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Phosphodiesterase 4B Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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Standard Type
▲
▼
Standard Values (in nM)
▲
▼
RolipramIC50741.0 [1]
RolipramKi220.0 [1], 221.0 [2], 223.87 [3], 1470.0 [4]
RoflumilastIC500.8 [1]
RoflumilastKi0.4 [1]
CilomilastIC5084.0 [1]
PiclamilastIC500.04 [1], 0.2 [2], 1.0 [3], 2.0 [4], 3.0 [5]
(R)-(-)-RolipramIC5039.81 [1], 231.0 [2], 500.0 [3]
N,N,2-Trimethyl-5-nitrobenzenesulfonamideIC501800.0 [1], 175000.0 [2]
Unii-G6gso9sdnjIC500.5 [1], 1.0 [2]
4-(3,4-Dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-oneIC50520.0 [1]
4-[8-(2,1,3-Benzoxadiazol-5-yl)-1,7-naphthyridin-6-yl]benzoic acidIC5034.0 [1]
3-[7-Methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-4-yl]-4-methyl-4,5-dihydro-1H-pyridazin-6-oneIC5042.0 [1], 70.0 [2]
(4As,8aR)-2-cycloheptyl-4-[4-methoxy-3-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4a,5,8,8a-tetrahydrophthalazin-1-oneIC500.5 [1], 0.63 [2]
(4As,8aR)-2-cycloheptyl-4-[4-methoxy-3-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4a,5,8,8a-tetrahydrophthalazin-1-oneKi0.63 [1]
3-Isobutyl-1-methylxanthineIC5028200.0 [1]
IbudilastIC5065.0 [1], 5000.0 [2]
CrisaboroleIC5055.0 [1]
6-(3-(Dimethylcarbamoyl)phenylsulfonyl)-4-(3-methoxyphenylamino)-8-methylquinoline-3-carboxamideIC500.01 [1]
2-[5-[(1S)-1-[3-Cyclopropyloxy-4-(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-3-yl)ethyl]-1,3-thiazol-2-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC500.4 [1]
3-(2,5-Dimethoxyphenyl)-6-[4-methoxy-3-[(3R)-oxolan-3-yl]oxyphenyl]-[1,2,4]triazolo[4,3-b]pyridazineIC502.9 [1], 4.1 [2]
3-(2,5-Dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5037.2 [1], 48.2 [2]
(4-{[2-(5-Chlorothiophen-2-Yl)-5-Ethyl-6-Methylpyrimidin-4-Yl]amino}phenyl)acetic AcidIC5015.0 [1], 55.0 [2]
8-(3-Methoxyphenyl)-6-(pyridin-4-ylmethyl)quinolineIC502.3 [1]
4-[(3-Methoxyphenyl)amino]-6-(methylsulfonyl)quinoline-3-carboxamideIC503.98 [1]
6-(Benzenesulfonyl)-4-(3-methoxyanilino)quinoline-3-carboxamideIC501.58 [1]
2-(Cyclopentylamino)-3-ethylthieno[3,2-d]pyrimidin-4-oneIC504900.0 [1]
(5Z)-5-[(3-Cyclopentyloxy-4-methoxyphenyl)methylidene]-2-imino-1,3-thiazolidin-4-oneIC50310.0 [1]
3-(2,5-Dimethoxyphenyl)-6-[4-methoxy-3-[(3R)-oxolan-3-yl]oxyphenyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC501.6 [1], 2.3 [2]
5-(3-(Cyclopentyloxy)-4-methoxybenzylidene)-2-thioxothiazolidin-4-oneIC50890.0 [1]
1-(2-Hydroxyethyl)-3-(2-methylbutan-2-yl)-5-[4-(2-methylimidazol-1-yl)phenyl]-6,7-dihydropyrazolo[4,3-e][1,4]diazepin-8-oneIC50378.0 [1]
2-[4-[(2-Phenyl-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl]acetic acidIC5029.0 [1], 210.0 [2]
2-[4-[(5,5-Dioxo-2-phenyl-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl]acetic acidIC5025.0 [1], 150.0 [2]
3-Tert-butyl-1-(2-hydroxyethyl)-5-[4-methoxy-3-(2-methoxypyrimidin-5-yl)phenyl]-6,7-dihydropyrazolo[4,3-e][1,4]diazepin-8-oneIC50562.0 [1]
N-Butyl-2-[4-[(5,5-dioxo-2-phenyl-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl]acetamideIC5022.0 [1], 70.0 [2]
4-[8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl]cyclohexane-1-carboxylic AcidIC5034.0 [1]
N-((3-(6-(2-Cyanopropan-2-yl)quinolin-8-yl)phenyl)methyl)-N-(4-(methylsulfonyl)phenyl)benzamideIC500.1 [1], 80.0 [2]
N-(4-Methylsulfonylphenyl)-N-[1-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]ethyl]cyclopropanecarboxamideIC500.6 [1], 800.0 [2]
1-[[3-[6-(2-Cyanopropan-2-yl)quinolin-8-yl]phenyl]methyl]-1-(4-methylsulfonylphenyl)-3-propan-2-ylureaIC500.1 [1], 140.0 [2]
N-(4-Methylsulfonylphenyl)-N-[1-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]ethyl]pyridine-3-carboxamideIC500.7 [1], 210.0 [2]
Isopropyl (3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phenyl)methyl(4-(methylsulfonyl)phenyl)carbamateIC500.3 [1], 80.0 [2]
2-[8-[3-[[N-[(4-Fluorophenyl)methyl]-4-methylsulfonylanilino]methyl]phenyl]quinolin-6-yl]-2-methylpropanenitrileIC500.1 [1], 1800.0 [2]
N-[[3-[6-(2-Cyanopropan-2-yl)quinolin-8-yl]phenyl]methyl]-5-methyl-N-(4-methylsulfonylphenyl)-1,2-oxazole-3-carboxamideIC500.1 [1], 30.0 [2]
1-[[2-Fluoro-5-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]methyl]-1-(4-methylsulfonylphenyl)-3-propan-2-ylureaIC500.3 [1], 50.0 [2]
4-Fluoro-N-(4-methylsulfonylphenyl)-N-[1-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]ethyl]benzamideIC500.6 [1], 560.0 [2]
N-(4-Methylsulfonylphenyl)-N-[1-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]ethyl]acetamideIC504.2 [1], 2000.0 [2]
1-((3-(6-(2-Cyanopropan-2-yl)quinolin-8-yl)phenyl)methyl)-1-(4-(methylsulfonyl)phenyl)-3-phenylureaIC500.03 [1], 40.0 [2]
4-(2-Hydroxypropan-2-yl)-N-(4-methylsulfonylphenyl)-N-[1-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]ethyl]benzamideIC500.4 [1], 270.0 [2]
trans-3-(3-Cyclopentoxy-4-methoxyphenyl)-1-methoxycarbonyl-4-(methylcarbonyl)pyrrolidineIC50320.0 [1]
trans-3-(3-Cyclopentoxy-4-methoxyphenyl)-1-methoxycarbonyl-4-(methylcarbonyl)pyrrolidineKi30.0 [1]
N-(3,4-Dimethoxyphenyl)-4-morpholin-4-yl-2-(trifluoromethyl)pyrimidine-5-carboxamideIC5067.0 [1]
4-(3,4-Dimethoxyphenyl)-N-pyridin-4-yl-2-(trifluoromethyl)pyrimidine-5-carboxamideIC5015.0 [1]
N-(3,5-Dichloropyridin-4-yl)-4-(3,4-dimethoxyphenyl)-2-(trifluoromethyl)pyrimidine-5-carboxamideIC5044.0 [1]
N-(3,4-Dimethoxyphenyl)-2-methylsulfanyl-4-morpholin-4-ylpyrimidine-5-carboxamideIC5031.0 [1]
N-[2-(3,4-Dimethoxyphenyl)ethyl]-2-methylsulfanyl-4-morpholin-4-ylpyrimidine-5-carboxamideIC5061.0 [1]
(R)-2-(4-Fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)nicotinamideIC50185.0 [1], 925.0 [2]
3-(6-(2-(Methylsulfonyl)propan-2-yl)quinolin-8-yl)-N-(pyridin-4-yl)benzamideIC500.9 [1], 200.0 [2]
1-[[2-Chloro-5-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]methyl]-1-(4-methylsulfonylphenyl)-3-propan-2-ylureaIC504.4 [1], 4000.0 [2]
1-(4-Methylsulfonylphenyl)-1-[1-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]ethyl]-3-propan-2-ylureaIC500.7 [1], 400.0 [2]
N-(3,5-Dichloropyridin-4-yl)-3-(6-(2-(methylsulfonyl)propan-2-yl)quinolin-8-yl)benzamideIC500.4 [1], 90.0 [2]
N-(4-(Methylsulfonyl)phenyl)-3-(6-(2-(methylsulfonyl)propan-2-yl)quinolin-8-yl)benzamideIC500.5 [1], 140.0 [2]
4-Methylsulfonyl-N-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]benzamideIC501.2 [1], 1000.0 [2]
1-(4-Methylsulfonylphenyl)-1-[[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]methyl]-3-propan-2-ylureaIC500.1 [1], 100.0 [2]
3-(6-(2-(Methylsulfonyl)propan-2-yl)quinolin-8-yl)-N-phenylbenzamideIC505.9 [1], 7000.0 [2]
[4-[3-[(4-Phenylpyridazino[4,5-b]indolizin-1-yl)amino]propyl]piperazin-1-yl]-pyrazin-2-ylmethanoneIC506700.0 [1]
[4-[3-[(4-Phenylpyridazino[4,5-b]indolizin-1-yl)amino]propyl]piperazin-1-yl]-pyrazin-2-ylmethanoneKi41.0 [1]
[4-[3-[[4-(3-Nitrophenyl)pyridazino[4,5-b]indolizin-1-yl]amino]propyl]piperazin-1-yl]-pyrazin-2-ylmethanoneIC50389.0 [1]
[4-[3-[[4-(3-Nitrophenyl)pyridazino[4,5-b]indolizin-1-yl]amino]propyl]piperazin-1-yl]-pyrazin-2-ylmethanoneKi5.6 [1]
4-Phenyl-N-[3-(4-pyrimidin-2-ylpiperazin-1-yl)propyl]pyridazino[4,5-b]indolizin-1-amineIC5013200.0 [1]
4-Phenyl-N-[3-(4-pyrimidin-2-ylpiperazin-1-yl)propyl]pyridazino[4,5-b]indolizin-1-amineKi2600.0 [1]
2-[3-[4-[[(3R,5S)-3,5-Dimethylpiperazin-1-yl]methyl]-2-(morpholin-4-ylmethyl)phenyl]phenoxy]-5-fluoro-N-[4-[(2-hydroxy-5-methylbenzoyl)amino]cyclohexyl]pyridine-3-carboxamideIC500.02 [1], 10.0 [2]
N-[4-[[2-[3-[4-[[(3R,5S)-3,5-Dimethylpiperazin-1-yl]methyl]-2-(morpholin-4-ylmethyl)phenyl]phenoxy]-5-fluoropyridine-3-carbonyl]amino]cyclohexyl]-4-methyl-1,3-thiazole-2-carboxamideIC500.03 [1], 10.0 [2]
4-[3-(3-Chlorophenyl)-7-methoxy-2,4-dioxopyrimido[5,4-c]quinolin-1-yl]cyclohexane-1-carboxylic acidIC5017.0 [1]
3-Benzo[1,3]dioxol-5-yl-1-cyclopentyl-7-methoxy-1H-pyrimido[5,4-c]quinoline-2,4-dioneIC50513.0 [1]
3-(3-Chlorophenyl)-7-methoxy-1-(1-methylsulfonylpiperidin-4-yl)pyrimido[5,4-c]quinoline-2,4-dioneIC5068.0 [1]
1-Cyclopentyl-3-ethyl-7-propylpyrimido[5,4-c]quinoline-2,4-dioneIC5025000.0 [1]
3-(3-Chlorophenyl)-7-methoxy-1-[(3S)-1-methylsulfonylpyrrolidin-3-yl]pyrimido[5,4-c]quinoline-2,4-dioneIC5080.0 [1]
1-Cyclopentyl-3-ethyl-7-propan-2-ylpyrimido[5,4-c]quinoline-2,4-dioneIC5012400.0 [1]
1-Cyclopentyl-7-methoxy-3-m-tolyl-1H-pyrimido[5,4-c]quinoline-2,4-dioneIC5078.0 [1]
3-(3-Chlorophenyl)-1-(1-ethylsulfonylpiperidin-4-yl)-7-methoxypyrimido[5,4-c]quinoline-2,4-dioneIC5026.0 [1]
3-(3-Chlorophenyl)-7-methoxy-1-[1-(methylsulfonylmethylsulfonyl)piperidin-4-yl]pyrimido[5,4-c]quinoline-2,4-dioneIC5039.0 [1]
1-Cyclopentyl-7-methoxy-3-(4-methyl-thiophen-2-yl)-1H-pyrimido[5,4-c]quinoline-2,4-dioneIC50126.0 [1]
7-Chloro-1-cyclopentyl-3-ethylpyrimido[5,4-c]quinoline-2,4-dioneIC5017000.0 [1]
N-[4-[3-(3-Chlorophenyl)-7-methoxy-2,4-dioxopyrimido[5,4-c]quinolin-1-yl]cyclohexyl]methanesulfonamideIC5025.0 [1]
TheophyllineIC50200000.0 [1]
PentoxifyllineIC5090000.0 [1]
TadalafilIC5050000.0 [1]
ZaprinastKi50000.0 [1]
4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinoneKi1930.0 [1]
ApremilastIC5030.0 [1]
2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamideIC50200000.0 [1]
I-Bet151 (gsk1210151A)IC503981.07 [1]
ZardaverineIC501410.0 [1]
4-(2-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-phenylethyl)pyridineIC501.4 [1]
4,5-Dihydro-6-(4-(imidazol-1-yl)phenyl)-5-methyl-3(2H)-pyridazinoneKi50000.0 [1]
1(2H)-PhthalazinoneIC50520.0 [1]
Moracin MIC504500.0 [1]
CartazolateIC50199.53 [1]
Moracin CIC5018100.0 [1]
N-(3,5-Dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline carboxamideIC5060.0 [1]
(2S,3R)-3-(6-Amino-9H-purin-9-yl)nonan-2-olIC5016000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Phosphodiesterase 4B Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/phosphodiesterase-4b-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Phosphodiesterase 4B Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/phosphodiesterase-4b-inhibitors-ic50-ki.
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