![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_ce2451a6dd9c86e3ec85025ead605266.svg) | Sildenafil | IC50 | 10000.0 [1], 100000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_b781b793b1bc8f43d525fd41ea01d9f2.svg) | 2-Methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrido[3,2-e]pyrazine | IC50 | 5000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_4a2f7aa95b8e5fa8d1122874409c701a.svg) | Tadalafil | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_fe3f92a2cc3d499742993c6ba3abb5e6.svg) | Rolipram | IC50 | 16000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_7ad97befb4c1dd57e9f2fd44275c5b12.svg) | (2S,3R)-3-(6-Amino-9H-purin-9-yl)nonan-2-ol | IC50 | 16000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_f6d18589912c3a3faacf5ce5718df28c.svg) | 8-[(4-Chlorophenyl)methyl]-10-thia-3,5,6,8-tetrazatetracyclo[7.7.0.02,6.011,16]hexadeca-1(9),2,4,11(16)-tetraen-7-one | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_93d0c1872906022d84620db4fcb98ef6.svg) | 4-(4-((8-(3-(Difluoromethoxy)phenyl)quinolin-6-yl)methoxy)phenyl)-2-methylbutan-2-ol | IC50 | 29000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_e6ca044946a4d12c3099afd6e3fdefaa.svg) | 3-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 2000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_6577747cd13a8cfc2779bc430d84b6be.svg) | 3-[(4-Hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 2000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_f31101e5d11c371914b8aff9a279bf1e.svg) | 7-(6-Methoxypyridin-3-yl)-3-(2-morpholin-4-ylethylamino)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 2000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_f3c12f7358e5d66a48285092ab2b2b0d.svg) | CID 46239428 | Ki | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_79c2df8ec8565daaf9bb589fd061e8c3.svg) | N-[(1S)-1-[3-Fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl]-7-methoxy-2-oxo-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide | IC50 | 30000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_4196f50842d7c7039f815b7e9fba51f1.svg) | N-(12-Methoxy-5-methyl-3-propyl-2,4,8,13-tetrazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaen-7-yl)methanesulfonamide | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_998fc95c5ddc1febcb78861b6aa74b44.svg) | 6,8-Dimethoxy-3,4-dimethyl-1-(3-methylpyridin-4-yl)imidazo[1,5-a]quinoxaline | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_c3d23f6a68880aeed075badec9650b84.svg) | 6-Methoxy-3,8-Dimethyl-4-(Morpholin-4-Ylmethyl)-1h-Pyrazolo[3,4-B]quinoline | Ki | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_7f343f149e1d8a1ac05f3b50b0850307.svg) | [1-(3-{[1-(Quinolin-2-Yl)azetidin-3-Yl]oxy}pyrazin-2-Yl)piperidin-4-Yl]methanol | IC50 | 30000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_6c9f00394f14f5a85fad5ec3f73074ae.svg) | (11R,15S)-5-Anilino-4-[[4-(6-fluoropyridin-2-yl)phenyl]methyl]-8-methyl-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-one;phosphoric acid | Ki | 3000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_872f9da3a4fa90887131aa199694f632.svg) | 5-Methyl-6-oxo-N-(1,3,4-thiadiazol-2-yl)-7H-furo[2,3-f]indole-7-carboxamide | IC50 | 16000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_4c51bae3fd17f001c74d42386b4dba6e.svg) | 2-Oxo-N-[1-[4-(trifluoromethoxy)phenyl]propyl]-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_d0646ebbfafd54790b2d25e6dd654114.svg) | (3-Bromo-4-fluorophenyl)-[(5S)-3,3-difluoro-5-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_77e5d7cfa8abd0ee377503627871aacd.svg) | (11R,15S)-5-Anilino-8-methyl-4-[(4-pyridin-2-ylphenyl)methyl]-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-one | Ki | 8200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_1002e63882f689cffc0d3fa717610b5a.svg) | (11R,15S)-5-Anilino-8-methyl-4-[(4-phenylphenyl)methyl]-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-one | Ki | 33000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_ad9e05ce0e6deada9d456463023ac317.svg) | (11R,15S)-5-Anilino-8-methyl-4-[[4-(trifluoromethyl)phenyl]methyl]-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-one | Ki | 54000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_97a12af5aa5b47cd8c7469d78f7adc37.svg) | (11R,15S)-5-Anilino-8-methyl-4-[[6-(trifluoromethyl)pyridin-3-yl]methyl]-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-one | Ki | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_a995364f35519b27d67c2c2cbe2e7de3.svg) | 3-Cyclopentyloxy-4-(difluoromethoxy)-N-[(4-methoxyphenyl)methyl]benzamide | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_0ecae9752c837ab199b542b4d4056d86.svg) | 8-Bromo-1-(6-fluoropyridin-3-yl)-6-methoxy-3,4-dimethylimidazo[1,5-a]quinoxaline | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_8a18771a85cecc68fa83c50be4917d45.svg) | 1,8-Bis(6-fluoropyridin-3-yl)-6-methoxy-3,4-dimethylimidazo[1,5-a]quinoxaline | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_4d1d9fa8793cd5927b08f3af3803255d.svg) | 8-Bromo-1-(2-fluoropyridin-3-yl)-6-methoxy-3,4-dimethylimidazo[1,5-a]quinoxaline | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_7c0c54ebb9c4c49622a6efe494bf31ed.svg) | 6-Methoxy-3,4-dimethyl-1,8-dipyridin-3-ylimidazo[1,5-a]quinoxaline | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_3cab69dd9d554142283758bf57e23909.svg) | 8-(6-Fluoropyridin-3-yl)-6-methoxy-3,4-dimethyl-1-pyridin-4-ylimidazo[1,5-a]quinoxaline | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_4b8a7656ec4aa8f8a14784798e2376cc.svg) | 8-(6-Fluoropyridin-3-yl)-6-methoxy-3,4-dimethyl-1-pyridin-3-ylimidazo[1,5-a]quinoxaline | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_e32d78361b8c3b16320bae8fe53cffd4.svg) | 1-(6-Fluoropyridin-3-yl)-6-methoxy-3,4-dimethyl-8-pyridin-4-ylimidazo[1,5-a]quinoxaline | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_bcd726e4900804209d351408917d0d64.svg) | 1-(6-Fluoropyridin-3-yl)-6-methoxy-3,4-dimethyl-8-pyridin-3-ylimidazo[1,5-a]quinoxaline | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_cacbfc34e7a6e240a44ad75d26663ae4.svg) | 1-(2-Fluoropyridin-3-yl)-6-methoxy-3,4-dimethyl-8-pyridin-3-ylimidazo[1,5-a]quinoxaline | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_5a79215ec75226212a72aa38c86c96c7.svg) | PDE5 Inhibitor C2 | IC50 | 6223.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_7094f2f5b3d372f845f3dac27c03680c.svg) | N-(2-Chlorophenyl)-3-cyclopentyloxy-4-(difluoromethoxy)benzamide | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_115a048d33fafeaeb29f0f6ece6cd052.svg) | 3-Cyclopentyloxy-4-(difluoromethoxy)-N-pyridin-3-ylbenzamide | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_8f424c5b3f8b15074283bc2c2f777058.svg) | 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)-N-pyridin-3-ylbenzamide | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_2d52bdadae6facaabcc4ec483626ae3b.svg) | N-(2-Chlorophenyl)-3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzamide | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_6e6f5372a9b65fbf4ad1f0806abab247.svg) | 3-Isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_78b1cf0fe3d2813feb0d8389ead0bec5.svg) | 5,6-Diethyl-2-{5-[(4-Methylpiperazin-1-Yl)sulfonyl]-2-Propoxyphenyl}pyrimidin-4(3h)-One | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_12abe747b740dd7f4d003c3de0de5c90.svg) | (2R)-2-[(1-Cyclopentyl-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]-N-(4-methoxyphenyl)propanamide | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_2394629c929d877d873cd7be1c96675b.svg) | 3-Propan-2-yl-5-[[(1S,2R)-2-(pyrimidin-2-ylamino)cyclohexyl]methyl]-2,6-dihydropyrazolo[4,3-d]pyrimidin-7-one | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_dca654c5d156e3ddadab9bbd175bb22b.svg) | 2-[[(1R,2S)-2-[(7-Oxo-3-propan-2-yl-2,6-dihydropyrazolo[4,3-d]pyrimidin-5-yl)methyl]cyclohexyl]amino]-4-(trifluoromethyl)pyrimidine-5-carboxylic acid | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_b696ef179e11aac01fb71111b0bba9e2.svg) | (2S)-2-[(1-Cyclopentyl-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]-N-(4-methoxyphenyl)propanamide | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_efd7006bcd69cb56093b23a0a1c2da2e.svg) | (2R)-2-[[1-(2-Chlorophenyl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N-(4-methoxyphenyl)propanamide | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_1f112b9561946f31ed587aec56168da3.svg) | (2S)-2-[[1-(2-Chlorophenyl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N-(4-methoxyphenyl)propanamide | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_42a395b364c4f5d2a1a2c0d8a780ff27.svg) | 4-Ethoxy-N-(6-hydroxyhexyl)-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_8dc8f1223b5a7090a4a683bd438aecfb.svg) | 2-[[1-(2-Chlorophenyl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N-(4-methoxyphenyl)propanamide | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_9771e80e0f6a35171f39f30bcec23b5c.svg) | 6-Methyl-N-[(1R)-1-[4-(trifluoromethoxy)phenyl]propyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_c75ba846aa1261f2e59a961a40b93ec9.svg) | Pde5-IN-2 | IC50 | 32000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_3111d95e7629c56d6ab3a3e1b2ae6aed.svg) | (2S,8R)-2-(5-Ethylthiophen-2-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione | IC50 | 4000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_05fe57898c5daa0d81101672466538ad.svg) | (10S,15S)-13-Ethyl-10-(5-ethylfuran-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione | IC50 | 3000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_2840d58156b90a993bfa87e31db0d6d5.svg) | Methyl 7-cyclopentyloxy-6-methoxy-2-[4-(trifluoromethoxy)benzoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylate | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_27883e705639bddfac232280ef99c256.svg) | N-[4-[(7-Cyclopentyloxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]phenyl]acetamide | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_d96e87b02f8c9adef2f0f370df042903.svg) | (R)-2-(4-Fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)nicotinamide | IC50 | 16000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_1829c26e901befae80ab926812fac128.svg) | 2-Methoxy-6,7-Dimethyl-9-(4-Methylpyridin-3-Yl)imidazo[1,5-A]pyrido[3,2-E]pyrazine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_fc80f2db536c6377f4f5538f1ac8185d.svg) | 3-(2,5-Dichlorophenyl)-12-methoxy-5,7-dimethyl-2,4,8,13-tetrazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_40d200e514011557c742f6102f5bbaf5.svg) | 12-Methoxy-5,7-dimethyl-3-(2-methylphenyl)-2,4,8,13-tetrazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_398ea05987396c273429bf9cd7d3e0d6.svg) | 3-(12-Methoxy-5,7-dimethyl-2,4,8,13-tetrazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaen-3-yl)benzamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_1ccd9f9b9b0eb18aba807c4012cebb44.svg) | 12-Methoxy-5,7-dimethyl-3-(3-methylthiophen-2-yl)-2,4,8,13-tetrazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_646abc667f67a2add81afe6998029524.svg) | 8-Fluoro-6-Methoxy-3,4-Dimethyl-1-(3-Methylpyridin-4-Yl)imidazo[1,5-A]quinoxaline | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_25f95954ed5d3e590c9a5cc38c4e7316.svg) | 8-Fluoro-6-methoxy-3,4-dimethyl-1-(2-methylpyridin-3-yl)imidazo[1,5-a]quinoxaline | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_825f82f247dbcaaf6d50d9bdb7c4459e.svg) | 6,8-Dimethoxy-3,4-dimethyl-1-(4-methylpyridin-3-yl)imidazo[1,5-a]quinoxaline | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_b58cdfecb87664712d3d6f5759794f6a.svg) | 6,8-Dimethoxy-3,4-dimethyl-1-(2-methylpyridin-3-yl)imidazo[1,5-a]quinoxaline | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_dc363f510099940e641844e02b8e77e2.svg) | (3R)-1-[(6-Methoxy-3,8-dimethyl-2H-pyrazolo[3,4-b]quinolin-4-yl)methyl]pyrrolidin-3-ol | Ki | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_7fe4a16132e6c25f67dc0f57633d1ae8.svg) | 4-[(6-Methoxy-3,8-dimethyl-2H-pyrazolo[3,4-b]quinolin-4-yl)methyl]-2-methylmorpholine | Ki | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_b849e7a1c8f095f2ec8e83ac9fd26c5a.svg) | 6-Chloro-3,4-Dimethyl-1-(3-Methylpyridin-4-Yl)-8-(Trifluoromethyl)imidazo[1,5-A]quinoxaline | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_e9cd36249599b535e97403eb3b9c9bf3.svg) | 6-Methoxy-3,4-dimethyl-1-(3-methylpyridin-4-yl)-8-(trifluoromethyl)imidazo[1,5-a]quinoxaline | IC50 | 500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_76c9a8bc83ce586183657893fd0359ec.svg) | 6-Chloro-8-methoxy-3,4-dimethyl-1-(3-methylpyridin-4-yl)imidazo[1,5-a]quinoxaline | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_49a118e7b66efb9ac8d88f0260b9a519.svg) | 5-Methyl-3-[[(2R)-4-(1,3-thiazol-2-ylmethyl)morpholin-2-yl]methyl]triazolo[4,5-d]pyrimidin-7-amine | IC50 | 1.9 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_8c07a51340e4e698cb65380bc641f68f.svg) | 1-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamide | IC50 | 1.8 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_cd327c83df4d24e19309b80d1320f10d.svg) | (3R,5R)-5-Ethyl-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamide | IC50 | 1.8 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_7ab957c2294c58436c9562155c5b4e11.svg) | 2-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]-3,4-dihydro-1H-isoquinoline-4-carboxamide | IC50 | 1.8 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_5d000f011c5758a5ce5d696e189a1e5c.svg) | 1-[4-[3-(1-Quinolin-2-ylazetidin-3-yl)oxypyrazin-2-yl]piperidin-1-yl]ethanone | IC50 | 30000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_22e041dde6d177c1dcb2317cdf84c8a9.svg) | 6-[3-(1-Quinolin-2-ylazetidin-3-yl)oxypyrazin-2-yl]quinazolin-2-amine | IC50 | 30000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_b673c82a26968654bc65b4676d5862bf.svg) | 3-(2-Chloro-4-fluorophenyl)-12-methoxy-5,7-dimethyl-2,4,8,13-tetrazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_7fe40cd780938bbf3fdedb54a348ac5d.svg) | 12-Methoxy-5,7-dimethyl-3-(1,3,5-trimethylpyrazol-4-yl)-2,4,8,13-tetrazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_92db31d597f9f9d67135110e56e92eec.svg) | 5-(12-Methoxy-5,7-dimethyl-2,4,8,13-tetrazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaen-3-yl)-2,4-dimethyl-1,3-thiazole | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_edd365994ba859a54c97a721298d582b.svg) | 3,4-Dimethyl-1-(3-methylpyridin-4-yl)-8-(trifluoromethoxy)imidazo[1,5-a]quinoxaline | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_a6817d341f58d30ad4e0afd666a799e2.svg) | 3,4-Dimethyl-1-(3-methylpyridin-4-yl)-8-(trifluoromethyl)imidazo[1,5-a]quinoxaline | IC50 | 5000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_0210f250a35f95e26395afa4c6be792b.svg) | 1-(Cyclopropylmethyl)-5-[2-(1,2-dihydroimidazo[1,2-a]benzimidazol-3-yl)ethoxy]-3-(2-phenylpyrazol-3-yl)pyridazin-4-one | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_b5f2229c8c49d963de94302659504e91.svg) | 1-[(2-Chloro-6-fluorophenyl)methyl]-N-[4-(diethylamino)phenyl]-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide | IC50 | 5000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_9295d8bd18a6036676fd81bc696d123e.svg) | 1-[(2-Chloro-6-fluorophenyl)methyl]-N-(4-morpholin-4-ylphenyl)-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_271c868945625ab7f1dd5a14b94b53ba.svg) | 8-[(4-Hydroxycyclohexyl)amino]-3-(6-methoxypyridin-3-yl)-5-(2-propoxyethyl)pyrimido[5,4-c]pyridazin-6-one | IC50 | 2000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_7508628dd11ff422606ae188c2dbc655.svg) | 4-[(3,8-Dimethyl-6-propan-2-yloxy-2H-pyrazolo[3,4-b]quinolin-4-yl)methyl]-1,4-oxazepane | Ki | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_9c0d8f3dd33820fbb23cc146be1e17b2.svg) | 4-[[6-(2-Methoxyethoxy)-3,8-dimethyl-2H-pyrazolo[3,4-b]quinolin-4-yl]methyl]-1,4-oxazepane | Ki | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_6c1034d0ee651863924397daf89c9c3f.svg) | 3,8-Dimethyl-4-(1,4-oxazepan-4-ylmethyl)-2H-pyrazolo[3,4-b]quinolin-6-ol | Ki | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_a5ee345bb9d51e1b38ec0bc105037e4d.svg) | [1-[4-(1-Quinolin-2-ylazetidin-3-yl)oxypyridin-3-yl]piperidin-4-yl]methanol | IC50 | 30000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_80f51ed08317022a32c154d64cf92c3d.svg) | 1-[4-(3-{[1-(Quinolin-2-Yl)azetidin-3-Yl]oxy}quinoxalin-2-Yl)piperidin-1-Yl]ethanone | IC50 | 30000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_b79455af417c6d6c28ab632849b783b5.svg) | [1-[3-(1-Quinolin-2-ylpiperidin-4-yl)oxypyrazin-2-yl]piperidin-4-yl]methanol | IC50 | 30000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_870cbd35bb76977a49442614fca024ff.svg) | [1-[3-(1-Quinolin-2-ylazetidin-3-yl)oxyquinoxalin-2-yl]piperidin-4-yl]methanol | IC50 | 30000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_14826d7e1c15cebb9d0c23685692d69e.svg) | [(1S)-1-[3-(Cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)ethyl] (2S)-3-[3-(dimethylcarbamoyl)phenyl]sulfonyl-1,3-thiazolidine-2-carboxylate | IC50 | 3560.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_7b68585570a2cf5643324b53a012ab0b.svg) | [(1S)-1-[3-(Cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)ethyl] (2S)-1-[3-(dimethylcarbamoyl)phenyl]sulfonylpyrrolidine-2-carboxylate | IC50 | 17000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_2aad6ec21a1913aa8142d9ff5f9378ae.svg) | 2-Ethyl-2-{[4-(Methylamino)-6-(1h-1,2,4-Triazol-1-Yl)-1,3,5-Triazin-2-Yl]amino}butanenitrile | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_91815be8867b069f28106229adcf8711.svg) | 8-[(2-Fluoro-4-methoxyphenyl)methyl]-13-(oxan-4-ylmethyl)-10-thia-3,5,6,8,13-pentazatetracyclo[7.7.0.02,6.011,16]hexadeca-1(9),2,4,11(16)-tetraen-7-one | IC50 | 8400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_47e3873ad011dc714c3ab428d52eb882.svg) | 4-[6-(1,3-Difluoropropan-2-yloxy)-3-[(3,4-dimethoxyphenyl)methyl]-2,4-dioxoquinazolin-1-yl]piperidine-1-carbaldehyde | IC50 | 140.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_44afd67478ae7fa0ba521ad657a6f460.svg) | 4-[6-(1,3-Difluoropropan-2-yloxy)-3-[[3-methoxy-4-(2-oxo-2-piperidin-1-ylethoxy)phenyl]methyl]-2,4-dioxoquinazolin-1-yl]piperidine-1-carbaldehyde | IC50 | 390.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-8a_057aaa639b7481ccfad1e3a0d909ef23.svg) | 5-[[6-(1,3-Difluoropropan-2-yloxy)-1-(1-formylpiperidin-4-yl)-2,4-dioxoquinazolin-3-yl]methyl]-2-phenylbenzonitrile | IC50 | 15.0 [1] |