| Tadalafil | IC50 | 10000.0 [1], 50000.0 [2] |
| Papaverine | IC50 | 1030.0 [1] |
| Papaverine | Ki | 417.0 [1] |
| Vesnarinone | IC50 | 13200.0 [1], 14540.0 [2] |
| Cilostamide | IC50 | 18.0 [1], 69.07 [2] |
| 6,7-Dimethoxy-4-[(3R)-3-(quinoxalin-2-yloxy)pyrrolidin-1-yl]quinazoline | Ki | 273.0 [1] |
| 6,7-Dimethoxy-4-[(3r)-3-(2-Naphthyloxy)pyrrolidin-1-Yl]quinazoline | Ki | 463.0 [1] |
| 6,7-Dimethoxy-4-[(3R)-3-[2-(trifluoromethyl)phenoxy]pyrrolidin-1-yl]quinazoline | Ki | 100.0 [1] |
| 6,7-Dimethoxy-4-[(3R)-3-(2-methoxyphenoxy)pyrrolidin-1-yl]quinazoline | Ki | 100.0 [1] |
| 2-{[(3R)-1-(6,7-Dimethoxyquinazolin-4-yl)pyrrolidin-3-yl]oxy}benzonitrile | Ki | 100.0 [1] |
| 4-[(3R)-3-(4-Ethoxyphenoxy)pyrrolidin-1-yl]-6,7-dimethoxyquinazoline | Ki | 328.0 [1] |
| 6,7-Dimethoxy-4-[(3R)-3-(3-phenylphenoxy)pyrrolidin-1-yl]quinazoline | Ki | 280.0 [1] |
| (R)-4-[3-(Indan-5-yloxy)-pyrrolidin-1-yl]-6,7-dimethoxy-quinazoline | Ki | 237.0 [1] |
| (R)-4-[3-(5-Chloro-pyrimidin-2-yloxy)-pyrrolidin-1-yl]-6,7-dimethoxy-quinazoline | Ki | 332.0 [1] |
| 6,7-Dimethoxy-4-[(3R)-3-(pyridin-2-yloxy)pyrrolidin-1-yl]quinazoline | Ki | 207.0 [1] |
| 6,7-Dimethoxy-4-[(3R)-3-(pyridin-4-yloxy)pyrrolidin-1-yl]quinazoline | Ki | 685.0 [1] |
| 6,7-Dimethoxy-4-[(3R)-3-(naphthalen-1-yloxy)pyrrolidin-1-yl]quinazoline | Ki | 56.0 [1] |
| 6,7-Dimethoxy-4-[(3R)-3-[(7-methoxynaphthalen-2-yl)oxy]pyrrolidin-1-yl]quinazoline | Ki | 305.0 [1] |
| 6,7-Dimethoxy-4-[(3R)-3-[(2-methylquinolin-6-yl)oxy]pyrrolidin-1-yl]quinazoline | Ki | 223.0 [1] |
| 4-[(3R)-3-(Isoquinolin-3-yloxy)pyrrolidin-1-yl]-6,7-dimethoxyquinazoline | Ki | 196.0 [1] |
| (R)-6,7-Dimethoxy-4-(3-o-tolyloxy-pyrrolidin-1-yl)-quinazoline | Ki | 100.0 [1] |
| 4-[(3R)-3-(2-Chlorophenoxy)pyrrolidin-1-yl]-6,7-dimethoxyquinazoline | Ki | 100.0 [1] |
| 4-{[(3R)-1-(6,7-Dimethoxyquinazolin-4-yl)pyrrolidin-3-yl]oxy}benzonitrile | Ki | 471.0 [1] |
| 4-[(3R)-3-(4-Tert-butylphenoxy)pyrrolidin-1-yl]-6,7-dimethoxyquinazoline | Ki | 1890.0 [1] |
| 4-[(3R)-3-(3-Ethoxyphenoxy)pyrrolidin-1-yl]-6,7-dimethoxyquinazoline | Ki | 88.0 [1] |
| 4-[(3R)-3-(3,4-Dimethoxyphenoxy)pyrrolidin-1-yl]-6,7-dimethoxyquinazoline | Ki | 260.0 [1] |
| 6,7-Dimethoxy-4-[(3R)-3-(pyridin-3-yloxy)pyrrolidin-1-yl]quinazoline | Ki | 748.0 [1] |
| 6,7-Dimethoxy-4-[(3R)-3-[(6-methoxynaphthalen-2-yl)oxy]pyrrolidin-1-yl]quinazoline | Ki | 280.0 [1] |
| 6,7-Dimethoxy-4-[(3R)-3-(quinolin-6-yloxy)pyrrolidin-1-yl]quinazoline | Ki | 201.0 [1] |
| 6,7-Dimethoxy-4-[(3R)-3-(quinolin-7-yloxy)pyrrolidin-1-yl]quinazoline | Ki | 240.0 [1] |
| (2R,8R)-2-(2,4-Dichlorophenyl)-6-ethyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione | IC50 | 50000.0 [1] |
| (10R,15S)-10-(2,4-Dichlorophenyl)-13-ethyl-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione | IC50 | 50000.0 [1] |
| (10R,15R)-10-(2,4-Dichlorophenyl)-13-ethyl-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione | IC50 | 50000.0 [1] |
| Milrinone | IC50 | 280.0 [1] |
| 2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol | IC50 | 5360.0 [1] |
| (R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone | IC50 | 37.0 [1] |
| 3-(2,5-Dimethoxyphenyl)-6-[4-methoxy-3-[(3R)-oxolan-3-yl]oxyphenyl]-[1,2,4]triazolo[4,3-b]pyridazine | IC50 | 2300.0 [1] |
| 3-(2,5-Dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine | IC50 | 720.0 [1] |
| 6-{(1S)-1-[6-(1-Methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl}quinoline | IC50 | 150.0 [1] |
| 3-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 2000.0 [1] |
| 3-[(4-Hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 2000.0 [1] |
| 7-(6-Methoxypyridin-3-yl)-3-(2-morpholin-4-ylethylamino)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 2000.0 [1] |
| 4-[[1-(2-Chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine | IC50 | 10000.0 [1] |
| 3-(2,5-Dimethoxyphenyl)-6-[4-methoxy-3-[(3R)-oxolan-3-yl]oxyphenyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine | IC50 | 4600.0 [1] |
| 1-(5-Butoxypyridin-3-Yl)-4-Methyl-8-(Morpholin-4-Ylmethyl)[1,2,4]triazolo[4,3-A]quinoxaline | IC50 | 10000.0 [1] |
| Pde2/pde10-IN-1 | IC50 | 10000.0 [1] |
| (11R,15S)-5-Anilino-4-[[4-(6-fluoropyridin-2-yl)phenyl]methyl]-8-methyl-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-one;phosphoric acid | Ki | 3100.0 [1] |
| CID 73211886 | IC50 | 24000.0 [1] |
| (4R)-3-[4-[(2-Benzyl-3-oxocyclohexen-1-yl)amino]phenyl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one | IC50 | 0.19 [1] |
| 3-[[2-[4-(4,4-Dimethyl-5-oxo-1H-pyrazol-3-yl)-2,3-difluoroanilino]-6-oxocyclohexen-1-yl]methyl]benzonitrile | IC50 | 0.33 [1] |
| 3-[2-Fluoro-4-[[2-[(3-nitrophenyl)methyl]-3-oxocyclohexen-1-yl]amino]phenyl]-4,4-dimethyl-1H-pyrazol-5-one | IC50 | 4.5 [1] |
| 3-{4-[(2-Benzyl-3-oxocyclohex-1-en-1-yl)amino]phenyl}-4,4-dimethyl-4,5-dihydro-1H-pyrazol-5-one | IC50 | 10.0 [1] |
| 3-[4-[(2-Benzyl-3-oxocyclohexen-1-yl)amino]-2-fluorophenyl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one | IC50 | 0.24 [1] |
| 4-Methoxy-2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline | IC50 | 3850.0 [1] |
| 3-[4-[[2-[(2,6-Dichlorophenyl)methyl]-3-oxocyclohexen-1-yl]amino]-2-fluorophenyl]-4,4-dimethyl-1H-pyrazol-5-one | IC50 | 0.13 [1] |
| 6-Fluoro-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline | IC50 | 23900.0 [1] |
| 1-[5-(6,7-Dimethoxycinnolin-4-yl)-3-methylpyridin-2-yl]-4-(6-fluoropyridin-3-yl)piperidin-4-ol | IC50 | 6540.0 [1] |
| (1-Methylbenzimidazol-2-yl)-[4-(3-pyridin-3-ylpyridin-2-yl)oxyphenyl]methanone | IC50 | 234000.0 [1] |
| (11R,15S)-5-Anilino-8-methyl-4-[(4-pyridin-2-ylphenyl)methyl]-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-one | Ki | 1200.0 [1] |
| (11R,15S)-5-Anilino-8-methyl-4-[(4-phenylphenyl)methyl]-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-one | Ki | 1500.0 [1] |
| (11R,15S)-5-Anilino-8-methyl-4-[[4-(trifluoromethyl)phenyl]methyl]-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-one | Ki | 30000.0 [1] |
| (11R,15S)-5-Anilino-8-methyl-4-[[6-(trifluoromethyl)pyridin-3-yl]methyl]-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-one | Ki | 42000.0 [1] |
| 4-(4-Methylphenyl)-2-[4-(2H-tetrazol-5-yl)pyrazol-1-yl]-1,3-thiazole | IC50 | 16720.0 [1] |
| 4-(3-Chlorophenyl)-2-[4-(2H-tetrazol-5-yl)pyrazol-1-yl]-1,3-thiazole | IC50 | 5010.0 [1] |
| 4-(4-Chlorophenyl)-2-[4-(2H-tetrazol-5-yl)pyrazol-1-yl]-1,3-thiazole | IC50 | 3830.0 [1] |
| 4-(2-Chlorophenyl)-2-[4-(2H-tetrazol-5-yl)pyrazol-1-yl]-1,3-thiazole | IC50 | 5920.0 [1] |
| 5-[1-[4-(4-Fluorophenyl)-2-thiazolyl]-1H-pyrazole-4-yl]-1H-tetrazole | IC50 | 2340.0 [1] |
| 4-(3-Fluorophenyl)-2-[4-(2H-tetrazol-5-yl)pyrazol-1-yl]-1,3-thiazole | IC50 | 4650.0 [1] |
| 4-(2-Fluorophenyl)-2-[4-(2H-tetrazol-5-yl)pyrazol-1-yl]-1,3-thiazole | IC50 | 4720.0 [1] |
| 4-(4-Nitrophenyl)-2-[4-(2H-tetrazol-5-yl)pyrazol-1-yl]-1,3-thiazole | IC50 | 7270.0 [1] |
| 4-(3-Nitrophenyl)-2-[4-(2H-tetrazol-5-yl)pyrazol-1-yl]-1,3-thiazole | IC50 | 8540.0 [1] |
| 4-(2-Nitrophenyl)-2-[4-(2H-tetrazol-5-yl)pyrazol-1-yl]-1,3-thiazole | IC50 | 10210.0 [1] |
| 4-(3-Methylphenyl)-2-[4-(2H-tetrazol-5-yl)pyrazol-1-yl]-1,3-thiazole | IC50 | 14490.0 [1] |
| 4-(2-Methylphenyl)-2-[4-(2H-tetrazol-5-yl)pyrazol-1-yl]-1,3-thiazole | IC50 | 16620.0 [1] |
| 4-(4-Methoxyphenyl)-2-[4-(2H-tetrazol-5-yl)pyrazol-1-yl]-1,3-thiazole | IC50 | 25620.0 [1] |
| 4-(3-Methoxyphenyl)-2-[4-(2H-tetrazol-5-yl)pyrazol-1-yl]-1,3-thiazole | IC50 | 25110.0 [1] |
| 4-(2-Methoxyphenyl)-2-[4-(2H-tetrazol-5-yl)pyrazol-1-yl]-1,3-thiazole | IC50 | 28020.0 [1] |
| 3-Cyclopentyloxy-4-(difluoromethoxy)-N-[(4-methoxyphenyl)methyl]benzamide | IC50 | 100000.0 [1] |
| 4-Fluoro-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline | IC50 | 103000.0 [1] |
| 4-(Fluoromethyl)-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline | IC50 | 5680.0 [1] |
| 4-(3-Fluoropropyl)-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline | IC50 | 19100.0 [1] |
| 4-(2-Fluoroethoxy)-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline | IC50 | 7760.0 [1] |
| 4-(2-Fluoroethoxymethyl)-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline | IC50 | 4550.0 [1] |
| 4-[2-(2-Fluoroethoxy)ethoxy]-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline | IC50 | 16200.0 [1] |
| 4-[2-[2-(2-Fluoroethoxy)ethoxy]ethoxy]-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline | IC50 | 61900.0 [1] |
| 4-[2-[2-[2-(2-Fluoroethoxy)ethoxy]ethoxy]ethoxy]-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline | IC50 | 29600.0 [1] |
| N-(2-Fluoroethyl)-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinolin-4-amine | IC50 | 3480.0 [1] |
| 4-[4-(2-Fluoroethyl)triazol-1-yl]-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline | IC50 | 3560.0 [1] |
| 3-(2-Fluoroethoxy)-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline | IC50 | 19900.0 [1] |
| 4-(2-Fluoroethoxy)-2-[[4-(2-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline | IC50 | 5610.0 [1] |
| 4-(2-Fluoroethoxymethyl)-2-[[4-(2-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline | IC50 | 1000000.0 [1] |
| 4-[2-(2-Fluoroethoxy)ethoxy]-2-[[4-(2-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline | IC50 | 50100.0 [1] |
| 4-[2-[2-(2-Fluoroethoxy)ethoxy]ethoxy]-2-[[4-(2-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline | IC50 | 51800.0 [1] |
| 4-[2-[2-[2-(2-Fluoroethoxy)ethoxy]ethoxy]ethoxy]-2-[[4-(2-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline | IC50 | 28130.0 [1] |
| N-(2-Fluoroethyl)-2-[[4-(2-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinolin-4-amine | IC50 | 38300.0 [1] |
| 4-[4-(2-Fluoroethyl)triazol-1-yl]-2-[[4-(2-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline | IC50 | 16200.0 [1] |
| 6-Fluoro-2-[[4-(2-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline | IC50 | 151000.0 [1] |
| Benzyl N-[4-(4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl)phenyl]carbamate | IC50 | 1.0 [1] |
| N-(2-Chlorophenyl)-3-cyclopentyloxy-4-(difluoromethoxy)benzamide | IC50 | 100000.0 [1] |
| 3-Cyclopentyloxy-4-(difluoromethoxy)-N-pyridin-3-ylbenzamide | IC50 | 100000.0 [1] |