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Phosphodiesterase 4 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
RolipramIC50860.0 [1]
RolipramKi4.5 [1]
PiclamilastIC501.0 [1]
PiclamilastKi0.85 [1], 1.0 [2], 1.5 [3]
CilomilastIC50100.0 [1]
CilomilastKi38.0 [1]
SildenafilIC508300.0 [1]
5-Cyclopentyloxy-1-(3,5-dichloropyridin-4-ylmethyl)-6-methoxy-phthalazineIC5052.48 [1], 53.0 [2]
5-Cyclopentyloxy-1-(3,5-dichloropyridin-4-ylmethyl)-6-methoxy-phthalazineKi149.0 [1]
4-(2-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-phenylethyl)pyridineIC5019.95 [1]
4-(2-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-phenylethyl)pyridineKi60.0 [1]
TheophyllineIC5081000.0 [1], 1780000.0 [2]
TheophyllineKi56800.0 [1]
AmrinoneIC5041000.0 [1], 101000.0 [2], 126000.0 [3], 150000.0 [4]
(R)-(-)-RolipramIC5050.12 [1], 300.0 [2], 1400.0 [3]
Unii-G6gso9sdnjIC500.16 [1], 1.0 [2], 11.0 [3], 160.0 [4]
CID 10125445IC50794.33 [1]
CID 10125445Ki5011.87 [1]
1-(3,5-Dichloro-pyridin-4-ylmethyl)-6-methoxy-4-[1,2,4]triazol-1-yl-phthalazineIC50239.88 [1], 241.0 [2]
1-(3,5-Dichloro-pyridin-4-ylmethyl)-6-methoxy-4-[1,2,4]triazol-1-yl-phthalazineKi383.0 [1]
(5-Cyclopentyloxy-6-methoxy-phthalazin-1-yl)-(3,5-dichloro-pyridin-4-yl)-amineIC5058.88 [1], 59.0 [2]
(5-Cyclopentyloxy-6-methoxy-phthalazin-1-yl)-(3,5-dichloro-pyridin-4-yl)-amineKi95.0 [1]
8-Cyclopentyloxy-4-[(3,5-dichloropyridin-4-yl)methyl]-7-methoxy-2-methylsulfonyl-1H-phthalazineIC502.0 [1]
8-Cyclopentyloxy-4-[(3,5-dichloropyridin-4-yl)methyl]-7-methoxy-2-methylsulfonyl-1H-phthalazineKi5.0 [1]
(3Ar,6aS)-5-cyano-5-(3-cyclopentyloxy-4-methoxyphenyl)-2,3,3a,4,6,6a-hexahydro-1H-pentalene-2-carboxylic acidIC509.0 [1], 150.0 [2], 300.0 [3]
1-(Cyclohexylmethyl)-N-(3,5-dichloropyridin-4-yl)-3-methylindole-6-carboxamideIC50100.0 [1]
1-(Cyclohexylmethyl)-N-(3,5-dichloropyridin-4-yl)-3-methylindole-6-carboxamideKi120.0 [1]
1-Benzyl-N-(3,5-dichloropyridin-4-yl)-3-methylindole-6-carboxamideIC5018.0 [1]
1-Benzyl-N-(3,5-dichloropyridin-4-yl)-3-methylindole-6-carboxamideKi135.0 [1]
1-(3,5-Dichloro-pyridin-4-ylmethyl)-6-methoxy-4-phenoxy-phthalazineIC50131.83 [1], 132.0 [2]
1-(3,5-Dichloro-pyridin-4-ylmethyl)-6-methoxy-4-phenoxy-phthalazineKi436.0 [1]
1-(3,5-Dichloro-pyridin-4-ylmethyl)-4-ethynyl-6-methoxy-phthalazineIC5093.0 [1], 93.33 [2]
1-(3,5-Dichloro-pyridin-4-ylmethyl)-4-ethynyl-6-methoxy-phthalazineKi204.0 [1]
1-(3,5-Dichloro-4-pyridinylmethyl)-5-(5-phenylpentyl)-6-methoxyphthalazineIC5030.0 [1], 30.2 [2]
1-(3,5-Dichloro-4-pyridinylmethyl)-5-(5-phenylpentyl)-6-methoxyphthalazineKi320.0 [1]
Ethyl 2-[4-[(3,5-dichloropyridin-4-yl)methyl]-7-methoxy-1H-phthalazin-2-yl]-2-oxoacetateIC50112.2 [1], 113.0 [2]
Ethyl 2-[4-[(3,5-dichloropyridin-4-yl)methyl]-7-methoxy-1H-phthalazin-2-yl]-2-oxoacetateKi212.0 [1]
1-(3,5-Dichloro-4-pyridinylmethyl)-5-(5-phenyl-1-pentynyl)-6-methoxyphthalazineIC5010.0 [1]
1-(3,5-Dichloro-4-pyridinylmethyl)-5-(5-phenyl-1-pentynyl)-6-methoxyphthalazineKi71.0 [1]
1-(3,5-Dichloro-4-pyridinylmethyl)-3-acetyl-6-methoxy-3,4-dihydrophthalazineIC5051.0 [1], 51.29 [2]
1-(3,5-Dichloro-4-pyridinylmethyl)-3-acetyl-6-methoxy-3,4-dihydrophthalazineKi397.0 [1]
1-(3,5-Dichloro-4-pyridinylmethyl)-5-(5-phenyl-1-pentenyl)-6-methoxyphthalazineIC5019.0 [1], 19.05 [2]
1-(3,5-Dichloro-4-pyridinylmethyl)-5-(5-phenyl-1-pentenyl)-6-methoxyphthalazineKi164.0 [1]
1-(3,5-Dichloropyridin-4-ylmethyl)-6-methoxy-4-pyrrolidin-1-yl-phthalazineIC5038.0 [1], 38.02 [2]
1-(3,5-Dichloropyridin-4-ylmethyl)-6-methoxy-4-pyrrolidin-1-yl-phthalazineKi89.0 [1]
5-Cyclopentyloxy-1-[(3,5-dichloropyridin-4-yl)methyl]-6-methoxy-3-oxidophthalazin-3-iumIC5041.69 [1], 42.0 [2]
5-Cyclopentyloxy-1-[(3,5-dichloropyridin-4-yl)methyl]-6-methoxy-3-oxidophthalazin-3-iumKi121.0 [1]
4-[(3,5-Dichloropyridin-4-yl)methyl]-7-methoxy-N-methyl-1H-phthalazine-2-carboxamideIC50131.0 [1], 131.83 [2]
4-[(3,5-Dichloropyridin-4-yl)methyl]-7-methoxy-N-methyl-1H-phthalazine-2-carboxamideKi235.0 [1]
1-(3,5-Dichloro-4-pyridinylmethyl)-6-methoxy-3,4-dihydrophthalazine-3-carboxamideIC5036.0 [1], 36.31 [2]
1-(3,5-Dichloro-4-pyridinylmethyl)-6-methoxy-3,4-dihydrophthalazine-3-carboxamideKi63.0 [1]
4-[(3,5-Dichloropyridin-4-yl)methyl]-N-hydroxy-7-methoxy-1H-phthalazine-2-carboxamideIC5085.0 [1], 85.11 [2]
4-[(3,5-Dichloropyridin-4-yl)methyl]-N-hydroxy-7-methoxy-1H-phthalazine-2-carboxamideKi208.0 [1]
1-(3,5-Dichloro-4-pyridinylmethyl)-3-acetyl-5-(cyclopentyloxy)-6-methoxy-3,4-dihydrophthalazineIC5030.0 [1], 30.2 [2]
1-(3,5-Dichloro-4-pyridinylmethyl)-3-acetyl-5-(cyclopentyloxy)-6-methoxy-3,4-dihydrophthalazineKi128.0 [1]
2-[4-[(3,5-Dichloro-1-oxidopyridin-1-ium-4-yl)methyl]-7-methoxyphthalazin-1-yl]-1,3-thiazoleIC503.98 [1], 4.0 [2]
2-[4-[(3,5-Dichloro-1-oxidopyridin-1-ium-4-yl)methyl]-7-methoxyphthalazin-1-yl]-1,3-thiazoleKi17.0 [1]
4-[(3,5-Dichloropyridin-4-yl)methyl]-7-methoxy-2-methylsulfonyl-1H-phthalazineIC5020.89 [1], 21.0 [2]
4-[(3,5-Dichloropyridin-4-yl)methyl]-7-methoxy-2-methylsulfonyl-1H-phthalazineKi60.0 [1]
1-(3,5-Dichloro-4-pyridylmethyl)-4-(2-thiazolyl)-6-methoxyphthalazineIC5014.0 [1], 14.13 [2]
1-(3,5-Dichloro-4-pyridylmethyl)-4-(2-thiazolyl)-6-methoxyphthalazineKi34.0 [1]
1-(3,5-Dichloro-4-pyridinylmethyl)-5-(cyclopentyloxy)-6-(difluoromethoxy)phthalazineIC5038.9 [1], 39.0 [2]
1-(3,5-Dichloro-4-pyridinylmethyl)-5-(cyclopentyloxy)-6-(difluoromethoxy)phthalazineKi46.0 [1]
1-(3,5-Dichloro-4-pyridinylmethyl)-5-(5-phenylpentoxy)-6-methoxyphthalazineIC5056.23 [1], 57.0 [2]
1-(3,5-Dichloro-4-pyridinylmethyl)-5-(5-phenylpentoxy)-6-methoxyphthalazineKi13.0 [1]
1-[4-(3,5-Dichloro-pyridin-4-ylmethyl)-7-methoxy-1H-phthalazin-2-yl]-2-methyl-propan-1-oneIC5025.0 [1], 25.12 [2]
1-[4-(3,5-Dichloro-pyridin-4-ylmethyl)-7-methoxy-1H-phthalazin-2-yl]-2-methyl-propan-1-oneKi498.0 [1]
1-(3,5-Dichloro-4-pyridinylmethyl)-5-(indan-2-yloxy)-6-methoxyphthalazineIC5030.0 [1], 30.2 [2]
1-(3,5-Dichloro-4-pyridinylmethyl)-5-(indan-2-yloxy)-6-methoxyphthalazineKi16.0 [1]
1-[4-(3,5-Dichloro-pyridin-4-ylmethyl)-7-methoxy-1H-phthalazin-2-yl]-propan-1-oneIC5028.0 [1], 28.18 [2]
1-[4-(3,5-Dichloro-pyridin-4-ylmethyl)-7-methoxy-1H-phthalazin-2-yl]-propan-1-oneKi237.0 [1]
1-(3,5-Dichloro-4-pyridylmethyl)-4-morpholino-6-methoxyphthalazineIC50131.83 [1], 132.0 [2]
1-(3,5-Dichloro-4-pyridylmethyl)-4-morpholino-6-methoxyphthalazineKi452.0 [1]
4-(3,5-Dichloro-pyridin-4-ylmethyl)-7-methoxy-1H-phthalazine-2-carboxylic acid methyl esterIC5072.0 [1], 72.44 [2]
4-(3,5-Dichloro-pyridin-4-ylmethyl)-7-methoxy-1H-phthalazine-2-carboxylic acid methyl esterKi199.0 [1]
1-(3,5-Dichloro-4-pyridinylmethyl)-4-phenyl-6-methoxyphthalazineIC5037.0 [1], 37.15 [2]
1-(3,5-Dichloro-4-pyridinylmethyl)-4-phenyl-6-methoxyphthalazineKi271.0 [1]
2-[4-[2,3-Bis(hydroxymethyl)-6,7-dimethoxynaphthalen-1-yl]pyridin-2-yl]-4-pyridin-3-ylphthalazin-1-oneIC500.63 [1], 0.7 [2]
2-[4-[2,3-Bis(hydroxymethyl)-6,7-dimethoxynaphthalen-1-yl]pyridin-2-yl]-4-pyridin-3-ylphthalazin-1-oneKi3.5 [1]
TadalafilIC509200.0 [1], 10000.0 [2]
ZaprinastIC5010000.0 [1], 53000.0 [2]
EnoximoneIC502900.0 [1], 5000.0 [2], 150000.0 [3]
RoflumilastIC500.3 [1], 0.8 [2]
ZardaverineIC50158.49 [1], 800.0 [2]
DenbufyllineIC500.17 [1], 170.0 [2]
DenbufyllineKi44900.0 [1]
N-(3,5-Dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline carboxamideIC5059.98 [1], 60.0 [2]
N-(3,5-Dichloropyridin-4-yl)-8-methoxy-2-(trifluoromethyl)quinoline-5-carboxamideIC5051.0 [1], 51.05 [2]
CI-1018IC501100.0 [1], 1140.0 [2]
1-(3,5-Dichloro-4-pyridinylmethyl)-3-benzoyl-6-methoxy-3,4-dihydrophthalazineIC5030.0 [1], 30.2 [2]
1-(3,5-Dichloro-4-pyridinylmethyl)-6-methoxy-7-(cyclopentyloxy)phthalazineIC50186.0 [1], 186.21 [2]
2-[4-[3-(Hydroxymethyl)-6,7-dimethoxynaphthalen-1-yl]pyridin-2-yl]-4-pyridin-3-ylphthalazin-1-one;hydrochlorideIC500.7 [1]
2-[4-[3-(Hydroxymethyl)-6,7-dimethoxynaphthalen-1-yl]pyridin-2-yl]-4-pyridin-3-ylphthalazin-1-one;hydrochlorideKi3.0 [1]
2-Acetyl-N-(3,5-dichloropyridin-4-yl)-7-methoxy-1-benzofuran-4-carboxamideIC501.0 [1], 1.6 [2]
1-(3,5-Dichloro-4-pyridinylmethyl)-3-(phenylacetyl)-6-methoxy-3,4-dihydrophthalazineIC5012.0 [1], 12.02 [2]
1-(3,5-Dichloro-4-pyridinylmethyl)-4-(phenylethynyl)-6-methoxyphthalazineIC5047.86 [1], 48.0 [2]
BcampIC507700.0 [1], 40000.0 [2]
VardenafilIC503800.0 [1], 4500.0 [2]
8-(4-Chlorophenylthio)-cAMPIC5022000.0 [1], 200000.0 [2]
4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinoneIC504800.0 [1], 26000.0 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Phosphodiesterase 4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/phosphodiesterase-4-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Phosphodiesterase 4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/phosphodiesterase-4-inhibitors-ic50-ki.
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