![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_ce2451a6dd9c86e3ec85025ead605266.svg) | Sildenafil | IC50 | 3.6 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_ce2451a6dd9c86e3ec85025ead605266.svg) | Sildenafil | Ki | 1.6 [1], 1.87 [2], 1.91 [3], 10.0 [4] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_4a2f7aa95b8e5fa8d1122874409c701a.svg) | Tadalafil | IC50 | 4.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_4a2f7aa95b8e5fa8d1122874409c701a.svg) | Tadalafil | Ki | 5.2 [1], 10.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_f2c1c04ef0787963213517a6b0b2b31c.svg) | Zaprinast | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_f2c1c04ef0787963213517a6b0b2b31c.svg) | Zaprinast | Ki | 130.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_611aee8360ba5f29cd9711190dfe1482.svg) | Vardenafil | IC50 | 0.7 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_611aee8360ba5f29cd9711190dfe1482.svg) | Vardenafil | Ki | 0.7 [1], 1.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_fe3f92a2cc3d499742993c6ba3abb5e6.svg) | Rolipram | IC50 | 16000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_fe3f92a2cc3d499742993c6ba3abb5e6.svg) | Rolipram | Ki | 200000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_d3dffa835ce10f367f77bd4b8604b4a1.svg) | 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one | IC50 | 26.92 [1], 27.0 [2], 40.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_dd9891f9bfcb4a714d4730718791a515.svg) | 1-(1,3-Benzodioxol-5-yl)-2-[5-(3,4-dimethoxyphenyl)pyrimidin-2-yl]-3,9-dihydro-1H-pyrido[3,4-b]indol-4-one | Ki | 8.0 [1], 8.86 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_4b00d5e82e9e2f9f2b102505bdd4a01a.svg) | Sildenafil citrate | IC50 | 2.2 [1], 3.5 [2], 5.1 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_dd66d02484c6308316368380ca57da10.svg) | Milrinone | IC50 | 740.0 [1], 100000.0 [2], 110000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_793104587ce53f5aead620b09e22dc10.svg) | 1-(3-Chlorophenylamino)-4-phenylphthalazine | IC50 | 500.0 [1], 1800.0 [2], 5000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_b54dea8f9570440a482f2acd5b78009c.svg) | (11R,15S)-4-Benzyl-8-ethyl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 19.0 [1], 39.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_7d7d5a0fe27f5520236e4e27d6c5a580.svg) | (10S,15R)-13-Butyl-10-(4-methoxyphenyl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione | IC50 | 5.0 [1], 5.01 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_5a5c81fd1965ace315c198fef48df11e.svg) | 1-(2,3-Dihydro-1-benzofuran-5-yl)-2-(5-pyridin-2-ylpyridin-2-yl)-1,3,4,9-tetrahydropyrido[3,4-b]indole | Ki | 4.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_e4495e05c3ab076dd1281cf16adb9de0.svg) | 2-(2-Ethoxyphenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one | IC50 | 5.0 [1], 5.01 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_c121e7d93bb9cf7db1275fda222c6c2e.svg) | N-Desmethylvardenafil | IC50 | 0.6 [1], 2.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_6f62efa2cf07147e22a12ca24c591111.svg) | 11-Benzyl-7,13-dimethyl-4-phenyl-5,6,8,11,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7,12-pentaen-10-one | IC50 | 160.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_0ed86b5f659fb513d4395af2d77fde7b.svg) | 5-(2-Ethoxyphenyl)-1,3-dimethyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one | IC50 | 316.23 [1], 330.0 [2], 331.13 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_5383804cb263a78b7c2fd60795c56865.svg) | 4-[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]-N-hydroxycyclohexane-1-carboxamide | IC50 | 53.0 [1], 146.0 [2], 190.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_f189de2d8f426169f04d7f81da7ffac9.svg) | 3-[[4-Ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxycyclobutane-1-carboxamide | IC50 | 34.0 [1], 45.0 [2], 60.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_2019d6686c0079c33ef9d229dcb67e59.svg) | Dipyridamole | IC50 | 520.0 [1], 574.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_3b8934fb4229a49cef5302fdbcc3af68.svg) | Hydroxyhomosildenafil | IC50 | 1.91 [1], 19.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_c15a5ab1b538d176aabb70f7db292229.svg) | Desmethylsildenafil | IC50 | 5.7 [1], 5.75 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_17306b0519122eb2e89b06aa125ceb17.svg) | Avanafil | IC50 | 6.99 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_17306b0519122eb2e89b06aa125ceb17.svg) | Avanafil | Ki | 5.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_3507da2c22f51cb8e7a063215aa04a7b.svg) | Sodium;1-[4-(1,3-benzodioxol-5-ylmethylamino)-6-chloroquinazolin-2-yl]piperidine-4-carboxylate | IC50 | 3.7 [1], 8.6 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_9de98a3452b540f3317d609a329441dd.svg) | Perlolyrine | IC50 | 9300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_51d10331127b3d73a312eb012230dc45.svg) | Cipamfylline | IC50 | 71000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_51d10331127b3d73a312eb012230dc45.svg) | Cipamfylline | Ki | 7500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_bba1b7c778a86e4eedf9232a1b87947e.svg) | 6H-Purin-6-one, 1,7-dihydro-2-(2-propoxyphenyl)- | IC50 | 80.0 [1], 1000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_b781b793b1bc8f43d525fd41ea01d9f2.svg) | 2-Methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrido[3,2-e]pyrazine | IC50 | 919.0 [1], 920.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_e6ca044946a4d12c3099afd6e3fdefaa.svg) | 3-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 0.2 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_d75dd4e38ff9aba05ee7ff7cf232ed43.svg) | (7R,8S)-2-Benzyl-5-methyl-7,8-propano-7,8-dihydro-3H-imidazo[2,1-b]purin-4(5H)-one | IC50 | 80.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_cd218304e1cc52f50f7fa306743a9ef0.svg) | 3-(4-Hydroxybenzyl)-1-(Thiophen-2-Yl)chromeno[2,3-C]pyrrol-9(2h)-One | IC50 | 17.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_6577747cd13a8cfc2779bc430d84b6be.svg) | 3-[(4-Hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 0.05 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_f31101e5d11c371914b8aff9a279bf1e.svg) | 7-(6-Methoxypyridin-3-yl)-3-(2-morpholin-4-ylethylamino)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 0.07 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_af07e798badb1badffa12d1f1a768f78.svg) | (11R,15S)-5-[(3-Bromo-4-hydroxyphenyl)methyl]-8-ethyl-4-methoxy-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 1.58 [1], 1.6 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_d8e756f10ef1779f0ceba81863623cfe.svg) | (7R)-7-Benzyl-3-[(3-chloro-4-hydroxyphenyl)methyl]-5-ethyl-2-phenylmethoxy-7,8-dihydroimidazo[2,1-b]purin-4-one | IC50 | 2.09 [1], 2.1 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_a23675040a21d500831019dce0ae773f.svg) | (7R)-7-Benzyl-3-[(3-chloro-4-hydroxyphenyl)methyl]-5-ethyl-2-methoxy-7,8-dihydroimidazo[2,1-b]purin-4-one | IC50 | 1.9 [1], 1.91 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_06ca3e6da6ba0b9598be24d924a8d0ee.svg) | 5-[[(7R)-7-Benzyl-5-ethyl-2-methoxy-4-oxo-7,8-dihydroimidazo[2,1-b]purin-3-yl]methyl]-2-methoxybenzonitrile | IC50 | 10.96 [1], 11.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_87f2766bd55212baf46155139e34874e.svg) | (7R)-7-Benzyl-3-[(3-bromo-4-hydroxyphenyl)methyl]-5-ethyl-2-methoxy-7,8-dihydroimidazo[2,1-b]purin-4-one | IC50 | 1.29 [1], 1.3 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_2778458b34be6c6e4886b867df3fa993.svg) | 1-(2-Ethoxyethyl)-3-ethyl-5-(piperazin-1-yl)-N-(pyridin-2-yl)-1H-pyrazolo[4,3-d]pyrimidin-7-amine | IC50 | 0.4 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_4f82a78e46b5c2aee1ed48321a0f7052.svg) | 11-Benzyl-13-methyl-4-phenyl-5,6,8,11,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7,12-pentaen-10-one | IC50 | 180.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_38afa323208c29573d5daadf85760161.svg) | 3-[2-(2-Hydroxyethylamino)ethylamino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 1.1 [1], 1.12 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_144ed950d79630999a789b657f1d5f37.svg) | 7-(6-Methoxypyridin-3-yl)-3-(2-morpholin-4-ylethylamino)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-one | IC50 | 0.34 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_fa45b9e13af64f94b073df536fac1057.svg) | 1-(4-Fluorobenzyl)-6-(3-carbamoyl-6-propoxyphenyl)-1H-imidazo[4,5-g]quinazoline-8(7H)-one | IC50 | 0.48 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_77f32cc17d785d3cfab236b0291af709.svg) | 3-Ethyl-5-[5-(4-ethylpiperazin-1-yl)sulfonyl-2-(2-methoxyethoxy)pyridin-3-yl]-2-(pyridin-2-ylmethyl)-6H-pyrazolo[4,3-d]pyrimidin-7-one | IC50 | 1.3 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_24c258e087a391cdaf0a56b6e950cc08.svg) | 1-Benzyl-6-[3-(4-methylpiperazinosulfonyl)-6-propoxyphenyl]-1H-imidazo[4,5-g]quinazoline-8(7H)-one | IC50 | 5.3 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_9015de2821f93cc2ac0755c59e1d2b73.svg) | Ethoxy-[[1-[3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperidin-4-yl]methyl]phosphinic acid | IC50 | 0.17 [1], 5888436553555.88 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_6e0475b9d1bec87d1653d9b5687e3a34.svg) | 5-(2-Ethoxyphenyl)-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one | IC50 | 50.0 [1], 82.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_fcaf9854f96f90ee3dcdddbcc5349835.svg) | 2-(5-(4-Methylpiperazin-1-ylsulfonyl)-2-propoxyphenyl)-9-propyl-1H-purin-6(9H)-one | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_b5142c37b80944acf8404854fffdba2a.svg) | 5-[5-[4-(Diethoxyphosphorylmethyl)piperazin-1-yl]sulfonyl-2-propoxyphenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one | IC50 | 0.58 [1], 1737800828749.38 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_d1e7fce91c01c50d5e519dec6dd893d5.svg) | 3-Ethyl-5-[5-(4-ethylpiperazin-1-yl)sulfonyl-2-propoxypyridin-3-yl]-2-(pyridin-2-ylmethyl)-6H-pyrazolo[4,3-d]pyrimidin-7-one | IC50 | 1.1 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_e1a7220647734c5a02f50261d2c7afb2.svg) | 2-(2-Propoxyphenyl)-9-propyl-1H-purin-6(9H)-one | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_ca1ace5794de20dcf8b0244c496a5ac6.svg) | Ethoxy-[[4-[3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperazin-1-yl]methyl]phosphinic acid | IC50 | 0.18 [1], 5495408738576.25 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_f117f0d96b6f6ccdc42bd8039f1ea33d.svg) | Ethoxy-[2-[4-[3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperazin-1-yl]ethyl]phosphinic acid | IC50 | 0.28 [1], 3548133892335.76 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_d397f49c767e60dbfc8d3fcf601a96a5.svg) | Ethoxy-[1-[3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperidin-4-yl]phosphinic acid | IC50 | 0.3 [1], 3311311214825.91 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_fdb9ca19e39d9d0bffa8b7847fb5372b.svg) | 5-[5-[4-(2-Diethoxyphosphorylethyl)piperazin-1-yl]sulfonyl-2-propoxyphenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one | IC50 | 1.05 [1], 954992586021.44 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_6a2d62204f9d6dea6427b4eed421b1c8.svg) | 5-[5-(4-Diethoxyphosphorylpiperidin-1-yl)sulfonyl-2-propoxyphenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one | IC50 | 0.41 [1], 2454708915685.03 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_b9cb6ee220e1ecdfe10979c603397ac0.svg) | 5-[5-[4-(Diethoxyphosphorylmethyl)piperidin-1-yl]sulfonyl-2-propoxyphenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one | IC50 | 0.34 [1], 2951209226666.39 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_0dbba8ac8d75fdefcfdba4037174ea7e.svg) | 2-[4-[3-(1-Methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperazin-1-yl]ethylphosphonic acid | IC50 | 0.94 [1], 1071519305237.6 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_2a969ffb0703e5a27df5299230f5659b.svg) | [1-[3-(1-Methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperidin-4-yl]phosphonic acid | IC50 | 0.7 [1], 1412537544622.76 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_e07985e8435a499a3cf4af46fb7dee51.svg) | [1-[3-(1-Methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperidin-4-yl]methylphosphonic acid | IC50 | 0.32 [1], 3090295432513.59 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_e31dcdabb93756eb8287fac0c67e4dae.svg) | 5-[[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxythiophene-2-carboxamide | IC50 | 11.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_ea29189abab2aef907ebc2e86b09dd09.svg) | 5-[[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxyfuran-2-carboxamide | IC50 | 3.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_5162bf93dc9817c9bc912f2c0b463892.svg) | 5-[[4-Ethoxy-3-(5-methyl-4-oxo-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-2-yl)phenyl]methyl]-N-hydroxythiophene-2-carboxamide | IC50 | 3.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_3773eba2651c5e82ce2ca6358972d45b.svg) | 3-(5-Ethylfuran-2-yl)-2-(5-pyridin-2-ylpyrimidin-2-yl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one | IC50 | 0.53 [1], 0.54 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_ce09d701990da34dda1148e67e1d9d00.svg) | 3-(5-Ethylthiophen-2-yl)-2-(5-pyridin-2-ylpyrimidin-2-yl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one | IC50 | 0.6 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_5c66c83c1704b1d650fd3412d809c7a2.svg) | 4-(1,3-Benzodioxol-5-ylmethoxy)-6,7,8-trimethoxy-quinazoline | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_c42aaa9de77c1477db85d39c42b2d9ba.svg) | 6-(6-Methoxypyridin-3-yl)-2-(2-morpholin-4-ylethylamino)-4-(2-propoxyethyl)pyrido[2,3-b]pyrazin-3-one | IC50 | 2.4 [1], 2.9 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_e1d9b57ab9f82c41e48701c26f14f601.svg) | (11R,15S)-4-Benzyl-8-ethyl-5-[(4-hydroxyphenyl)methyl]-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 3.89 [1], 3.9 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_2ac891960c6f389e265a45012440628f.svg) | (11R,15S)-5-[(3-Bromo-4-methoxyphenyl)methyl]-8-ethyl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 6.46 [1], 6.5 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_228f3275a8c4b7bda079e8cc4095c21a.svg) | (11R,15S)-4-Ethoxy-8-ethyl-5-[(4-hydroxyphenyl)methyl]-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 0.89 [1], 0.9 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_e39289d16b4f3b43ddae8ac8d674eeb7.svg) | (11R,15S)-5-[(3-Chloro-4-hydroxyphenyl)methyl]-8-ethyl-4-methoxy-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 2.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_76fff70934faf7829eb24b458e0d3be5.svg) | (11R,15S)-5-[(3-Chloro-4-methoxyphenyl)methyl]-8-ethyl-4-methoxy-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 5.0 [1], 5.01 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_ba18ad625c46f8bb0335adcbff18064e.svg) | (7R)-7-Benzyl-3-[(3-chloro-4-methoxyphenyl)methyl]-5-ethyl-4-oxo-7,8-dihydroimidazo[2,1-b]purine-2-carboxamide | IC50 | 2.8 [1], 2.82 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_ca5258e909e7ba0025136a076a7e552e.svg) | 3-Benzo[1,3]dioxol-5-ylmethyl-6,7,8-trimethoxy-3H-quinazolin-4-one | IC50 | 530.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_480ab056a3642a3aa58e908d3012d32f.svg) | 3-(1,3-Benzodioxol-5-yl)-2-benzoyl-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one | Ki | 2.49 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_ba10c861a3ceedd2420627348ed3658b.svg) | (11R,15S)-8-Ethyl-5-[(4-methoxyphenyl)methyl]-7-oxo-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-triene-4-carboxamide | IC50 | 3.98 [1], 4.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_119c239245c813c32e1ca5cc5eb1e9c9.svg) | (11R,15S)-5-[(3-Chloro-4-hydroxyphenyl)methyl]-8-ethyl-N-methyl-7-oxo-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-triene-4-carboxamide | IC50 | 1.29 [1], 1.3 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_340f3c7db2470648331b20c21383838e.svg) | 5-[[(7R)-7-Benzyl-5-ethyl-2-methoxy-4-oxo-7,8-dihydroimidazo[2,1-b]purin-3-yl]methyl]-2-hydroxybenzonitrile | IC50 | 42.66 [1], 43.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_3fcf199356ee198224deda0c2203c5a9.svg) | (7R)-7-Benzyl-3-[(3-bromo-4-methoxyphenyl)methyl]-5-ethyl-2-methoxy-7,8-dihydroimidazo[2,1-b]purin-4-one | IC50 | 2.19 [1], 2.2 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_0f0adf4ce7672efaf882455c87f52918.svg) | (11R,15S)-5-[(3-Bromo-4-methoxyphenyl)methyl]-8-ethyl-4-methoxy-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 2.8 [1], 2.82 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_b17e94e6e87d0b116ab1ebb5adb64e18.svg) | (11R,15S)-5-[(3-Chloro-4-hydroxyphenyl)methyl]-4-ethoxy-8-ethyl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 2.09 [1], 2.1 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_07be232683fef6759e37983ff0a8b19a.svg) | (11R,15S)-5-[(3-Chloro-4-methoxyphenyl)methyl]-4-ethoxy-8-ethyl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 6.46 [1], 6.5 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_7e7df73ae2b97ea222b42e9d15d6335a.svg) | (11R,15S)-5-[(3-Bromo-4-methoxyphenyl)methyl]-4-ethoxy-8-ethyl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 5.37 [1], 5.4 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_12ad5a4975917841c1f1c9d5a6c887dc.svg) | (7R)-2,7-Dibenzyl-5-ethyl-7,8-dihydro-3H-imidazo[2,1-b]purin-4-one | IC50 | 4.5 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_5215f9273ce3f7b3d91d23a764a88e2b.svg) | (11R,15S)-5-[(4-Chlorophenyl)methyl]-8-ethyl-4-(2-phenylethynyl)-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 5.0 [1], 5.01 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_cbe7ed95ed851e3b886f674e4242424e.svg) | (11R,15S)-5-(1,3-Benzodioxol-5-ylmethyl)-4-benzyl-8-ethyl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 45.71 [1], 46.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_77e5336bc58bdd324a2bd0daef69c7ed.svg) | (11R,15S)-4-Benzyl-5-[(3-chloro-4-methoxyphenyl)methyl]-8-ethyl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 57.54 [1], 58.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_c7daa3cae91ccb563bb1fb49d9593458.svg) | (11R,15S)-5-[(4-Aminophenyl)methyl]-4-benzyl-8-ethyl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 549.54 [1], 550.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_b5fd10c33719024b03ffda8dcc84ebc7.svg) | (11R,15S)-4-Benzyl-8-ethyl-5-[(4-methoxyphenyl)methyl]-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 19.95 [1], 20.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_be5e503b582d760732333aab4505ef27.svg) | (11R,15S)-4-Benzyl-5-[(4-chlorophenyl)methyl]-8-ethyl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 158.49 [1], 160.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_2f91836808b832540404e78a43df357f.svg) | (11R,15S)-4-Benzyl-8-ethyl-5-[(4-methylphenyl)methyl]-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 39.81 [1], 40.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_ceab1d0845383ba6f74d2def77fa15c2.svg) | (11R,15S)-8-Ethyl-4-ethylsulfanyl-5-[(4-hydroxyphenyl)methyl]-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 1.8 [1], 1.82 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-5a_85c4a95528e460015d995d9bf877da6d.svg) | (11R,15S)-8-Ethyl-5-[(4-hydroxyphenyl)methyl]-7-oxo-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-triene-4-carboxamide | IC50 | 2.09 [1], 2.1 [2] |