmethyl)triazolo[4,5-d]pyrimidin-7-amine | IC50 | 17.1 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_c1f95062d32326327045c78b77b80a3a.svg) | 5-Cyclopropyl-3-[(3-phenyl-1H-1,2,4-triazol-5-yl)methyl]triazolo[4,5-d]pyrimidin-7-amine | IC50 | 55.1 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_29dad9c5891f64722d79d729e2dbfea3.svg) | 5-Cyclopropyl-3-[2-(4-methyl-1,3-thiazol-5-yl)ethyl]triazolo[4,5-d]pyrimidin-7-amine | IC50 | 79.4 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_fefeddb63567d0dede5199f12cbf7e54.svg) | 5-Cyclopropyl-3-[(2-phenyltriazol-4-yl)methyl]triazolo[4,5-d]pyrimidin-7-amine | IC50 | 52.4 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_8514743bb02ec5e740b3f55d84610c84.svg) | 3-[(1S)-1-Cyclohexylethyl]-5-cyclopropyltriazolo[4,5-d]pyrimidin-7-amine | IC50 | 74.6 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_f69f324ca9a31bbb94c8a30e4dacff12.svg) | 5-Cyclopropyl-3-[2-(furan-2-ylmethylsulfanyl)ethyl]triazolo[4,5-d]pyrimidin-7-amine | IC50 | 136.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8b_8efe0d3793e5ffedde299ed877462133.svg) | 3-(Oxan-2-ylmethyl)triazolo[4,5-d]pyrimidin-7-amine | IC50 | 1400.0 [1] |