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Phosphodiesterase 4C Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
RolipramIC502630.0 [1]
CilomilastIC50610.0 [1], 813.0 [2], 840.0 [3]
PiclamilastIC503.8 [1], 14.0 [2]
Unii-G6gso9sdnjIC509.1 [1]
2-[5-[(1S)-1-[3-Cyclopropyloxy-4-(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-3-yl)ethyl]-1,3-thiazol-2-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC501.0 [1]
4-[8-(3-Nitrophenyl)-1,7-naphthyridin-6-yl]benzoic AcidIC5068.0 [1]
8-(3-Methoxyphenyl)-6-(pyridin-4-ylmethyl)quinolineIC503.3 [1]
IbudilastIC50239.0 [1]
CrisaboroleIC5055.0 [1]
4-(2-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-phenylethyl)pyridineIC504.5 [1]
2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanolIC5010000.0 [1]
(R)-(-)-RolipramIC503690.0 [1]
(2S,3R)-3-(6-Amino-9H-purin-9-yl)nonan-2-olIC5016000.0 [1]
PF-04447943IC5010000.0 [1]
(R)-5-(6-Cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxamideIC502400.0 [1]
3-(2,5-Dimethoxyphenyl)-6-[4-methoxy-3-[(3R)-oxolan-3-yl]oxyphenyl]-[1,2,4]triazolo[4,3-b]pyridazineIC50106.0 [1]
4-(4-((8-(3-(Difluoromethoxy)phenyl)quinolin-6-yl)methoxy)phenyl)-2-methylbutan-2-olIC50151.0 [1]
3-(2,5-Dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC50452.0 [1]
6-{(1S)-1-[6-(1-Methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl}quinolineIC506700.0 [1]
3-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC502000.0 [1]
4-[8-(2,1,3-Benzoxadiazol-5-yl)-1,7-naphthyridin-6-yl]benzoic acidIC501230.0 [1]
TofimilastIC50100.0 [1]
N-[4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfinylimidazol-4-yl]pyridin-2-yl]acetamideIC506400.0 [1]
3-[(4-Hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC502000.0 [1]
7-(6-Methoxypyridin-3-yl)-3-(2-morpholin-4-ylethylamino)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC502000.0 [1]
4-ChloroquinazolineIC503690.0 [1]
N-(3-(6-(Pyridin-4-ylmethyl)quinolin-8-yl)phenyl)benzenesulfonamideIC5011.9 [1]
2-[5-[(1R)-1-[3-Cyclopropyloxy-4-(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-3-yl)ethyl]-1,3-thiazol-2-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC50135.0 [1]
1-Cyclopentyl-6-[(3S,4S)-4-methyl-1-(quinoxalin-6-ylmethyl)pyrrolidin-3-yl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC501000.0 [1]
3-(2,5-Dimethoxyphenyl)-6-[4-methoxy-3-[(3R)-oxolan-3-yl]oxyphenyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5046.0 [1]
3-(3-Cyclopentyloxy-4-methoxyphenyl)-N-hydroxy-4,5-dihydro-1,2-oxazole-5-carboxamideIC5018.0 [1]
(E)-3-[3-[6-(2-Cyanopropan-2-yl)quinolin-8-yl]phenyl]-2-(4-methylsulfonylphenyl)-N-propan-2-ylprop-2-enamideIC506.8 [1]
(Z)-3-[3-[6-(2-Cyanopropan-2-yl)quinolin-8-yl]phenyl]-2-(4-methylsulfonylphenyl)-N-propan-2-ylprop-2-enamideIC5011.4 [1]
N-((3-(6-(2-Cyanopropan-2-yl)quinolin-8-yl)phenyl)methyl)-N-(4-(methylsulfonyl)phenyl)benzamideIC501.0 [1]
N-(4-Methylsulfonylphenyl)-N-[1-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]ethyl]cyclopropanecarboxamideIC5017.0 [1]
1-[[3-[6-(2-Cyanopropan-2-yl)quinolin-8-yl]phenyl]methyl]-1-(4-methylsulfonylphenyl)-3-propan-2-ylureaIC501.7 [1]
N-(4-Methylsulfonylphenyl)-N-[1-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]ethyl]pyridine-3-carboxamideIC5014.0 [1]
5-(2-Chlorophenyl)-12-cyclopentyl-10-ethyl-3,4,6,11,12-pentazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,10-tetraeneIC5077.0 [1]
8-(3-(1-(4-Chlorophenyl)-2-(pyridin-4-yl)ethyl)phenyl)-6-isopropylquinolineIC5022.0 [1]
(E)-3-(3-(6-Isopropylquinolin-8-yl)phenyl)-2-(4-(methylsulfonyl)phenyl)acrylic acidIC503.8 [1]
3-Methyl-5-[(E)-1-(4-methylsulfonylphenyl)-2-[3-(6-propan-2-ylquinolin-8-yl)phenyl]ethenyl]-1,2,4-oxadiazoleIC501.2 [1]
Isopropyl (3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phenyl)methyl(4-(methylsulfonyl)phenyl)carbamateIC504.2 [1]
2-[8-[3-[[N-[(4-Fluorophenyl)methyl]-4-methylsulfonylanilino]methyl]phenyl]quinolin-6-yl]-2-methylpropanenitrileIC509.5 [1]
N-[[3-[6-(2-Cyanopropan-2-yl)quinolin-8-yl]phenyl]methyl]-5-methyl-N-(4-methylsulfonylphenyl)-1,2-oxazole-3-carboxamideIC500.9 [1]
1-[[2-Fluoro-5-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]methyl]-1-(4-methylsulfonylphenyl)-3-propan-2-ylureaIC506.4 [1]
4-Fluoro-N-(4-methylsulfonylphenyl)-N-[1-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]ethyl]benzamideIC5012.0 [1]
8-[3-[1-(4-Chlorophenyl)-2-(1-oxidopyridin-1-ium-4-yl)ethyl]phenyl]-6-propan-2-ylquinolineIC5068.0 [1]
(E)-2-(4-Methylsulfonylphenyl)-3-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]-N-propan-2-ylprop-2-enamideIC5014.0 [1]
3-Methyl-5-[(Z)-1-(4-methylsulfonylphenyl)-2-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]ethenyl]-1,2,4-oxadiazoleIC5014.0 [1]
N-(4-Methylsulfonylphenyl)-N-[1-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]ethyl]acetamideIC5041.0 [1]
1-((3-(6-(2-Cyanopropan-2-yl)quinolin-8-yl)phenyl)methyl)-1-(4-(methylsulfonyl)phenyl)-3-phenylureaIC500.05 [1]
(E)-6-Isopropyl-8-(3-(2-(5-methylpyridin-2-yl)-2-(4-(methylsulfonyl)phenyl)vinyl)phenyl)quinolineIC500.4 [1]
4-(2-Hydroxypropan-2-yl)-N-(4-methylsulfonylphenyl)-N-[1-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]ethyl]benzamideIC505.9 [1]
4-[8-(3-Chloro-phenyl)-[1,7]naphthyridin-6-yl]-benzoic acidIC50190.0 [1]
8-(3-Nitro-phenyl)-6-o-tolyl-[1,7]naphthyridineIC5010000.0 [1]
(4-Methylpiperazin-1-yl)-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]methanoneIC5010000.0 [1]
Trifluoro-methanesulfonic acid 8-(3-cyano-phenyl)-[1,7]naphthyridin-6-yl esterIC506400.0 [1]
8-(3-Nitrophenyl)-1,7-naphthyridin-6-amineIC5010000.0 [1]
6-Allyl-8-(3-nitro-phenyl)-[1,7]naphthyridineIC50890.0 [1]
8-(3-Nitro-phenyl)-6-pyridin-3-yl-[1,7]naphthyridineIC50610.0 [1]
8-(3-Nitro-phenyl)-[1,7]naphthyridineIC5010000.0 [1]
Trifluoro-methanesulfonic acid 8-(3-chloro-phenyl)-[1,7]naphthyridin-6-yl esterIC504300.0 [1]
6-Phenyl-8-(3-nitrophenyl)-1,7-naphthyridineIC502000.0 [1]
6-Furan-2-yl-8-(3-nitro-phenyl)-[1,7]naphthyridineIC5010000.0 [1]
6-Trifluoromethylsulfonyloxy-8-(3-nitrophenyl)-1,7-naphthyridineIC503200.0 [1]
5-Methyl-6-oxo-N-(1,3,4-thiadiazol-2-yl)-7H-furo[2,3-f]indole-7-carboxamideIC5016000.0 [1]
CID 130366728IC5031.4 [1]
Azetidin-1-yl-[3-(4-chloro-2,5-difluorophenyl)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazin-2-yl]methanoneIC50104.0 [1]
Azetidin-1-yl-[3-(4-chloro-2-methylphenyl)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazin-2-yl]methanoneIC50653.0 [1]
N-Cyclopropyl-3-[2-(difluoromethoxy)pyridin-4-yl]-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamideIC50389.0 [1]
Azetidin-1-yl-[3-(3-chlorophenyl)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazin-2-yl]methanoneIC5048.2 [1]
3-(4-Cyano-5-fluoro-2-methylphenyl)-N-cyclopropyl-6-fluoro-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamideIC50108.0 [1]
3-(4-Chloro-2-methylphenyl)-N-cyclopropyl-6-fluoro-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamideIC50160.0 [1]
N-(2-Chlorophenyl)-3-cyclopentyloxy-4-(difluoromethoxy)benzamideIC50400.0 [1]
3-Cyclopentyloxy-4-(difluoromethoxy)-N-pyridin-3-ylbenzamideIC50294.0 [1]
3-(Cyclopropylmethoxy)-4-(difluoromethoxy)-N-pyridin-3-ylbenzamideIC50269.0 [1]
N-(2-Chlorophenyl)-3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzamideIC50501.0 [1]
3-Isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-oneIC5010000.0 [1]
3-Propan-2-yl-5-[[(1S,2R)-2-(pyrimidin-2-ylamino)cyclohexyl]methyl]-2,6-dihydropyrazolo[4,3-d]pyrimidin-7-oneIC5010000.0 [1]
2-[[(1R,2S)-2-[(7-Oxo-3-propan-2-yl-2,6-dihydropyrazolo[4,3-d]pyrimidin-5-yl)methyl]cyclohexyl]amino]-4-(trifluoromethyl)pyrimidine-5-carboxylic acidIC501000.0 [1]
4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfinylimidazol-4-yl]pyridin-2-amineIC5010000.0 [1]
N-(3,4-Dimethoxyphenyl)-4-morpholin-4-yl-2-(trifluoromethyl)pyrimidine-5-carboxamideIC50156.0 [1]
4-(3,4-Dimethoxyphenyl)-N-pyridin-4-yl-2-(trifluoromethyl)pyrimidine-5-carboxamideIC5057.0 [1]
N-(3,5-Dichloropyridin-4-yl)-4-(3,4-dimethoxyphenyl)-2-(trifluoromethyl)pyrimidine-5-carboxamideIC5039.0 [1]
N-(3,4-Dimethoxyphenyl)-2-methylsulfanyl-4-morpholin-4-ylpyrimidine-5-carboxamideIC5077.0 [1]
N-[2-(3,4-Dimethoxyphenyl)ethyl]-2-methylsulfanyl-4-morpholin-4-ylpyrimidine-5-carboxamideIC50326.0 [1]
Azetidin-1-yl-[3-(4-chlorophenyl)-5-methyl-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazin-2-yl]methanone;hydrochlorideIC5017000.0 [1]
12-Cyclopentyl-10-ethyl-5-pyridin-3-yl-3,4,6,11,12-pentazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,10-tetraeneIC50700.0 [1]
12-Cyclopentyl-10-ethyl-5-(3-methoxyphenyl)-3,4,6,11,12-pentazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,10-tetraeneIC502440.0 [1]
(R)-2-(4-Fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)nicotinamideIC501378.0 [1]
4-(3-(6-Isopropylquinolin-8-yl)phenyl)-2-methyl-3-(pyridin-4-yl)butan-2-olIC50106.0 [1]
3-(6-(2-(Methylsulfonyl)propan-2-yl)quinolin-8-yl)-N-(pyridin-4-yl)benzamideIC5017.0 [1]
1-[[2-Chloro-5-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]methyl]-1-(4-methylsulfonylphenyl)-3-propan-2-ylureaIC5070.0 [1]
1-(4-Methylsulfonylphenyl)-1-[1-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]ethyl]-3-propan-2-ylureaIC5025.0 [1]
N-(3,5-Dichloropyridin-4-yl)-3-(6-(2-(methylsulfonyl)propan-2-yl)quinolin-8-yl)benzamideIC505.5 [1]
N-(4-(Methylsulfonyl)phenyl)-3-(6-(2-(methylsulfonyl)propan-2-yl)quinolin-8-yl)benzamideIC5026.0 [1]
2-[2-[(E)-2-[3-[6-(1-Methylsulfonylethyl)quinolin-8-yl]phenyl]-1-(4-methylsulfonylphenyl)ethenyl]-1,3-thiazol-5-yl]propan-2-olIC5011.0 [1]
6-Isopropyl-8-(3-(2-(4-(methylsulfonyl)phenyl)-2-(thiazol-2-yl)vinyl)phenyl)quinolineIC500.7 [1]
(E)-2-(4-Methylsulfonylphenyl)-N-propan-2-yl-3-[3-(6-propan-2-ylquinolin-8-yl)phenyl]prop-2-enamideIC502.9 [1]
3-Cyclopentyloxy-N-(1-hydroxycarbamoyl-ethyl)-4-methoxy-benzamideIC50125.9 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Phosphodiesterase 4C Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/phosphodiesterase-4c-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Phosphodiesterase 4C Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/phosphodiesterase-4c-inhibitors-ic50-ki.
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