![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_fe3f92a2cc3d499742993c6ba3abb5e6.svg) | Rolipram | IC50 | 403.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_fe3f92a2cc3d499742993c6ba3abb5e6.svg) | Rolipram | Ki | 382.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_d96e87b02f8c9adef2f0f370df042903.svg) | (R)-2-(4-Fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)nicotinamide | IC50 | 1.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_f279a08ed16335ac7dd922ae328f130a.svg) | Roflumilast | IC50 | 0.27 [1], 0.56 [2], 0.7 [3], 1.1 [4], 460.0 [5] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_fac02fc38056dabaf3130f9076a3bc63.svg) | Cilomilast | IC50 | 11.0 [1], 27.0 [2], 39.0 [3], 63.0 [4], 79.0 [5] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_af33a544c4dc2cfd1b4085854dee053b.svg) | 1-[(E)-(3-Cyclopentyloxy-4-methoxyphenyl)methylideneamino]oxy-3-(2,6-dimethylmorpholin-4-yl)propan-2-ol | IC50 | 2860.0 [1], 3460.0 [2], 7090.0 [3], 7340.0 [4] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_a8cc40c95c0baa0b0f176da302f94815.svg) | 4-[8-(2,1,3-Benzoxadiazol-5-yl)-1,7-naphthyridin-6-yl]benzoic acid | IC50 | 1.5 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_f2c1c04ef0787963213517a6b0b2b31c.svg) | Zaprinast | Ki | 8760.0 [1], 50000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_eb9db9b84b76fbcd81744f1acddb03dc.svg) | Piclamilast | IC50 | 0.02 [1], 0.8 [2], 2.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_b12e5f0bc97c098ef64ad34f70617967.svg) | Zardaverine | IC50 | 390.0 [1], 800.0 [2], 2000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_3f42d5e14336d453141c46493d827f47.svg) | 4,5-Dihydro-6-(4-(imidazol-1-yl)phenyl)-5-methyl-3(2H)-pyridazinone | Ki | 50000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_602ffc7429097215cfe38917d302d660.svg) | Unii-G6gso9sdnj | IC50 | 1.0 [1], 1.2 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_ef73231acf7332b1a5331173f6d3da57.svg) | 4-[8-(3-Nitrophenyl)-1,7-naphthyridin-6-yl]benzoic Acid | IC50 | 1.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_9c97b003649a43777a3e9be8ae70f4e6.svg) | 2-[(E)-(3-Cyclopentyloxy-4-methoxyphenyl)methylideneamino]oxy-1-(2,6-dimethylmorpholin-4-yl)ethanone | IC50 | 670.0 [1], 1910.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_ca40196c3ca0e364a022c1ef571311d8.svg) | 3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl-adenine | Ki | 141.0 [1], 172.0 [2], 2890.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_d6ea2c499087d6ad1b3c5eda29634dcd.svg) | 6-Amino-3-(3-cyclopentyloxy-4-methoxy-benzyl)-8-(1-hydroxy-1-methyl-ethyl)-3H-purine hydrochloride | Ki | 4.1 [1], 5.7 [2], 413.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_29b80227f54274a1b55e9ab7ad45041e.svg) | 2-[4-[2-[3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-6-imino-7H-purin-8-yl]-2-methylpropoxy]-2-(2-oxoethoxy)phenoxy]acetaldehyde | Ki | 3.7 [1], 6.6 [2], 218.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_9ffaa3eff8e517d3db15f191ce37b1a3.svg) | 3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[1-(2-methoxyphenoxy)-2-methylpropan-2-yl]-7H-purin-6-imine | Ki | 5.1 [1], 7.1 [2], 255.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_b39a98a8192a8ce9722df5d015ef84f7.svg) | Methyl 4-[2-[3-[(3-cyclopentyloxy-4-methoxyphenyl)methyl]-6-imino-7H-purin-8-yl]-2-methylpropoxy]benzoate | Ki | 3.0 [1], 5.5 [2], 246.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_1aa8c85494aec34ae0522d1d9379ac39.svg) | 3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[1-(3-fluorophenoxy)-2-methylpropan-2-yl]-7H-purin-6-imine | Ki | 7.4 [1], 8.4 [2], 369.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_2826011e26c80e97537ae689040a655e.svg) | 3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[(2R)-1-phenoxypropan-2-yl]-7H-purin-6-imine | Ki | 590.0 [1], 640.0 [2], 4450.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_0f464b88641b5213e2e3cdc5e8e37979.svg) | 4-[2-[3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-6-imino-7H-purin-8-yl]-2-methylpropoxy]benzamide | Ki | 4.9 [1], 8.0 [2], 312.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_261cb6962863689af91d3685dcebe70e.svg) | 3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[1-(3,4-dimethoxyphenoxy)-2-methylpropan-2-yl]-7H-purin-6-imine | Ki | 7.8 [1], 15.0 [2], 2640.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_df7b0bbc6ce3f4cd710cc97fe99d75fd.svg) | 3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[(2R)-1-(3-methoxyphenoxy)propan-2-yl]-7H-purin-6-imine | Ki | 322.0 [1], 493.0 [2], 5050.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_9b6c1e807fc1d214dd8fce830c832bbc.svg) | 3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[1-(3-methoxyphenoxy)-2-methylpropan-2-yl]-7H-purin-6-imine | Ki | 5.1 [1], 6.0 [2], 296.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_bc5fd45a143af7c5849ebb471fb0988d.svg) | 4-[2-[3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-6-imino-7H-purin-8-yl]-2-methylpropoxy]benzoic acid | Ki | 4300.0 [1], 50000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_42da394761f750249d3a975d825c4842.svg) | 3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[1-(3,5-dimethoxyphenoxy)-2-methylpropan-2-yl]-7H-purin-6-imine | Ki | 7.9 [1], 9.0 [2], 340.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_9629c4cd2dc6432445e1fb9c4ade5fb6.svg) | 3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[(2R)-1-(3-fluorophenoxy)propan-2-yl]-7H-purin-6-imine | Ki | 114.7 [1], 231.0 [2], 4300.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_669aec227e02fef13e2932ed1ec3c905.svg) | 3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[1-(4-methoxyphenoxy)-2-methylpropan-2-yl]-7H-purin-6-imine | Ki | 5.6 [1], 8.1 [2], 347.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_6858d2d407523eb88b900ee152b47667.svg) | 3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[2-methyl-1-[4-(trifluoromethyl)phenoxy]propan-2-yl]-7H-purin-6-imine | Ki | 9.9 [1], 10.3 [2], 580.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_af6ef2445934806118e83ce0e9046ee2.svg) | 3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[2-methyl-1-(4-methylphenoxy)propan-2-yl]-7H-purin-6-imine | Ki | 6.6 [1], 7.6 [2], 347.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_05b08ca97bb99c92c589481a5341cd35.svg) | 3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[1-(3,4-difluorophenoxy)-2-methylpropan-2-yl]-7H-purin-6-imine | Ki | 13.0 [1], 13.3 [2], 459.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_e5192e3fee297e217026e0c1c8bacc5b.svg) | 3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[1-(3,4-dichlorophenoxy)-2-methylpropan-2-yl]-7H-purin-6-imine | Ki | 6.6 [1], 10.6 [2], 355.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_a265842884861c86d481c8209d12d72d.svg) | 4-[2-[3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-6-imino-7H-purin-8-yl]-2-methylpropoxy]benzonitrile | Ki | 19.4 [1], 33.4 [2], 1840.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_6f372382b56368c21092d24bb8ea0996.svg) | 8-[1-(4-Tert-butylphenoxy)-2-methylpropan-2-yl]-3-[(3-cyclopentyloxy-4-methoxyphenyl)methyl]-7H-purin-6-imine | Ki | 4.3 [1], 5.0 [2], 255.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_82e4d77a28d56255a7fee78a0ff11b1f.svg) | 8-[1-(4-Chlorophenoxy)-2-methylpropan-2-yl]-3-[(3-cyclopentyloxy-4-methoxyphenyl)methyl]-7H-purin-6-imine | Ki | 4.8 [1], 5.8 [2], 205.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_3b6b976e9f0ac4edc5022afe76e68520.svg) | 3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[2-methyl-1-(2-thiophen-2-ylphenoxy)propan-2-yl]-7H-purin-6-imine | Ki | 6.3 [1], 7.0 [2], 412.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_38c83776758c76281b4c2163189f1f75.svg) | 3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[2-methyl-1-[4-(trifluoromethoxy)phenoxy]propan-2-yl]-7H-purin-6-imine | Ki | 6.5 [1], 7.2 [2], 782.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_3de59c5f789380d54097ce641d020d32.svg) | 3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[1-(2-fluorophenoxy)-2-methylpropan-2-yl]-7H-purin-6-imine | Ki | 6.8 [1], 11.0 [2], 427.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_727b0e7ab94989795143b2bd9e73bc1d.svg) | 3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-8-[2-methyl-1-(3-thiophen-3-ylphenoxy)propan-2-yl]-7H-purin-6-imine | Ki | 6.6 [1], 9.0 [2], 2680.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_8cca9e4d06aa1ff65012531f8a6b3dcf.svg) | Moracin M | IC50 | 2900.0 [1], 2910.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_3da06991b1195679241e18f04574d574.svg) | (S)-(+)-Rolipram | IC50 | 1000.0 [1], 1062.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_572f212f3affa282b0780fd20872a3e8.svg) | 2-[5-[(1S)-1-[3-Cyclopropyloxy-4-(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-3-yl)ethyl]-1,3-thiazol-2-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol | IC50 | 0.4 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_cea9bc66839f462ca9abdd86ba5ee87b.svg) | (cis)-4-(3,4-Dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one | IC50 | 85.0 [1], 213.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_77075fce6267e15da886031723ed518a.svg) | 4-(3,4-Dimethoxy-phenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one | IC50 | 213.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_77075fce6267e15da886031723ed518a.svg) | 4-(3,4-Dimethoxy-phenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one | Ki | 6.3 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_42496a2ac6869d2e8d7f76051d516e53.svg) | N-[4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfinylimidazol-4-yl]pyridin-2-yl]acetamide | IC50 | 800.0 [1], 1100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_1ae816ca0c0208caeefd6eaba9f52d62.svg) | (4-{[2-(5-Chlorothiophen-2-Yl)-5-Ethyl-6-Methylpyrimidin-4-Yl]amino}phenyl)acetic Acid | IC50 | 1700.0 [1], 1997.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_d689ac000771bea7b6124d8a43d0149b.svg) | 8-(3-Methoxyphenyl)-6-(pyridin-4-ylmethyl)quinoline | IC50 | 2.5 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_e096cf6e0f4ec9da6410f250b9ae488c.svg) | 4-[8-(3-Methoxy-phenyl)-[1,7]naphthyridin-6-yl]-cyclohexanecarboxylic acid | IC50 | 64.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_503471f8e68cd4442f7736f86da2b8c5.svg) | 4-[8-(3-Cyano-phenyl)-[1,7]naphthyridin-6-yl]-cyclohexanecarboxylic acid | IC50 | 41.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_e02b39772b3565d6ca9b59ed54de7576.svg) | (cis)-2-(5-Bromopentyl)-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one | IC50 | 2.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_e02b39772b3565d6ca9b59ed54de7576.svg) | (cis)-2-(5-Bromopentyl)-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one | Ki | 2.3 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_ad800cceaf0975cfdaeb903bf2028dec.svg) | 2-[4-[(2-Phenyl-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl]acetic acid | IC50 | 1300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_86d54748b1ae55fc03564da4556cfb73.svg) | 2-[4-[(5,5-Dioxo-2-phenyl-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl]acetic acid | IC50 | 550.0 [1], 2800.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_a15575ea816b962c9b838c512863340a.svg) | N-Butyl-2-[4-[(5,5-dioxo-2-phenyl-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl]acetamide | IC50 | 180.0 [1], 260.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_e69bbb58878494180d8c4afc17c22c6b.svg) | 4-[8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl]cyclohexane-1-carboxylic Acid | IC50 | 32.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_2a6a4f193edfff9c699bdc178d1362d0.svg) | 1-(8-(3-Cyanophenyl)-1,7-naphthyridine-6-yl)piperidine-4-carboxylic acid | IC50 | 19.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_653993f6baf7101e99dc09bbb214f24e.svg) | 1-(8-(3-Fluorophenyl)-1,7-naphthyridine-6-yl)piperidine-4-carboxylic acid | IC50 | 51.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_e81ad570f0f26cd3adbed5c1d0b35c61.svg) | 4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfinylimidazol-4-yl]pyridin-2-amine | IC50 | 700.0 [1], 2400.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_3aa1e709170a30962cff946068b22ab9.svg) | (E)-N-[2-Chloro-3-(2,6-dimethylmorpholin-4-yl)propoxy]-1-(3-cyclopentyloxy-4-methoxyphenyl)methanimine | IC50 | 3420.0 [1], 4270.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_af352b0fdadaffcf78e886a9909b33df.svg) | [4-[3-[(4-Phenylpyridazino[4,5-b]indolizin-1-yl)amino]propyl]piperazin-1-yl]-pyrazin-2-ylmethanone | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_af352b0fdadaffcf78e886a9909b33df.svg) | [4-[3-[(4-Phenylpyridazino[4,5-b]indolizin-1-yl)amino]propyl]piperazin-1-yl]-pyrazin-2-ylmethanone | Ki | 8370.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_e3c29e20a5b2628a41776e9d92871fce.svg) | [4-[3-[[4-(3-Nitrophenyl)pyridazino[4,5-b]indolizin-1-yl]amino]propyl]piperazin-1-yl]-pyrazin-2-ylmethanone | IC50 | 4900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_e3c29e20a5b2628a41776e9d92871fce.svg) | [4-[3-[[4-(3-Nitrophenyl)pyridazino[4,5-b]indolizin-1-yl]amino]propyl]piperazin-1-yl]-pyrazin-2-ylmethanone | Ki | 147.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_75098f2c6f5f2c1417b08774971dd6c3.svg) | 4-Phenyl-N-[3-(4-pyrimidin-2-ylpiperazin-1-yl)propyl]pyridazino[4,5-b]indolizin-1-amine | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_75098f2c6f5f2c1417b08774971dd6c3.svg) | 4-Phenyl-N-[3-(4-pyrimidin-2-ylpiperazin-1-yl)propyl]pyridazino[4,5-b]indolizin-1-amine | Ki | 59000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_7e9d1b6ac6d6b13ee52e80df5a58b0cd.svg) | 4-[3-(3-Chlorophenyl)-7-methoxy-2,4-dioxopyrimido[5,4-c]quinolin-1-yl]cyclohexane-1-carboxylic acid | IC50 | 55.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_efb3dd439dc7e8227b1e5e16e4918d9c.svg) | 3-Benzo[1,3]dioxol-5-yl-1-cyclopentyl-7-methoxy-1H-pyrimido[5,4-c]quinoline-2,4-dione | IC50 | 827.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_e070f56d99b0c360fb44f58b684bf4fa.svg) | 3-(3-Chlorophenyl)-7-methoxy-1-(1-methylsulfonylpiperidin-4-yl)pyrimido[5,4-c]quinoline-2,4-dione | IC50 | 151.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_eb7c14c951adfc421f823d2374e57eb9.svg) | 1-Cyclopentyl-3-ethyl-7-propylpyrimido[5,4-c]quinoline-2,4-dione | IC50 | 25000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_0973f019fbe735aaa012e98545a9e8c5.svg) | 3-(3-Chlorophenyl)-7-methoxy-1-[(3S)-1-methylsulfonylpyrrolidin-3-yl]pyrimido[5,4-c]quinoline-2,4-dione | IC50 | 163.0 [1], 206.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_2bac1b542fa516319543b1780a5c09ab.svg) | 1-Cyclopentyl-3-ethyl-7-propan-2-ylpyrimido[5,4-c]quinoline-2,4-dione | IC50 | 25000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_0f9a7015812faf9fbb57e6ce842b26b5.svg) | 1-Cyclopentyl-7-methoxy-3-m-tolyl-1H-pyrimido[5,4-c]quinoline-2,4-dione | IC50 | 338.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_41b988e386de0353cf38d30df2f02799.svg) | 3-(3-Chlorophenyl)-1-(1-ethylsulfonylpiperidin-4-yl)-7-methoxypyrimido[5,4-c]quinoline-2,4-dione | IC50 | 59.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_5eb162b4eb9fd558c0b544daf4a2d68a.svg) | 3-(3-Chlorophenyl)-7-methoxy-1-[1-(methylsulfonylmethylsulfonyl)piperidin-4-yl]pyrimido[5,4-c]quinoline-2,4-dione | IC50 | 80.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_8d690a434b9f74c9d8d754c22df6e88e.svg) | 1-Cyclopentyl-7-methoxy-3-(4-methyl-thiophen-2-yl)-1H-pyrimido[5,4-c]quinoline-2,4-dione | IC50 | 616.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_85ba1034f696a9cb5b9064c610d9fc8d.svg) | 7-Chloro-1-cyclopentyl-3-ethylpyrimido[5,4-c]quinoline-2,4-dione | IC50 | 25000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_160ab916bab2ddf396cd5a0cf96de333.svg) | N-[4-[3-(3-Chlorophenyl)-7-methoxy-2,4-dioxopyrimido[5,4-c]quinolin-1-yl]cyclohexyl]methanesulfonamide | IC50 | 73.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_ce2451a6dd9c86e3ec85025ead605266.svg) | Sildenafil | IC50 | 20000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_fac222a9fee62d9cda063e5aabf1d4d4.svg) | 3-Isobutyl-1-methylxanthine | IC50 | 38000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_5f0600361a17dbd156ef4515f7f7a2d7.svg) | Clioquinol | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_8a68bbeb0744f0f5ab368058ba5e3136.svg) | CID 14521039 | IC50 | 20000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_652ebcef50c758c7dd332e47ddf02915.svg) | Ibudilast | IC50 | 166.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_2e05fb469b67eced0151ee1032c8621f.svg) | Morusin | IC50 | 900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_9c107458ca6d84cb77af3513ad77addc.svg) | Crisaborole | IC50 | 55.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_e39e3bc989cee0b1a0a409acf38c8621.svg) | Cipargamin | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_498600de77801844019dd25a5605e657.svg) | 4-(2-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-phenylethyl)pyridine | IC50 | 2.1 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_14411dd3120773160cc07f6ade4c2560.svg) | 2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_ceed4606a126c6936b5413cbcaf96d6c.svg) | N,N,2-Trimethyl-5-nitrobenzenesulfonamide | IC50 | 1280.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_1b6f778cc12dda22e42b17d5f7c22c74.svg) | (R)-(-)-Rolipram | IC50 | 622.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_f3b5859478acd9937f411f524aa3767a.svg) | Mulberrin | IC50 | 310.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_552f75c4be61cbd8c6e959fb4481c8c5.svg) | Licoflavone C | IC50 | 630.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_b942b67851a5c47a73c616c1c844ed0a.svg) | Moracin C | IC50 | 26000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_7ad97befb4c1dd57e9f2fd44275c5b12.svg) | (2S,3R)-3-(6-Amino-9H-purin-9-yl)nonan-2-ol | IC50 | 16000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_73bc9310a28387e84e894ffe9d61f0fa.svg) | Leniolisib | IC50 | 4700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_e51434a719331aa216810ff47aa00ef6.svg) | 1-(4-((3'-Chloro-6-methoxy-[1,1'-biphenyl]-3-yl)methyl)phenyl)urea | IC50 | 27.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_40ee47a0590473be817cd0a1a7aafcc0.svg) | (R)-5-(6-Cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxamide | IC50 | 900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_11cc06bd74304f956353ec2aeccf0701.svg) | Cudraflavone C | IC50 | 260.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4d_4629995a378b38e0c79a12da69169888.svg) | Eggmanone | IC50 | 380.0 [1] |