![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_ce2451a6dd9c86e3ec85025ead605266.svg) | Sildenafil | IC50 | 24.0 [1], 39.2 [2], 160.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_4a2f7aa95b8e5fa8d1122874409c701a.svg) | Tadalafil | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_f6d18589912c3a3faacf5ce5718df28c.svg) | 8-[(4-Chlorophenyl)methyl]-10-thia-3,5,6,8-tetrazatetracyclo[7.7.0.02,6.011,16]hexadeca-1(9),2,4,11(16)-tetraen-7-one | IC50 | 460.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_f5ae800d1e78f0f982e7eb04ccb7036a.svg) | 3,7-Bis(2-hydroxyethyl)icaritin | IC50 | 30900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_99ec6bfce473cc6e10e2f87c913fc0bf.svg) | 5-(5-Acetyl-2-butoxypyridin-3-yl)-3-ethyl-2-(1-ethylazetidin-3-yl)-6H-pyrazolo[4,3-d]pyrimidin-7-one | IC50 | 840.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_2cb0809d99bd4e90be0b5e5dec8ec77f.svg) | 3-Phenyl-2-(propylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_5d359dd60744ef1e1a81c5ab9be56846.svg) | 3-Phenyl-[1,3,5]triazino[2,1-b][1,3]benzothiazole-2,4-dione | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_77f32cc17d785d3cfab236b0291af709.svg) | 3-Ethyl-5-[5-(4-ethylpiperazin-1-yl)sulfonyl-2-(2-methoxyethoxy)pyridin-3-yl]-2-(pyridin-2-ylmethyl)-6H-pyrazolo[4,3-d]pyrimidin-7-one | IC50 | 386.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_e31dcdabb93756eb8287fac0c67e4dae.svg) | 5-[[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxythiophene-2-carboxamide | IC50 | 1.4 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_3773eba2651c5e82ce2ca6358972d45b.svg) | 3-(5-Ethylfuran-2-yl)-2-(5-pyridin-2-ylpyrimidin-2-yl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one | IC50 | 2.3 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_ce09d701990da34dda1148e67e1d9d00.svg) | 3-(5-Ethylthiophen-2-yl)-2-(5-pyridin-2-ylpyrimidin-2-yl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one | IC50 | 4.8 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_b5078dafc0d4efabf40e62c5fc7ace62.svg) | N,N-Diethyl-3-methyl-1-(2-methylphenyl)-6-thiophen-2-ylpyrazolo[3,4-b]pyridine-4-carboxamide | IC50 | 25000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_079d402b10dd5b3928c1172ae9e5d752.svg) | 9-[(3-Chloro-4-methoxyphenyl)methylamino]-2-ethyl-1-oxo-3H-pyrrolo[3,4-b]quinoline-7-carbonitrile | IC50 | 6.6 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_d0646ebbfafd54790b2d25e6dd654114.svg) | (3-Bromo-4-fluorophenyl)-[(5S)-3,3-difluoro-5-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_a995364f35519b27d67c2c2cbe2e7de3.svg) | 3-Cyclopentyloxy-4-(difluoromethoxy)-N-[(4-methoxyphenyl)methyl]benzamide | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_7094f2f5b3d372f845f3dac27c03680c.svg) | N-(2-Chlorophenyl)-3-cyclopentyloxy-4-(difluoromethoxy)benzamide | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_115a048d33fafeaeb29f0f6ece6cd052.svg) | 3-Cyclopentyloxy-4-(difluoromethoxy)-N-pyridin-3-ylbenzamide | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_8f424c5b3f8b15074283bc2c2f777058.svg) | 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)-N-pyridin-3-ylbenzamide | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_2d52bdadae6facaabcc4ec483626ae3b.svg) | N-(2-Chlorophenyl)-3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzamide | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_03993a5c10bd5c9abb430a598ad109dd.svg) | Morpholinoacetildenafil | IC50 | 1.4 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_a56e718c5390080b4d0aec3b78e5cf2f.svg) | Gendenafil | IC50 | 0.9 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_78b1cf0fe3d2813feb0d8389ead0bec5.svg) | 5,6-Diethyl-2-{5-[(4-Methylpiperazin-1-Yl)sulfonyl]-2-Propoxyphenyl}pyrimidin-4(3h)-One | IC50 | 45.6 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_a18427abbf856c7f97f6cc742fb9f682.svg) | 5-(5-Acetyl-2-butoxypyridin-3-yl)-3-propyl-2-(pyridin-2-ylmethyl)-6H-pyrazolo[4,3-d]pyrimidin-7-one | IC50 | 183.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_42a395b364c4f5d2a1a2c0d8a780ff27.svg) | 4-Ethoxy-N-(6-hydroxyhexyl)-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonamide | IC50 | 5.2 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_f189de2d8f426169f04d7f81da7ffac9.svg) | 3-[[4-Ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxycyclobutane-1-carboxamide | IC50 | 2.6 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_ec43fb5106ec2dffb17c289abb453e90.svg) | 2-[4-[4-Ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenoxy]piperidin-1-yl]-N-hydroxypyrimidine-5-carboxamide | IC50 | 0.13 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_c75ba846aa1261f2e59a961a40b93ec9.svg) | Pde5-IN-2 | IC50 | 1.2 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_454df302d53f1142bd0621e6e5e6de43.svg) | (3S)-3-(5-Ethylthiophen-2-yl)-2-(5-pyridin-2-ylpyrimidin-2-yl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one | IC50 | 1.2 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_c75c1479cab001f3bf70fd2243fc4494.svg) | (3R)-3-(5-Ethylthiophen-2-yl)-2-(5-pyridin-2-ylpyrimidin-2-yl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one | IC50 | 34.1 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_09eef8c88befe13442fd2cbb52f1d4d2.svg) | 3-(5-Ethylthiophen-2-yl)-2-pyrimidin-2-yl-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one | IC50 | 3.7 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_f9ea61dde05c77381ddd3aed148acd72.svg) | (3S)-3-(5-Ethylfuran-2-yl)-2-(5-pyridin-2-ylpyrimidin-2-yl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one | IC50 | 1.5 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_cf81bfabcbc4204689b992a3e271670f.svg) | (3R)-3-(5-Ethylfuran-2-yl)-2-(5-pyridin-2-ylpyrimidin-2-yl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one | IC50 | 3.8 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_554b3c13263207d7253270a36fcad917.svg) | 3-(5-Ethylfuran-2-yl)-2-pyrimidin-2-yl-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one | IC50 | 6.2 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_502ea07816d48fa78dab05db0031dcae.svg) | 2-[5-(3,4-Dimethoxyphenyl)pyrimidin-2-yl]-1-(5-ethylthiophen-2-yl)-3,9-dihydro-1H-pyrido[3,4-b]indol-4-one | IC50 | 253.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_3d6a7c1af6a0a550ede4ab8a3690ea70.svg) | (2R,8S)-2-(5-Ethylthiophen-2-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_95c0d03d769aadd3f33c917f49059300.svg) | (10S,15R)-13-Ethyl-10-(5-ethylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_cfa8f7b02561ad5195e48dd19b3fe701.svg) | (10S,15S)-13-Ethyl-10-(3-methylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione | IC50 | 13.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_1a31e0bcf509663cf290e8efab710189.svg) | (10S,15S)-13-Butyl-10-(5-ethylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione | IC50 | 107.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_39f7dcc4866fca2db4920c555863cdc6.svg) | (10S,15R)-13-Ethyl-10-(5-ethylfuran-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_b0763b78d0ab9c3952520e2ef137de51.svg) | (10S,15R)-13-Butyl-10-(5-ethylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_f32ed528661bf1d1f49abd0a7b3271f9.svg) | (2S,8R)-2-(5-Ethylfuran-2-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_3f2f265f6cffbca27fd49cb8b3be7ef2.svg) | (2S,8R)-6-Methyl-2-(5-methylthiophen-2-yl)-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_e52d8d851180e814e79a8cb53e3c2971.svg) | (10S,15S)-13-Ethyl-10-(5-ethylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione | IC50 | 56.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_3111d95e7629c56d6ab3a3e1b2ae6aed.svg) | (2S,8R)-2-(5-Ethylthiophen-2-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_c97a309fb4412c68d2826b981a3f33f1.svg) | 2-[5-(3,4-Dimethoxyphenyl)pyrimidin-2-yl]-1-(5-ethylfuran-2-yl)-3,9-dihydro-1H-pyrido[3,4-b]indol-4-one | IC50 | 288.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_d7bc1eb0c3b3792d93439f4fbfb38fbe.svg) | (10R,15R)-13-Ethyl-10-(5-ethylfuran-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_b1e6cdf5222a8d925b1dbc6ca09725b4.svg) | (10S,15S)-13-Ethyl-10-(5-methylfuran-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione | IC50 | 62.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_05fe57898c5daa0d81101672466538ad.svg) | (10S,15S)-13-Ethyl-10-(5-ethylfuran-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione | IC50 | 127.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_2840d58156b90a993bfa87e31db0d6d5.svg) | Methyl 7-cyclopentyloxy-6-methoxy-2-[4-(trifluoromethoxy)benzoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylate | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_27883e705639bddfac232280ef99c256.svg) | N-[4-[(7-Cyclopentyloxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]phenyl]acetamide | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_4d4f87c0ae8b861621c8ae2be18fca56.svg) | 7-(4-Fluorophenyl)-N-(2-methylphenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_91815be8867b069f28106229adcf8711.svg) | 8-[(2-Fluoro-4-methoxyphenyl)methyl]-13-(oxan-4-ylmethyl)-10-thia-3,5,6,8,13-pentazatetracyclo[7.7.0.02,6.011,16]hexadeca-1(9),2,4,11(16)-tetraen-7-one | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_1ceb52fd704a3b5a80f086679d8b72a3.svg) | PDE5-IN-6c | IC50 | 30.1 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_71f586fac1344620d8df3d56016c12bf.svg) | (2S,8R)-2-(5-Bromothiophen-2-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione | IC50 | 136.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_5253d900b7013e866d87dc82b2e93b78.svg) | 2-(Propylthio)-3-(p-tolyl)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_f5990d047d4c41da225b0e9ed139561f.svg) | 2-(Butylthio)-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_18d1e60f70a15b4482ceea1a375d6466.svg) | 3-(2-Methoxyphenyl)-2-(propylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6c_189405bf541c726ab325b665579fb88c.svg) | 2-(Sec-butylthio)-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one | IC50 | 51200.0 [1] |