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Phosphodiesterase 4D Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
RolipramIC50403.0 [1]
RolipramKi382.0 [1]
(R)-2-(4-Fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)nicotinamideIC501.0 [1]
RoflumilastIC500.27 [1], 0.56 [2], 0.7 [3], 1.1 [4], 460.0 [5]
CilomilastIC5011.0 [1], 27.0 [2], 39.0 [3], 63.0 [4], 79.0 [5]
1-[(E)-(3-Cyclopentyloxy-4-methoxyphenyl)methylideneamino]oxy-3-(2,6-dimethylmorpholin-4-yl)propan-2-olIC502860.0 [1], 3460.0 [2], 7090.0 [3], 7340.0 [4]
4-[8-(2,1,3-Benzoxadiazol-5-yl)-1,7-naphthyridin-6-yl]benzoic acidIC501.5 [1]
ZaprinastKi8760.0 [1], 50000.0 [2]
PiclamilastIC500.02 [1], 0.8 [2], 2.0 [3]
ZardaverineIC50390.0 [1], 800.0 [2], 2000.0 [3]
4,5-Dihydro-6-(4-(imidazol-1-yl)phenyl)-5-methyl-3(2H)-pyridazinoneKi50000.0 [1]
Unii-G6gso9sdnjIC501.0 [1], 1.2 [2]
4-[8-(3-Nitrophenyl)-1,7-naphthyridin-6-yl]benzoic AcidIC501.0 [1]
2-[(E)-(3-Cyclopentyloxy-4-methoxyphenyl)methylideneamino]oxy-1-(2,6-dimethylmorpholin-4-yl)ethanoneIC50670.0 [1], 1910.0 [2]
3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl-adenineKi141.0 [1], 172.0 [2], 2890.0 [3]
6-Amino-3-(3-cyclopentyloxy-4-methoxy-benzyl)-8-(1-hydroxy-1-methyl-ethyl)-3H-purine hydrochlorideKi4.1 [1], 5.7 [2], 413.0 [3]
2-[4-[2-[3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-6-imino-7H-purin-8-yl]-2-methylpropoxy]-2-(2-oxoethoxy)phenoxy]acetaldehydeKi3.7 [1], 6.6 [2], 218.0 [3]
3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[1-(2-methoxyphenoxy)-2-methylpropan-2-yl]-7H-purin-6-imineKi5.1 [1], 7.1 [2], 255.0 [3]
Methyl 4-[2-[3-[(3-cyclopentyloxy-4-methoxyphenyl)methyl]-6-imino-7H-purin-8-yl]-2-methylpropoxy]benzoateKi3.0 [1], 5.5 [2], 246.0 [3]
3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[1-(3-fluorophenoxy)-2-methylpropan-2-yl]-7H-purin-6-imineKi7.4 [1], 8.4 [2], 369.0 [3]
3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[(2R)-1-phenoxypropan-2-yl]-7H-purin-6-imineKi590.0 [1], 640.0 [2], 4450.0 [3]
4-[2-[3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-6-imino-7H-purin-8-yl]-2-methylpropoxy]benzamideKi4.9 [1], 8.0 [2], 312.0 [3]
3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[1-(3,4-dimethoxyphenoxy)-2-methylpropan-2-yl]-7H-purin-6-imineKi7.8 [1], 15.0 [2], 2640.0 [3]
3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[(2R)-1-(3-methoxyphenoxy)propan-2-yl]-7H-purin-6-imineKi322.0 [1], 493.0 [2], 5050.0 [3]
3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[1-(3-methoxyphenoxy)-2-methylpropan-2-yl]-7H-purin-6-imineKi5.1 [1], 6.0 [2], 296.0 [3]
4-[2-[3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-6-imino-7H-purin-8-yl]-2-methylpropoxy]benzoic acidKi4300.0 [1], 50000.0 [2]
3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[1-(3,5-dimethoxyphenoxy)-2-methylpropan-2-yl]-7H-purin-6-imineKi7.9 [1], 9.0 [2], 340.0 [3]
3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[(2R)-1-(3-fluorophenoxy)propan-2-yl]-7H-purin-6-imineKi114.7 [1], 231.0 [2], 4300.0 [3]
3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[1-(4-methoxyphenoxy)-2-methylpropan-2-yl]-7H-purin-6-imineKi5.6 [1], 8.1 [2], 347.0 [3]
3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[2-methyl-1-[4-(trifluoromethyl)phenoxy]propan-2-yl]-7H-purin-6-imineKi9.9 [1], 10.3 [2], 580.0 [3]
3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[2-methyl-1-(4-methylphenoxy)propan-2-yl]-7H-purin-6-imineKi6.6 [1], 7.6 [2], 347.0 [3]
3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[1-(3,4-difluorophenoxy)-2-methylpropan-2-yl]-7H-purin-6-imineKi13.0 [1], 13.3 [2], 459.0 [3]
3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[1-(3,4-dichlorophenoxy)-2-methylpropan-2-yl]-7H-purin-6-imineKi6.6 [1], 10.6 [2], 355.0 [3]
4-[2-[3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-6-imino-7H-purin-8-yl]-2-methylpropoxy]benzonitrileKi19.4 [1], 33.4 [2], 1840.0 [3]
8-[1-(4-Tert-butylphenoxy)-2-methylpropan-2-yl]-3-[(3-cyclopentyloxy-4-methoxyphenyl)methyl]-7H-purin-6-imineKi4.3 [1], 5.0 [2], 255.0 [3]
8-[1-(4-Chlorophenoxy)-2-methylpropan-2-yl]-3-[(3-cyclopentyloxy-4-methoxyphenyl)methyl]-7H-purin-6-imineKi4.8 [1], 5.8 [2], 205.0 [3]
3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[2-methyl-1-(2-thiophen-2-ylphenoxy)propan-2-yl]-7H-purin-6-imineKi6.3 [1], 7.0 [2], 412.0 [3]
3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[2-methyl-1-[4-(trifluoromethoxy)phenoxy]propan-2-yl]-7H-purin-6-imineKi6.5 [1], 7.2 [2], 782.0 [3]
3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[1-(2-fluorophenoxy)-2-methylpropan-2-yl]-7H-purin-6-imineKi6.8 [1], 11.0 [2], 427.0 [3]
3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[2-methyl-1-(3-thiophen-3-ylphenoxy)propan-2-yl]-7H-purin-6-imineKi6.6 [1], 9.0 [2], 2680.0 [3]
Moracin MIC502900.0 [1], 2910.0 [2]
(S)-(+)-RolipramIC501000.0 [1], 1062.0 [2]
2-[5-[(1S)-1-[3-Cyclopropyloxy-4-(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-3-yl)ethyl]-1,3-thiazol-2-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC500.4 [1]
(cis)-4-(3,4-Dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-oneIC5085.0 [1], 213.0 [2]
4-(3,4-Dimethoxy-phenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-oneIC50213.0 [1]
4-(3,4-Dimethoxy-phenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-oneKi6.3 [1]
N-[4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfinylimidazol-4-yl]pyridin-2-yl]acetamideIC50800.0 [1], 1100.0 [2]
(4-{[2-(5-Chlorothiophen-2-Yl)-5-Ethyl-6-Methylpyrimidin-4-Yl]amino}phenyl)acetic AcidIC501700.0 [1], 1997.0 [2]
8-(3-Methoxyphenyl)-6-(pyridin-4-ylmethyl)quinolineIC502.5 [1]
4-[8-(3-Methoxy-phenyl)-[1,7]naphthyridin-6-yl]-cyclohexanecarboxylic acidIC5064.0 [1]
4-[8-(3-Cyano-phenyl)-[1,7]naphthyridin-6-yl]-cyclohexanecarboxylic acidIC5041.0 [1]
(cis)-2-(5-Bromopentyl)-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-oneIC502.0 [1]
(cis)-2-(5-Bromopentyl)-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-oneKi2.3 [1]
2-[4-[(2-Phenyl-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl]acetic acidIC501300.0 [1]
2-[4-[(5,5-Dioxo-2-phenyl-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl]acetic acidIC50550.0 [1], 2800.0 [2]
N-Butyl-2-[4-[(5,5-dioxo-2-phenyl-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl]acetamideIC50180.0 [1], 260.0 [2]
4-[8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl]cyclohexane-1-carboxylic AcidIC5032.0 [1]
1-(8-(3-Cyanophenyl)-1,7-naphthyridine-6-yl)piperidine-4-carboxylic acidIC5019.0 [1]
1-(8-(3-Fluorophenyl)-1,7-naphthyridine-6-yl)piperidine-4-carboxylic acidIC5051.0 [1]
4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfinylimidazol-4-yl]pyridin-2-amineIC50700.0 [1], 2400.0 [2]
(E)-N-[2-Chloro-3-(2,6-dimethylmorpholin-4-yl)propoxy]-1-(3-cyclopentyloxy-4-methoxyphenyl)methanimineIC503420.0 [1], 4270.0 [2]
[4-[3-[(4-Phenylpyridazino[4,5-b]indolizin-1-yl)amino]propyl]piperazin-1-yl]-pyrazin-2-ylmethanoneIC50100000.0 [1]
[4-[3-[(4-Phenylpyridazino[4,5-b]indolizin-1-yl)amino]propyl]piperazin-1-yl]-pyrazin-2-ylmethanoneKi8370.0 [1]
[4-[3-[[4-(3-Nitrophenyl)pyridazino[4,5-b]indolizin-1-yl]amino]propyl]piperazin-1-yl]-pyrazin-2-ylmethanoneIC504900.0 [1]
[4-[3-[[4-(3-Nitrophenyl)pyridazino[4,5-b]indolizin-1-yl]amino]propyl]piperazin-1-yl]-pyrazin-2-ylmethanoneKi147.0 [1]
4-Phenyl-N-[3-(4-pyrimidin-2-ylpiperazin-1-yl)propyl]pyridazino[4,5-b]indolizin-1-amineIC50100000.0 [1]
4-Phenyl-N-[3-(4-pyrimidin-2-ylpiperazin-1-yl)propyl]pyridazino[4,5-b]indolizin-1-amineKi59000.0 [1]
4-[3-(3-Chlorophenyl)-7-methoxy-2,4-dioxopyrimido[5,4-c]quinolin-1-yl]cyclohexane-1-carboxylic acidIC5055.0 [1]
3-Benzo[1,3]dioxol-5-yl-1-cyclopentyl-7-methoxy-1H-pyrimido[5,4-c]quinoline-2,4-dioneIC50827.0 [1]
3-(3-Chlorophenyl)-7-methoxy-1-(1-methylsulfonylpiperidin-4-yl)pyrimido[5,4-c]quinoline-2,4-dioneIC50151.0 [1]
1-Cyclopentyl-3-ethyl-7-propylpyrimido[5,4-c]quinoline-2,4-dioneIC5025000.0 [1]
3-(3-Chlorophenyl)-7-methoxy-1-[(3S)-1-methylsulfonylpyrrolidin-3-yl]pyrimido[5,4-c]quinoline-2,4-dioneIC50163.0 [1], 206.0 [2]
1-Cyclopentyl-3-ethyl-7-propan-2-ylpyrimido[5,4-c]quinoline-2,4-dioneIC5025000.0 [1]
1-Cyclopentyl-7-methoxy-3-m-tolyl-1H-pyrimido[5,4-c]quinoline-2,4-dioneIC50338.0 [1]
3-(3-Chlorophenyl)-1-(1-ethylsulfonylpiperidin-4-yl)-7-methoxypyrimido[5,4-c]quinoline-2,4-dioneIC5059.0 [1]
3-(3-Chlorophenyl)-7-methoxy-1-[1-(methylsulfonylmethylsulfonyl)piperidin-4-yl]pyrimido[5,4-c]quinoline-2,4-dioneIC5080.0 [1]
1-Cyclopentyl-7-methoxy-3-(4-methyl-thiophen-2-yl)-1H-pyrimido[5,4-c]quinoline-2,4-dioneIC50616.0 [1]
7-Chloro-1-cyclopentyl-3-ethylpyrimido[5,4-c]quinoline-2,4-dioneIC5025000.0 [1]
N-[4-[3-(3-Chlorophenyl)-7-methoxy-2,4-dioxopyrimido[5,4-c]quinolin-1-yl]cyclohexyl]methanesulfonamideIC5073.0 [1]
SildenafilIC5020000.0 [1]
3-Isobutyl-1-methylxanthineIC5038000.0 [1]
ClioquinolIC5010000.0 [1]
CID 14521039IC5020000.0 [1]
IbudilastIC50166.0 [1]
MorusinIC50900.0 [1]
CrisaboroleIC5055.0 [1]
CipargaminIC5010000.0 [1]
4-(2-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-phenylethyl)pyridineIC502.1 [1]
2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanolIC5010000.0 [1]
N,N,2-Trimethyl-5-nitrobenzenesulfonamideIC501280.0 [1]
(R)-(-)-RolipramIC50622.0 [1]
MulberrinIC50310.0 [1]
Licoflavone CIC50630.0 [1]
Moracin CIC5026000.0 [1]
(2S,3R)-3-(6-Amino-9H-purin-9-yl)nonan-2-olIC5016000.0 [1]
LeniolisibIC504700.0 [1]
1-(4-((3'-Chloro-6-methoxy-[1,1'-biphenyl]-3-yl)methyl)phenyl)ureaIC5027.0 [1]
(R)-5-(6-Cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxamideIC50900.0 [1]
Cudraflavone CIC50260.0 [1]
EggmanoneIC50380.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Phosphodiesterase 4D Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/phosphodiesterase-4d-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Phosphodiesterase 4D Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/phosphodiesterase-4d-inhibitors-ic50-ki.
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