![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_ce2451a6dd9c86e3ec85025ead605266.svg) | Sildenafil | IC50 | 0.5 [1], 25.0 [2], 40.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_ce2451a6dd9c86e3ec85025ead605266.svg) | Sildenafil | Ki | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_4a2f7aa95b8e5fa8d1122874409c701a.svg) | Tadalafil | IC50 | 980.0 [1], 1260.0 [2], 2000.0 [3], 5200.0 [4] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_611aee8360ba5f29cd9711190dfe1482.svg) | Vardenafil | IC50 | 1.0 [1], 11.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_2019d6686c0079c33ef9d229dcb67e59.svg) | Dipyridamole | Ki | 125.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_f2c1c04ef0787963213517a6b0b2b31c.svg) | Zaprinast | Ki | 400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_4459390b32dda515cb7b8b07a81ab93e.svg) | N-(2-Fluoroethyl)-1-[(6-methoxy-5-methylpyrimidin-4-yl)methyl]pyrrolo[3,2-b]pyridine-3-carboxamide | IC50 | 9000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_215d5647c2cf174850da8ea59c2469fe.svg) | DprE1-IN-1 | IC50 | 6000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_9baac863bbc84a8c41131cd763eacddb.svg) | (2R,8R)-2-(1,3-Benzodioxol-5-yl)-6-[(3R)-1-benzylpyrrolidin-3-yl]-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione | IC50 | 249.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_89f3c4ba226ea44f46e922aa80cd3bd1.svg) | 4-(3-(1-Acetylpiperidine-4-yl)pyrazine-2-yloxy)phenyl(1H-benzoimidazole-2-yl)methanone | IC50 | 30000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_7557644051f9249ab38fd6c88bad55c2.svg) | (2R,8R)-2-(1,3-Benzodioxol-5-yl)-6-(1-benzylpiperidin-4-yl)-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione | IC50 | 1619.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_4bd4116bdb52967877c5df16bc89db7f.svg) | 4-[[1-(2-Chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine | IC50 | 2280.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_21efc3079383ece6ef1bff281d6d88a2.svg) | N-(Cyclopropylmethyl)-1-[(6-methoxy-5-methylpyrimidin-4-yl)methyl]pyrrolo[3,2-b]pyridine-3-carboxamide | IC50 | 3000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_6e327c66cf5e44efa4a89d0c9730d059.svg) | N-(2-Fluoroethyl)-1-[(6-methoxy-5-methylpyrimidin-4-yl)methyl]-6-methylpyrrolo[3,2-b]pyridine-3-carboxamide | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_57c71b25c2e24be63dbe98f423579255.svg) | 1-[[6-(Dimethylamino)-5-methylpyrimidin-4-yl]methyl]-N-(2-fluoroethyl)pyrrolo[3,2-b]pyridine-3-carboxamide | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_9dfed3d608d02acad7f7e0bf16f5744b.svg) | (2R,8R)-2-(1,3-Benzodioxol-5-yl)-6-(2-morpholin-4-ylethyl)-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione | IC50 | 2966.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_4f82a78e46b5c2aee1ed48321a0f7052.svg) | 11-Benzyl-13-methyl-4-phenyl-5,6,8,11,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7,12-pentaen-10-one | IC50 | 860.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_e610b6c86ba4bf3aab02bc75ba4b902a.svg) | 5-Bromo-2-[5-(4-methylpiperazin-1-yl)sulfonyl-2-propoxyphenyl]-4-propan-2-yl-1H-pyrimidin-6-one | IC50 | 7.4 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_69530a3c9d8e3ae069fc0ff8b8291d3f.svg) | 3-(2-Chlorophenyl)-12-methoxy-5-methyl-2,4,7,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene | IC50 | 435.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_97191d4bffad26c484b8d0263553b195.svg) | 4-[(3-Chloro-4-methoxyphenyl)methylamino]-8-cyclopropyl-3-(hydroxymethyl)quinoline-6-carbonitrile | IC50 | 339.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_20b9553a0e4af0edbe6be5a6f4724126.svg) | 6-Methoxy-3-methyl-1-(3-methylpyridin-4-yl)-8-(trifluoromethyl)imidazo[5,1-c][1,2,4]benzotriazine | IC50 | 1790.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_e6baa9a96c34018ca600f99177c4347b.svg) | 1-(2-Chlorophenyl)-6,8-Dimethoxy-3-Methylimidazo[5,1-C][1,2,4]benzotriazine | IC50 | 73.15 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_a0dbce63a38de5ad4560c6cdf55ccc90.svg) | 8-Fluoro-1-(3-fluoro-2-methylphenyl)-6-methoxy-3-methylimidazo[5,1-c][1,2,4]benzotriazine | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_b712c6ff498c52f64cc1e301e50cbafd.svg) | 1-(5-Butoxypyridin-3-Yl)-4-Methyl-8-(Morpholin-4-Ylmethyl)[1,2,4]triazolo[4,3-A]quinoxaline | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_52a7c830bb619af744b123a78e1b4a1d.svg) | Pde2/pde10-IN-1 | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_264d80c5e8058152d9b0733904a732fb.svg) | (2R,8R)-2-(1,3-Benzodioxol-5-yl)-6-[2-(dimethylamino)ethyl]-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione | IC50 | 8224.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_6b07d9070fe55fa8ba47b3a5be43225f.svg) | (7R)-7-Benzyl-2-bromo-5-ethyl-3-[(4-hydroxyphenyl)methyl]-7,8-dihydroimidazo[2,1-b]purin-4-one | IC50 | 180.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_bf3c549071431d5efc2138bc4510e561.svg) | 11-Benzyl-7,13-dimethyl-4-pyridin-3-yl-5,6,8,11,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7,12-pentaen-10-one | IC50 | 280.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_110a587652196a680ec46558af8dda50.svg) | 11-Benzyl-7,13-dimethyl-4-thiophen-3-yl-5,6,8,11,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7,12-pentaen-10-one | IC50 | 2200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_c0bde7b6050b8c17f23d56ec38b6f79f.svg) | 11-Benzyl-4-(furan-3-yl)-7,13-dimethyl-5,6,8,11,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7,12-pentaen-10-one | IC50 | 330.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_3c0b51989a40b4ef7d0cde204ac86bef.svg) | 11-Benzyl-7-ethyl-13-methyl-4-phenyl-5,6,8,11,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7,12-pentaen-10-one | IC50 | 550.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_34982d7e40324e38fe6ac6b748bc7a04.svg) | 11-Benzyl-13-methyl-4-phenyl-7-propyl-5,6,8,11,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7,12-pentaen-10-one | IC50 | 610.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_acf112fba605e872ff0f618f89f54e77.svg) | 11-Benzyl-13-methyl-4-phenyl-7-propan-2-yl-5,6,8,11,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7,12-pentaen-10-one | IC50 | 62.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_3ff05c0613757ccb13e07f2c2d9e15c7.svg) | 11-Benzyl-4-(4-chlorophenyl)-7,13-dimethyl-5,6,8,11,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7,12-pentaen-10-one | IC50 | 4700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_07344a1948d190b3a3d8aacd695fd292.svg) | 7,11,13-Trimethyl-4-phenyl-5,6,8,11,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7,12-pentaen-10-one | IC50 | 2600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_4c3d2eb32346548f4b4d36914ace4c1b.svg) | 11-Benzyl-13-(ethoxymethyl)-7-methyl-4-phenyl-5,6,8,11,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7,12-pentaen-10-one | IC50 | 330.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_4abdf4005b81e7f50b4d79b129f5b461.svg) | 11-Benzyl-13-[(dimethylamino)methyl]-7-methyl-4-phenyl-5,6,8,11,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7,12-pentaen-10-one | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_bda176ca8fccef65eb516558c9510183.svg) | N-[3-(5-Bromo-6-oxo-4-propan-2-yl-1H-pyrimidin-2-yl)-4-propoxyphenyl]methanesulfonamide | IC50 | 1600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_55446233cb5dbc15be81297af28bf0d1.svg) | (2S)-1-[3-(5-Bromo-6-oxo-4-propan-2-yl-1H-pyrimidin-2-yl)-4-propoxyphenyl]sulfonylpyrrolidine-2-carboxylic acid | IC50 | 2.2 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_6cadce3f6c597ca3db783d0d479751bd.svg) | 3-[(3R)-3-[(2R,8R)-2-(1,3-Benzodioxol-5-yl)-4,7-dioxo-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraen-6-yl]pyrrolidin-1-yl]-N-ethylpropanamide | IC50 | 620.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_1494a7d3de8de7c32ddb1a3982feee81.svg) | (2R,8R)-6-[(3R)-1-[3-(Azetidin-1-yl)-3-oxopropyl]pyrrolidin-3-yl]-2-(1,3-benzodioxol-5-yl)-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione | IC50 | 846.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_8de3361b384218d94ead38f64865e2f0.svg) | 3-[(3R)-3-[(2R,8R)-2-(1,3-Benzodioxol-5-yl)-4,7-dioxo-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraen-6-yl]pyrrolidin-1-yl]propanamide | IC50 | 1601.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_85a3dbbf0791b5e1cf6c262bff949b74.svg) | 3-[(3R)-3-[(2R,8R)-2-(1,3-Benzodioxol-5-yl)-4,7-dioxo-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraen-6-yl]pyrrolidin-1-yl]-N,N-dimethylpropanamide | IC50 | 807.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_f0e5f2c7c693bcadc6217cd813f0c827.svg) | (2R,8R)-2-(1,3-Benzodioxol-5-yl)-6-[(3R)-1-[2-(1H-imidazol-2-yl)ethyl]pyrrolidin-3-yl]-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione | IC50 | 357.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_3345897db94b8e2cb4886fef3fa88e8c.svg) | (2R,8R)-2-(1,3-Benzodioxol-5-yl)-6-[(3R)-1-[2-(1-methylimidazol-2-yl)ethyl]pyrrolidin-3-yl]-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione | IC50 | 494.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_4f1009d83bdd48a2569d6130778f1fbe.svg) | (2R,8R)-2-(1,3-Benzodioxol-5-yl)-6-[(3R)-1-pentylpyrrolidin-3-yl]-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione | IC50 | 1770.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_594a40dcd4a1aca9bb0a2a83e1e77642.svg) | (2R,8R)-2-(1,3-Benzodioxol-5-yl)-6-[(3R)-1-propylpyrrolidin-3-yl]-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_589a5019642800b5a4e29f8005d4525f.svg) | (2R,8R)-2-(1,3-Benzodioxol-5-yl)-6-[(3R)-1-(2-pyridin-2-ylethyl)pyrrolidin-3-yl]-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione | IC50 | 226.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_19b08e1995d9166f733acf9305115b3f.svg) | (2R,8R)-2-(1,3-Benzodioxol-5-yl)-6-[(3R)-1-(2-pyrazin-2-ylethyl)pyrrolidin-3-yl]-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione | IC50 | 358.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_1f21bb7e7eb9329573896526f092ae91.svg) | (2R,8R)-2-(1,3-Benzodioxol-5-yl)-6-[(3R)-1-(2-pyridin-3-ylethyl)pyrrolidin-3-yl]-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione | IC50 | 271.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_23b1390ff69785cc80b78f013438776a.svg) | (2R,8R)-2-(1,3-Benzodioxol-5-yl)-6-[(3R)-1-(2-cyclopropylethyl)pyrrolidin-3-yl]-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione | IC50 | 2660.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_db51a77fda61731fb93133b886918ef1.svg) | (2R,8R)-2-(1,3-Benzodioxol-5-yl)-6-[(3R)-1-(3-methoxypropyl)pyrrolidin-3-yl]-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione | IC50 | 1340.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_348df407f428c63ace1f500e554cf9f0.svg) | 4-(3-Chloro-4-methoxy-benzylamino)-7-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester | IC50 | 20000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_2376022fa093b00b456cb926dc1da8a6.svg) | 3-(4-Fluoro-2-methylphenyl)-12-methoxy-5-methyl-2,4,7,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene | IC50 | 1150.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_5cab23a615300f840d8c45fc01e4cec0.svg) | 12-Methoxy-5-methyl-3-(2-methylphenyl)-2,4,7,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene | IC50 | 1570.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_8ff2ab9d8e5d2f5a007009baa5988369.svg) | 10-Methoxy-5-methyl-3-(2-methylpyridin-3-yl)-2,4,7,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,7,9,11-hexaene | IC50 | 5000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_8e49979a5ca99664a83cdfa03bd21726.svg) | 10-Methoxy-5-methyl-3-(3-methylpyridin-4-yl)-2,4,7,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,7,9,11-hexaene | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_6b5a831a0c5c77f1a08c930bd05b379e.svg) | 6-Methoxy-3-methyl-1-(2-methylphenyl)imidazo[5,1-c][1,2,4]benzotriazine | IC50 | 1980.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_c70d5a198779a5b9c3304f9a3f521c5e.svg) | 6,8-Dimethoxy-3-methyl-1-(2-methylpyridin-3-yl)imidazo[5,1-c][1,2,4]benzotriazine | IC50 | 493.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_75c283a88244b56242d344fdbfc63f21.svg) | 6,8-Dimethoxy-3-methyl-1-(4-methylpyridin-3-yl)imidazo[5,1-c][1,2,4]benzotriazine | IC50 | 1822.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_1a3ab2ac981eaff019fb722ada1bc72b.svg) | 6,8-Dimethoxy-3-methyl-1-(3-methylpyridin-4-yl)imidazo[5,1-c][1,2,4]benzotriazine | IC50 | 1240.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_847773e4772b7552a216224181655522.svg) | 4-[6-Methoxy-3-methyl-1-(2-methylphenyl)imidazo[5,1-c][1,2,4]benzotriazin-8-yl]morpholine | IC50 | 693.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_5d9c5aee7a3bca31ce3ff2c7b1c05afd.svg) | 1-(2-Chlorophenyl)-6-methoxy-3-methylimidazo[5,1-c][1,2,4]benzotriazine | IC50 | 1060.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_99e084900b5bb19c2176654b64232edd.svg) | 4-[6-Methoxy-3-methyl-1-(3-methylpyridin-4-yl)imidazo[5,1-c][1,2,4]benzotriazin-8-yl]morpholine | IC50 | 3120.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_b4cadcf1cade8083b335d0faa485d014.svg) | 3-(2,4-Dichlorophenyl)-12-methoxy-5-methyl-2,4,7,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_b342e511c7a30c49c534496b5fb9ea5a.svg) | 3-(2-Fluoro-5-methoxyphenyl)-12-methoxy-5-methyl-2,4,7,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene | IC50 | 734.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_2fb82208e69640b8d478725e3a206a0f.svg) | 6-Fluoro-8-methoxy-1-(2-methoxyphenyl)-3-methylimidazo[5,1-c][1,2,4]benzotriazine | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_ab21b72c6c060f3e8a0945e52dbb8f9d.svg) | 6-Fluoro-8-methoxy-3-methyl-1-(3-methylthiophen-2-yl)imidazo[5,1-c][1,2,4]benzotriazine | IC50 | 1230.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_c18780190ed4b7c098caad23c40d7d43.svg) | 6-Methoxy-3,8-dimethyl-N-(oxan-2-ylmethyl)-2H-pyrazolo[3,4-b]quinolin-4-amine | Ki | 843.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_91d644e1a3e4b4dbf1d2051903789ffa.svg) | 6-Methoxy-3,8-dimethyl-N-(morpholin-2-ylmethyl)-2H-pyrazolo[3,4-b]quinolin-4-amine | Ki | 13882.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_761cedb73eeae1f4a21ddc343f9f6f49.svg) | 6-Methoxy-3,8-dimethyl-N-(piperidin-4-ylmethyl)-2H-pyrazolo[3,4-b]quinolin-4-amine | Ki | 14782.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_63c0a8894621c60658faf410b3a40ace.svg) | 6-Methoxy-3,8-dimethyl-N-(oxan-4-ylmethyl)-2H-pyrazolo[3,4-b]quinolin-4-amine | Ki | 697.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_fa1803a348862ad7e00209bef55a2267.svg) | 6-Methoxy-3,8-dimethyl-N-(2-pyridin-4-ylethyl)-2H-pyrazolo[3,4-b]quinolin-4-amine | Ki | 554.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_17af85a639c750b9b5330a20090fe854.svg) | 6-Methoxy-N,3,8-trimethyl-N-(oxan-4-yl)-2H-pyrazolo[3,4-b]quinolin-4-amine | Ki | 7383.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_7cb967c1e357f3191ad1378f1dc5d546.svg) | 6-Methoxy-3,8-Dimethyl-4-(Piperazin-1-Yl)-1h-Pyrazolo[3,4-B]quinoline | Ki | 770.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_7f4fbfa9588a717b99d3030c6c67d50f.svg) | 6-Methoxy-3,8-dimethyl-N-(oxan-4-yl)-2H-pyrazolo[3,4-b]quinolin-4-amine | Ki | 278.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_2598b49d2f3c167d570ada1ab6178fa9.svg) | 4-[(3-Chloro-4-methoxyphenyl)methylamino]-8-(dimethylamino)-3-(hydroxymethyl)quinoline-6-carbonitrile | IC50 | 5100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_d3d98268e78c7868d006dc333b380507.svg) | 1-(3-Pyridyl)-8,9-dimethoxy-5,6-dihydroimidazo[5,1-a]isoquinoline | Ki | 4274.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_15f34ccd1f8c197c034a95e99eebd92a.svg) | 5-(8,9-Dimethoxy-3-methyl-5,6-dihydroimidazo[5,1-a]isoquinolin-1-yl)-1,3-thiazole | Ki | 7100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_8ae8d31839b3e94d87386d209ada5162.svg) | 1-(3-Pyridyl)-8,9-dimethoxy-3-methyl-5,6-dihydroimidazo[5,1-a]isoquinoline | Ki | 7950.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_b5585a0648ddbb26b4b268acceac5482.svg) | N-Tert-butyl-5-(8,9-dimethoxy-5,6-dihydroimidazo[5,1-a]isoquinolin-1-yl)-N-methyl-1,3-thiazole-2-carboxamide | Ki | 2000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_4c112501728f4fff266271035c781f4e.svg) | 8,9-Dimethoxy-1-(1,3-Thiazol-5-Yl)-5,6-Dihydroimidazo[5,1-A]isoquinoline | Ki | 2000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_fcf8a52b79fb4c95980937a30cdf4414.svg) | 6-Methoxy-3,8-dimethyl-N-(pyridin-4-ylmethyl)-2H-pyrazolo[3,4-b]quinolin-4-amine | Ki | 211.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_921e5bddd30a403b88f3aaffbb95f1f9.svg) | 6-Methoxy-3,8-dimethyl-N-(pyridin-2-ylmethyl)-2H-pyrazolo[3,4-b]quinolin-4-amine | Ki | 1811.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_346c1d1cae1073bb3f0657ffcefb7ef4.svg) | 3-(2,5-Dichlorophenyl)-12-methoxy-5-methyl-2,4,7,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene | IC50 | 829.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_b1ef17ae8d993314f073235f8edd0aa7.svg) | 8-(Difluoromethoxy)-6-methoxy-3-methyl-1-(3-methylpyridin-4-yl)imidazo[5,1-c][1,2,4]benzotriazine | IC50 | 909.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_7c346bc82bb8e97345d1a4548da50c48.svg) | 6-Methoxy-3-methyl-1-(4-methylpyridin-3-yl)-8-(trifluoromethyl)imidazo[5,1-c][1,2,4]benzotriazine | IC50 | 5250.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_3e236695ab7508421d52ec8c892dadc2.svg) | 1-(3-Fluoro-2-methylphenyl)-6-methoxy-3-methyl-8-(trifluoromethyl)imidazo[5,1-c][1,2,4]benzotriazine | IC50 | 1260.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_e3345e6a6debb2588149b8263c4de1fd.svg) | 3-(2-Chloro-4-fluorophenyl)-12-methoxy-5-methyl-2,4,7,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene | IC50 | 462.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_23f1aed39e1642dd378687cc79c906af.svg) | 8-Fluoro-6-methoxy-3-methyl-1-(3-methylthiophen-2-yl)imidazo[5,1-c][1,2,4]benzotriazine | IC50 | 3270.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_e6bb270adc563bcba1ab044aa11e7ede.svg) | 8-Fluoro-6-methoxy-3-methyl-1-(1,3,5-trimethylpyrazol-4-yl)imidazo[5,1-c][1,2,4]benzotriazine | IC50 | 5000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_3b4e7fadf6d5e80f723c32d91c9b06b5.svg) | 8-Fluoro-6-methoxy-1-(2-methoxyphenyl)-3-methylimidazo[5,1-c][1,2,4]benzotriazine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_363b62ef808c2ca930289fc291ce6b2e.svg) | 8-Fluoro-6-methoxy-3-methyl-1-(4-methylpyridin-3-yl)imidazo[5,1-c][1,2,4]benzotriazine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_2fc08cdaf2e10fcf12eb14451d8b41de.svg) | 4-[1-(2-Chlorophenyl)-6-methoxy-3-methylimidazo[5,1-c][1,2,4]benzotriazin-8-yl]morpholine | IC50 | 276.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_a2557d0fd332a71aa8701ad149bcffd7.svg) | 8-Fluoro-6-methoxy-1-(3-methoxyphenyl)-3-methylimidazo[5,1-c][1,2,4]benzotriazine | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_13e4a1117c54627b74de8ddd8e1bfaf2.svg) | 5-(8-Fluoro-6-methoxy-3-methylimidazo[5,1-c][1,2,4]benzotriazin-1-yl)-2,4-dimethyl-1,3-thiazole | IC50 | 3880.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_5373afb46921700d61e3dcdbe6581274.svg) | 8-Fluoro-6-methoxy-3-methyl-1-(2-methylpyridin-3-yl)imidazo[5,1-c][1,2,4]benzotriazine | IC50 | 2830.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_b1addfbd297c27e04df67e6d6dd67f08.svg) | 8-Fluoro-6-methoxy-3-methyl-1-(3-methylpyridin-4-yl)imidazo[5,1-c][1,2,4]benzotriazine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_18724f0188ec87da05307d344f63860a.svg) | 6,8-Dimethoxy-3-methyl-1-(2-methylphenyl)imidazo[5,1-c][1,2,4]benzotriazine | IC50 | 349.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-6_15078b2e84a3b10e46d9ecb5a890a73e.svg) | 6,8-Dimethoxy-3-methyl-1-[2-(trifluoromethyl)phenyl]imidazo[5,1-c][1,2,4]benzotriazine | IC50 | 1000.0 [1] |