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Phosphodiesterase 7B Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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Standard Type
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Standard Values (in nM)
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▼
PF-04447943IC5010000.0 [1]
2-Methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrido[3,2-e]pyrazineIC503100.0 [1]
3-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC502000.0 [1]
Unii-7eis09YY11IC5012000.0 [1]
3-[(4-Hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC502000.0 [1]
7-(6-Methoxypyridin-3-yl)-3-(2-morpholin-4-ylethylamino)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC502000.0 [1]
5-(1h-Benzimidazol-2-Ylmethylsulfanyl)-2-Methyl-[1,2,4]triazolo[1,5-C]quinazolineIC5010000.0 [1]
N-[(1S)-1-[3-Fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl]-7-methoxy-2-oxo-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamideIC5030000.0 [1]
1-Cyclopentyl-6-[(3S,4S)-4-methyl-1-(quinoxalin-6-ylmethyl)pyrrolidin-3-yl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC501000.0 [1]
N-(4-{5-[(Z)-Cyclohexylimino]-4-methyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl}-phenyl)-acetamideIC50144.0 [1]
N-(12-Methoxy-5-methyl-3-propyl-2,4,8,13-tetrazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaen-7-yl)methanesulfonamideIC501000.0 [1]
4-Chloro-2-nitro-1-(phenylthio)benzeneIC501500.0 [1]
2,9-Dimethyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)ethyl)pyrazolo[1,5-c]quinazolineIC5010000.0 [1]
1-Methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)pyrazolo[3,4-b]pyrazineIC5010000.0 [1]
(11R,15S)-5-Anilino-4-[[4-(6-fluoropyridin-2-yl)phenyl]methyl]-8-methyl-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-one;phosphoric acidKi360.0 [1]
4-[(2-Nitro-4-chlorophenyl)thio]pyridineIC5013900.0 [1]
2-Bromophenyl 4-chloro-2-nitrophenyl sulfideIC501410.0 [1]
2-Bromophenyl 2-nitro-5-chlorophenyl sulfideIC502200.0 [1]
2-Oxo-N-[1-[4-(trifluoromethoxy)phenyl]propyl]-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamideIC5010000.0 [1]
(11R,15S)-5-Anilino-8-methyl-4-[(4-pyridin-2-ylphenyl)methyl]-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-oneKi300.0 [1]
(11R,15S)-5-Anilino-8-methyl-4-[(4-phenylphenyl)methyl]-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-oneKi910.0 [1]
(11R,15S)-5-Anilino-8-methyl-4-[[4-(trifluoromethyl)phenyl]methyl]-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-oneKi1200.0 [1]
(11R,15S)-5-Anilino-8-methyl-4-[[6-(trifluoromethyl)pyridin-3-yl]methyl]-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-oneKi6100.0 [1]
8-Bromo-1-(6-fluoropyridin-3-yl)-6-methoxy-3,4-dimethylimidazo[1,5-a]quinoxalineIC501000.0 [1]
1,8-Bis(6-fluoropyridin-3-yl)-6-methoxy-3,4-dimethylimidazo[1,5-a]quinoxalineIC501000.0 [1]
8-Bromo-1-(2-fluoropyridin-3-yl)-6-methoxy-3,4-dimethylimidazo[1,5-a]quinoxalineIC501000.0 [1]
6-Methoxy-3,4-dimethyl-1,8-dipyridin-3-ylimidazo[1,5-a]quinoxalineIC501000.0 [1]
8-(6-Fluoropyridin-3-yl)-6-methoxy-3,4-dimethyl-1-pyridin-4-ylimidazo[1,5-a]quinoxalineIC501000.0 [1]
8-(6-Fluoropyridin-3-yl)-6-methoxy-3,4-dimethyl-1-pyridin-3-ylimidazo[1,5-a]quinoxalineIC501000.0 [1]
1-(6-Fluoropyridin-3-yl)-6-methoxy-3,4-dimethyl-8-pyridin-4-ylimidazo[1,5-a]quinoxalineIC501000.0 [1]
1-(6-Fluoropyridin-3-yl)-6-methoxy-3,4-dimethyl-8-pyridin-3-ylimidazo[1,5-a]quinoxalineIC501000.0 [1]
1-(2-Fluoropyridin-3-yl)-6-methoxy-3,4-dimethyl-8-pyridin-3-ylimidazo[1,5-a]quinoxalineIC501000.0 [1]
3-Isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-oneIC5010000.0 [1]
3-Propan-2-yl-5-[[(1S,2R)-2-(pyrimidin-2-ylamino)cyclohexyl]methyl]-2,6-dihydropyrazolo[4,3-d]pyrimidin-7-oneIC5010000.0 [1]
6-(4-Amino-2-methoxyphenyl)-3-cyclohexyl-5H-[1,2]thiazolo[5,4-d]pyrimidin-4-oneIC5031.0 [1]
6-[4-(4-Acetylpiperazin-1-yl)-2-methoxyphenyl]-3-cyclohexyl-5H-[1,2]thiazolo[5,4-d]pyrimidin-4-oneIC508.0 [1]
2-[[(1R,2S)-2-[(7-Oxo-3-propan-2-yl-2,6-dihydropyrazolo[4,3-d]pyrimidin-5-yl)methyl]cyclohexyl]amino]-4-(trifluoromethyl)pyrimidine-5-carboxylic acidIC501000.0 [1]
2-(4-Amino-2-methoxyphenyl)-5-cyclohexyl-7-methyl-3H-imidazo[4,5-d]pyridazin-4-oneIC5043.0 [1]
2-[4-(4-Aminopiperidin-1-yl)-2-methoxyphenyl]-5-cyclohexyl-7-methyl-3H-imidazo[4,5-d]pyridazin-4-oneIC5011.0 [1]
5-Cyclohexyl-2-[4-(1,4-diazepan-1-yl)-2-methoxyphenyl]-7-methyl-3H-imidazo[4,5-d]pyridazin-4-oneIC5019.0 [1]
3-Cyclohexyl-6-[4-(1,4-diazepan-1-yl)-2-methoxyphenyl]-5H-[1,2]thiazolo[5,4-d]pyrimidin-4-oneIC5017.0 [1]
6-Methyl-N-[(1R)-1-[4-(trifluoromethoxy)phenyl]propyl]pyrazolo[1,5-a]pyrimidine-3-carboxamideIC5010000.0 [1]
4-(4-Chloro-2-nitrophenylthio)anilineIC503000.0 [1]
4-[(2-Chloro-4-nitrophenyl)thio]pyridineIC50600.0 [1]
1-(Cyclopropylmethyl)-5-[2-(1,2-dihydroimidazo[1,2-a]benzimidazol-3-yl)ethoxy]-3-(2-phenylpyrazol-3-yl)pyridazin-4-oneIC5010000.0 [1]
8-[(4-Hydroxycyclohexyl)amino]-3-(6-methoxypyridin-3-yl)-5-(2-propoxyethyl)pyrimido[5,4-c]pyridazin-6-oneIC502000.0 [1]
7,8-Dimethoxy-N-[(2s)-1-(3-Methyl-1h-Pyrazol-5-Yl)propan-2-Yl]quinazolin-4-AmineIC5041.3 [1]
1-[(1S)-6-Chloro-2,3-dihydro-1H-inden-1-yl]-5,6-dimethoxyisoquinolineIC5029800.0 [1]
5-(4-Amino-2-methoxyphenyl)-1-cyclohexyl-3-methyl-6H-pyrazolo[4,3-d]pyrimidin-7-oneIC509.27 [1]
8-Chloro-5-propoxyspiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-oneIC50106.0 [1]
6-(4-Amino-2-methoxyphenyl)-3-cyclohexyl-1-methyl-3,5-dihydropyrazolo[4,3-c]pyridin-1-ium-4-oneIC504.8 [1]
Items per page: 1 - 10 of 51
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References

This online tool may be cited as follows

MLA

"Quest Database™ Phosphodiesterase 7B Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/phosphodiesterase-7b-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ Phosphodiesterase 7B Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/phosphodiesterase-7b-inhibitors-ic50-ki.
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