![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_b892462b277acb6c79a58e69517da542.svg) | Unii-7eis09YY11 | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_6577747cd13a8cfc2779bc430d84b6be.svg) | 3-[(4-Hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 9.8 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_f31101e5d11c371914b8aff9a279bf1e.svg) | 7-(6-Methoxypyridin-3-yl)-3-(2-morpholin-4-ylethylamino)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 11.3 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_38afa323208c29573d5daadf85760161.svg) | 3-[2-(2-Hydroxyethylamino)ethylamino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 272.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_144ed950d79630999a789b657f1d5f37.svg) | 7-(6-Methoxypyridin-3-yl)-3-(2-morpholin-4-ylethylamino)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-one | IC50 | 61.8 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_019c2fc02efdd49b41e2f380f5b59596.svg) | CID 45486504 | IC50 | 4.7 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_0eca2f9a8593719818cfdf6ca1f4dfa0.svg) | 3-[(4-Hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-one | IC50 | 15.3 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_7a88dc9254d987a67a059a089591c0fb.svg) | 3-(2-Aminoethylamino)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 1210.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_a92987c05c9abd3aa2365ce8b02b0ce3.svg) | 1-Methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)pyrazolo[3,4-b]pyrazine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_8a509203e789ad49b562e713002e48f2.svg) | 2-[[7-(6-Methoxypyridin-3-yl)-2-oxo-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-3-yl]amino]-N,N-dimethylacetamide | IC50 | 86.6 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_2dd178e25282bde78d044e772adddf2b.svg) | 3-(2-Hydroxyethylamino)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 26.3 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_15782ad0aeb28604c01db2c76df8c121.svg) | 3-(3-Hydroxypropylamino)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 13.8 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_b5d9e2b5bae5a3be8d8cd229bac793f0.svg) | 3-(2-Ethoxyethylamino)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 9.3 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_0969416e5df53a0fa2c2e2cbbc00db6b.svg) | 2-[[7-(6-Methoxypyridin-3-yl)-2-oxo-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-3-yl]amino]acetic acid | IC50 | 45.5 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_5ccea3369a69a696ced12c37a412e4e8.svg) | 3-[2-(Dimethylamino)ethylamino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 261.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_c09b4645123a15d535e4fe025d278510.svg) | 3-[[(2R)-2-Hydroxypropyl]amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 15.1 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_64e10c9e5423a52285c3b7bed1e6d5ef.svg) | 3-[[(2S)-2-Hydroxypropyl]amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 15.3 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_de2ab5e23687e938d4f59ade9c753629.svg) | 3-[[(2R)-1-Hydroxypropan-2-yl]amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 17.7 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_8e87398ea11e48235c2a8480ee461988.svg) | 3-[[(2R)-1-Hydroxybutan-2-yl]amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 23.2 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_62b522b1102f2dc52817c5cf09b83de3.svg) | 3-[[(2S)-1-Hydroxypropan-2-yl]amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 17.9 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_7522bd36ff32dbd9f98ee4af8fc84571.svg) | 2-[[7-(6-Methoxypyridin-3-yl)-2-oxo-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-3-yl]amino]-N-methylacetamide | IC50 | 15.2 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_caa1028a5d3ef8e2166525f344925e1a.svg) | 7-(6-Methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(pyridin-2-ylmethylamino)pyrido[3,4-b]pyrazin-2-one | IC50 | 10.8 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_f3e9c886ea50dc0645b2d7daafb9e636.svg) | 7-(6-Methoxypyridin-3-yl)-3-(oxolan-2-ylmethylamino)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 8.6 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_3f527b6fa4f40a0da4d952579d9c7fd7.svg) | 2-[[7-(6-Methoxypyridin-3-yl)-2-oxo-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-3-yl]amino]-N,N-dimethylacetamide | IC50 | 398.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_7cc5b64d422d5ded15cc20e3f6bbe088.svg) | 7-(6-Methoxypyridin-3-yl)-3-(oxan-4-ylmethylamino)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-one | IC50 | 31.4 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_daeb8947b98c7eec235710f66b2f689a.svg) | 7-(6-Methoxypyridin-3-yl)-3-[(2-morpholin-4-yl-2-oxoethyl)amino]-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 16.1 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_c97dd40934372ccc27c594b72ec6a6c9.svg) | 2-[[7-(6-Methoxypyridin-3-yl)-2-oxo-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-3-yl]amino]-N-methylacetamide | IC50 | 115.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_46f6b5b73decea43846af67fc086f260.svg) | 7-(6-Methoxypyridin-3-yl)-3-[(2-morpholin-4-yl-2-oxoethyl)amino]-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-one | IC50 | 114.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_9aac904d9548a4f98a6e54807a0d9510.svg) | 3-[[2-(4-Ethylpiperazin-1-yl)-2-oxoethyl]amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 55.9 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_ea74d44dbf6619bcb7b3d59921830d33.svg) | 7-(6-Methoxypyridin-3-yl)-3-[(2-oxo-2-pyrrolidin-1-ylethyl)amino]-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 39.5 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_821cab2bdece220275668b23468c45df.svg) | 7-(6-Methoxypyridin-3-yl)-3-[(2-oxo-2-piperazin-1-ylethyl)amino]-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_0146c1950a0273a8b797521f2c2320ed.svg) | 7-(6-Methoxypyridin-3-yl)-3-[[2-(4-methylpiperazin-1-yl)-2-oxoethyl]amino]-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 14.7 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_ca5c9de6039694ad3a054c25807af505.svg) | 3-[[2-(4-Hydroxypiperidin-1-yl)-2-oxoethyl]amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 24.6 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_5a79215ec75226212a72aa38c86c96c7.svg) | PDE5 Inhibitor C2 | IC50 | 58.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_2c603f5924d057f28c282155f73985ec.svg) | 3-(2-Hydroxyethylamino)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-one | IC50 | 114.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_41b4a0d404c8bef5a3fc86a3c65690fc.svg) | 3-(2-Ethoxyethylamino)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-one | IC50 | 57.4 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_c7dfbcf5309a80b6ce8274802e44f397.svg) | 7-(6-Methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(pyrazin-2-ylmethylamino)pyrido[2,3-b]pyrazin-2-one | IC50 | 23.6 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_3779612e4e1406176a8e70841784d3e0.svg) | 3-[[2-(4-Ethylpiperazin-1-yl)-2-oxoethyl]amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-one | IC50 | 98.9 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_40a169419970d4a4629189cade156ebe.svg) | 3-[[(2S)-1-Hydroxypropan-2-yl]amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-one | IC50 | 68.2 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_fa3402f3af5698835c91ac529a409e4e.svg) | 3-(3-Hydroxypropylamino)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-one | IC50 | 124.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_88b43c8b622882ab6bfef53acde8d0bf.svg) | 3-(2-Aminoethylamino)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-one | IC50 | 2000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_4404ab95a1c0cb36640f3e2f05f35554.svg) | 2-[[7-(6-Methoxypyridin-3-yl)-2-oxo-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-3-yl]amino]acetamide | IC50 | 398.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_f0b603aaf06b9ea38f14770beb0c5f35.svg) | 2-[[7-(6-Methoxypyridin-3-yl)-2-oxo-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-3-yl]amino]acetamide | IC50 | 86.6 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_0219c3a4fe03c75483179c5bcbfbe344.svg) | 2-[[7-(6-Methoxypyridin-3-yl)-2-oxo-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-3-yl]amino]acetic acid | IC50 | 576.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_8b0a7da5e514f1a573f58e31987fe466.svg) | 3-[[(2S)-2-Hydroxypropyl]amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-one | IC50 | 51.8 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_574f4108a40403c0fc4d69cad28196f4.svg) | 3-[[(2R)-2-Hydroxypropyl]amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-one | IC50 | 49.7 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_b604fda481f5d962963d97831a7b1db5.svg) | 3-[2-(Dimethylamino)ethylamino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-one | IC50 | 1590.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_7e0ec238646df512720ba57fc365cdde.svg) | 7-(6-Methoxypyridin-3-yl)-3-[[2-(4-methylpiperazin-1-yl)-2-oxoethyl]amino]-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-one | IC50 | 80.2 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_b31d7a3f539162ab5585d122782252b1.svg) | 3-[[(2R)-1-Hydroxypropan-2-yl]amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-one | IC50 | 63.2 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_cb71c1f42acb727b41be67017fec895a.svg) | 7-(6-Methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(pyridin-2-ylmethylamino)pyrido[2,3-b]pyrazin-2-one | IC50 | 34.5 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_1c802986dd8f6b9ef93debf5c039e52e.svg) | 4-[3-[1-(2-Methoxyethyl)pyrazol-4-yl]imidazo[1,2-a]pyrazin-8-yl]morpholine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_b7c66e8f91043fe3c560418a1ca7aa2b.svg) | 4-[3-(3,4,5-Trimethoxyphenyl)imidazo[1,2-a]pyrazin-8-yl]morpholine | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6a_abc2fbdd1db8b3b762d4979d370c9aa5.svg) | 1-[(1S)-6-Chloro-2,3-dihydro-1H-inden-1-yl]-5,6-dimethoxyisoquinoline | IC50 | 29500.0 [1] |