![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_fe3f92a2cc3d499742993c6ba3abb5e6.svg) | Rolipram | IC50 | 741.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_fe3f92a2cc3d499742993c6ba3abb5e6.svg) | Rolipram | Ki | 220.0 [1], 221.0 [2], 223.87 [3], 1470.0 [4] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_f279a08ed16335ac7dd922ae328f130a.svg) | Roflumilast | IC50 | 0.8 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_f279a08ed16335ac7dd922ae328f130a.svg) | Roflumilast | Ki | 0.4 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_fac02fc38056dabaf3130f9076a3bc63.svg) | Cilomilast | IC50 | 84.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_eb9db9b84b76fbcd81744f1acddb03dc.svg) | Piclamilast | IC50 | 0.04 [1], 0.2 [2], 1.0 [3], 2.0 [4], 3.0 [5] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_1b6f778cc12dda22e42b17d5f7c22c74.svg) | (R)-(-)-Rolipram | IC50 | 39.81 [1], 231.0 [2], 500.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_ceed4606a126c6936b5413cbcaf96d6c.svg) | N,N,2-Trimethyl-5-nitrobenzenesulfonamide | IC50 | 1800.0 [1], 175000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_602ffc7429097215cfe38917d302d660.svg) | Unii-G6gso9sdnj | IC50 | 0.5 [1], 1.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_067164b5a89130aff2fd4c3a9b657b19.svg) | 4-(3,4-Dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one | IC50 | 520.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_a8cc40c95c0baa0b0f176da302f94815.svg) | 4-[8-(2,1,3-Benzoxadiazol-5-yl)-1,7-naphthyridin-6-yl]benzoic acid | IC50 | 34.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_f621063a1617175052e1f5733ae65ba0.svg) | 3-[7-Methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-4-yl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one | IC50 | 42.0 [1], 70.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_e08e3d5d067ce17bc18c4729515013a5.svg) | (4As,8aR)-2-cycloheptyl-4-[4-methoxy-3-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4a,5,8,8a-tetrahydrophthalazin-1-one | IC50 | 0.5 [1], 0.63 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_e08e3d5d067ce17bc18c4729515013a5.svg) | (4As,8aR)-2-cycloheptyl-4-[4-methoxy-3-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4a,5,8,8a-tetrahydrophthalazin-1-one | Ki | 0.63 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_fac222a9fee62d9cda063e5aabf1d4d4.svg) | 3-Isobutyl-1-methylxanthine | IC50 | 28200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_652ebcef50c758c7dd332e47ddf02915.svg) | Ibudilast | IC50 | 65.0 [1], 5000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_9c107458ca6d84cb77af3513ad77addc.svg) | Crisaborole | IC50 | 55.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_65c0e65a1b27b73b491025c3edd44ba1.svg) | 6-(3-(Dimethylcarbamoyl)phenylsulfonyl)-4-(3-methoxyphenylamino)-8-methylquinoline-3-carboxamide | IC50 | 0.01 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_572f212f3affa282b0780fd20872a3e8.svg) | 2-[5-[(1S)-1-[3-Cyclopropyloxy-4-(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-3-yl)ethyl]-1,3-thiazol-2-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol | IC50 | 0.4 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_70e4a8e98b0d02a4f2bb3e840c510bf7.svg) | 3-(2,5-Dimethoxyphenyl)-6-[4-methoxy-3-[(3R)-oxolan-3-yl]oxyphenyl]-[1,2,4]triazolo[4,3-b]pyridazine | IC50 | 2.9 [1], 4.1 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_775ff73a0dc923c8eec91b9d44cc6c8b.svg) | 3-(2,5-Dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine | IC50 | 37.2 [1], 48.2 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_1ae816ca0c0208caeefd6eaba9f52d62.svg) | (4-{[2-(5-Chlorothiophen-2-Yl)-5-Ethyl-6-Methylpyrimidin-4-Yl]amino}phenyl)acetic Acid | IC50 | 15.0 [1], 55.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_d689ac000771bea7b6124d8a43d0149b.svg) | 8-(3-Methoxyphenyl)-6-(pyridin-4-ylmethyl)quinoline | IC50 | 2.3 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_6308ef17a405a850942df0c7b06f9fc1.svg) | 4-[(3-Methoxyphenyl)amino]-6-(methylsulfonyl)quinoline-3-carboxamide | IC50 | 3.98 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_0fcedd3b090b43c0caddb60028dc6a1b.svg) | 6-(Benzenesulfonyl)-4-(3-methoxyanilino)quinoline-3-carboxamide | IC50 | 1.58 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_4ead754e9371dfaffaa94d7bba2d24f3.svg) | 2-(Cyclopentylamino)-3-ethylthieno[3,2-d]pyrimidin-4-one | IC50 | 4900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_2fdc9b5d6ccaa41b23b1f6a64aa62940.svg) | (5Z)-5-[(3-Cyclopentyloxy-4-methoxyphenyl)methylidene]-2-imino-1,3-thiazolidin-4-one | IC50 | 310.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_399ef5df1234505feb4468ccd770da0a.svg) | 3-(2,5-Dimethoxyphenyl)-6-[4-methoxy-3-[(3R)-oxolan-3-yl]oxyphenyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine | IC50 | 1.6 [1], 2.3 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_6b16a27a7ee123eb9aa21ef4af22323b.svg) | 5-(3-(Cyclopentyloxy)-4-methoxybenzylidene)-2-thioxothiazolidin-4-one | IC50 | 890.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_0fb17b7f358c04f4ec242fd88f8b8e45.svg) | 1-(2-Hydroxyethyl)-3-(2-methylbutan-2-yl)-5-[4-(2-methylimidazol-1-yl)phenyl]-6,7-dihydropyrazolo[4,3-e][1,4]diazepin-8-one | IC50 | 378.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_ad800cceaf0975cfdaeb903bf2028dec.svg) | 2-[4-[(2-Phenyl-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl]acetic acid | IC50 | 29.0 [1], 210.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_86d54748b1ae55fc03564da4556cfb73.svg) | 2-[4-[(5,5-Dioxo-2-phenyl-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl]acetic acid | IC50 | 25.0 [1], 150.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_bcd39e39f02a90e09cda851eb634e354.svg) | 3-Tert-butyl-1-(2-hydroxyethyl)-5-[4-methoxy-3-(2-methoxypyrimidin-5-yl)phenyl]-6,7-dihydropyrazolo[4,3-e][1,4]diazepin-8-one | IC50 | 562.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_a15575ea816b962c9b838c512863340a.svg) | N-Butyl-2-[4-[(5,5-dioxo-2-phenyl-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl]acetamide | IC50 | 22.0 [1], 70.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_e69bbb58878494180d8c4afc17c22c6b.svg) | 4-[8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl]cyclohexane-1-carboxylic Acid | IC50 | 34.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_f82c213b05bcb1622442798a96b4f5e6.svg) | N-((3-(6-(2-Cyanopropan-2-yl)quinolin-8-yl)phenyl)methyl)-N-(4-(methylsulfonyl)phenyl)benzamide | IC50 | 0.1 [1], 80.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_9d04e01dccf44aca7774114cd8b6c982.svg) | N-(4-Methylsulfonylphenyl)-N-[1-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]ethyl]cyclopropanecarboxamide | IC50 | 0.6 [1], 800.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_ce4947a63ffd2b64dc5d55a520fa8952.svg) | 1-[[3-[6-(2-Cyanopropan-2-yl)quinolin-8-yl]phenyl]methyl]-1-(4-methylsulfonylphenyl)-3-propan-2-ylurea | IC50 | 0.1 [1], 140.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_c003ca03db7ace1925a26cf62dd18f1a.svg) | N-(4-Methylsulfonylphenyl)-N-[1-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]ethyl]pyridine-3-carboxamide | IC50 | 0.7 [1], 210.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_72d16e5346cebbc0b3c8c13dc90f78fd.svg) | Isopropyl (3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phenyl)methyl(4-(methylsulfonyl)phenyl)carbamate | IC50 | 0.3 [1], 80.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_a92549dd7655b28dd1a2d4566a6db601.svg) | 2-[8-[3-[[N-[(4-Fluorophenyl)methyl]-4-methylsulfonylanilino]methyl]phenyl]quinolin-6-yl]-2-methylpropanenitrile | IC50 | 0.1 [1], 1800.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_20e1b0f1b3e58bcb95b7f5462528937a.svg) | N-[[3-[6-(2-Cyanopropan-2-yl)quinolin-8-yl]phenyl]methyl]-5-methyl-N-(4-methylsulfonylphenyl)-1,2-oxazole-3-carboxamide | IC50 | 0.1 [1], 30.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_4c9562ad159ff74722234db2315b0492.svg) | 1-[[2-Fluoro-5-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]methyl]-1-(4-methylsulfonylphenyl)-3-propan-2-ylurea | IC50 | 0.3 [1], 50.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_b469fa7163768b448045d697469683f2.svg) | 4-Fluoro-N-(4-methylsulfonylphenyl)-N-[1-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]ethyl]benzamide | IC50 | 0.6 [1], 560.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_030239d5064a2362a06f49abfe170c2f.svg) | N-(4-Methylsulfonylphenyl)-N-[1-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]ethyl]acetamide | IC50 | 4.2 [1], 2000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_93c1638f9f58d4702854a65cc65d815f.svg) | 1-((3-(6-(2-Cyanopropan-2-yl)quinolin-8-yl)phenyl)methyl)-1-(4-(methylsulfonyl)phenyl)-3-phenylurea | IC50 | 0.03 [1], 40.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_cba85456a1b8e69f53fb9e0cf65f5f5b.svg) | 4-(2-Hydroxypropan-2-yl)-N-(4-methylsulfonylphenyl)-N-[1-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]ethyl]benzamide | IC50 | 0.4 [1], 270.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_876bef1fc523a6ef68923a62d3797c0a.svg) | trans-3-(3-Cyclopentoxy-4-methoxyphenyl)-1-methoxycarbonyl-4-(methylcarbonyl)pyrrolidine | IC50 | 320.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_876bef1fc523a6ef68923a62d3797c0a.svg) | trans-3-(3-Cyclopentoxy-4-methoxyphenyl)-1-methoxycarbonyl-4-(methylcarbonyl)pyrrolidine | Ki | 30.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_7ada7dcb8eb122bbf91b2742db032c87.svg) | N-(3,4-Dimethoxyphenyl)-4-morpholin-4-yl-2-(trifluoromethyl)pyrimidine-5-carboxamide | IC50 | 67.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_2d371d2ac82dbb8b04876f7c8ef06705.svg) | 4-(3,4-Dimethoxyphenyl)-N-pyridin-4-yl-2-(trifluoromethyl)pyrimidine-5-carboxamide | IC50 | 15.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_820259189058ec5fc02d28629dabb212.svg) | N-(3,5-Dichloropyridin-4-yl)-4-(3,4-dimethoxyphenyl)-2-(trifluoromethyl)pyrimidine-5-carboxamide | IC50 | 44.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_087dacaf18ff8812f7647fe55e39d69a.svg) | N-(3,4-Dimethoxyphenyl)-2-methylsulfanyl-4-morpholin-4-ylpyrimidine-5-carboxamide | IC50 | 31.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_fa19a91b9f8f810b93917d9b2caeb1ef.svg) | N-[2-(3,4-Dimethoxyphenyl)ethyl]-2-methylsulfanyl-4-morpholin-4-ylpyrimidine-5-carboxamide | IC50 | 61.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_d96e87b02f8c9adef2f0f370df042903.svg) | (R)-2-(4-Fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)nicotinamide | IC50 | 185.0 [1], 925.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_117a66e573e57e5753e12c4d2d9a25c0.svg) | 3-(6-(2-(Methylsulfonyl)propan-2-yl)quinolin-8-yl)-N-(pyridin-4-yl)benzamide | IC50 | 0.9 [1], 200.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_3cc606a36be78b58820611c1cc234354.svg) | 1-[[2-Chloro-5-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]methyl]-1-(4-methylsulfonylphenyl)-3-propan-2-ylurea | IC50 | 4.4 [1], 4000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_8a463abe519bbbec431c714a20a32ed1.svg) | 1-(4-Methylsulfonylphenyl)-1-[1-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]ethyl]-3-propan-2-ylurea | IC50 | 0.7 [1], 400.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_0fe06fdb335ca44a887d4105f910a47a.svg) | N-(3,5-Dichloropyridin-4-yl)-3-(6-(2-(methylsulfonyl)propan-2-yl)quinolin-8-yl)benzamide | IC50 | 0.4 [1], 90.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_571e60509311e2a4713c81e22d06d2ce.svg) | N-(4-(Methylsulfonyl)phenyl)-3-(6-(2-(methylsulfonyl)propan-2-yl)quinolin-8-yl)benzamide | IC50 | 0.5 [1], 140.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_ba0d0e3da4f2d1b135da8a86c92e6548.svg) | 4-Methylsulfonyl-N-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]benzamide | IC50 | 1.2 [1], 1000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_f59ac409f82cff9c7fdd617dc6d19dc5.svg) | 1-(4-Methylsulfonylphenyl)-1-[[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]methyl]-3-propan-2-ylurea | IC50 | 0.1 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_8a8d9d839e7089beb0d641caf5172ff8.svg) | 3-(6-(2-(Methylsulfonyl)propan-2-yl)quinolin-8-yl)-N-phenylbenzamide | IC50 | 5.9 [1], 7000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_af352b0fdadaffcf78e886a9909b33df.svg) | [4-[3-[(4-Phenylpyridazino[4,5-b]indolizin-1-yl)amino]propyl]piperazin-1-yl]-pyrazin-2-ylmethanone | IC50 | 6700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_af352b0fdadaffcf78e886a9909b33df.svg) | [4-[3-[(4-Phenylpyridazino[4,5-b]indolizin-1-yl)amino]propyl]piperazin-1-yl]-pyrazin-2-ylmethanone | Ki | 41.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_e3c29e20a5b2628a41776e9d92871fce.svg) | [4-[3-[[4-(3-Nitrophenyl)pyridazino[4,5-b]indolizin-1-yl]amino]propyl]piperazin-1-yl]-pyrazin-2-ylmethanone | IC50 | 389.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_e3c29e20a5b2628a41776e9d92871fce.svg) | [4-[3-[[4-(3-Nitrophenyl)pyridazino[4,5-b]indolizin-1-yl]amino]propyl]piperazin-1-yl]-pyrazin-2-ylmethanone | Ki | 5.6 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_75098f2c6f5f2c1417b08774971dd6c3.svg) | 4-Phenyl-N-[3-(4-pyrimidin-2-ylpiperazin-1-yl)propyl]pyridazino[4,5-b]indolizin-1-amine | IC50 | 13200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_75098f2c6f5f2c1417b08774971dd6c3.svg) | 4-Phenyl-N-[3-(4-pyrimidin-2-ylpiperazin-1-yl)propyl]pyridazino[4,5-b]indolizin-1-amine | Ki | 2600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_2bb6aef0e7aec77d0d840f315167b5e0.svg) | 2-[3-[4-[[(3R,5S)-3,5-Dimethylpiperazin-1-yl]methyl]-2-(morpholin-4-ylmethyl)phenyl]phenoxy]-5-fluoro-N-[4-[(2-hydroxy-5-methylbenzoyl)amino]cyclohexyl]pyridine-3-carboxamide | IC50 | 0.02 [1], 10.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_692e799b6f2cbb355054a5e4e4476963.svg) | N-[4-[[2-[3-[4-[[(3R,5S)-3,5-Dimethylpiperazin-1-yl]methyl]-2-(morpholin-4-ylmethyl)phenyl]phenoxy]-5-fluoropyridine-3-carbonyl]amino]cyclohexyl]-4-methyl-1,3-thiazole-2-carboxamide | IC50 | 0.03 [1], 10.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_7e9d1b6ac6d6b13ee52e80df5a58b0cd.svg) | 4-[3-(3-Chlorophenyl)-7-methoxy-2,4-dioxopyrimido[5,4-c]quinolin-1-yl]cyclohexane-1-carboxylic acid | IC50 | 17.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_efb3dd439dc7e8227b1e5e16e4918d9c.svg) | 3-Benzo[1,3]dioxol-5-yl-1-cyclopentyl-7-methoxy-1H-pyrimido[5,4-c]quinoline-2,4-dione | IC50 | 513.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_e070f56d99b0c360fb44f58b684bf4fa.svg) | 3-(3-Chlorophenyl)-7-methoxy-1-(1-methylsulfonylpiperidin-4-yl)pyrimido[5,4-c]quinoline-2,4-dione | IC50 | 68.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_eb7c14c951adfc421f823d2374e57eb9.svg) | 1-Cyclopentyl-3-ethyl-7-propylpyrimido[5,4-c]quinoline-2,4-dione | IC50 | 25000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_0973f019fbe735aaa012e98545a9e8c5.svg) | 3-(3-Chlorophenyl)-7-methoxy-1-[(3S)-1-methylsulfonylpyrrolidin-3-yl]pyrimido[5,4-c]quinoline-2,4-dione | IC50 | 80.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_2bac1b542fa516319543b1780a5c09ab.svg) | 1-Cyclopentyl-3-ethyl-7-propan-2-ylpyrimido[5,4-c]quinoline-2,4-dione | IC50 | 12400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_0f9a7015812faf9fbb57e6ce842b26b5.svg) | 1-Cyclopentyl-7-methoxy-3-m-tolyl-1H-pyrimido[5,4-c]quinoline-2,4-dione | IC50 | 78.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_41b988e386de0353cf38d30df2f02799.svg) | 3-(3-Chlorophenyl)-1-(1-ethylsulfonylpiperidin-4-yl)-7-methoxypyrimido[5,4-c]quinoline-2,4-dione | IC50 | 26.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_5eb162b4eb9fd558c0b544daf4a2d68a.svg) | 3-(3-Chlorophenyl)-7-methoxy-1-[1-(methylsulfonylmethylsulfonyl)piperidin-4-yl]pyrimido[5,4-c]quinoline-2,4-dione | IC50 | 39.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_8d690a434b9f74c9d8d754c22df6e88e.svg) | 1-Cyclopentyl-7-methoxy-3-(4-methyl-thiophen-2-yl)-1H-pyrimido[5,4-c]quinoline-2,4-dione | IC50 | 126.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_85ba1034f696a9cb5b9064c610d9fc8d.svg) | 7-Chloro-1-cyclopentyl-3-ethylpyrimido[5,4-c]quinoline-2,4-dione | IC50 | 17000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_160ab916bab2ddf396cd5a0cf96de333.svg) | N-[4-[3-(3-Chlorophenyl)-7-methoxy-2,4-dioxopyrimido[5,4-c]quinolin-1-yl]cyclohexyl]methanesulfonamide | IC50 | 25.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_29f872b26cb31380c7e625ee9fa67f34.svg) | Theophylline | IC50 | 200000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_a521c39bf58f8faba04fbd5657cd5b12.svg) | Pentoxifylline | IC50 | 90000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_4a2f7aa95b8e5fa8d1122874409c701a.svg) | Tadalafil | IC50 | 50000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_f2c1c04ef0787963213517a6b0b2b31c.svg) | Zaprinast | Ki | 50000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_995eee843180fa94f19222bf69596b41.svg) | 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone | Ki | 1930.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_cf710614f005b90650d73f93df7f32d4.svg) | Apremilast | IC50 | 30.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_4c05926d5ee65b1a2488e4715d630b32.svg) | 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide | IC50 | 200000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_9f19db9cc81ca0167ba33b930365fd0f.svg) | I-Bet151 (gsk1210151A) | IC50 | 3981.07 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_b12e5f0bc97c098ef64ad34f70617967.svg) | Zardaverine | IC50 | 1410.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_498600de77801844019dd25a5605e657.svg) | 4-(2-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-phenylethyl)pyridine | IC50 | 1.4 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_3f42d5e14336d453141c46493d827f47.svg) | 4,5-Dihydro-6-(4-(imidazol-1-yl)phenyl)-5-methyl-3(2H)-pyridazinone | Ki | 50000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_33b7625540204277f96d1ca71fd5b9aa.svg) | 1(2H)-Phthalazinone | IC50 | 520.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_8cca9e4d06aa1ff65012531f8a6b3dcf.svg) | Moracin M | IC50 | 4500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_8fd78d25f623b2b5d44aa638f3a00e81.svg) | Cartazolate | IC50 | 199.53 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_b942b67851a5c47a73c616c1c844ed0a.svg) | Moracin C | IC50 | 18100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_3e0d14e80d459fe9df62dcc4d0d02418.svg) | N-(3,5-Dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline carboxamide | IC50 | 60.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-4b_7ad97befb4c1dd57e9f2fd44275c5b12.svg) | (2S,3R)-3-(6-Amino-9H-purin-9-yl)nonan-2-ol | IC50 | 16000.0 [1] |