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Phosphodiesterase 3 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
MilrinoneIC501500.0 [1]
MilrinoneKi150.0 [1]
RolipramIC50100000.0 [1]
RolipramKi200000.0 [1]
ImazodanIC506100.0 [1]
SildenafilIC5010000.0 [1]
AmrinoneIC5046000.0 [1]
4,5-Dihydro-6-(4-(imidazol-1-yl)phenyl)-5-methyl-3(2H)-pyridazinoneIC50600.0 [1]
AnagrelideIC5080.0 [1]
EnoximoneIC503800.0 [1], 14000.0 [2]
SulmazoleIC5050118.72 [1], 150000.0 [2], 500000.0 [3]
CilostamideIC5010.0 [1], 170.0 [2]
CilostamideKi5.0 [1], 20.0 [2]
ZardaverineIC50110.0 [1], 575.44 [2], 630.96 [3]
LixazinoneIC503.0 [1], 10.0 [2], 10.2 [3]
CilostazolIC50190.0 [1], 280.0 [2], 840.0 [3]
ZaprinastIC50100000.0 [1], 133000.0 [2], 660000.0 [3]
CilomilastIC503162.28 [1], 10000.0 [2]
5-[1-(3,4-Dimethoxybenzoyl)-3,4-dihydro-2H-quinolin-6-yl]-6-methyl-3,6-dihydro-1,3,4-thiadiazin-2-oneIC5050.0 [1], 1940.0 [2]
PiroximoneIC508600.0 [1], 100000.0 [2]
1,3-Dihydro-7,8-dimethyl-2H-imidazo(4,5-b)quinolin-2-oneIC5010.0 [1], 13.0 [2]
TetrahydrobenximidazoleIC50110.0 [1], 150.0 [2], 501.19 [3]
TheophyllineIC50240000.0 [1], 360000.0 [2]
TadalafilIC5010000.0 [1]
VardenafilIC50580.0 [1], 2100.0 [2]
IsomazoleIC5031622.78 [1], 42000.0 [2]
2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanolIC501300.0 [1], 7000.0 [2]
IndolidanIC5080.0 [1], 7000.0 [2]
BemoradanIC50300.0 [1]
5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-oneIC50500.0 [1], 100000.0 [2]
2(1H)-Quinolinone, 3,4-dihydro-1-methyl-6-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)-IC50100.0 [1], 120.0 [2]
4-[8-(3-Nitrophenyl)-1,7-naphthyridin-6-yl]benzoic AcidIC5010000.0 [1], 100000.0 [2]
CI-1018IC5035800.0 [1], 100000.0 [2]
6-(4-Imidazol-1-yl-phenyl)-2H-pyridazin-3-oneIC507200.0 [1]
6-[4-(1H-Imidazol-2-yl)-phenyl]-2H-pyridazin-3-oneIC5012000.0 [1]
6-(3-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazin-3-oneIC5040000.0 [1]
6-(4-(1H-Imidazol-1-yl)phenyl)-5-methylpyridazin-3(2H)-oneIC5050000.0 [1]
N-[(11R)-6-Methoxy-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]isoquinoline-3-carboxamideIC5082000.0 [1], 82300.0 [2]
4-Amino-3,5-dichloro-N-[(11R)-6-methyl-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]benzamideIC5010300.0 [1], 17500.0 [2]
N-[(11R)-6-Methyl-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]isoquinoline-3-carboxamideIC50100000.0 [1]
2-Methoxy-N-[(11R)-6-methyl-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]benzamideIC5028800.0 [1], 100000.0 [2]
N-[(11R)-12-Oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]isoquinoline-3-carboxamideIC50100000.0 [1]
N-[(11R)-6-Methoxy-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyridine-4-carboxamideIC5040800.0 [1], 41000.0 [2]
7-Methoxy-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-oneIC501500.0 [1]
4-(2-Oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazolin-7-yloxy)-butyric acidIC5040.0 [1], 280.0 [2]
Ethyl 4-[(2-oxo-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-7-yl)oxy]butanoateIC5070.0 [1], 240.0 [2]
7-Hexoxy-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-oneIC50290.0 [1]
2,4,4a,5-Tetrahydro-7-(1H-imidazol-1-yl)-3H-indeno[1,2-c]pyridazin-3-oneIC501800.0 [1]
2,5-Dihydro-7-(1H-imidazol-1-yl)-3H-indeno[1,2-c]pyridazin-3-oneIC501600.0 [1]
6,7-Dimethoxy-9-(3,4,5-trimethoxy-phenyl)-3H-naphtho[2,3-c]furan-1-oneIC50300.0 [1], 320.0 [2]
4-Methyl-7-(4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl)-1,4-benzoxazin-3-oneIC50300.0 [1]
8-(3-Chlorophenyl)-6-(pyridin-4-ylmethyl)pyrido[2,3-d]pyridazin-5-oneIC505100.0 [1]
[3-Hydroxymethyl-6,7-dimethoxy-1-(3,4,5-trimethoxy-phenyl)-naphthalen-2-yl]-methanolIC50880.0 [1], 900.0 [2]
2-Butyl-4-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methylsulfanyl]quinazolineIC508.0 [1], 8000.0 [2]
4,7-Dimethyl-N-[(11R)-6-methyl-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyrazolo[5,1-c][1,2,4]triazine-3-carboxamideIC50100000.0 [1]
9-[(2-Fluorophenyl)methyl]-N-methylpurin-6-amine;methanesulfonic acidIC50121000.0 [1]
9-[(2-Fluorophenyl)methyl]-N-methylpurin-6-amine;methanesulfonic acidKi35000.0 [1]
Cyclic guanosine monophosphateIC502400.0 [1]
LosartanIC5013000.0 [1]
DipyridamoleIC5043000.0 [1]
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneIC50100000.0 [1]
Losartan potassiumIC5013000.0 [1]
HydroxyhomosildenafilIC5062000.0 [1]
DesmethylsildenafilIC50100000.0 [1]
LevosimendanIC508.0 [1]
SimendanIC501500.0 [1]
Vardenafil hydrochlorideIC50500.0 [1]
4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinoneIC50300000.0 [1]
(2R,3S)-3-(6-Amino-9H-purin-9-yl)nonan-2-olKi200000.0 [1]
PimobendanIC50410.0 [1]
VesnarinoneIC506200.0 [1]
EtazolateKi12000.0 [1]
ProxyphyllineKi1000000.0 [1]
CrisaboroleIC506400.0 [1]
9-BenzyladenineIC50200000.0 [1]
CipargaminIC5010000.0 [1]
QuazinoneIC50240.0 [1]
OxagrelateKi1400.0 [1]
Sodium;1-[4-(1,3-benzodioxol-5-ylmethylamino)-6-chloroquinazolin-2-yl]piperidine-4-carboxylateIC50100000.0 [1]
Sgx-523IC503000.0 [1]
1,5-Dihydro-7-(1-piperidinyl)-imidazo(2,1-b)quinazolin-2(3H)-oneIC50150.0 [1]
1-(3-Chlorophenylamino)-4-phenylphthalazineKi16000.0 [1]
(R)-(-)-RolipramIC503162.28 [1]
Jnj-38877605IC504000.0 [1]
CI-1044IC50100000.0 [1]
Chf-6001IC501000.0 [1]
Methyl 2-(4-aminophenyl)-1-oxo-7-(pyridin-2-ylmethoxy)-4-(3,4,5-trimethoxyphenyl)isoquinoline-3-carboxylate;sulfuric acidIC50100000.0 [1]
1H-Purine-2,6-dione, 3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-, (S)-Ki1200000.0 [1]
(2S,3R)-3-(6-Amino-9H-purin-9-yl)nonan-2-olIC5016000.0 [1]
T 0156 HydrochlorideIC50100000.0 [1]
N-[(11R)-9-(2-Fluorophenyl)-12-oxo-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]-1H-indole-2-carboxamideIC50100000.0 [1]
4-Acetyl-1-methyl-7-(4-pyridyl)-5,6,7,8-tetrahydro-3(2H)-isoquinolinoneIC501500.0 [1]
6-(Pyridin-3-yl)-3,4-dihydroquinolin-2(1H)-oneIC504400.0 [1]
NitraquazoneIC50200000.0 [1]
N-Benzyl-2-phenyl-4-quinazolinamineIC50100000.0 [1]
3,3-Dimethyl-5-(4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl)-1H-indol-2-oneIC5012.59 [1]
6-{(1S)-1-[6-(1-Methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl}quinolineIC50170.0 [1]
N-Benzyl-2-(pyridin-3-yl)quinazolin-4-amineIC50100000.0 [1]
4-Ethyl-1,3-dihydro-5-(4-(2-methyl-1H-imidazol-1-yl)benzoyl)-2H-imidazol-2-oneIC5037000.0 [1]
7-Bromo-3,6-dimethyl-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-oneIC5070.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Phosphodiesterase 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/phosphodiesterase-3-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Phosphodiesterase 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/phosphodiesterase-3-inhibitors-ic50-ki.
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